J M Brophy

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention
    James M Brophy
    Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec, Canada
    Am Heart J 152:263-9. 2006
  2. ncbi request reprint The epidemiology of acute myocardial infarction and ischemic heart disease in Canada: data from 1976 to 1991
    J M Brophy
    Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
    Can J Cardiol 13:474-8. 1997
  3. ncbi request reprint Public policy and coronary stenting: a different perspective
    J M Brophy
    Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
    Can J Cardiol 14:54-7. 1998
  4. ncbi request reprint Falling hospital mortality for acute myocardial infarction in Quebec hospitals
    J Brophy
    Department of Medicine, Centre Hospitalier, l Université de Montréal, Quebec
    Can J Cardiol 14:1358-62. 1998
  5. ncbi request reprint A multivariate model for predicting mortality in patients with heart failure and systolic dysfunction
    James M Brophy
    Division of Cardiology and Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
    Am J Med 116:300-4. 2004
  6. ncbi request reprint Medical decision making in the choice of a thrombolytic agent for acute myocardial infarction. Quebec Acute Coronary Care Working Group
    J M Brophy
    Department of Medicine of Centre Hospitalier de l Université de Montreal, Quebec, Canada
    Med Decis Making 19:411-8. 1999
  7. ncbi request reprint Beta-blockers in congestive heart failure. A Bayesian meta-analysis
    J M Brophy
    Service de cardiologie, Centre Hospitalier de l Universite de Montreal, Pavillon Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
    Ann Intern Med 134:550-60. 2001
  8. pmc The coronary risk of cyclo-oxygenase-2 inhibitors in patients with a previous myocardial infarction
    J M Brophy
    Department of Epidemiology and Biostatistics, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Heart 93:189-94. 2007
  9. pmc Misplaced pacemaker wire as a cause of mitral regurgitation
    J M Brophy
    Heart 89:246. 2003
  10. doi request reprint Risk of upper gastrointestinal bleeding with oral bisphosphonates and non steroidal anti-inflammatory drugs: a case-control study
    M Etminan
    Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Aliment Pharmacol Ther 29:1188-92. 2009

Detail Information

Publications64

  1. ncbi request reprint A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention
    James M Brophy
    Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec, Canada
    Am Heart J 152:263-9. 2006
    ....
  2. ncbi request reprint The epidemiology of acute myocardial infarction and ischemic heart disease in Canada: data from 1976 to 1991
    J M Brophy
    Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
    Can J Cardiol 13:474-8. 1997
    ..To present national trends in mortality rates for myocardial infarction and cardiovascular disease...
  3. ncbi request reprint Public policy and coronary stenting: a different perspective
    J M Brophy
    Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
    Can J Cardiol 14:54-7. 1998
    ..Further research is required to ascertain fully the safety, efficacy and cost effectiveness of coronary stenting in routine practice before public policy can be formulated sensibly...
  4. ncbi request reprint Falling hospital mortality for acute myocardial infarction in Quebec hospitals
    J Brophy
    Department of Medicine, Centre Hospitalier, l Université de Montréal, Quebec
    Can J Cardiol 14:1358-62. 1998
    ..To present in-hospital mortality trends for acute myocardial infarction (AMI)...
  5. ncbi request reprint A multivariate model for predicting mortality in patients with heart failure and systolic dysfunction
    James M Brophy
    Division of Cardiology and Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
    Am J Med 116:300-4. 2004
    ..Heart failure is a leading cause of morbidity and mortality, but there are no reliable models based on readily available clinical variables to predict outcomes in patients taking angiotensin-converting enzyme (ACE) inhibitors...
  6. ncbi request reprint Medical decision making in the choice of a thrombolytic agent for acute myocardial infarction. Quebec Acute Coronary Care Working Group
    J M Brophy
    Department of Medicine of Centre Hospitalier de l Université de Montreal, Quebec, Canada
    Med Decis Making 19:411-8. 1999
    ..However, they also preferentially treated younger patients, where only a small absolute advantage appears to exist...
