J Bourbeau

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Patient adherence in COPD
    J Bourbeau
    Montreal Chest Institute, McGill University Health Centre, 3650 St Urbain, Office K1 30, Montreal, Quebec
    Thorax 63:831-8. 2008
  2. ncbi New and controversial therapies for chronic obstructive pulmonary disease
    Jean Bourbeau
    Montreal Chest Institute, Montreal, QC H2X 2P4 Canada
    Proc Am Thorac Soc 6:553-4. 2009
  3. ncbi Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease
    Jessica Nadigel
    Meakins Christie Laboratories, Faculty of Medicine, McGill University, Montreal, QC, Canada
    Respir Res 12:149. 2011
  4. ncbi CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, 3626 rue St, Urbain, Montreal, QC, H2X 2P2 Canada
    Respir Res 12:43. 2011
  5. ncbi Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review
    Marie Westwood
    Kleijnen Systematic Reviews Ltd, York, UK
    Respir Res 12:40. 2011
  6. ncbi Detecting exacerbations using the Clinical COPD Questionnaire
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Health Qual Life Outcomes 8:102. 2010
  7. ncbi How do COPD patients respond to exacerbations?
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    BMC Pulm Med 11:43. 2011
  8. ncbi Action Plan to enhance self-management and early detection of exacerbations in COPD patients; a multicenter RCT
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    BMC Pulm Med 9:52. 2009
  9. ncbi The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD
    Francesco Sava
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:55. 2010
  10. ncbi Activities of life: the COPD patient
    Jean Bourbeau
    Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, 3650 St Urbain, Rm K1 32, Montreal, Quebec, Canada H2X 2P4
    COPD 6:192-200. 2009

Detail Information

Publications66

  1. ncbi Patient adherence in COPD
    J Bourbeau
    Montreal Chest Institute, McGill University Health Centre, 3650 St Urbain, Office K1 30, Montreal, Quebec
    Thorax 63:831-8. 2008
    ..This review addresses adherence related issues in COPD, assesses current efforts to improve adherence and highlights opportunities to improve adherence for both providers and patients...
  2. ncbi New and controversial therapies for chronic obstructive pulmonary disease
    Jean Bourbeau
    Montreal Chest Institute, Montreal, QC H2X 2P4 Canada
    Proc Am Thorac Soc 6:553-4. 2009
    ..Conceptualization of a research plan for COPD self-management is needed for future research to be successful...
  3. ncbi Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease
    Jessica Nadigel
    Meakins Christie Laboratories, Faculty of Medicine, McGill University, Montreal, QC, Canada
    Respir Res 12:149. 2011
    ..We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor (TLR) expression compared to control subjects due to the exposure of cigarette smoke in the airways...
  4. ncbi CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, 3626 rue St, Urbain, Montreal, QC, H2X 2P2 Canada
    Respir Res 12:43. 2011
    ..This study analyzed the expression of IL-17A and IL-17F as well as the phenotype of cells producing them in bronchial biopsies from COPD patients...
  5. ncbi Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review
    Marie Westwood
    Kleijnen Systematic Reviews Ltd, York, UK
    Respir Res 12:40. 2011
    ..This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with bronchodilator therapy...
  6. ncbi Detecting exacerbations using the Clinical COPD Questionnaire
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Health Qual Life Outcomes 8:102. 2010
    ..Little is known whether (low burden) strategies are able to capture these unreported exacerbations...
  7. ncbi How do COPD patients respond to exacerbations?
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    BMC Pulm Med 11:43. 2011
    ..The current prospective study aims at determining the relative incidence, timing and determinants of three types of patient responses...
  8. ncbi Action Plan to enhance self-management and early detection of exacerbations in COPD patients; a multicenter RCT
    Jaap C A Trappenburg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    BMC Pulm Med 9:52. 2009
    ..Early detection of exacerbations by COPD patients initiating prompt interventions has shown to be clinically relevant. Until now, research failed to identify the effectiveness of a written individualized Action Plan (AP) to achieve this...
  9. ncbi The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD
    Francesco Sava
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:55. 2010
    ..We examined the influence of overweight and obesity on pulmonary function, exercise tolerance, quality of life and response to pulmonary rehabilitation in COPD...
