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Species | Howard ChertkowSummaryAffiliation: McGill University Country: Canada Publications
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Mild cognitive impairmentHoward Chertkow
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Chemin de la Cote St Catherine, Montreal, Quebec, Canada H3T 1E2
Curr Opin Neurol 15:401-7. 2002..New treatments to prevent development of Alzheimer's disease are targeting mild cognitive impairment as a treatment group and neurologists will increasingly be called upon to make this diagnosis...
Dual-tasking and gait in people with mild cognitive impairment. The effect of working memoryManuel Montero-Odasso
Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada
BMC Geriatr 9:41. 2009..In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI...
Multilingualism (but not always bilingualism) delays the onset of Alzheimer disease: evidence from a bilingual communityHoward Chertkow
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, and Jewish General Hospital McGill University Memory Clinic, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Alzheimer Dis Assoc Disord 24:118-25. 2010..In contrast, in nonimmigrants whose first language was English, no such effect was found. These results are discussed in relation to the earlier findings and the theory of cognitive reserve...- Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementiaHoward Chertkow
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Que
CMAJ 178:1273-85. 2008.... - Cognitive neuroscience studies of semantic memory in Alzheimer's diseaseHoward Chertkow
Bloomfield Centre for Research in Aging, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
Prog Brain Res 169:393-407. 2008..AD individuals, who are impaired in a variety of semantic tasks, show functional deficits in this area, and fail to activate it normally... - Diagnosis and treatment of dementia: introduction. Introducing a series based on the Third Canadian Consensus Conference on the Diagnosis and Treatment of DementiaHoward Chertkow
Department of Neurology, McGill University and the Bloomfield Centre for Research in Aging, Lady Davis Institute, Sir Mortimer B. Davis-Jewish General Hospital, , Que
CMAJ 178:316-21. 2008 - Can an 18-point clock-drawing scoring system predict dementia in elderly individuals with mild cognitive impairment?Lennie Babins
Memory Clinic and Department of Clinical Neuroscience, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
J Clin Exp Neuropsychol 30:173-86. 2008..004), all showed significant differences between progressors and nonprogressors. The 18-point clock-drawing scoring system may have advantages in better indicating MCI individuals more likely to progress to dementia... - rCBF to the hippocampal complex covaries with superior semantic memory retrievalChristine Whatmough
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
Behav Brain Res 181:262-9. 2007..In both experiments CBF to the lateral temporal cortex covaried with hippocampal CBF in a way that suggests that the hippocampus provides complementary support to activation within the association cortex... - Selective attention impairments in Alzheimer's disease: evidence for dissociable componentsElise J Levinoff
Bloomfield Centre for Research on Aging, Lady Davis Institute for Medical Research, Montreal, PQ, Canada
Neuropsychology 18:580-8. 2004..These results provide evidence that inhibition is the most strikingly affected aspect of selective attention that is observed to be impaired in early stages of AD... - Can clinical data predict progression to dementia in amnestic mild cognitive impairment?Lesley Fellows
Dept of Neurology and Neurosurgery, Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada
Can J Neurol Sci 35:314-22. 2008..To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment... - Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairmentSylvie Belleville
Research CenterInstitut Universitaire de Geriatrie de Montreal, Montreal, PQ, Canada
Neuropsychology 21:458-69. 2007..These data suggest that control of attention tasks can track AD at a preclinical stage and that impairment increases gradually during the preclinical phase of AD... - Focused attention deficits in patients with Alzheimer's disease and mild cognitive impairmentElise J Levinoff
Department of Neurology and Neurosurgery, McGill University, Montreal, Que, Canada H3T 1E2
