Research Topics
| J M BrophySummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
The interpretation of systematic reviews with meta-analyses: an objective or subjective process?Ian Shrier
Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Canada
BMC Med Inform Decis Mak 8:19. 2008..The objective of this study was to determine the discordance in interpretations when meta-analysts are presented with identical data...
The potential interaction between clopidogrel and proton pump inhibitors: a systematic reviewJoao Paulo de Aquino Lima
Federal University of Ceará School of Medicine, Fortaleza, Brazil
BMC Med 8:81. 2010..In an attempt to clarify the situation, we performed a systematic review with a critical analysis of study methodologies to determine whether varying study quality (that is, bias) could explain the discordant results...
Acute ischemic heart disease and interventional cardiology: a time for pausePeter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, 2725 Chemin Ste Foy, Quebec, G1V 4G5, Canada
BMC Med 4:25. 2006....
Validity of electron beam computed tomography for coronary artery disease: asystematic review and meta-analysisNandini Dendukuri
Technology Assessment Unit, McGill University Health Center, 687 Pine Avenue West R4, 09, Montreal, PQ, H3A 1A1 Canada
BMC Med 5:35. 2007..Our objective was to carry out a systematic review and meta-analysis of EBCT for the screening of asymptomatic patients and the diagnosis of symptomatic patients for CAD...
The risk of death associated with delayed coronary artery bypass surgeryBoris G Sobolev
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada
BMC Health Serv Res 6:85. 2006..Therefore, we sought to improve the estimates of the risk of death associated with delayed surgical treatment of coronary artery disease...
Routine invasive management after fibrinolysis in patients with ST-elevation myocardial infarction: a systematic review of randomized clinical trialsPeter Bogaty
Institut Universitaire de Cardiologie et Pneumologie de Québec, Quebec, Canada
BMC Cardiovasc Disord 11:34. 2011..We sought to examine the randomized clinical trials (RCTs) on which this approach is based...
Lifestyle variables and the risk of myocardial infarction in the general practice research databaseJoseph A C Delaney
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
BMC Cardiovasc Disord 7:38. 2007..As a secondary objective, we considered the association between other lifestyle variables, smoking and heavy alcohol use, and AMI risk...
Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of randomized controlled trialsKristian B Filion
Department of Medicine, McGill University, Montreal, Quebec, Canada
BMC Cardiovasc Disord 10:24. 2010..A meta-analysis of these RCTs to estimate efficacy and safety and potential sources of heterogeneity may be helpful...
Microvolt T-wave alternans as a predictor of mortality and severe arrhythmias in patients with left-ventricular dysfunction: a systematic review and meta-analysisCharlotte J van der Avoort
Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
BMC Cardiovasc Disord 9:5. 2009..Microvolt T-wave alternans (MTWA) has been proposed to assist in this stratification...
Cardiovascular effects of cyclooxygenase-2 inhibitorsJames M Brophy
Department of Medicine, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Curr Opin Gastroenterol 23:617-24. 2007..Cardiotoxicity has been an adverse outcome of cyclooxygenase-2 inhibitors and this article will critically review the evidence...
The coronary risk of cyclo-oxygenase-2 inhibitors in patients with a previous myocardial infarctionJ M Brophy
Department of Epidemiology and Biostatistics, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Heart 93:189-94. 2007....
Pravastatin and cancer: an unproven associationJames M Brophy
Division of Cardiology, Department of Medicine, , and CHUM/MUHC Technology Assessment Unit, Royal Victoria Hospital,
CMAJ 176:646-7. 2007
The benefit of cholesterol-lowering medications after coronary revascularization: a population studyJames M Brophy
Department of Medicine, McGill University Health Center, McGill University, Montreal, Quebec, Canada
Am Heart J 150:282-6. 2005..In routine practice, the translation of these benefits to elderly patients with recent coronary revascularization is less well known...
Cost-effectiveness of drug-eluting coronary stents in Quebec, CanadaJames M Brophy
McGill University, Quebec, Canada
Int J Technol Assess Health Care 21:326-33. 2005..The aim of this investigation was to assess the incremental cost-effectiveness of replacing bare metal coronary stents (BMS) with drug-eluting stents (DES) in the Province of Quebec, Canada...
