K Cianflone

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Acylation stimulating protein and triacylglycerol synthesis: potential drug targets?
    K Cianflone
    McGill Unit for the Prevention of Cardiovascular Disease, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Pharm Des 9:1397-410. 2003
  2. ncbi request reprint Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 62:567-72. 2005
  3. ncbi request reprint ApoE phenotype influences plasma ASP in hyperapoB subjects
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, H7 30, 687 Pine Ave West, Quebec, Montreal, Canada H3A 1A1
    Atherosclerosis 170:285-91. 2003
  4. ncbi request reprint Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec H3A 1A1, Canada
    J Lipid Res 45:124-31. 2004
  5. ncbi request reprint Critical review of acylation-stimulating protein physiology in humans and rodents
    Katherine Cianflone
    McGill University, Cardiology, H7 30, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Biochim Biophys Acta 1609:127-43. 2003
  6. ncbi request reprint Enhanced dietary fat clearance in postobese women
    M Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Lipid Res 42:571-80. 2001
  7. ncbi request reprint Reduced body weight, adipose tissue, and leptin levels despite increased energy intake in female mice lacking acylation-stimulating protein
    I Murray
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec, Canada
    Endocrinology 141:1041-9. 2000
  8. ncbi request reprint Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents
    J Saleh
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Int J Obes Relat Metab Disord 25:705-13. 2001
  9. ncbi request reprint Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line
    Y Tao
    McGill Unit for the Prevention of Cardiovascular Disease, Royal Victoria Hospital, Montreal, Que, Canada
    Biochim Biophys Acta 1344:221-9. 1997
  10. ncbi request reprint Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period
    J Saleh
    McGill Unit for the Prevention of Cardiovascular Diseases, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Lipid Res 39:884-91. 1998

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Acylation stimulating protein and triacylglycerol synthesis: potential drug targets?
    K Cianflone
    McGill Unit for the Prevention of Cardiovascular Disease, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Pharm Des 9:1397-410. 2003
    ..We propose that interference of the ASP-receptor interaction using an antagonist offers future prospect for an anti-obesity target...
  2. ncbi request reprint Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 62:567-72. 2005
    ..All three adipose tissue secreted factors are involved in fat metabolism, and little is known of the levels in very young children...
  3. ncbi request reprint ApoE phenotype influences plasma ASP in hyperapoB subjects
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, H7 30, 687 Pine Ave West, Quebec, Montreal, Canada H3A 1A1
    Atherosclerosis 170:285-91. 2003
    ..407, P=0.001. These data suggest that apoE phenotype may potentially influence ASP, although primarily in rare apoE phenotypes...
  4. ncbi request reprint Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec H3A 1A1, Canada
    J Lipid Res 45:124-31. 2004
    ..Plasma ASP may be useful as a fasting variable that will provide additional information regarding ppTG and NEFA clearance...
  5. ncbi request reprint Critical review of acylation-stimulating protein physiology in humans and rodents
    Katherine Cianflone
    McGill University, Cardiology, H7 30, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Biochim Biophys Acta 1609:127-43. 2003
    ..The aim of the present review is to provide a comprehensive overview of the recent literature on ASP, with particular emphasis on those studies carried out in rodents and humans...
  6. ncbi request reprint Enhanced dietary fat clearance in postobese women
    M Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Lipid Res 42:571-80. 2001
    ..These findings are compatible with an increased efficiency of dietary fat storage and suggest one possible mechanism for promotion of weight regain in postobese individuals...
  7. ncbi request reprint Reduced body weight, adipose tissue, and leptin levels despite increased energy intake in female mice lacking acylation-stimulating protein
    I Murray
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec, Canada
    Endocrinology 141:1041-9. 2000
    ..Thus, ASP appears to have an important role in the regulation of energy balance in mice...
  8. ncbi request reprint Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents
    J Saleh
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Int J Obes Relat Metab Disord 25:705-13. 2001
    ..We have previously demonstrated that intraperitoneal (i.p.) injection of ASP in C57BL/6J mice accelerated TG clearance following an orally-administered fat load as well as reducing postprandial glucose levels...