  7. ncbi request reprint Beta-blockers in congestive heart failure. A Bayesian meta-analysis
    J M Brophy
    Service de cardiologie, Centre Hospitalier de l Universite de Montreal, Pavillon Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
    Ann Intern Med 134:550-60. 2001
    ..Although several randomized clinical trials have compared beta-blockers with placebo for treatment of congestive heart failure, a meta-analysis quantifying the effect on mortality and morbidity has not been performed recently...
  8. pmc The coronary risk of cyclo-oxygenase-2 inhibitors in patients with a previous myocardial infarction
    J M Brophy
    Department of Epidemiology and Biostatistics, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Heart 93:189-94. 2007
    ....
  9. pmc Misplaced pacemaker wire as a cause of mitral regurgitation
    J M Brophy
    Heart 89:246. 2003
  10. doi request reprint Risk of upper gastrointestinal bleeding with oral bisphosphonates and non steroidal anti-inflammatory drugs: a case-control study
    M Etminan
    Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Aliment Pharmacol Ther 29:1188-92. 2009
    ..Similarly, the risk of UGB among users of both bisphosphonates and non steroidal anti-inflammatory drugs (NSAIDs) in the community is also unknown...
  11. doi request reprint A panel study in congestive heart failure to estimate the short-term effects from personal factors and environmental conditions on oxygen saturation and pulse rate
    M S Goldberg
    Department of Medicine, Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, R4 29, Montreal, Quebec H3A1A1
    Occup Environ Med 65:659-66. 2008
    ..This daily diary panel study in Montreal, Quebec, was carried out to determine whether oxygen saturation and pulse rate were associated with selected personal factors, weather conditions and air pollution...
  12. pmc Treating the right patient at the right time: access to heart failure care
    H Ross
    Department of Medicine, University Health Network, University of Toronto, Toronto, Canada
    Can J Cardiol 22:749-54. 2006
    ....
  13. ncbi request reprint ACE-inhibitor use and the long-term risk of renal failure in diabetes
    S Suissa
    The Department of Epidemiology and Biostatistics, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 429, Montreal, Quebec, Canada H3A 1A1
    Kidney Int 69:913-9. 2006
    ..Our data suggest instead that ACE inhibitors might actually increase this risk, which may possibly contribute to the continued increasing incidence of ESRD owing to diabetes...
  14. ncbi request reprint Use of abciximab (c7E3 Fab, ReoPro) as an adjunct to balloon angioplasty
    M McGregor
    McGill University Health Centre, Montreal, Quebec
    Can J Cardiol 15:201-7. 1999
    ..To estimate the magnitude of the clinical benefits that may result from use of abciximab at the time of angioplasty and the cost of achieving them...
  15. pmc The interpretation of systematic reviews with meta-analyses: an objective or subjective process?
    Ian Shrier
    Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Canada
    BMC Med Inform Decis Mak 8:19. 2008
    ..The objective of this study was to determine the discordance in interpretations when meta-analysts are presented with identical data...
  16. pmc Treating the right patient at the right time: access to specialist consultation and non-invasive testing
    Merril L Knudtson
    Libin Cardiovascular Institute of Alberta
    Can J Cardiol 22:819-24. 2006
    ....
  17. ncbi request reprint The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research Database
    Kristian B Filion
    McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Canada
    Pharmacoepidemiol Drug Saf 16:1-4. 2007
    ..We assessed the impact of this policy change on statin prescribing...
  18. pmc Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding
    Joseph A Delaney
    Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Que
    CMAJ 177:347-51. 2007
    ..We assessed whether antithrombotic drug combinations increased the risk of such bleeding in a general practice population...
  19. pmc The risk of death associated with delayed coronary artery bypass surgery
    Boris G Sobolev
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada
    BMC Health Serv Res 6:85. 2006
    ..Therefore, we sought to improve the estimates of the risk of death associated with delayed surgical treatment of coronary artery disease...
  20. ncbi request reprint Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease
    G B John Mancini
    Division of Cardiology, Vancouver Hospital, Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 47:2554-60. 2006
    ....
  21. pmc Time variations in the risk of myocardial infarction among elderly users of COX-2 inhibitors
    Linda E Levesque
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
    CMAJ 174:1563-9. 2006
    ....
