Mohamed Rachid Boulassel

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
    Marie Lise Dion
    Laboratoire d Immunologie, Centre de Recherches du CHUM, Hotel Dieu, Montreal, Quebec H2X 1P1, Canada
    Immunity 21:757-68. 2004
  2. ncbi Gender and long-term metabolic toxicities from antiretroviral therapy in HIV-1 infected persons
    Mohamed Rachid Boulassel
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    J Med Virol 78:1158-63. 2006
  3. doi CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy
    Mohamed Rachid Boulassel
    Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Virol 53:29-32. 2012
  4. doi Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
    Alexandre Iannello
    Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, University of Montreal, Montreal, Canada
    J Immunol 184:114-26. 2010
  5. doi IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication
    Alexandre Iannello
    Laboratory of Innate Immunity, CHU Sainte Justine Research Center, McGill University, Montreal, Canada
    J Leukoc Biol 87:857-67. 2010
  6. doi HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replication
    Alexandre Iannello
    Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada
    J Infect Dis 201:608-17. 2010
  7. ncbi Potential role of IL-18 in the immunopathogenesis of AIDS, HIV-associated lipodystrophy and related clinical conditions
    Alexandre Iannello
    Laboratory of Innate Immunity, CHU Sainte Justine Research Center Department of Microbiology and Immunology, University of Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec H3T1C5, Canada
    Curr HIV Res 8:147-64. 2010
  8. pmc The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
    Vanessa Sue Wacleche
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e32964. 2012
  9. doi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
  10. ncbi Virologic and immunologic response to a boosted double-protease inhibitor-based therapy in highly pretreated HIV-1-infected patients
    Graham H R Smith
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, 3650 rue St Urbain, Montreal, Quebec, H2X 2P4 Canada
    HIV Clin Trials 6:63-72. 2005

