Research Topics
Genomes and Genes | Mohamed Rachid BoulasselSummaryAffiliation: McGill University Country: Canada Publications
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Publications
HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferationMarie-Lise Dion
Laboratoire d'Immunologie, Centre de Recherches du CHUM, , , , Canada
Immunity 21:757-68. 2004..Our findings reveal a substantial reduction in intrathymic proliferation. The analysis also indicates the existence of a compensatory mechanism acting to sustain the numbers of recent thymic emigrants (RTEs) in the periphery...- Gender and long-term metabolic toxicities from antiretroviral therapy in HIV-1 infected personsMohamed Rachid Boulassel
Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
J Med Virol 78:1158-63. 2006..4 (95% CI: 2.1-9.3)). Collectively, these data suggest that metabolic toxicities after HAART do not differ by gender but that lactic acidosis and hypersensitivity reactions are more frequent in women than men... 
CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapyMohamed Rachid Boulassel
Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
J Clin Virol 53:29-32. 2012..However, the relevance of reservoir level while on efficient antiretroviral therapy (ART) is still unknown...- Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional studyAlexandre Iannello
Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, University of Montreal, Montreal, Canada
J Immunol 184:114-26. 2010..Together, our results suggest that serum IL-21 concentrations may serve as a useful biomarker for monitoring HIV disease progression and the cytokine may be considered for immunotherapy in HIV-infected patients... - IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replicationAlexandre Iannello
Laboratory of Innate Immunity, CHU Sainte Justine Research Center, McGill University, Montreal, Canada
J Leukoc Biol 87:857-67. 2010..These data suggest that IL-21 may serve as a valuable therapeutic tool for enhancing NK cell responses and inhibiting viral replication in HIV-infected patients... - HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: implications for enhanced viral replicationAlexandre Iannello
Laboratory of Innate Immunity, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada
J Infect Dis 201:608-17. 2010..However, nothing is known concerning the regulation of IL-18-binding protein (IL-18BP), which neutralizes IL-18 in vivo. This issue is addressed in the present study... - Potential role of IL-18 in the immunopathogenesis of AIDS, HIV-associated lipodystrophy and related clinical conditionsAlexandre Iannello
Laboratory of Innate Immunity, CHU Sainte Justine Research Center Department of Microbiology and Immunology, University of Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec H3T1C5, Canada
Curr HIV Res 8:147-64. 2010..The cytokine may prove to be a useful target for therapeutic intervention in these patients... 
The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acidVanessa Sue Wacleche
Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
PLoS ONE 7:e32964. 2012....- Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7Patricia Monteiro
Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
J Immunol 186:4618-30. 2011.... - Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell countsAlexandre Iannello
Laboratory of Innate Immunity, Ste Justine Hospital Research Center, Montreal, Quebec, Canada
Viral Immunol 21:385-8. 2008..These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS... - Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infectionAnnie Gosselin
Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
J Immunol 184:1604-16. 2010..It is necessary that new therapeutic strategies against HIV interfere with viral replication/persistence in discrete CCR6(+) T cell subsets... - Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infectionJulien van Grevenynghe
Laboratoire d Immunologie, Centre de Recherche, Hopital Saint Luc, Centre Hospitalier de l Universite de Montreal, 264 Boulevard Rene Levesque Est, Montreal, Quebec H2X 1P1, Canada
Nat Med 14:266-74. 2008..The crucial role of FOXO3a in the survival of memory cells will help shed light on the underlying immunological mechanisms that control viral replication in EC subjects... - Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionLydie Trautmann
Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, 264 Rene Levesque Est, Montreal, Québec H2X1P1, Canada
Nat Med 12:1198-202. 2006..The accumulation of HIV-specific dysfunctional CD8(+) T cells in the infected host could prevent the renewal of a functionally competent HIV-specific CD8(+) repertoire... - Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cellsAlexandre Iannello
Department of Microbiology and Immunology, Laboratory of Innate Immunity, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
J Virol 83:5999-6010. 2009..These results suggest that increased IL-18 concentrations present in the circulation of HIV-infected persons contribute to the immunopathogenesis of AIDS by altering NK cell homeostasis... - CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunctionYoav Peretz
Caprion ImmuneCarta Services, Montreal, Quebec, Canada
PLoS Pathog 8:e1002840. 2012.... - A dual color ELISPOT method for the simultaneous detection of IL-2 and IFN-gamma HIV-specific immune responsesSalix Boulet