Brain Cogn 57:127-30. 2005..The implications of the impairments related to the MCI group could potentially prove useful in early diagnosis of cognitive impairments in the elderly... - The profile of executive functioning in amnestic mild cognitive impairment: disproportionate deficits in inhibitory controlErin K Johns
Department of Psychology Centre for Research in Human Development, Concordia University, Montreal, Quebec
J Int Neuropsychol Soc 18:541-55. 2012.... - Cognitive predictors of donepezil therapy response in Alzheimer diseaseDaniel Saumier
Bloomfield Centre for Research in Aging and Lady Davis Institute, McGill University, Montreal, Que, Canada
Dement Geriatr Cogn Disord 24:28-35. 2007..To examine whether the presence of domain-specific cognitive impairments would predict a response to donepezil medication in patients with mild-to-moderate Alzheimer disease (AD)... - Cognitive estimation impairment in Alzheimer disease and mild cognitive impairmentElise J Levinoff
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Montreal, PQ, Canada
Neuropsychology 20:123-32. 2006..The authors conclude that AD patients display deficits in working memory, semantic memory, and executive function, which are required for adequate CET performance... - The nature of lexico-semantic processing deficits in mild cognitive impairmentAnh Duong
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Canada
Neuropsychologia 44:1928-35. 2006..Findings are discussed in light of executive dysfunctions within the framework of semantic memory theories... - The relation between depressive symptoms and semantic memory in amnestic mild cognitive impairment and in late-life depressionJulie Brunet
Departement de Psychologie, Universite de Montreal, Montreal, Canada
J Int Neuropsychol Soc 17:865-74. 2011..Future studies should aim at clarifying the association between depression and semantic deficits in older adults meeting aMCI criteria. (JINS, 2011, 17, 865-874)... - Executive functions in frontotemporal dementia and Lewy body dementiaErin K Johns
Department of Psychology, Concordia University, Quebec, Canada
Neuropsychology 23:765-77. 2009..Only the Stroop test produced results that could potentially differentiate the patient groups. These findings suggest that both FTD and LBD should be considered disorders involving executive dysfunction... - Increased variability accompanies frontal lobe damage in dementiaSusan Murtha
Bloomfield Centre for Research in Aging, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada
J Int Neuropsychol Soc 8:360-72. 2002..The hypothesis that variability will be increased in frontal lobe dementia is thus confirmed, and the independence of the three forms of variability measurement is demonstrated in dementia subjects... - Mild cognitive impairment subcategories depend on the source of normsGeneviève Arsenault-Lapierre
Bloomfield Centre for Research on Aging, Lady Davis Institute of Medical Research, Sir B Davis Jewish General Hospital, Montreal, QC, Canada
J Clin Exp Neuropsychol 33:596-603. 2011..In general, local norms were more stringent than published norms. We discuss the implications of these results for MCI diagnosis and categorization... - Autobiographical memory in mild cognitive impairment and Alzheimer's disease: a comparison between the Levine and Kopelman interview methodologiesAlexandra Barnabe
Bloomfield Centre for Research on Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada
Hippocampus 22:1809-25. 2012..These data show the importance of technical details of the different tests in favouring one versus another LTM theory. The data are not purely compatible with either theory... - Can you have dementia with an MMSE score of 30?Jonah S Shiroky
Bloomfield Center for Research in Aging, Montreal, Canada
Am J Alzheimers Dis Other Demen 22:406-15. 2007..To investigate the possibility that a patient with a diagnosis oF probable Alzheimer's disease (AD) can still obtain a score oF 30/30 on the Mini-Mental State Exam (MMSE)... - Functional and anatomical memory indices in patients with or at risk for Alzheimer's diseaseNatalie A Phillips
Centre for Research in Human Development Department of Psychology, Concordia University, Montreal, Quebec, Canada
J Int Neuropsychol Soc 10:200-10. 2004..These results support the utility of neuropsychological and neuroanatomical measures in diagnosing dementia and do not support the notion that P300 amplitude is sensitive to mild memory dysfunction when measured using the current task... - A predictive depression pattern in mild cognitive impairmentMichèle Houde