  9. ncbi request reprint Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line
    Y Tao
    McGill Unit for the Prevention of Cardiovascular Disease, Royal Victoria Hospital, Montreal, Que, Canada
    Biochim Biophys Acta 1344:221-9. 1997
    ..These results suggest that muscle is also responsive to ASP and that ASP may play a role in glucose metabolism in both muscle and adipose tissue...
  10. ncbi request reprint Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period
    J Saleh
    McGill Unit for the Prevention of Cardiovascular Diseases, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Lipid Res 39:884-91. 1998
    ....
  11. ncbi request reprint Of mice and men (and women) and the acylation-stimulating protein pathway
    A D Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Curr Opin Lipidol 11:291-6. 2000
    ..Accordingly, to understand the impact of any intervention on energy storage and release by adipocytes, the effects of both insulin and ASP must be taken into account...
  12. ncbi request reprint Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice
    I Murray
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada, H3A 1A1 Canada
    J Biol Chem 274:36219-25. 1999
    ..These results demonstrate that ASP plays an important role in adipose tissue metabolism and fat partitioning...
  13. doi request reprint Effect of secretin on preadipocyte, differentiating and mature adipocyte functions
    P Miegueu
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada
    Int J Obes (Lond) 37:366-74. 2013
    ..Several gastrointestinal peptides are now recognized to have target functions beyond the intestinal wall, including effects on adipocytes. Secretin (SEC), one of the first identified, has not been evaluated in this context...
  14. ncbi request reprint Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissue
    R MacLaren
    Experimental Medicine, McGill University Health Centre, Montreal, Canada
    J Lipid Res 49:308-23. 2008
    ..05). Together, microarray and real-time PCR data demonstrate that insulin resistance rather than obesity is associated with altered gene expression of insulin signaling genes, especially in OM adipose tissue...
  15. ncbi request reprint Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice
    Sabina Paglialunga
    Department of Biochemistry, McGill University, Montreal
    Am J Physiol Endocrinol Metab 294:E521-9. 2008
    ..Overall, a reduction/deficiency in ASP is associated with an antiadipogenic state and ASP may provide a target for controlling fat storage...
  16. ncbi request reprint Visfatin expression is hormonally regulated by metabolic and sex hormones in 3T3-L1 pre-adipocytes and adipocytes
    R MacLaren
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Canada
    Diabetes Obes Metab 9:490-7. 2007
    ..The novel adipokine visfatin has 'insulin-mimicking' effects and is increased in models of diet-induced obesity, but factors that regulate visfatin have not been fully elucidated...
  17. ncbi request reprint Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice
    Sabina Paglialunga
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Endocrinol 194:293-304. 2007
    ..05) were significantly increased in C5L2KO mice versus WT (100%). The study shows that in response to reduced TG storage in white adipose tissue, C5L2KO mice have developed a compensatory mechanism of increased muscle fat oxidation...
  18. ncbi request reprint Acylation-stimulating protein precursor proteins in adipose tissue in human obesity
    Zhunan Xia
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada
    Metabolism 52:1360-6. 2003
    ..In males, there is increased expression in OM tissue. In addition, relative OM/SC expression increases with obesity and these changes may contribute to the development of visceral adipose tissue...
  19. doi request reprint Inflammatory markers and adipokines alter adipocyte-derived ASP production through direct and indirect immune interaction
    H Lu
    Centre de Recherche Institut Universitaire de Cardiologie and Pneumologie de Québec, Universite Laval, Quebec, Canada
    Exp Clin Endocrinol Diabetes 121:194-200. 2013
    ..As an adipokine, ASP could constitute a new link between adipocytes and macrophages...