  10. ncbi Activities of life: the COPD patient
    Jean Bourbeau
    Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, 3650 St Urbain, Rm K1 32, Montreal, Quebec, Canada H2X 2P4
    COPD 6:192-200. 2009
    ..If we are to progress in the treatment of acute exacerbation of COPD, it is evident that the effects of interventions on activities of daily living should be considered as an essential component of our goal of treatment...
  11. ncbi Self-management strategies in chronic obstructive pulmonary disease
    Jean Bourbeau
    Division of Pulmonary Medicine, McGill University, Montreal, Quebec, Canada
    Clin Chest Med 28:617-28, vii. 2007
    ....
  12. ncbi Making pulmonary rehabilitation a success in COPD
    J Bourbeau
    Montreal Chest Institute, Montreal, Canada
    Swiss Med Wkly 140:w13067. 2010
    ..Future research should evaluate the effect of self-management interventions combined with pulmonary rehabilitation to improve long-term activity and exercise maintenance...
  13. ncbi Economic benefits of self-management education in COPD
    Jean Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Royal Victoria Hospital, McGill University Health Centre, 3650 St Urbain, Office K1 32, Montreal, QC, Canada H2X 2P4
    Chest 130:1704-11. 2006
    ..There is emerging evidence that disease management with self-management education provided by a case manager might benefit COPD patients...
  14. ncbi Practice patterns in the management of chronic obstructive pulmonary disease in primary practice: the CAGE study
    J Bourbeau
    Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    Can Respir J 15:13-9. 2008
    ..The information on usual care for patients with chronic obstructive pulmonary disease (COPD) in primary care is limited in Canada...
  15. ncbi The role of collaborative self-management in pulmonary rehabilitation
    Jean Bourbeau
    Division of Pulmonary Medicine, McGill University, Montreal, Quebec, Canada
    Semin Respir Crit Care Med 30:700-7. 2009
    ..Changing patient behavior and ensuring maintenance are complex processes and require time...
  16. ncbi Preventing hospitalization for COPD exacerbations
    Jean Bourbeau
    Department of Medicine, Division of Pulmonary Medicine, McGill University, Montreal, Quebec, Canada
    Semin Respir Crit Care Med 31:313-20. 2010
    ..This needs to be evaluated in a properly designed randomized clinical trial before it becomes the standard of care for COPD patients...
  17. ncbi Impact on patients' health status following early identification of a COPD exacerbation
    J Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, 3650 St Urbain, Montreal, QC, Canada
    Eur Respir J 30:907-13. 2007
    ..The current study provides valuable information on the change in health status during an acute exacerbation of chronic obstructive pulmonary disease that can be utilised for future trials that evaluate therapeutic intervention...
  18. ncbi Self-management and behaviour modification in COPD
    Jean Bourbeau
    Respiratory Epidemiology Unit, McGill University, and Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, Montreal, Que, Canada
    Patient Educ Couns 52:271-7. 2004
    ..Further research is needed to develop strategies on how to intervene and facilitate behaviour modification in chronic disease and as such the relevance for the implementation of self-management programs in COPD...
  19. ncbi Inhaled corticosteroids should not be prescribed to all chronic obstructive pulmonary disease patients
    Jean Bourbeau
    Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
    Can Respir J 10:148-9. 2003
  20. ncbi Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention
    Jean Bourbeau
    Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, and Respiratory Epidemiology Unit, McGill University, Montreal, Quebec, Canada
    Arch Intern Med 163:585-91. 2003
    ..We evaluated the effect of a continuum of self-management, specific to COPD, on the use of hospital services and health status among patients with moderate to severe disease...
  21. ncbi French-Canadian version of the Chronic Respiratory and St George's Respiratory questionnaires: an assessment of their psychometric properties in patients with chronic obstructive pulmonary disease
    Jean Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec
    Can Respir J 11:480-6. 2004
    ....
  22. ncbi Dyspnea as clinical indicator in patients with chronic obstructive pulmonary disease
    N F Schlecht
    Respiratory Epidemiology Unit, Joint Department of Epidemiology, McGill University, Montreal, Canada
    Chron Respir Dis 2:183-91. 2005
    ..Although spirometry is often used to evaluate disease severity, dyspnea which is a patient centered outcome better reflect overall disease impact among COPD patients...
