Research Topics
| Derek BowieSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Ion-dependent gating of kainate receptorsDerek Bowie
Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3A 1Y6
J Physiol 588:67-81. 2010..Consequently, ion-dependent gating of KARs looks set to continue to be a subject of topical inquiry well into the future...- Redefining the classification of AMPA-selective ionotropic glutamate receptorsDerek Bowie
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Physiol 590:49-61. 2012..Consequently, this emerging AMPAR subclass need not be assembled from novel subunits, yet to be cloned, but could simply occur by varying the stoichiometry of existing proteins... - Ionotropic glutamate receptors & CNS disordersDerek Bowie
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
CNS Neurol Disord Drug Targets 7:129-43. 2008..Finally, I discuss how parallel advances in studies of other neurotransmitter systems may allow pharmacologists to work towards a cure for many CNS disorders rather than developing drugs to treat their symptoms... 
External ions are coactivators of kainate receptorsAdrian Y C Wong
Department of Pharmacology and Therapeutics, McGill University, Montreal, , H3A 1Y6, Canada
J Neurosci 26:5750-5. 2006..Our findings identify a novel allosteric site that singles out KARs from all other ligand-gated ion channels...
Cations but not anions regulate the responsiveness of kainate receptorsDavid M MacLean
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G OB1
J Neurosci 31:2136-44. 2011....- Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonistsAnne Marie L Fay
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Mol Pharmacol 75:1096-107. 2009..Finally, our study identifies the responsiveness to several neurotransmitter candidates establishing the possibility that endogenous amino acids other than L-Glu may regulate native KARs at central synapses... - Na+/Cl- dipole couples agonist binding to kainate receptor activationAdrian Y C Wong
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Neurosci 27:6800-9. 2007..Together, our findings identify the dipole as a novel gating feature that couples neurotransmitter binding to KAR activation... - Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retinaIngrid K Osswald
Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, Room 1317, McGill University, Montreal, Quebec, Canada H3A 1Y6
J Physiol 582:95-111. 2007..Eye-opening coincides with the consolidation of inhibitory cell connections suggesting that the developmental switch to a Ca2+-permeable AMPAR with novel pharmacology may be critical to synapse maturation in the mammalian retina... - Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosisBeibei Zhao
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Cell Signal 20:1769-79. 2008..Furthermore, that this process appears to be an evolutionarily conserved mechanism amongst functionally homologous cotransporters... - Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptorAnne Marie L Fay
Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, Room 1317, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
J Physiol 572:201-13. 2006..However, other interpretations are possible suggesting future work is required if this issue is to be resolved... - Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteinsDerek Bowie
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Physiol 547:373-85. 2003..Our results show that Con-A and PSD-95 regulate kainate receptors via distinct allosteric mechanisms targeting selective molecular steps in the transduction pathway... - Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretationDavid M MacLean
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 0B1
J Physiol 589:5383-90. 2011..Consequently, CNQX primarily reports the proportion of AMPARs available for activation but may also impose additional block by receptor desensitization... - Thinking of Co²⁺-staining explant tissue or cultured cells? How to make it reliable and specificMark R P Aurousseau
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Eur J Neurosci 35:1201-7. 2012..Here we show that recent advances have resolved these issues, opening this straightforward and valuable technique to a much larger neuroscience audience... - Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanismFrédéric Lebrun-Julien
Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
J Neurosci 29:5536-45. 2009..Thus, our data reveal a novel non-cell-autonomous mechanism by which glial cells can profoundly exacerbate neuronal death following excitotoxic injury... - Functional stoichiometry of glutamate receptor desensitizationDerek Bowie
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 22:3392-403. 2002..Although sharing many structural correlates with K+ channels, iGluRs have evolved unique subunit-subunit interactions, tailoring their gating behavior to fulfill distinct roles in neuronal signaling... - External anions and cations distinguish between AMPA and kainate receptor gating mechanismsDerek Bowie
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
J Physiol 539:725-33. 2002..These results identify a novel mechanism that distinguishes AMPA and kainate receptors. External ions regulate the gating machinery of kainate receptors through an allosteric mechanism that involves both anions and cations...