Collaborators

Detail Information

Publications34

  1. ncbi HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
    Marie Lise Dion
    Laboratoire d Immunologie, Centre de Recherches du CHUM, Hotel Dieu, Montreal, Quebec H2X 1P1, Canada
    Immunity 21:757-68. 2004
    ..Our findings reveal a substantial reduction in intrathymic proliferation. The analysis also indicates the existence of a compensatory mechanism acting to sustain the numbers of recent thymic emigrants (RTEs) in the periphery...
  2. ncbi Gender and long-term metabolic toxicities from antiretroviral therapy in HIV-1 infected persons
    Mohamed Rachid Boulassel
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    J Med Virol 78:1158-63. 2006
    ..4 (95% CI: 2.1-9.3)). Collectively, these data suggest that metabolic toxicities after HAART do not differ by gender but that lactic acidosis and hypersensitivity reactions are more frequent in women than men...
  3. doi CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy
    Mohamed Rachid Boulassel
    Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Virol 53:29-32. 2012
    ..However, the relevance of reservoir level while on efficient antiretroviral therapy (ART) is still unknown...
  4. doi Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
    Alexandre Iannello
    Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, University of Montreal, Montreal, Canada
    J Immunol 184:114-26. 2010
    ..Together, our results suggest that serum IL-21 concentrations may serve as a useful biomarker for monitoring HIV disease progression and the cytokine may be considered for immunotherapy in HIV-infected patients...
  5. doi IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication
    Alexandre Iannello
    Laboratory of Innate Immunity, CHU Sainte Justine Research Center, McGill University, Montreal, Canada
    J Leukoc Biol 87:857-67. 2010
    ..These data suggest that IL-21 may serve as a valuable therapeutic tool for enhancing NK cell responses and inhibiting viral replication in HIV-infected patients...
  6. doi HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replication
    Alexandre Iannello
    Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada
    J Infect Dis 201:608-17. 2010
    ..However, nothing is known concerning the regulation of IL-18-binding protein (IL-18BP), which neutralizes IL-18 in vivo. This issue is addressed in the present study...
  7. ncbi Potential role of IL-18 in the immunopathogenesis of AIDS, HIV-associated lipodystrophy and related clinical conditions
    Alexandre Iannello
    Laboratory of Innate Immunity, CHU Sainte Justine Research Center Department of Microbiology and Immunology, University of Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec H3T1C5, Canada
    Curr HIV Res 8:147-64. 2010
    ..The cytokine may prove to be a useful target for therapeutic intervention in these patients...
  8. pmc The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
    Vanessa Sue Wacleche
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e32964. 2012
    ....
  9. doi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
    ....
  10. ncbi Virologic and immunologic response to a boosted double-protease inhibitor-based therapy in highly pretreated HIV-1-infected patients
    Graham H R Smith
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, 3650 rue St Urbain, Montreal, Quebec, H2X 2P4 Canada
    HIV Clin Trials 6:63-72. 2005
    ..To assess the virologic and immunologic response to a boosted double-protease inhibitor (PI) regimen of highly pretreated patients infected with HIV-1 and to examine the role of PI resistance and concentration of serum saquinavir...
  11. pmc Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides
    Mehrnoosh Doroudchi
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, Montreal, Quebec, Canada
    PLoS ONE 7:e49562. 2012
    ..To determine the function and phenotype of CD8(+) T-cells targeting consensus and autologous sequences of entire HIV-1 Nef protein...
  12. doi Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell counts
    Alexandre Iannello
    Laboratory of Innate Immunity, Ste Justine Hospital Research Center, Montreal, Quebec, Canada
    Viral Immunol 21:385-8. 2008
    ..These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS...
  13. pmc CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
    Yoav Peretz
    Caprion ImmuneCarta Services, Montreal, Quebec, Canada
    PLoS Pathog 8:e1002840. 2012
    ....
  14. doi Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection
    Annie Gosselin
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 184:1604-16. 2010
    ..It is necessary that new therapeutic strategies against HIV interfere with viral replication/persistence in discrete CCR6(+) T cell subsets...
  15. pmc Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells
    Alexandre Iannello
    Department of Microbiology and Immunology, Laboratory of Innate Immunity, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
    J Virol 83:5999-6010. 2009
    ..These results suggest that increased IL-18 concentrations present in the circulation of HIV-infected persons contribute to the immunopathogenesis of AIDS by altering NK cell homeostasis...
  16. pmc Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection
    Gaelle Breton
    Laboratoire d Immunologie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Saint Luc, Montreal, Quebec H2X 1P1, Canada
    J Immunol 191:2194-204. 2013
    ..Our findings identify PD-1 as a marker for aberrant distribution of T cell subsets in HIV-1 infection. ..
  17. doi Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection
    Julien van Grevenynghe
    Laboratoire d Immunologie, Centre de Recherche, Hopital Saint Luc, Centre Hospitalier de l Universite de Montreal, 264 Boulevard Rene Levesque Est, Montreal, Quebec H2X 1P1, Canada
    Nat Med 14:266-74. 2008
    ..The crucial role of FOXO3a in the survival of memory cells will help shed light on the underlying immunological mechanisms that control viral replication in EC subjects...