Resource allocation among cardiovascular specialists and trainees: a pilot surveyJames M Brophy
Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
Can J Cardiol 24:118-20. 2008..To assess the relative importance that cardiovascular specialists assign to new technologies...
Celecoxib and cardiovascular risksJames M Brophy
McGill University Health Centre, Division of Cardiology, Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
Expert Opin Drug Saf 4:1005-15. 2005..Specific modifying factors of the cardiovascular risk of COX-2 inhibitors including dose, concomitant drugs, individual cardiac and genetic risk profiles, will require further study...
A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary interventionJames M Brophy
Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec, Canada
Am Heart J 152:263-9. 2006....
Statin wars following coronary revascularization--evidence-based clinical practice?James M Brophy
Division of Cardiology, Royal Victoria Hospital McGill University Health Center, Montreal, Quebec
Can J Cardiol 22:54-8. 2006..Pharmaceutical companies spend enormous amounts of money on both clinical trials and marketing. The relative influence of information from clinical trials on physician prescription patterns for statins is unknown...
Medical decision making with incomplete evidence--choosing a platelet glycoprotein IIbIIIa receptor inhibitor for percutaneous coronary interventionsJames M Brophy
Division of Cardiology, Department of Medicine, and Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
Med Decis Making 25:222-8. 2005..Substantial cost differentials are also present between the drugs...
Primary angioplasty and thrombolysis are both reasonable options in acute myocardial infarctionJames M Brophy
Division of Cardiology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Ann Intern Med 141:292-7. 2004..Thrombolysis remains a clinically and economically attractive option for the treatment of acute myocardial infarction that does not require the radical restructuring of our health care systems...
The use of cholesterol-lowering medications after coronary revascularizationJames M Brophy
Department of Medicine, McGill University Health Center, McGill University, Royal Victoria Hospital, Montreal, Que
CMAJ 169:1153-7. 2003..Whether physicians and patients follow this recommendation is unknown. Our objective was to determine the rate at which patients fill at least one prescription for cholesterol-lowering medications after coronary revascularization...
The dollars and sense of drug-eluting stentsJames M Brophy
Division of Cardiology and Clinical Epidemiology, McGill University Health Centre Technology Assessment Unit, Royal Victoria Hospital, , Que
CMAJ 172:361-2. 2005
Evidence for use of coronary stents. A hierarchical bayesian meta-analysisJames M Brophy
McGill University, Montreal, Quebec, Canada
Ann Intern Med 138:777-86. 2003....
Misplaced pacemaker wire as a cause of mitral regurgitationJ M Brophy
Heart 89:246. 2003
Medical decision making in the choice of a thrombolytic agent for acute myocardial infarction. Quebec Acute Coronary Care Working GroupJ M Brophy
Department of Medicine of Centre Hospitalier de l Université de Montreal, Quebec, Canada
Med Decis Making 19:411-8. 1999..However, they also preferentially treated younger patients, where only a small absolute advantage appears to exist...
Risk of upper gastrointestinal bleeding with oral bisphosphonates and non steroidal anti-inflammatory drugs: a case-control studyM Etminan
Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Aliment Pharmacol Ther 29:1188-92. 2009..Similarly, the risk of UGB among users of both bisphosphonates and non steroidal anti-inflammatory drugs (NSAIDs) in the community is also unknown...
Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugsChristine G St Germaine
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
Am J Cardiol 105:1740-5. 2010....
Investigation of an interaction between statins and clopidogrel after percutaneous coronary intervention: a cohort studyAna Blagojevic
Department of Medicine, McGill University Health Center, Quebec, Canada
Pharmacoepidemiol Drug Saf 18:362-9. 2009..Previous studies have suggested that some statins may inhibit the antiplatelet effects of clopidogrel via competitive metabolism of its activating enzyme cytochrome P450 3A4 (CYP3A4)...
A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stentsMohan N Babapulle
Division of Cardiology, Royal Victoria Hospital/McGill University Health Center, Montreal, Quebec, Canada
Lancet 364:583-91. 2004..They also appear to be safe in the short to medium term, although definitive conclusions are not possible. Larger studies with longer follow-up are needed to define better the role of these new devices...
Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysisVerena Schneider
Division of Clinical Epidemiology, Royal Victoria Hospital, Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Am J Epidemiol 164:881-9. 2006..54, 95% CI: 1.14, 2.09; test for interaction comparing celecoxib with rofecoxib, p = 0.057). There was a significant association for both selective and nonselective NSAIDs with acute renal failure, but confirmatory studies are required...
Fluctuating inflammatory markers in patients with stable ischemic heart diseasePeter Bogaty
Quebec Heart Institute, Laval Hospital, Laval University, Quebec City, Quebec, Canada
Arch Intern Med 165:221-6. 2005..However, little is known about how inflammatory markers fluctuate over time in patients with stable ischemic heart disease...
Public policy and coronary stenting: a different perspectiveJ M Brophy
Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
Can J Cardiol 14:54-7. 1998..Further research is required to ascertain fully the safety, efficacy and cost effectiveness of coronary stenting in routine practice before public policy can be formulated sensibly...
Microvolt T-wave alternans and the selective use of implantable cardioverter defibrillators for primary prevention: a cost-effectiveness studyKristian B Filion
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, 1020 Pine Avenue West Montreal, Quebec H3A 1A2, Canada
Int J Technol Assess Health Care 25:151-60. 2009..Recent studies suggest that microvolt T-wave alternans (MTWA) predicts mortality and severe arrhythmic events in this population. However, the impact of MTWA on ICD cost-effectiveness is unknown...
Shortness of breath at night and health status in congestive heart failure: effects of environmental conditions and health-related and dietary factorsMark S Goldberg
Department of Medicine, McGill University, 687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1
Environ Res 109:166-74. 2009....
Clinical utility of C-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease. The RISCA (recurrence and inflammation in the acute coronary syndromes) studyPeter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, Quebec City, Quebec, Canada
J Am Coll Cardiol 51:2339-46. 2008....
Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysisKristian B Filion
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
Pharmacoepidemiol Drug Saf 18:973-6. 2009..The objective of this study was to describe trends in the prescription of anti-diabetic medications among patients with type 2 diabetes in the United Kingdom (UK)...
The cost-effectiveness of Maze procedures using ablation techniques at the time of mitral valve surgeryStéphane P Quenneville
Department of Cardiology, Royal Victoria Hospital, McGill University Health Centre, Quebec, Canada
Int J Technol Assess Health Care 25:485-96. 2009..This study sought to systematically review the efficacy and safety of these newer techniques and to evaluate their long-term cost-effectiveness at the time of scheduled mitral valve (MV) surgery...
Therapeutic management in patients with renal failure who experience an acute coronary syndromeHeloise Cardinal
Centre Hospitalier de l Universite de Montreal, 1058 Saint Denis, Montreal, Quebec, Canada, H2X 3J4
Clin J Am Soc Nephrol 5:87-94. 2010..The aim of this study was to determine whether this held true in a contemporary cohort, after thorough adjustment for cotreatments/comorbidities...
Usefulness of soluble fas levels for improving diagnostic accuracy and prognosis for acute coronary syndromesHeloise Cardinal
Department of Medicine, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Am J Cardiol 105:797-803. 2010..In conclusion, our results suggest that in suspected ACS cases, sFas, but not hs-CRP, helps to improve the diagnostic accuracy and timeliness over and above standard diagnostic criteria...
Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic reviewNandini Dendukuri
Technology Assessment Unit, McGill University Health Centre, McGill University, Montreal, Que
CMAJ 173:167-70. 2005..We performed a systematic review of randomized controlled trials to assess the effectiveness of probiotic therapy...
End-user involvement in health technology assessment (HTA) development: a way to increase impactMaurice McGregor
Department of Medicine, Division of Cardiology, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
Int J Technol Assess Health Care 21:263-7. 2005..A mechanism to increase the influence of Health Technology Assessments (HTAs) on hospital policy decisions was developed...
Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trialAnique Ducharme
Department of Medicine, Montreal Heart Institute, University of Montreal, Que
CMAJ 173:40-5. 2005..When our results are integrated with those from other, similar trials, multidisciplinary disease management strategies for congestive heart failure are associated with clinically worthwhile improvements in survival...