  20. pmc Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity
    I Murray
    Mike Rosenbloom Laboratory for Cardiovascular Research, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Biochem J 342:41-8. 1999
    ..This contrasts markedly with the structure-function studies of C3a where both binding competency and function were dependent on the C-terminal Arg. Thus ASP demonstrates distinct bioactivity...
  21. ncbi request reprint Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance
    I Murray
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada H3A 1A1
    J Lipid Res 40:1671-6. 1999
    ..The data are consistent therefore, with the hypothesis that the ASP pathway is an important physiologic determinant of normal postprandial triglyceride clearance...
  22. pmc Regulation by retinoic acid of acylation-stimulating protein and complement C3 in human adipocytes
    T Scantlebury
    Chemistry and Biochemistry Department, Concordia University, 1455 de Maisonneuve Blvd. Ouest, Montreal, Quebec H3G 1M8, Canada
    Biochem J 356:445-52. 2001
    ..This is the first evidence documenting stimulation by RA of the C3 gene. Thus we propose RA as a novel cellular trigger in chylomicrons that subsequently results in increased ASP production by adipocytes after a meal...
  23. ncbi request reprint Hypertriglyceridemic hyperapob: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus
    A D Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, Room H7.22, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Ann Intern Med 135:447-59. 2001
    ..An understanding of these principles should provide the physician with a more physiologic basis on which to choose appropriate therapy...
  24. ncbi request reprint Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill Univ Health Centre, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec H3A 1A1, Canada
    Am J Physiol Endocrinol Metab 287:E150-9. 2004
    ....
  25. ncbi request reprint Effects on apoB-100 secretion and bile acid synthesis by redirecting cholesterol efflux from HepG2 cells
    Allan D Sniderman
    Mike Rosenbloom Laboratories for Cardiovascular Research, Cardiovascular Genetics Laboratory, McGill University, Montreal, Canada
    J Lipid Res 44:527-32. 2003
    ..They also point to physiologically important, although still only partially understood, metabolic relationships amongst hepatic apoB-100 secretion, cholesterol efflux, and bile acid synthesis...
  26. ncbi request reprint Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 88:1594-602. 2003
    ....
  27. doi request reprint Randomized clinical trial of the impact of insulin therapy on liver function in patients undergoing major liver resection
    M Hassanain
    Department of Surgery, Royal Victoria Hospital, McGill University Health Centre, Canada
    Br J Surg 100:610-8. 2013
    ..This study tested the benefits of a metabolic support protocol based on insulin infusion, for reducing liver dysfunction following hepatic resection...
  28. doi request reprint Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men
    M Faraj
    Unité métabolique, Departement de Nutrition, Faculte de Medecine, Universite de Montreal, 2405, chemin Cote Ste Catherine, Montreal, Quebec, H3T 1A8, Canada
    Diabetes Metab 34:334-42. 2008
    ..Our aim was to examine whether or not acute hyperinsulinaemia and/or hyperglycaemia per se have differential regulation of these hormones in healthy subjects...
  29. ncbi request reprint Regulation of postprandial lipemia: an update on current trends
    Sabina Paglialunga
    McGill University, Department of Biochemistry, Montreal, QC H3G 1Y6, Canada
    Appl Physiol Nutr Metab 32:61-75. 2007
    ....
  30. pmc Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects
    Robin E Maclaren
    Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, Canada
    BMC Med Genomics 3:3. 2010
    ..Subcutaneous (SC) and omental (OM) adipose tissues (n = 21) were analysed by microarray, and biologic pathways in lipid metabolism and inflammation were specifically examined...
  31. ncbi request reprint Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice
    Zhunan Xia
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 277:45874-9. 2002
    ..9 ml/h; ob/ob, 102 +/- 4.5 ml/h; p < 0.01; wild type, 144 +/- 8.9 ml/h). These results suggest that the ASP regulation of energy storage may influence energy expenditure and dynamic metabolic balance...
  32. ncbi request reprint An investigation of hormone and lipid associations after weight loss in women
    Sylvia Santosa
    School of Dietetics and Human Nutrition, McGill University, Montreal, Canada
    J Am Coll Nutr 26:250-8. 2007
    ....