  22. ncbi request reprint Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysis
    Verena Schneider
    Division of Clinical Epidemiology, Royal Victoria Hospital, Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 164:881-9. 2006
    ..54, 95% CI: 1.14, 2.09; test for interaction comparing celecoxib with rofecoxib, p = 0.057). There was a significant association for both selective and nonselective NSAIDs with acute renal failure, but confirmatory studies are required...
  23. pmc The cost-effectiveness of drug-eluting stents: a systematic review
    Suzanne Ligthart
    Department of Medical Technology Assessment, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    CMAJ 176:199-205. 2007
    ..We conducted a systematic review of all published comparative cost-effectiveness analyses to identify the factors contributing to the heterogeneity of their conclusions...
  24. doi request reprint Primary PCI in ST-segment elevation myocardial infarction
    Peter Bogaty
    N Engl J Med 358:1751; author reply 1752-3. 2008
  25. doi request reprint Confounding in database pharmacoepidemiology studies
    Joseph A C Delaney
    Epidemiology 19:360-1. 2008
  26. pmc Resource allocation among cardiovascular specialists and trainees: a pilot survey
    James M Brophy
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Can J Cardiol 24:118-20. 2008
    ..To assess the relative importance that cardiovascular specialists assign to new technologies...
  27. doi request reprint Clinical utility of C-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease. The RISCA (recurrence and inflammation in the acute coronary syndromes) study
    Peter Bogaty
    Quebec Heart Institute Laval Hospital, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 51:2339-46. 2008
    ....
  28. pmc Validity of electron beam computed tomography for coronary artery disease: asystematic review and meta-analysis
    Nandini Dendukuri
    Technology Assessment Unit, McGill University Health Center, 687 Pine Avenue West R4, 09, Montreal, PQ, H3A 1A1 Canada
    BMC Med 5:35. 2007
    ..Our objective was to carry out a systematic review and meta-analysis of EBCT for the screening of asymptomatic patients and the diagnosis of symptomatic patients for CAD...
  29. ncbi request reprint Cardiovascular effects of cyclooxygenase-2 inhibitors
    James M Brophy
    Department of Medicine, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Curr Opin Gastroenterol 23:617-24. 2007
    ..Cardiotoxicity has been an adverse outcome of cyclooxygenase-2 inhibitors and this article will critically review the evidence...
  30. ncbi request reprint Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) and the risk of age-related macular degeneration: nested case-control study
    Mahyar Etminan
    Centre for Clinical Epidemiology and Evaluation, Vancouver General Hospital, 7 Floor 828 West 10 Ave, Vancouver, British Columbia, Canada
    Curr Drug Saf 3:24-6. 2008
    ..We sought to further explore this association and also explore the role of angiotensin-converting enzyme inhibitors (ACE-Is) with respect to the development of AMD...
  31. pmc Pravastatin and cancer: an unproven association
    James M Brophy
    Division of Cardiology, Department of Medicine, McGill University and Université de Montréal, and CHUM MUHC Technology Assessment Unit, Royal Victoria Hospital, Montreal Que
    CMAJ 176:646-7. 2007
  32. pmc Lifestyle variables and the risk of myocardial infarction in the general practice research database
    Joseph A C Delaney
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    BMC Cardiovasc Disord 7:38. 2007
    ..As a secondary objective, we considered the association between other lifestyle variables, smoking and heavy alcohol use, and AMI risk...
  33. ncbi request reprint Do angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers decrease the risk of hospitalization secondary to community-acquired pneumonia? A nested case-control study
    Mahyar Etminan
    Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Pharmacotherapy 26:479-82. 2006
    ..In addition, the putative protection against pneumonia may instead be related to general inhibition of the renin-angiotensin system...
  34. pmc Statin wars following coronary revascularization--evidence-based clinical practice?
    James M Brophy
    Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec
    Can J Cardiol 22:54-8. 2006
    ..Pharmaceutical companies spend enormous amounts of money on both clinical trials and marketing. The relative influence of information from clinical trials on physician prescription patterns for statins is unknown...