Departement de Psychiatrie, Centre hospitalier de l Universite Laval, Quebec, Canada
Int J Geriatr Psychiatry 23:1028-33. 2008..To evaluate the prognostic utility of the presence, persistence, and patterns of depression in subjects with amnestic Mild Cognitive Impairment (MCI)... - Establishing visual category boundaries between objects: a PET studyDaniel Saumier
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital McGill University, Canada
Brain Cogn 59:299-302. 2005..It is proposed that the functional role of the parietal and frontal cortical regions in establishing visual boundaries between categories of objects may be relevant for understanding object recognition impairments in AD... - A randomized controlled trial of estrogen treatment in men with mild cognitive impairmentBarbara B Sherwin
Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
Neurobiol Aging 32:1808-17. 2011.... - Mild cognitive impairment and cognitive impairment, no dementia: Part B, therapyFadi Massoud
, , , , Montreal, Quebec, Canada
Alzheimers Dement 3:283-91. 2007..Close monitoring and treatment of vascular risk factors are justified and were also supported... - Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's diseaseGeneviève Arsenault-Lapierre
Bloomfield Centre for Research on Aging, Lady Davis Institute for Medical Research, Sir B Mortimer Jewish General Hospital, Montreal, Quebec, Canada
Neurobiol Aging 31:1051-4. 2010..This suggests that controlling for the season of sampling may help elucidate subtle effects of normal and pathological aging on basal cortisol secretion... - Common and constrasting areas of activation for abstract and concrete concepts: an H2 15O PET studyChristine Whatmough
Lady Davis Institutue and McGill University, Montreal, Quebec, Canada
J Cogn Neurosci 16:1211-26. 2004..Increased processing complexity may proceed in a posterior-anterior direction in the lateral temporal cortex... - Imaging biomarkers and their role in dementia clinical trialsHoward Chertkow
Department of Clinical Neuroscience, Sir Mortimer B Davis Jewish General Hospital, Toronto, ON, Canada
Can J Neurol Sci 34:S77-83. 2007..At the present time, however, no single measure has sufficient proven reliability, replicability, or robustness, to replace clinical primary outcome measures... - The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairmentZiad S Nasreddine
Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
J Am Geriatr Soc 53:695-9. 2005..To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia... - Mild cognitive impairmentSerge Gauthier
McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
Lancet 367:1262-70. 2006..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia... - Word-reading thresholds in Alzheimer disease and mild memory loss: a pilot studyFadi Massoud
Division of Geriatric Medicine, , University of Montreal, Montreal, , Canada
Alzheimer Dis Assoc Disord 16:31-9. 2002..CONCLUSION: Word Reading Threshold determination discriminates mild AD subjects from ENC, and correlates with severity of cognitive impairment. It may have diagnostic and prognostic utility in early AD and MCI subjects... - Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCIDaniel Berlin
Blomfield Centre for Research in Aging, Montreal, Que, Canada
Neurobiol Aging 25:465-74. 2004..Recent reports suggest that heterozygosity for the two common hfe mutations responsible for hereditary hemochromatosis (HH) may be a risk factor for AD, possibly by accelerating brain iron accumulation... - Magnetization transfer ratio in mild cognitive impairment and dementia of Alzheimer's typeNoor Jehan Kabani
Bloomfield Centre for Research in Aging, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
Neuroimage 15:604-10. 2002..Furthermore, MTR changes may present a novel MRI measure for the early diagnosis of dementia of Alzheimer's type... - Amnestic MCI future clinical status prediction using baseline MRI featuresSimon Duchesne
Radiology Department, Universite Laval, Quebec, Canada
Neurobiol Aging 31:1606-17. 2010..Prediction using aMCI data reached 81% accuracy, 70% sensitivity and 100% specificity. This automated and objective method has potential in helping predict future clinical status in aMCI... - Increased neural efficiency in the temporal association cortex as the result of semantic task repetitionChristine Whatmough