  33. ncbi request reprint Acylation-stimulating protein (ASP)/complement C3adesArg deficiency results in increased energy expenditure in mice
    Zhunan Xia
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal H3A 1A1, Canada
    J Biol Chem 279:4051-7. 2004
    ..These results suggest that ASP deficiency results in energy repartitioning through different mechanisms in male and female mice...
  34. pmc Acylation stimulating protein reduction precedes insulin sensitization after BPD-DS bariatric surgery in severely obese women
    M N Munkonda
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Nutr Diabetes 2:e41. 2012
    ..351, P<0.001).Conclusion:Acute postoperative decreases in ASP are associated with early improvement of insulin resistance/diabetes after BPD-DS surgery...
  35. ncbi request reprint Lipids and vascular disease: what we do and do not know
    A D Sniderman
    Mike Robenbloom Laboratory for Cardiovascular Research, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Clin Chim Acta 286:7-22. 1999
    ..More fundamentally, inadequacies in what has become the traditional approach to characterize risk are becoming increasingly evident. This paper will outline issues that remain unresolved and suggest clinical approaches to deal with them...
  36. doi request reprint Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity
    J Smith
    Institut Universitaire de Cardiologie et Pneumologie de Québec, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 94:4275-83. 2009
    ....
  37. ncbi request reprint Protease inhibitor effects on triglyceride synthesis and adipokine secretion in human omental and subcutaneous adipose tissue
    Katherine Cianflone
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada
    Antivir Ther 11:681-91. 2006
    ....
  38. ncbi request reprint Visfatin concentration in Asian Indians is correlated with high density lipoprotein cholesterol and apolipoprotein A1
    Jessica Smith
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Canada
    Clin Endocrinol (Oxf) 65:667-72. 2006
    ..Visfatin is a recently described adipose tissue derived hormone whose role in humans remains largely unknown...
  39. ncbi request reprint Diabetes, lipids, and adipocyte secretagogues
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada
    Biochem Cell Biol 82:170-90. 2004
    ....
  40. ncbi request reprint Regulation of fatty acid transport
    David Kalant
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Curr Opin Lipidol 15:309-14. 2004
    ..The aim of the present review is to summarize recent developments in the area of regulation of fatty acid transport...
  41. pmc Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
    Olivier Le Bacquer
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 117:387-96. 2007
    ..These data clearly demonstrate the role of 4E-BPs as a metabolic brake in the development of obesity and reinforce the idea that deregulated mTOR signaling is associated with the development of the metabolic syndrome...
  42. ncbi request reprint The ASP receptor C5L2 is regulated by metabolic hormones associated with insulin resistance
    R MacLaren
    Medicine, McGill University Health Center, Montreal, Canada
    Biochem Cell Biol 85:11-21. 2007
    ....
  43. pmc Lipoprotein lipase deficiency is associated with elevated acylation stimulating protein plasma levels
    Sabina Paglialunga
    Biochemistry Department and Faculty of Medicine, McGill University, Montreal, QC, Canada
    J Lipid Res 50:1109-19. 2009
    ..ASP enhances adipose tissue fatty-acid trapping following a meal; however in LPL deficiency, high ASP levels are coupled with delayed lipid clearance...
  44. ncbi request reprint Targeting the signaling pathway of acylation stimulating protein
    Magdalena Maslowska
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Quebec, Canada
    J Lipid Res 47:643-52. 2006
    ..ASP signaling involves sequential activation of PI3K and PLC, with downstream activation of protein kinase C, Akt, MAPK/ERK(1/2), and cPLA(2), all of which leads to an effective and prolonged stimulation of TGS...