  35. ncbi request reprint Medical decision making with incomplete evidence--choosing a platelet glycoprotein IIbIIIa receptor inhibitor for percutaneous coronary interventions
    James M Brophy
    Division of Cardiology, Department of Medicine, and Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
    Med Decis Making 25:222-8. 2005
    ..Substantial cost differentials are also present between the drugs...
  36. ncbi request reprint Evidence for use of coronary stents. A hierarchical bayesian meta-analysis
    James M Brophy
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 138:777-86. 2003
    ....
  37. pmc The dollars and sense of drug-eluting stents
    James M Brophy
    Division of Cardiology and Clinical Epidemiology, McGill University Health Centre Technology Assessment Unit, Royal Victoria Hospital, Montreal, Que
    CMAJ 172:361-2. 2005
  38. ncbi request reprint GRACIA: implications for clinical practice
    Peter Bogaty
    Lancet 365:381; author reply 382. 2005
  39. ncbi request reprint Fluctuating inflammatory markers in patients with stable ischemic heart disease
    Peter Bogaty
    Quebec Heart Institute, Laval Hospital, Laval University, Quebec City, Quebec, Canada
    Arch Intern Med 165:221-6. 2005
    ..However, little is known about how inflammatory markers fluctuate over time in patients with stable ischemic heart disease...
  40. ncbi request reprint Primary angioplasty and thrombolysis are both reasonable options in acute myocardial infarction
    James M Brophy
    Division of Cardiology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Ann Intern Med 141:292-7. 2004
    ..Thrombolysis remains a clinically and economically attractive option for the treatment of acute myocardial infarction that does not require the radical restructuring of our health care systems...
  41. ncbi request reprint A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents
    Mohan N Babapulle
    Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec, Canada
    Lancet 364:583-91. 2004
    ..We undertook a meta-analysis of randomised trials comparing BMS and stents eluting sirolimus or paclitaxel...
  42. ncbi request reprint Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study
    Peter Bogaty
    Quebec Heart Institute Laval Hospital, Laval University, 2725 Chemin Ste Foy, Quebec City, Quebec, Canada G1V 4G5
    Circulation 110:934-9. 2004
    ..We investigated the effect of prolonged COX-2 inhibition on inflammatory profile and endothelial function in patients with ischemic heart disease and high serum C-reactive protein (CRP) values...
  43. pmc The use of cholesterol-lowering medications after coronary revascularization
    James M Brophy
    Department of Medicine, McGill University Health Center, McGill University, Royal Victoria Hospital, Montreal, Que
    CMAJ 169:1153-7. 2003
    ..Whether physicians and patients follow this recommendation is unknown. Our objective was to determine the rate at which patients fill at least one prescription for cholesterol-lowering medications after coronary revascularization...
  44. ncbi request reprint The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults
    Linda E Levesque
    McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Ann Intern Med 142:481-9. 2005
    ..Debate about their cardiac safety has culminated in the recent withdrawal of rofecoxib. Additional studies are needed to better understand this risk and to determine whether this safety concern represents a class effect...
  45. pmc Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review
    Nandini Dendukuri
    Technology Assessment Unit, McGill University Health Centre, McGill University, Montreal, Que
    CMAJ 173:167-70. 2005
    ..We performed a systematic review of randomized controlled trials to assess the effectiveness of probiotic therapy...
  46. ncbi request reprint End-user involvement in health technology assessment (HTA) development: a way to increase impact
    Maurice McGregor
    Department of Medicine, Division of Cardiology, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Int J Technol Assess Health Care 21:263-7. 2005
    ..A mechanism to increase the influence of Health Technology Assessments (HTAs) on hospital policy decisions was developed...
  47. ncbi request reprint The benefit of cholesterol-lowering medications after coronary revascularization: a population study
    James M Brophy
    Department of Medicine, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Am Heart J 150:282-6. 2005
    ..In routine practice, the translation of these benefits to elderly patients with recent coronary revascularization is less well known...
  48. ncbi request reprint Cost-effectiveness of drug-eluting coronary stents in Quebec, Canada
    James M Brophy
    McGill University, Quebec, Canada
    Int J Technol Assess Health Care 21:326-33. 2005
    ..The aim of this investigation was to assess the incremental cost-effectiveness of replacing bare metal coronary stents (BMS) with drug-eluting stents (DES) in the Province of Quebec, Canada...