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
Hum Brain Mapp 29:922-30. 2008..This efficiency is abolished by interruptions such as performing a different task... - Word reading threshold and mild cognitive impairment: a validation studyGeneviève Arsenault-Lapierre
Bloomfield Center for Research on Aging, Lady Davis Institute in Medical Research, Sir Mortimer B, Davis Jewish General Hospital, Montreal, Canada
BMC Geriatr 12:38. 2012..We wish to confirm in a larger group the sensitivity and specificity of the WRT test and determine whether it is influenced by deterioration on other cognitive domains... - Semantic memoryDaniel Saumier
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, and Jewish General Hospital/ McGill University Memory Clinic, McGill University, Montreal, Quebec H3T 1E2, Canada
Curr Neurol Neurosci Rep 2:516-22. 2002.... - Effects of anosognosia on perceived stress and cortisol levels in Alzheimer's diseaseGeneviève Arsenault-Lapierre
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada H3T 1E2
Int J Alzheimers Dis 2012:209570. 2012..However, no correlation between cortisol levels and either anosognosia for dementia or perceived stress was observed. Our results suggest that measuring perceived stress in AD patients may be influenced by anosognosia... - Behavioral and electrical brain measures of semantic priming in patients with Alzheimer's disease: implications for access failure versus deterioration hypothesesSarah Auchterlonie
Department of Psychology, Concordia University, Montreal, Quebec, Canada
Brain Cogn 48:264-7. 2002..In DAT patients, priming for unnamed pictures was heterogeneous. The results are discussed in terms of current hypotheses of semantic memory deficits in DAT... - Semantic category differences in cross-form primingDavid Gold
Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Canada
J Int Neuropsychol Soc 9:796-805. 2003..Results are discussed in the context of theoretical accounts of the category-specific impairments observed in brain-damaged populations... - Olfaction in patients with mild cognitive impairment and Alzheimer's diseaseJelena Djordjevic
Montreal Neurological Institute, 3801 University Street, Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4, Quebec, Canada
Neurobiol Aging 29:693-706. 2008..High detection thresholds, together with impaired identification, may be useful as an early indicator of AD... - Visual retinocortical function in dementia of the Alzheimer typeHélène Kergoat
School of Optometry, University of Montreal, Que, Canada
Gerontology 48:197-203. 2002..Some histological investigations have reported anomalies in the primary visual pathways of individuals with dementia of the Alzheimer type (DAT), while others have suggested that these visual structures are spared by the disease process... - Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4)Serge Gauthier
McGill Center for Studies in Aging, Montreal, QC
Can Geriatr J 15:120-6. 2012.... - A case study of pure word deafness: modularity in auditory processing?Minola Pinard
Department of Clinical Neurosciences, Sir Mortimer Davis Jewish General Hospital and McGill University, Montreal, Canada
Neurocase 8:40-55. 2002..The diagnosis of pure word deafness should not be based on a limited set of auditory stimuli; additionally, a careful assessment using modern audiological techniques should be performed to evaluate peripheral auditory functions... - Diurnal variations in salivary protein carbonyl levels in normal and cognitively impaired human subjectsHaixiang Su
Centre for Neurotranslational Research and Bloomfield Centre for Research in Aging, Lady Davis Institute of Medical Research, Montreal, QC, H3T 1E2, Canada
Age (Dordr) 30:1-9. 2008..Apolipoprotein E varepsilon4 allele carrier status may attenuate this temporal variability in salivary redox homeostasis and thereby impact the natural history of oropharyngeal diseases... - Regional magnetization transfer ratio changes in mild cognitive impairmentNoor Jehan Kabani
Bloomfield Center for Research in Aging, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
Magn Reson Med 47:143-8. 2002..We conclude that changes in MTR have the potential to mark the progression of MCI to DAT, before volumetric changes are detected on conventional MRI scans... - Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementiaDavid B Hogan
