Derek Bowie

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Ion-dependent gating of kainate receptors
    Derek Bowie
    Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3A 1Y6
    J Physiol 588:67-81. 2010
  2. pmc Redefining the classification of AMPA-selective ionotropic glutamate receptors
    Derek Bowie
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Physiol 590:49-61. 2012
  3. pmc Ionotropic glutamate receptors & CNS disorders
    Derek Bowie
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    CNS Neurol Disord Drug Targets 7:129-43. 2008
  4. ncbi request reprint External ions are coactivators of kainate receptors
    Adrian Y C Wong
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3A 1Y6, Canada
    J Neurosci 26:5750-5. 2006
  5. doi request reprint Defining the structural relationship between kainate-receptor deactivation and desensitization
    G Brent Dawe
    1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada 2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada 3
    Nat Struct Mol Biol 20:1054-61. 2013
  6. doi request reprint Cations but not anions regulate the responsiveness of kainate receptors
    David M MacLean
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G OB1
    J Neurosci 31:2136-44. 2011
  7. doi request reprint Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists
    Anne Marie L Fay
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 75:1096-107. 2009
  8. ncbi request reprint Na+/Cl- dipole couples agonist binding to kainate receptor activation
    Adrian Y C Wong
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:6800-9. 2007
  9. pmc Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina
    Ingrid K Osswald
    Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, Room 1317, McGill University, Montreal, Quebec, Canada H3A 1Y6
    J Physiol 582:95-111. 2007
  10. doi request reprint Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis
    Beibei Zhao
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Cell Signal 20:1769-79. 2008

Collaborators

Detail Information

Publications20

  1. pmc Ion-dependent gating of kainate receptors
    Derek Bowie
    Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3A 1Y6
    J Physiol 588:67-81. 2010
    ..Consequently, ion-dependent gating of KARs looks set to continue to be a subject of topical inquiry well into the future...
  2. pmc Redefining the classification of AMPA-selective ionotropic glutamate receptors
    Derek Bowie
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Physiol 590:49-61. 2012
    ..Consequently, this emerging AMPAR subclass need not be assembled from novel subunits, yet to be cloned, but could simply occur by varying the stoichiometry of existing proteins...
  3. pmc Ionotropic glutamate receptors & CNS disorders
    Derek Bowie
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    CNS Neurol Disord Drug Targets 7:129-43. 2008
    ..Finally, I discuss how parallel advances in studies of other neurotransmitter systems may allow pharmacologists to work towards a cure for many CNS disorders rather than developing drugs to treat their symptoms...
  4. ncbi request reprint External ions are coactivators of kainate receptors
    Adrian Y C Wong
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3A 1Y6, Canada
    J Neurosci 26:5750-5. 2006
    ..Our findings identify a novel allosteric site that singles out KARs from all other ligand-gated ion channels...
  5. doi request reprint Defining the structural relationship between kainate-receptor deactivation and desensitization
    G Brent Dawe
    1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada 2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada 3
    Nat Struct Mol Biol 20:1054-61. 2013
    ..This sequence of events is absent from AMPA-type iGluRs; thus, cations are identified as gatekeepers of KAR gating, a role unique among even closely related LGICs. ..
  6. doi request reprint Cations but not anions regulate the responsiveness of kainate receptors
    David M MacLean
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G OB1
    J Neurosci 31:2136-44. 2011
    ....
  7. doi request reprint Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists
    Anne Marie L Fay
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 75:1096-107. 2009
    ..Finally, our study identifies the responsiveness to several neurotransmitter candidates establishing the possibility that endogenous amino acids other than L-Glu may regulate native KARs at central synapses...
  8. ncbi request reprint Na+/Cl- dipole couples agonist binding to kainate receptor activation
    Adrian Y C Wong
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:6800-9. 2007
    ..Together, our findings identify the dipole as a novel gating feature that couples neurotransmitter binding to KAR activation...
  9. pmc Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina
    Ingrid K Osswald
    Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, Room 1317, McGill University, Montreal, Quebec, Canada H3A 1Y6
    J Physiol 582:95-111. 2007
    ..Eye-opening coincides with the consolidation of inhibitory cell connections suggesting that the developmental switch to a Ca2+-permeable AMPAR with novel pharmacology may be critical to synapse maturation in the mammalian retina...
  10. doi request reprint Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis
    Beibei Zhao
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Cell Signal 20:1769-79. 2008
    ..Furthermore, that this process appears to be an evolutionarily conserved mechanism amongst functionally homologous cotransporters...
  11. pmc Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor
    Anne Marie L Fay
    Department of Pharmacology and Therapeutics, McIntyre Medical Sciences Building, Room 1317, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
    J Physiol 572:201-13. 2006
    ..However, other interpretations are possible suggesting future work is required if this issue is to be resolved...
  12. pmc Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins
    Derek Bowie
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Physiol 547:373-85. 2003
    ..Our results show that Con-A and PSD-95 regulate kainate receptors via distinct allosteric mechanisms targeting selective molecular steps in the transduction pathway...
  13. pmc Automating single subunit counting of membrane proteins in mammalian cells
    Hugo McGuire
    Groupe d étude des protéines membranaires, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 287:35912-21. 2012
    ..Our approach permits the elucidation of stoichiometry for a wide variety of plasma membrane proteins in mammalian cells with any commercially available TIRF microscope...
  14. doi request reprint Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission
    Michael V Accardi
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3B 0B1
    Nat Commun 5:3168. 2014
    ..Although traditionally associated with oxidative stress in neurodegenerative disease, our data identify mROS as a putative homeostatic signalling molecule coupling cellular metabolism to the strength of inhibitory transmission. ..
  15. doi request reprint Thinking of Co²⁺-staining explant tissue or cultured cells? How to make it reliable and specific
    Mark R P Aurousseau
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Eur J Neurosci 35:1201-7. 2012
    ..Here we show that recent advances have resolved these issues, opening this straightforward and valuable technique to a much larger neuroscience audience...
  16. pmc Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation
    David M MacLean
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 0B1
    J Physiol 589:5383-90. 2011
    ..Consequently, CNQX primarily reports the proportion of AMPARs available for activation but may also impose additional block by receptor desensitization...
  17. pmc Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state
    Bryan A Daniels
    Department of Pharmacology and Therapeutics, Bellini Building, Room 164, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada
    J Physiol 591:3873-85. 2013
    ..Working within the limits of a common architectural design, we propose functionally diverse iGluR families were able to emerge during evolution by re-deploying existing gating structures to fulfil different tasks...
  18. doi request reprint Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism
    Frédéric Lebrun-Julien
    Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 29:5536-45. 2009
    ..Thus, our data reveal a novel non-cell-autonomous mechanism by which glial cells can profoundly exacerbate neuronal death following excitotoxic injury...
  19. ncbi request reprint Functional stoichiometry of glutamate receptor desensitization
    Derek Bowie
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:3392-403. 2002
    ..Although sharing many structural correlates with K+ channels, iGluRs have evolved unique subunit-subunit interactions, tailoring their gating behavior to fulfill distinct roles in neuronal signaling...
  20. pmc External anions and cations distinguish between AMPA and kainate receptor gating mechanisms
    Derek Bowie
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Physiol 539:725-33. 2002
    ..These results identify a novel mechanism that distinguishes AMPA and kainate receptors. External ions regulate the gating machinery of kainate receptors through an allosteric mechanism that involves both anions and cations...