A multivariate model for predicting mortality in patients with heart failure and systolic dysfunctionJames M Brophy
Division of Cardiology and Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
Am J Med 116:300-4. 2004..Heart failure is a leading cause of morbidity and mortality, but there are no reliable models based on readily available clinical variables to predict outcomes in patients taking angiotensin-converting enzyme (ACE) inhibitors...
Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleedingJoseph A Delaney
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Que
CMAJ 177:347-51. 2007..We assessed whether antithrombotic drug combinations increased the risk of such bleeding in a general practice population...
Discontinuation of statin therapy following an acute myocardial infarction: a population-based studyStella S Daskalopoulou
Division of Internal Medicine, Department of Medicine, McGill University, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, B2 236, Montreal, QC, Canada
Eur Heart J 29:2083-91. 2008..Our objective was to estimate the extent to which different patterns of statin use are associated with post-AMI mortality...
Beta-blockers in congestive heart failure. A Bayesian meta-analysisJ M Brophy
Service de cardiologie, Centre Hospitalier de l Universite de Montreal, Pavillon Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
Ann Intern Med 134:550-60. 2001..Although several randomized clinical trials have compared beta-blockers with placebo for treatment of congestive heart failure, a meta-analysis quantifying the effect on mortality and morbidity has not been performed recently...
Use of abciximab (c7E3 Fab, ReoPro) as an adjunct to balloon angioplastyM McGregor
McGill University Health Centre, Montreal, Quebec
Can J Cardiol 15:201-7. 1999..To estimate the magnitude of the clinical benefits that may result from use of abciximab at the time of angioplasty and the cost of achieving them...
The epidemiology of acute myocardial infarction and ischemic heart disease in Canada: data from 1976 to 1991J M Brophy
Department of Medicine, Centre Hospitalier Angrignon, Verdun, Quebec
Can J Cardiol 13:474-8. 1997..To present national trends in mortality rates for myocardial infarction and cardiovascular disease...
The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research DatabaseKristian B Filion
McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Canada
Pharmacoepidemiol Drug Saf 16:1-4. 2007..We assessed the impact of this policy change on statin prescribing...
A panel study in congestive heart failure to estimate the short-term effects from personal factors and environmental conditions on oxygen saturation and pulse rateM S Goldberg
Department of Medicine, Division of Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, R4 29, Montreal, Quebec H3A1A1
Occup Environ Med 65:659-66. 2008..This daily diary panel study in Montreal, Quebec, was carried out to determine whether oxygen saturation and pulse rate were associated with selected personal factors, weather conditions and air pollution...
Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary diseaseG B John Mancini
Division of Cardiology, Vancouver Hospital, Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 47:2554-60. 2006....
ACE-inhibitor use and the long-term risk of renal failure in diabetesS Suissa
The Department of Epidemiology and Biostatistics, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Ross 429, Montreal, Quebec, Canada H3A 1A1
Kidney Int 69:913-9. 2006..Our data suggest instead that ACE inhibitors might actually increase this risk, which may possibly contribute to the continued increasing incidence of ESRD owing to diabetes...
Treating the right patient at the right time: access to heart failure careH Ross
Department of Medicine, University Health Network, University of Toronto, Toronto, Canada
Can J Cardiol 22:749-54. 2006....
The cost-effectiveness of stem cell transplantations from unrelated donors in adult patients with acute leukemiaVania Costa
Technology Assessment Unit, McGill University Health Centre, Montreal, QC, Canada
Value Health 10:247-55. 2007....
Canadian Cardiovascular Society commentary on implantable cardioverter defibrillators in Canada: waiting times and access to care issuesC S Simpson
Department of Medicine, Division of Cardiology, Queen s University, Kingston, Ontario
Can J Cardiol 21:19A-24A. 2005..A maximum recommended waiting time is proposed and the framework for a solution-oriented approach is presented...