  23. ncbi Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year
    W Xu
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 35:1022-30. 2010
    ..61 (95% CI 0.09-9.13)). Development and evaluation of self-management programmes emphasising early recognition of exacerbations and consequent action appear to be warranted...
  24. ncbi Assessing the impact of pulmonary rehabilitation on functional status in COPD
    L Laviolette
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Thorax 63:115-21. 2008
    ....
  25. ncbi Does seasonal employment in grain elevators increase nonspecific airways responsiveness?
    R E Dales
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    J Occup Med 30:613-6. 1988
    ..Our results do not support the hypothesis that seasonal exposure to grain dust increases AR...
  26. ncbi Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort
    Lisa Langsetmo
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, 3650 St Urbain, Montreal, PQ, Canada
    Am J Respir Crit Care Med 177:396-401. 2008
    ..Unreported exacerbations and failure to seek medical attention may have consequences on the health of patients with chronic obstructive pulmonary disease...
  27. ncbi Self-management reduces both short- and long-term hospitalisation in COPD
    M-A Gadoury
    Respiratory Epidemiology and Clinical Research Unit, 3650 St Urbain Street, , , H2X 2P4, Canada
    Eur Respir J 26:853-7. 2005
    ....
  28. ncbi Trajectories of endurance activity following pulmonary rehabilitation in COPD patients
    J E Soicher
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, 3650 St Urbain, Office K1 32, Montreal, H2X 2P4 Canada
    Eur Respir J 39:272-8. 2012
    ..Pulmonary rehabilitation should include interventions aimed at minimising barriers, in order to induce long-term behaviour change...
  29. ncbi Inhaled corticosteroids and hospitalisation due to exacerbation of COPD
    J Bourbeau
    Respiratory Epidemiology Unit, Joint Depts of Epidemiology and Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 22:286-9. 2003
    ..No reduction in chronic obstructive pulmonary disease exacerbations requiring hospitalisation, in relation to the use of inhaled corticosteroids, were observed...
  30. ncbi Feasibility and reliability of health-related quality of life measurements among tuberculosis patients
    M J Dion
    Respiratory Epidemiology Unit, McGill University, Montreal, Quebec, Canada
    Qual Life Res 13:653-65. 2004
    ..Intraclass correlation coefficients were 0.66 for the SF-36 physical component summary, 0.79 for the mental component summary, and 0.73 for the EQ-5D. These instruments appeared reliable in a highly selected group of TB patients...
  31. ncbi Validation and clinical interpretation of the St George's Respiratory Questionnaire among COPD patients, China
    W Xu
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 13:181-9. 2009
    ..It is therefore difficult to adequately evaluate the equivalence of this instrument in Chinese populations...
  32. ncbi A self-management education program including an action plan for acute COPD exacerbations
    Maria F Sedeno
    Respiratory Epidemiology and Clinical Research Unit, Montréal Chest Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    COPD 6:352-8. 2009
    ..2% vs. 36.3% exacerbations resulted in a hospitalization (p < 0.001). Self-management with the successful use of an action plan for acute exacerbation of COPD holds promise for reducing health care use...
  33. ncbi Paced-walk and step tests to assess exertional dyspnea in COPD
    Helene Perrault
    Respiratory Epidemiology and Clinical Research Unit of the Montreal Chest Institute, McGill University Health Center, Montreal, Quebec, Canada
    COPD 6:330-9. 2009
    ..5 to 4.0 km x h(- 1) and the 3-min of step testing at rates between 18 and 26 steps x min(- 1). Both field tests were highly reproducible in patients with COPD...
  34. ncbi Respiratory infection: how important is oral health?
    Philippe Mojon
    McGill University, Montreal, Quebec, Canada
    Curr Opin Pulm Med 9:166-70. 2003
    ..It is the aim of this paper to review the recent literature on this topic...
  35. ncbi Independent effect of depression and anxiety on chronic obstructive pulmonary disease exacerbations and hospitalizations
    Wanning Xu
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada
    Am J Respir Crit Care Med 178:913-20. 2008
    ..Depression and anxiety are significant comorbid and potentially modifiable conditions in chronic obstructive pulmonary disease (COPD), but their effects on exacerbations are not clear...