Research Institute of the McGill University Health Center, Montreal, Canada
J Immunol Methods 320:18-29. 2007..Features of this assay such as high throughput, cell number requirement and cytokine choice should make this assay a valuable tool for screening for HIV-specific immune responses in several clinically relevant settings... - Predictive value of interleukin-7 levels for virological response to treatment in HIV-1-infected childrenMohamed Rachid Boulassel
Division of Hematology, Immunodeficiency Service, McGill University Health Centre, Quebec, Canada
Viral Immunol 20:649-56. 2007..Collectively, these results indicate that IL-7 levels at baseline are predictive of virological but not immunological response to ART in children infected with HIV-1... - Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapyJean Pierre Routy
Immunodeficiency Service and Division of Hematology, McGill University Health Centre, McGill University, Montreal, QC, Canada
Clin Immunol 134:140-7. 2010..No evidence of autoimmunity, changes in viral load, or significant changes in absolute CD4(+) and CD8(+) T cell counts were observed. This pilot study supports the further clinical investigation of AGS-004... - Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjectsMohamed Rachid Boulassel
Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
Clin Immunol 124:149-57. 2007.... - HIV Gag p24 specific responses secreting IFN-gamma and/or IL-2 in treatment-naïve individuals in acute infection early disease (AIED) are associated with low viral loadMichel L Ndongala
Research Institute of the McGill University Health Center, Montreal General Hospital, Quebec, Canada
Clin Immunol 131:277-87. 2009..Therefore the early appearance of broader and more intense Gag-p24-specific responses may be a determinant of subsequent VL... - Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA allelesYoav Peretz
National Immune Monitoring Laboratory NIML, Genome Quebec, Montreal, Quebec, Canada
Viral Immunol 24:189-98. 2011..HLA haplotypes influence the relative functional composition of HIV-specific responses... - HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationNicolas Chomont
Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
Nat Med 15:893-900. 2009.... - T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite ControllersPhilomena Kamya
Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
AIDS Res Ther 8:20. 2011..abstract:.. - HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processingAngelique Bellemare-Pelletier
Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, CP 6128, Quebec, Canada
J Leukoc Biol 78:95-105. 2005..These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy... - Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57Philomena Kamya
Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
J Virol 85:5949-60. 2011..The protective effect of HLA-B*57 on slow progression to AIDS and low VL may be mediated through its interaction with KIR3DL1 alleles to educate NK cells for potent activity upon stimulation... - Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responsesAbdul Mohammad Pezeshki
Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Immunol 187:74-81. 2011..Taken together, our results suggest that the overexpression of HLA-DMY at the plasma membrane of DCs may improve quantitatively, but also qualitatively, the presentation of CD4 T cell epitopes in cellular vaccine therapies for cancer... - Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptidesMehrnoosh Doroudchi
Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, Montreal, Quebec, Canada
PLoS ONE 7:e49562. 2012..To determine the function and phenotype of CD8(+) T-cells targeting consensus and autologous sequences of entire HIV-1 Nef protein... - Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balanceJessica Godin-Ethier
Research Centre, Centre Hospitalier de l Université de Montréal Hôpital Notre Dame, Université de Montréal and Institut du Cancer de Montréal, Montreal, Quebec, Canada
J Immunol 183:7752-60. 2009..These findings demonstrate complex control of immune activity within tumors. Future immune therapeutic interventions should thus include strategies to counteract these negative mechanisms... - Role of interleukin-18 in the development and pathogenesis of AIDSAlexandre Iannello
Laboratory of Innate Immunity, CHU Sainte Justine Research Center, University of Montreal, Montreal, Quebec, Canada
AIDS Rev 11:115-25. 2009..It may delay AIDS progression and improve the immune status of infected persons. The best way to achieve this goal may be using exogenous interleukin-18 binding protein... - Virologic and immunologic response to a boosted double-protease inhibitor-based therapy in highly pretreated HIV-1-infected patientsGraham H R Smith
Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, 3650 rue St-Urbain, Montreal, Quebec, H2X 2P4 Canada
HIV Clin Trials 6:63-72. 2005..CONCLUSION: These findings suggest that baseline PI resistance and saquinavir concentration were associated with virologic response and should be considered when planning salvage therapy... - HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacitySouheil-Antoine Younes
, , 2900 Edouard-Montpetit Boulevard, , Canada
J Exp Med 198:1909-22. 2003..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...