Department of Clinical Neurosciences, Health Sciences Centre, University of Calgary, 3330 Hospital Dr NW, Calgary, ABT2N4N1
CMAJ 179:1019-26. 2008.... - Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's diseaseVivek Singh
Sunnybrook and Women's College Health Sciences Centre Ontario, Canada
Brain 129:2885-93. 2006..These novel findings support the notion of increased isocortical involvement with the progression of disease... - Memory for gist and detail information in Alzheimer's disease and mild cognitive impairmentCarol Hudon
Centre de recherche de l Institut universitaire de geriatrie de Montreal, PQ, Canada
Neuropsychology 20:566-77. 2006..The discrepancy in MCI participants might be explained by differences in the degree of sensitivity of the experimental procedures and/or by the differences in the cognitive processes these procedures assessed... - Comprehension of grammatical and emotional prosody is impaired in Alzheimer's diseaseVanessa Taler
Bloomfield Centre for Research in Aging and Centre for Research on Language, Mind and Brain, McGill University
Neuropsychology 22:188-95. 2008..AD participants were at a very mild stage of the disease, suggesting that prosody impairments occur early in the disease course... - Diagnosis and treatment of dementia: 2. DiagnosisHoward H Feldman
Division of Neurology, Department of Medicine, University of British Columbia, and the University of British Columbia Hospital Clinic for Alzheimer s Disease and Related Disorders, Vancouver, BC
CMAJ 178:825-36. 2008..In this article, we provide physicians with practical guidance on the diagnosis of dementia based on recommendations from the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia, held in March 2006... - Task switching capacities in persons with Alzheimer's disease and mild cognitive impairmentSylvie Belleville
Research Center, Institut Universitaire de Geriatrie de Montreal, Canada
Neuropsychologia 46:2225-33. 2008..The pattern across condition is coherent with a continuum between those two clinical groups... - Progress in clinical neurosciences: Canadian guidelines for the development of antidementia therapies: a conceptual summaryHoward H Feldman
Division of Neurology, University of British Columbia, Clinic for Alzheimer's Disease and Related Disorders, Vancouver, BC, Canada
Can J Neurol Sci 33:6-26. 2006..They are intended to provide a common point of reference and guidance in Canada for therapeutic development of the dementias... - Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptomsGlen M Doniger
Department of Clinical Science, NeuroTrax Corporation, New York, New York, USA
Am J Alzheimers Dis Other Demen 21:28-36. 2006..05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression... - The effect of Alzheimer's disease and aging on conceptual combinationVanessa Taler
, Que, Canada H3W 1W5
Brain Cogn 59:306-9. 2005.... - Towards practical cognitive assessment for detection of early dementia: a 30-minute computerized battery discriminates as well as longer testingGlen M Doniger
Department of Clinical Science, NeuroTrax Corporation, New Brunswick, NJ 08901, USA
Curr Alzheimer Res 2:117-24. 2005..54, p<0.001). Hence a reduced NeuroTrax battery (30 minutes) with MCI Score is a useful clinical tool for summarizing cognitive data relevant to early dementia detection... - Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementiaDavid B Hogan
Departments of Medicine and Clinical Neurosciences, University of Calgary, Calgary, Alta
CMAJ 179:787-93. 2008..In this article, we provide practical guidance on management based on recommendations from the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia... - Validity of the Mindstreams computerized cognitive battery for mild cognitive impairmentTzvi Dwolatzky
Memory Disorders Clinic and Department of Geriatrics, Shaare Zedek Medical Center, Jerusalem, Israel
J Mol Neurosci 24:33-44. 2004..Further, the enhanced precision and ease of use of these computerized tests make the NeuroTrax system a valuable clinical tool in the identification of elders at high risk for dementia... - Is mild cognitive impairment a valid target of therapyKenneth Rockwood
Department of Medicine Geriatric Medicine and Neurology, Dalhousie University, Halifax, NS, Canada
Can J Neurol Sci 34:S90-6. 2007..The phenomenon of slowing or non-progression itself should be investigated, and such investigations likely should extend to people now classified as having mild dementia...