Hugh J Clarke

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Post-transcriptional control of gene expression during mouse oogenesis
    Hugh J Clarke
    Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, QC, Canada
    Results Probl Cell Differ 55:1-21. 2012
  2. ncbi request reprint The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis
    Patrick Allard
    Department of Biology, McGill University, Montreal, QC, Canada
    Dev Biol 286:195-206. 2005
  3. pmc Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice
    Qin Yang
    Departments of Obstetrics and Gynecology, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 82:123-31. 2010
  4. doi request reprint Regulation of mitochondrial DNA accumulation during oocyte growth and meiotic maturation in the mouse
    Enas Mahrous
    Department of Biology, Centre for the Study of Reproduction, McGill University, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Reproduction 144:177-85. 2012
  5. ncbi request reprint Stem-loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouse
    Daniel R Arnold
    Department of Obstetrics and Gynecology, McGill University, Montreal, Canada
    Dev Biol 313:347-58. 2008
  6. ncbi request reprint Mouse oocytes and early embryos express multiple histone H1 subtypes
    Germaine Fu
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Biol Reprod 68:1569-76. 2003
  7. doi request reprint Maternally encoded stem-loop-binding protein is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways
    Wenling Zhang
    Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada
    Dev Biol 328:140-7. 2009
  8. doi request reprint Follicle-stimulating hormone accelerates mouse oocyte development in vivo
    Isabelle Demeestere
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Biol Reprod 87:3, 1-11. 2012
  9. pmc Uterine Wnt/beta-catenin signaling is required for implantation
    Othman A Mohamed
    Department of Biology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 102:8579-84. 2005
  10. ncbi request reprint Methylation dynamics of imprinted genes in mouse germ cells
    Diana Lucifero
    McGill University Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics, and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada
    Genomics 79:530-8. 2002

Collaborators

Detail Information

Publications13

  1. doi request reprint Post-transcriptional control of gene expression during mouse oogenesis
    Hugh J Clarke
    Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, QC, Canada
    Results Probl Cell Differ 55:1-21. 2012
    ..We close by highlighting areas for future research including the potential key role of small RNAs in regulating gene expression in oocytes...
  2. ncbi request reprint The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis
    Patrick Allard
    Department of Biology, McGill University, Montreal, QC, Canada
    Dev Biol 286:195-206. 2005
    ..These results demonstrate that histone synthesis in immature and maturing oocytes is governed by a translational control mechanism that is directly regulated by changes in the amount of SLBP...
  3. pmc Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice
    Qin Yang
    Departments of Obstetrics and Gynecology, McGill University and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 82:123-31. 2010
    ..These results identify a new role for proteasomal activity in initiating and sustaining translational activation during meiotic maturation...
  4. doi request reprint Regulation of mitochondrial DNA accumulation during oocyte growth and meiotic maturation in the mouse
    Enas Mahrous
    Department of Biology, Centre for the Study of Reproduction, McGill University, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Reproduction 144:177-85. 2012
    ....
  5. ncbi request reprint Stem-loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouse
    Daniel R Arnold
    Department of Obstetrics and Gynecology, McGill University, Montreal, Canada
    Dev Biol 313:347-58. 2008
    ..Thus, SLBP is an essential component of the mechanism by which growing oocytes of the mouse accumulate the histones that support early embryonic development...
  6. ncbi request reprint Mouse oocytes and early embryos express multiple histone H1 subtypes
    Germaine Fu
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Biol Reprod 68:1569-76. 2003
    ....
  7. doi request reprint Maternally encoded stem-loop-binding protein is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways
    Wenling Zhang
    Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada
    Dev Biol 328:140-7. 2009
    ..Thus, the co-ordinated activity of two separately regulated pathways eliminates maternally encoded SLBP from early mouse embryos...
  8. doi request reprint Follicle-stimulating hormone accelerates mouse oocyte development in vivo
    Isabelle Demeestere
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Biol Reprod 87:3, 1-11. 2012
    ..We suggest that FSH may coordinate the development of the germline and somatic compartments of the follicle, ensuring that ovulation releases a developmentally competent egg...
  9. pmc Uterine Wnt/beta-catenin signaling is required for implantation
    Othman A Mohamed
    Department of Biology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 102:8579-84. 2005
    ..Our results demonstrate that the Wnt/beta-catenin signaling pathway plays a central role in coordinating uterus-embryo interactions required for implantation...
  10. ncbi request reprint Methylation dynamics of imprinted genes in mouse germ cells
    Diana Lucifero
    McGill University Montreal Children s Hospital Research Institute and Departments of Pediatrics, Human Genetics, and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada
    Genomics 79:530-8. 2002
    ..These findings raise the possibility that assisted reproductive technologies that involve in vitro maturation of oocytes may result in developmental abnormalities due to incomplete methylation imprints in immature oocytes...
  11. ncbi request reprint Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo
    Patrick Allard
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Cell Sci 115:4577-86. 2002
    ..This distinctive pattern of SLBP expression may be required for accumulation of histone proteins required for sperm chromatin remodelling and assembly of newly synthesized embryonic DNA into chromatin...
  12. doi request reprint Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility
    Nathalie Bedard
    Polypeptide Laboratory, Department of Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 85:594-604. 2011
    ..We demonstrate for the first time, using mouse transgenic approaches, a role for the ubiquitin system in fertilization...
  13. ncbi request reprint The ability to develop an activity that transfers histones onto sperm chromatin is acquired with meiotic competence during oocyte growth
    David W McLay
    Department of Biology, McGill University, Montreal, Canada
    Dev Biol 241:195-206. 2002
    ....