  49. ncbi request reprint Cardiovascular risk associated with celecoxib
    James M Brophy
    N Engl J Med 352:2648-50; author reply 2648-50. 2005
  50. ncbi request reprint Celecoxib and cardiovascular risks
    James M Brophy
    McGill University Health Centre, Division of Cardiology, Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
    Expert Opin Drug Saf 4:1005-15. 2005
    ..Specific modifying factors of the cardiovascular risk of COX-2 inhibitors including dose, concomitant drugs, individual cardiac and genetic risk profiles, will require further study...
  51. pmc Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial
    Anique Ducharme
    Department of Medicine, Montreal Heart Institute, University of Montreal, Que
    CMAJ 173:40-5. 2005
    ..We sought to determine the impact of care at a multidisciplinary specialized outpatient congestive heart failure clinic compared with standard care...
  52. pmc A meta-analysis of antibiotic use for the secondary prevention of cardiovascular diseases
    Zhi Song
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
    Can J Cardiol 24:391-5. 2008
    ..However, results have occasionally been conflicting, and a meta-analysis may provide additional clarification...
  53. ncbi request reprint Selling safety--lessons from muraglitazar
    James M Brophy
    JAMA 294:2633-5. 2005
  54. pmc Primary angioplasty or thrombolysis? A topical parable
    Peter Bogaty
    Quebec Heart Institute, Laval University, Ste Foy, Quebec, Canada G1V 4G5
    BMJ 328:1257-8. 2004
  55. ncbi request reprint Rehabilitating digoxin
    James M Brophy
    Eur Heart J 27:127-9. 2006
  56. ncbi request reprint Primary data collection in health technology assessment
    Michelle L McIsaac
    McGill University and University of Montreal Health Centres, and Department of Community Health Sciences, University of Calgary, 1403 29 Street NW, Calgary, Alberta, Canada
    Int J Technol Assess Health Care 23:24-9. 2007
    ..The authors conclude that, under specific conditions, primary data collection is a worthwhile endeavor in the HTA process...
  57. ncbi request reprint Use of oral bisphosphonates and the risk of aseptic osteonecrosis: a nested case-control study
    Mahyar Etminan
    Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, BC, Canada
    J Rheumatol 35:691-5. 2008
    ..To determine whether use of oral bisphosphonates is associated with an increased risk of aseptic osteonecrosis (AON) among a cohort of elderly cardiovascular patients...
  58. ncbi request reprint Geographical variations in post myocardial infarction mortality and their impact on risk selection
    Abdelouahed Naslafkih
    Faculty of Graduate Studies, University of Montreal, Montreal, Quebec, Canada
    J Insur Med 36:282-91. 2004
    ..The objective is to assess the impact of geographical variations in mortality on risk selection in patients after acute myocardial infarction...
  59. pmc Vaccination against human papillomavirus
    James M Brophy
    CMAJ 177:1525-6; author reply 1527-8. 2007
  60. pmc Risk stratification following non-ST segment elevation myocardial infarction: is the glass half-full or half-empty?
    James M Brophy
    Can J Cardiol 23:1080-1. 2007
  61. ncbi request reprint Friendly fire and continuing medical education
    James M Brophy
    Can J Cardiol 21:23-4. 2005
  62. pmc Acute ischemic heart disease and interventional cardiology: a time for pause
    Peter Bogaty
    Quebec Heart Institute Laval Hospital, Laval University, 2725 Chemin Ste Foy, Quebec, G1V 4G5, Canada
    BMC Med 4:25. 2006
    ....
  63. ncbi request reprint The cost-effectiveness of stem cell transplantations from unrelated donors in adult patients with acute leukemia
    Vania Costa
    Technology Assessment Unit, McGill University Health Centre, Montreal, QC, Canada
    Value Health 10:247-55. 2007
    ....
  64. pmc Has thrombolysis lost its mojo?
    James M Brophy
    Heart 93:1167-9. 2007