  18. pmc A dual color ELISPOT method for the simultaneous detection of IL-2 and IFN-gamma HIV-specific immune responses
    Salix Boulet
    Research Institute of the McGill University Health Center, Montreal, Canada
    J Immunol Methods 320:18-29. 2007
    ..Features of this assay such as high throughput, cell number requirement and cytokine choice should make this assay a valuable tool for screening for HIV-specific immune responses in several clinically relevant settings...
  19. pmc Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy
    Jean Pierre Routy
    Immunodeficiency Service and Division of Hematology, McGill University Health Centre, McGill University, Montreal, QC, Canada
    Clin Immunol 134:140-7. 2010
    ..No evidence of autoimmunity, changes in viral load, or significant changes in absolute CD4(+) and CD8(+) T cell counts were observed. This pilot study supports the further clinical investigation of AGS-004...
  20. ncbi Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    Lydie Trautmann
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, 264 Rene Levesque Est, Montreal, Québec H2X1P1, Canada
    Nat Med 12:1198-202. 2006
    ..The accumulation of HIV-specific dysfunctional CD8(+) T cells in the infected host could prevent the renewal of a functionally competent HIV-specific CD8(+) repertoire...
  21. doi Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responses
    Abdul Mohammad Pezeshki
    Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Immunol 187:74-81. 2011
    ..Taken together, our results suggest that the overexpression of HLA-DMY at the plasma membrane of DCs may improve quantitatively, but also qualitatively, the presentation of CD4 T cell epitopes in cellular vaccine therapies for cancer...
  22. doi HIV Gag p24 specific responses secreting IFN-gamma and/or IL-2 in treatment-naïve individuals in acute infection early disease (AIED) are associated with low viral load
    Michel L Ndongala
    Research Institute of the McGill University Health Center, Montreal General Hospital, Quebec, Canada
    Clin Immunol 131:277-87. 2009
    ..Therefore the early appearance of broader and more intense Gag-p24-specific responses may be a determinant of subsequent VL...
  23. doi Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles
    Yoav Peretz
    National Immune Monitoring Laboratory NIML, Genome Quebec, Montreal, Quebec, Canada
    Viral Immunol 24:189-98. 2011
    ..HLA haplotypes influence the relative functional composition of HIV-specific responses...
  24. ncbi Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects
    Mohamed Rachid Boulassel
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Clin Immunol 124:149-57. 2007
    ....
  25. ncbi Predictive value of interleukin-7 levels for virological response to treatment in HIV-1-infected children
    Mohamed Rachid Boulassel
    Division of Hematology, Immunodeficiency Service, McGill University Health Centre, Quebec, Canada
    Viral Immunol 20:649-56. 2007
    ..Collectively, these results indicate that IL-7 levels at baseline are predictive of virological but not immunological response to ART in children infected with HIV-1...
  26. pmc HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    Nicolas Chomont
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    Nat Med 15:893-900. 2009
    ....
  27. pmc T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers
    Philomena Kamya
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    AIDS Res Ther 8:20. 2011
    ..abstract:..
  28. pmc Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57
    Philomena Kamya
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Virol 85:5949-60. 2011
    ..The protective effect of HLA-B*57 on slow progression to AIDS and low VL may be mediated through its interaction with KIR3DL1 alleles to educate NK cells for potent activity upon stimulation...
  29. ncbi HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing
    Angelique Bellemare-Pelletier
    Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, CP 6128, Quebec, Canada
    J Leukoc Biol 78:95-105. 2005
    ..These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy...
  30. doi Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance
    Jessica Godin-Ethier
    Research Centre, Centre Hospitalier de l Université de Montréal Hôpital Notre Dame, Université de Montréal and Institut du Cancer de Montréal, Montreal, Quebec, Canada
    J Immunol 183:7752-60. 2009
    ..These findings demonstrate complex control of immune activity within tumors. Future immune therapeutic interventions should thus include strategies to counteract these negative mechanisms...
  31. doi HHV-8 linked to Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in a HIV-1-infected man
    Alain Bestawros
    Department of Internal Medicine, Montreal General Hospital and McGill University Health Centre, Montreal, Canada
    J Clin Virol 42:179-81. 2008
  32. doi Multiple cycles of rituximab therapy in chronic refractory immune thrombocytopenia: a case report with a 10-year follow-up
    Bertrand Routy
    Division of Hematology, Department of Medicine Royal Victoria Hospital, McGill University Heath Centre, Montreal, Quebec, Canada
    Am J Ther 20:219-22. 2013
    ..The data show that rituximab can be an effective therapy over 10 years, and monitoring B cells may help to herald ITP recurrence...
  33. ncbi Role of interleukin-18 in the development and pathogenesis of AIDS
    Alexandre Iannello
    Laboratory of Innate Immunity, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
    AIDS Rev 11:115-25. 2009
    ..It may delay AIDS progression and improve the immune status of infected persons. The best way to achieve this goal may be using exogenous interleukin-18 binding protein...
  34. pmc HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    Souheil Antoine Younes
    Departement de Microbiologie et Immunologie, Universite de Montreal, 2900 Edouard Montpetit Boulevard, Montreal H3T 1J4, Canada
    J Exp Med 198:1909-22. 2003
    ..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...