Geographical variations in post myocardial infarction mortality and their impact on risk selectionAbdelouahed Naslafkih
Faculty of Graduate Studies, University of Montreal, Montreal, Quebec, Canada
J Insur Med 36:282-91. 2004..This highlights the interest of risk assessment using mortality analysis methodology, which makes the geographic variation in post-myocardial infarction mortality disappear...
A meta-analysis of antibiotic use for the secondary prevention of cardiovascular diseasesZhi Song
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
Can J Cardiol 24:391-5. 2008..However, results have occasionally been conflicting, and a meta-analysis may provide additional clarification...
Primary PCI in ST-segment elevation myocardial infarctionPeter Bogaty
N Engl J Med 358:1751; author reply 1752-3. 2008
The cost-effectiveness of drug-eluting stents: a systematic reviewSuzanne Ligthart
Department of Medical Technology Assessment, University Medical Centre Nijmegen, Nijmegen, The Netherlands
CMAJ 176:199-205. 2007..We conducted a systematic review of all published comparative cost-effectiveness analyses to identify the factors contributing to the heterogeneity of their conclusions...
Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled studyPeter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, 2725 Chemin Ste Foy, Quebec City, Quebec, Canada G1V 4G5
Circulation 110:934-9. 2004..We investigated the effect of prolonged COX-2 inhibition on inflammatory profile and endothelial function in patients with ischemic heart disease and high serum C-reactive protein (CRP) values...
GRACIA: implications for clinical practicePeter Bogaty
Lancet 365:381; author reply 382. 2005
Treating the right patient at the right time: access to specialist consultation and non-invasive testingMerril L Knudtson
Libin Cardiovascular Institute of Alberta
Can J Cardiol 22:819-24. 2006....
Do angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers decrease the risk of hospitalization secondary to community-acquired pneumonia? A nested case-control studyMahyar Etminan
Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada
Pharmacotherapy 26:479-82. 2006..In addition, the putative protection against pneumonia may instead be related to general inhibition of the renin-angiotensin system...
Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) and the risk of age-related macular degeneration: nested case-control studyMahyar Etminan
Centre for Clinical Epidemiology and Evaluation, Vancouver General Hospital, 7 Floor 828 West 10 Ave, Vancouver, British Columbia, Canada
Curr Drug Saf 3:24-6. 2008..We sought to further explore this association and also explore the role of angiotensin-converting enzyme inhibitors (ACE-Is) with respect to the development of AMD...
Cardiovascular risk associated with celecoxibJames M Brophy
N Engl J Med 352:2648-50; author reply 2648-50. 2005
Confounding in database pharmacoepidemiology studiesJoseph A C Delaney
Epidemiology 19:360-1. 2008
Primary data collection in health technology assessmentMichelle L McIsaac
McGill University and University of Montreal Health Centres, and Department of Community Health Sciences, University of Calgary, 1403 29 Street NW, Calgary, Alberta, Canada
Int J Technol Assess Health Care 23:24-9. 2007..The authors conclude that, under specific conditions, primary data collection is a worthwhile endeavor in the HTA process...
Rehabilitating digoxinJames M Brophy
Eur Heart J 27:127-9. 2006
Vaccination against human papillomavirusJames M Brophy
CMAJ 177:1525-6; author reply 1527-8. 2007
Has thrombolysis lost its mojo?James M Brophy
Heart 93:1167-9. 2007
Friendly fire and continuing medical educationJames M Brophy
Can J Cardiol 21:23-4. 2005
Selling safety--lessons from muraglitazarJames M Brophy
JAMA 294:2633-5. 2005
Risk stratification following non-ST segment elevation myocardial infarction: is the glass half-full or half-empty?James M Brophy
Can J Cardiol 23:1080-1. 2007
Use of oral bisphosphonates and the risk of aseptic osteonecrosis: a nested case-control studyMahyar Etminan
Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, BC, Canada
J Rheumatol 35:691-5. 2008..To determine whether use of oral bisphosphonates is associated with an increased risk of aseptic osteonecrosis (AON) among a cohort of elderly cardiovascular patients...
Primary angioplasty or thrombolysis? A topical parablePeter Bogaty
Quebec Heart Institute, Laval University, Ste-Foy, Quebec, Canada G1V 4G5
BMJ 328:1257-8. 2004