  36. ncbi The Oort structural equation modeling approach detected a response shift after a COPD self-management program not detected by the Schmitt technique
    Sara Ahmed
    Faculty of Medicine, McGill University, School of Physical and Occupational Therapy, 3654 Prom Sir William Osler, Montreal, Quebec, Canada
    J Clin Epidemiol 62:1165-72. 2009
    ..The second objective was to compare the Oort and Schmitt structural equation modeling (SEM) approaches...
  37. ncbi Cycling efficiency is not compromised for moderate exercise in moderately severe COPD
    Helene Perrault
    Respiratory Clinical Research Unit of the Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    Med Sci Sports Exerc 39:918-25. 2007
    ....
  38. ncbi Teaching time for metered-dose inhalers in the emergency setting
    Yuka Numata
    Respiratory Epidemiology Unit, McGill University, Montreal, PQ, Canada
    Chest 122:498-504. 2002
    ..CONCLUSIONS: Successful MDI/DED teaching followed by self-medication is feasible in the emergency setting, based on a simple protocol. A single bronchodilator dose administered by wet nebulization may facilitate subsequent MDI teaching...
  39. ncbi Outcomes and health-related quality of life following hospitalization for an acute exacerbation of COPD
    Qiuyue Wang
    Respiratory Epidemiology Unit, McGill University, Montreal, Canada
    Respirology 10:334-40. 2005
    ..The purpose of this study was to understand the outcomes for patients admitted to hospital for an acute exacerbation of COPD, and to determine the factors influencing quality of life and health service utilization of patients with COPD...
  40. ncbi Inhaled corticosteroids in COPD: determinants of use and trends in patient persistence with treatment
    Lucie Blais
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec
    Can Respir J 11:27-32. 2004
    ..In addition to that, changes in treatment persistence over time, from 1990 to 1995, were investigated by estimating the yearly proportion of patients persisting for less than one year...
  41. ncbi Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial
    Francois Maltais
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Université Laval and Centre Hospitalier Universitaire Associé, Quebec City, Quebec, Canada
    Ann Intern Med 149:869-78. 2008
    ..Home-based rehabilitation is a promising approach to improve access to pulmonary rehabilitation...
  42. ncbi Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease
    M E Hamelin
    , Sainte-Foy, QC, Canada
    Clin Infect Dis 41:498-502. 2005
    ..1%) of 145 adult patients who presented to the emergency department for pneumonia or acute exacerbation of chronic obstructive pulmonary disease during 2 winter/spring seasons in Quebec, Canada...
  43. ncbi Measurement of health preferences among patients with tuberculous infection and disease
    Marie Josée Dion
    Respiratory Epidemiology Unit, McGill University, Montreal, Quebec, Canada
    Med Decis Making 22:S102-14. 2002
    ..Administration of the visual analogue scale and standard gamble instruments appeared reliable in a selected group of tuberculosis patients. Major barriers to recruitment were language and mobility in this largely foreign-born population...
  44. ncbi Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada
    Can Respir J 10:11A-65A. 2003
    ..Patients with advanced COPD and respiratory failure require a comprehensive management plan that incorporates structured end-of-life care...
  45. ncbi Living with chronic obstructive pulmonary disease: a survey of patients' knowledge and attitudes
    Paul Hernandez
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Respir Med 103:1004-12. 2009
    ..The purpose of this study was to determine whether Canadians with COPD are properly educated and supported, and to recommend solutions to any care gaps identified...
  46. ncbi Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial
    Jean Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Thorax 62:938-43. 2007
    ..A study was therefore undertaken to evaluate combined salmeterol/fluticasone propionate (SFC) and fluticasone propionate (FP) alone on inflammatory cells in the airways of patients with COPD...
  47. ncbi Isokinetic muscle function in COPD
    Charles Haccoun
    Montreal Children's Hospital-McGill University Health Centre, Montreal, PQ, Canada
    Chest 121:1079-84. 2002
    ..CONCLUSIONS: Both ventilatory function and leg muscle function contribute to exercise limitation, and a 20-s isokinetic test can be utilized to assess leg function in patients with COPD...
  48. ncbi Germicidal ultraviolet irradiation in air conditioning systems: effect on office worker health and wellbeing: a pilot study
    D Menzies
    Department of Medicine and Epidemiology and Biostatistics, McGill University, Montreal, Canada
    Occup Environ Med 56:397-402. 1999
    ....