  45. ncbi request reprint Acylation-stimulating protein/C5L2-neutralizing antibodies alter triglyceride metabolism in vitro and in vivo
    Wei Cui
    Department of Experimental Medicine, McGill University, Montreal, Canada
    Am J Physiol Endocrinol Metab 293:E1482-91. 2007
    ..4, P < 0.05) and AMPK activity (+53.9%, P < 0.05) in muscle. ASP/C5L2-neutralizing antibodies effectively block ASP-C5L2 interaction, altering lipid distribution and energy utilization...
  46. ncbi request reprint Adipokines and the immune system: an adipocentric view
    Robin MacLaren
    Department of Experimental Medicine, McGill University, Montreal, Canada
    Adv Exp Med Biol 632:1-21. 2008
    ..Both roles remain controversial, and will only be resolved with further studies...
  47. ncbi request reprint ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes
    May Faraj
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Center, Montreal, Canada
    J Lipid Res 45:657-66. 2004
    ....
  48. ncbi request reprint The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
    David Kalant
    Mike Rosenbloom Laboratory for Cardiovascular Research, Division of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 278:11123-9. 2003
    ..Thus C5L2, a promiscuous complement fragment-binding protein with a high affinity site that binds C3a des-Arg(77)/ASP, may mediate the acylation-stimulating properties of this peptide...
  49. doi request reprint Intestinally derived lipids: metabolic regulation and consequences--an overview
    Katherine Cianflone
    Department of Biochemistry, McGill University, Montreal, Canada
    Atheroscler Suppl 9:63-8. 2008
    ..Intestinal, peripheral and hepatic gatekeepers serve important and individual roles in regulating postprandial lipemia and provide potential targets for regulation...
  50. ncbi request reprint C5L2 is a functional receptor for acylation-stimulating protein
    David Kalant
    Mike Rosenbloom Laboratory for Cardiovascular Research, Division of Cardiology, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 280:23936-44. 2005
    ..This is the first demonstration that C5L2 is a functional receptor, mediating ASP triglyceride stimulation...
  51. ncbi request reprint Body composition and the apoB/apoA-I ratio in migrant Asian Indians and white Caucasians in Canada
    Jessica Smith
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Clin Sci (Lond) 111:201-7. 2006
    ..It also relates differences in body fat distribution to differences in the apoB/apoA-I ratio, providing at least part of the answer as to why South Asians may be at increased risk of vascular disease...
  52. ncbi request reprint Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia
    Michel Marcil
    Centre de recherche Hopital Laval, Universite Laval, Y2186, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5
    Arterioscler Thromb Vasc Biol 26:1619-25. 2006
    ..Impaired ASP-mediated triglyceride synthesis has previously been described in a subset of hyperapolipoprotein B/familial combined hyperlipidemia subjects...
  53. ncbi request reprint Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3
    Antonie J van Oostrom
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 79:510-5. 2004
    ..C3 is the central component of the complement system and the precursor of acylation-stimulating protein (ASP). Insulin and ASP are principal determinants of free fatty acid (FFA) trapping by adipose tissue...
  54. doi request reprint Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet
    Christian Roy
    Centre de recherche Hopital Laval, Y 2186, Chemin Ste Foy, QC, Canada
    Am J Physiol Endocrinol Metab 294:E1051-9. 2008
    ..However, these in vivo data suggest that ASP inhibition could be a potentially viable approach in correcting muscle metabolic dysfunction in obesity...
  55. doi request reprint Cord blood ASP is predicted by maternal lipids and correlates with fetal birth weight
    Jumana Saleh
    Department of Biochemistry, Sultan Qaboos University, Muscat, Oman
    Obesity (Silver Spring) 16:1193-8. 2008
    ..The acylation stimulating protein (ASP) is a potent lipogenic adipokine that correlates with postprandial triglyceride (TG) clearance and is linked to the pathophysiology of obesity and related disorders...
  56. doi request reprint Increased plasma acylation-stimulating protein in pediatric proteinuric renal disease
    Jin Hui Tang
    Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Pediatr Nephrol 23:959-64. 2008
    ..05 to p<0.001), and this increase was correlated with changes in lipid parameters (triglycerides and apoA1). In summary, these results demonstrate alterations in C3 and ASP that may contribute to or compensate for dyslipidemia...