  49. ncbi Heat awareness and response among Montreal residents with chronic cardiac and pulmonary disease
    Tom Kosatsky
    DSP de Montréal Public Health, Montreal, QC
    Can J Public Health 100:237-40. 2009
    ..Here we describe their knowledge and awareness of the risks, and the degree to which they practice the protective behaviours recommended by public health and meteorological authorities...
  50. ncbi Home-based pulmonary rehabilitation in chronic obstructive pulmonary disease patients
    Danielle S R Vieira
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Opin Pulm Med 16:134-43. 2010
    ....
  51. ncbi Does dynamic hyperinflation impair submaximal exercise cardiac output in chronic obstructive pulmonary disease?
    Jacinthe Baril
    McGill University Health Centre, Montreal Chest Institute, Montreal, Canada
    Clin Invest Med 29:104-9. 2006
  52. ncbi Implementing practice guidelines: a workshop on guidelines dissemination and implementation with a focus on asthma and COPD
    Louis Philippe Boulet
    Hopital Laval, 2725 Chemin Sainte Foy, Quebec, Canada
    Can Respir J 13:5-47. 2006
    ..It is hoped that this event will be followed by other meetings that focus on how to improve the transfer of key recommendations from evidence-based guidelines into current care, and how to stimulate research to accomplish this...
  53. ncbi Effects of written action plan adherence on COPD exacerbation recovery
    Erik W M A Bischoff
    Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thorax 66:26-31. 2011
    ..The aims of this study were to assess the effects of adherence to a written action plan on exacerbation recovery time and unscheduled healthcare utilisation and to explore factors associated with action plan adherence...
  54. ncbi A cohort study showed that health insurance databases were accurate to distinguish chronic obstructive pulmonary disease from asthma and classify disease severity
    Jason McKnight
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, 3650 St-Urbain Street, Montreal, Quebec, H2X 2P4, Canada
    J Clin Epidemiol 58:206-8. 2005
  55. ncbi The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction?
    Martin Picard
    Department of Kinesiology and Physical Education, McGill University, Montreal, PQ, Canada
    Am J Respir Crit Care Med 178:1040-7. 2008
    ..Objectives: To describe the mitochondrial phenotype in a moderate to severe COPD population and age-matched controls...
  56. ncbi Increased expression of ADAM33 and ADAM8 with disease progression in asthma
    Susan C Foley
    Meakins Christie Laboratories, McGill University, Montreal Chest Institute, Montreal, Quebec, Canada
    J Allergy Clin Immunol 119:863-71. 2007
    ..ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma...
  57. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  58. ncbi Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
    Shawn D Aaron
    The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 146:545-55. 2007
    ..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...
  59. ncbi The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment
    Shawn D Aaron
    The Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Can Respir J 11:581-5. 2004
    ....
  60. ncbi Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care
    Denis E O'Donnell
    Queen s University, Kingston, Canada
    Can Respir J 15:1A-8A. 2008
    ....
  61. ncbi Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update
    Shaw Aaron
    Queen s University, Kingston, Canada
    Can Respir J 14:5B-32B. 2007
    ..The Panel hopes that these new practice guidelines, which reflect a rigorous analysis of the recent literature, will assist caregivers in the diagnosis and management of this common condition...
  62. ncbi [Canadian Thoracic Society COPD guidelines: summary of highlights for family doctors]
    Paul Hernandez
    Can Respir J 10:463-6. 2003
  63. ncbi Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2275 Chemin Ste Foy, Ste Foy, Quebec G1V 4G5, Canada
    Am J Respir Crit Care Med 165:698-703. 2002
    ....
  64. ncbi [Canadian Thoracic Society COPD guidelines: summary of highlights for family doctors]
    Paul Hernandez
    Can Respir J 10:316-9. 2003
  65. ncbi A Canadian, multicentre, randomized clinical trial of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease: rationale and methods
    Francois Maltais
    Centre de rechereche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Canada
    Can Respir J 12:193-8. 2005
    ..Pulmonary rehabilitation remains largely underused. Self-monitored, home-based rehabilitation is a promising approach to improving the availability of pulmonary rehabilitation...
  66. ncbi Canadian Thoracic Society COPD Guidelines: summary of highlights for family doctors
    Paul Hernandez
    CTS COPD Guideline Development Committee
    Can Respir J 10:183-5. 2003