  57. ncbi request reprint Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  58. ncbi request reprint Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin
    May Faraj
    Laboratoire des dysfonctions Métabolique, Departement de Nutrition, Faculte de Medicine, Universite de Montreal, 2405 Chemin Cote Ste Catherine, Montreal, Quebec, Canada H3T 1A8
    J Endocrinol 191:427-35. 2006
    ..We hypothesize that insulin-mediated regulation of adiponutrin expression is under the PI3K pathway. The relevance of the present findings to reduced adiponutrin expression in type 2 diabetes is discussed...
  59. ncbi request reprint Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study
    David H St-Pierre
    Departement de Nutrition, Universite de Montreal, Montreal, Quebec, Canada, H3T 1A8
    Eur J Endocrinol 157:419-26. 2007
    ....
  60. ncbi request reprint Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women
    David H St-Pierre
    Departement de Nutrition, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Clin Endocrinol Metab 92:264-9. 2007
    ....
  61. ncbi request reprint Effects of fatty acid regulation on visfatin gene expression in adipocytes
    Yu Wen
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 119:1701-8. 2006
    ....
  62. ncbi request reprint 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
    Magalie Berthiaume
    Faculty of Medicine, Laval Hospital Research Center, Laval Univ, 2725 Ch Sainte Foy, QC, Canada G1V 4G5
    Am J Physiol Endocrinol Metab 293:E1045-52. 2007
    ....
  63. ncbi request reprint Increased plasma acylation-stimulating protein correlates with hyperlipidemia at late gestation
    Jumana Saleh
    Biochemistry Department, Faculty of Medicine, Sultan Qaboos University, P O Box 35, Postal Code 123, Muscat, Oman
    Obesity (Silver Spring) 15:646-52. 2007
    ..The role of ASP during a normal pregnancy is unknown. The objective of this study was to investigate plasma ASP levels in correlation with the lipid profile during late gestation...
  64. ncbi request reprint Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors
    Christian Lemieux
    Laval Hospital Research Center, Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada G1K 7P4
    J Lipid Res 46:1285-94. 2005
    ....
  65. pmc Functional roles for C5a receptors in sepsis
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    Nat Med 14:551-7. 2008
    ..Thus, contrary to earlier speculation, C5l2 is a functional receptor rather than merely a default receptor...
  66. ncbi request reprint Metformin decreases circulating acylation-stimulating protein levels in polycystic ovary syndrome
    Cagatay Oktenli
    Division of Internal Medicine, GATA Haydarpasa Training Hospital, Kadikoy Istanbul, Turkey
    Gynecol Endocrinol 23:710-5. 2007
    ..The present study was designed to determine the ASP levels in PCOS and to evaluate the effect of metformin on plasma fasting ASP concentrations...
  67. ncbi request reprint Relationship between ghrelin and energy expenditure in healthy young women
    David H St-Pierre
    Unité métabolique, Departement de Nutrition, Faculte de Medicine, Universite de Montreal, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 89:5993-7. 2004
    ..Although speculative, serum ghrelin may play a role in the regulation of energy homeostasis by acting as a hormonal marker of increased energy efficiency...
  68. ncbi request reprint Novel roles for acylation stimulating protein/C3adesArg: a review of recent in vitro and in vivo evidence
    Magdalena Maslowska
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Vitam Horm 70:309-32. 2005
    ..Finally, the potential implication of C5L2, the newly discovered ASP receptor, and its expression profile in various tissues are discussed relative to ASP function...
  69. ncbi request reprint Cystatin C, associated with hemorrhagic and ischemic stroke, is a strong predictor of the risk of cardiovascular events and death in Chinese
    Li Ni
    Stroke 38:3287-8. 2007
    ..We investigated the association between cystatin C and first-ever stroke and evaluated the predictive value of cystatin C in cardiovascular events and death from all causes based on the outcomes of a 5-year follow-up...