P Boksa

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Effects of prenatal infection on brain development and behavior: a review of findings from animal models
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Verdun, Quebec, Canada
    Brain Behav Immun 24:881-97. 2010
  2. ncbi request reprint Animal models of obstetric complications in relation to schizophrenia
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Brain Res Brain Res Rev 45:1-17. 2004
  3. ncbi request reprint Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
    Exp Neurol 175:388-97. 2002
  4. doi request reprint Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat
    Patricia Boksa
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Psychopharmacology (Berl) 200:381-91. 2008
  5. doi request reprint Global birth hypoxia increases the neonatal testosterone surge in the rat
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Que, Canada
    Neuroendocrinology 88:266-75. 2008
  6. ncbi request reprint Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disorders
    P Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 27:91-101. 2003
  7. doi request reprint Effects of prenatal immune activation on hippocampal neurogenesis in the rat
    Ke Cui
    Department of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Schizophr Res 113:288-97. 2009
  8. ncbi request reprint Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
    Marie Eve Fortier
    Department of Psychiatry and Neurology, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    J Psychiatr Res 38:335-45. 2004
  9. ncbi request reprint Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in rats
    H Ashdown
    McGill University, Department of Psychiatry, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Am J Physiol Regul Integr Comp Physiol 292:R1667-74. 2007
  10. ncbi request reprint Birth insults involving hypoxia produce long-term increases in hippocampal [125I]insulin-like growth factor-I and -II receptor binding in the rat
    P Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    Neuroscience 139:451-62. 2006

Collaborators

Detail Information

Publications34

  1. doi request reprint Effects of prenatal infection on brain development and behavior: a review of findings from animal models
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Verdun, Quebec, Canada
    Brain Behav Immun 24:881-97. 2010
    ..Directions for further research are discussed...
  2. ncbi request reprint Animal models of obstetric complications in relation to schizophrenia
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Brain Res Brain Res Rev 45:1-17. 2004
    ..In this way, animal modeling may provide the framework for human studies to ask further more refined questions concerning the role of specific obstetric factors contributing to schizophrenia, and may provide clues to prevention...
  3. ncbi request reprint Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
    Exp Neurol 175:388-97. 2002
    ..These studies indicate that C-section birth, from either anesthetized or unanesthetized dams, results in postpubertal increases in D1-like receptor binding and enhanced functional responses to D1 receptor activation...
  4. doi request reprint Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat
    Patricia Boksa
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Psychopharmacology (Berl) 200:381-91. 2008
    ..Using a rat model, it has been found that C-section birth can produce long-term changes in central nervous system (CNS) dopamine function, compared to vaginal birth...
  5. doi request reprint Global birth hypoxia increases the neonatal testosterone surge in the rat
    Patricia Boksa
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Que, Canada
    Neuroendocrinology 88:266-75. 2008
    ..Birth hypoxia alters levels of several circulating hormones, but it is unknown if it affects neonatal testosterone...
  6. ncbi request reprint Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disorders
    P Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 27:91-101. 2003
    ..In addition, birth insult alters the manner in which dopaminergic function is regulated by stress at adulthood. The possible relevance of these finding to effects of human birth procedures is discussed...
  7. doi request reprint Effects of prenatal immune activation on hippocampal neurogenesis in the rat
    Ke Cui
    Department of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Schizophr Res 113:288-97. 2009
    ..This indicates that deficits in neurogenesis caused by prenatal LPS are not mediated by LPS-induced fever or eicosanoid induction, but could be mediated by LPS-induced increases in maternal cytokines or corticosterone...
  8. ncbi request reprint Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
    Marie Eve Fortier
    Department of Psychiatry and Neurology, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    J Psychiatr Res 38:335-45. 2004
    ..It is concluded that maternal LPS exposure during pregnancy in the rat may be a useful model to study mechanisms responsible for effects of maternal infection on behaviors relevant to schizophrenia, in offspring...
  9. ncbi request reprint Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in rats
    H Ashdown
    McGill University, Department of Psychiatry, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Am J Physiol Regul Integr Comp Physiol 292:R1667-74. 2007
    ..This may be an important mechanism that protects the developing fetus from potentially deleterious consequences of maternal fever during pregnancy...
  10. ncbi request reprint Birth insults involving hypoxia produce long-term increases in hippocampal [125I]insulin-like growth factor-I and -II receptor binding in the rat
    P Boksa
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    Neuroscience 139:451-62. 2006
    ....
  11. ncbi request reprint Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site
    H Mount
    Douglas Hospital Research Center, Department of Pharmacology and Therapeutics, McGill University, Verdun, Quebec, Canada
    Can J Physiol Pharmacol 68:1200-6. 1990
    ..It remains conceivable that blocking actions of PCP-like compounds at voltage-regulated K+ channels may at least partly explain the response. These results are discussed in comparison with findings in intact brain...
  12. ncbi request reprint Caesarean section birth produces long term changes in dopamine D1 receptors and in stress-induced regulation of D3 and D4 receptors in the rat brain
    B El-Khodor
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, Montreal, Quebec, Canada
    Neuropsychopharmacology 25:423-39. 2001
    ....
  13. ncbi request reprint Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle
    Ridha Joober
    Department of Psychiatry and of Neurology and Neurosurgery, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:765-81. 2002
    ..If confirmed, these QTLs may suggest candidate genes directing novel mechanisms for regulation of PPI..
  14. ncbi request reprint Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy
    Marie Eve Fortier
    McGill University, Department of Psychiatry, Douglas Hospital Research Centre, Neuroscience Division, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Behav Brain Res 181:270-7. 2007
    ..These findings support the idea that maternal infection during critical windows of pregnancy could contribute to sensorimotor gating deficits in schizophrenia...
  15. ncbi request reprint Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of mice
    Adam Torkamanzehi
    Douglas Hospital Research Centre, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Behav Genet 36:903-13. 2006
    ....
  16. pmc Genetics of schizophrenia: from animal models to clinical studies
    Ridha Joober
    Departments of Psychiatry and of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, Montreal, Que
    J Psychiatry Neurosci 27:336-47. 2002
    ....
  17. pmc Genetics of developmental psychiatric disorders: pathways to discovery
    Ridha Joober
    Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:349-54. 2005
    ..We also consider the implications of psychiatric genetic research for individual and public health...
  18. pmc The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion
    P B Clarke
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 111:397-405. 1994
    ....
  19. ncbi request reprint Maternal care is similar for rat pups subjected to birth hypoxia and for controls
    Yonina Levine
    Douglas Hospital Research Center, Department of Psychiatry, McGill University Montreal, Quebec, Canada
    Neuroreport 17:45-9. 2006
    ..The results indicate that altered central nervous system function in anoxic animals in this model are not due to differential maternal care, but may be mediated by other mechanisms such as direct hypoxic insult to neurons...
  20. ncbi request reprint Effects of birth insult and stress at adulthood on in vivo tyrosine hydroxylase and tryptophan hydroxylase activities in rat brain
    Bassem F El-Khodor
    Department of Psychiatry, McGill University, and Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Synapse 47:87-9. 2003
  21. ncbi request reprint Effects of ovariectomy and estradiol on acoustic startle responses in rats
    Cathy Vaillancourt
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, H4H 1R3, Verdun, Quebec, Canada
    Pharmacol Biochem Behav 74:103-9. 2002
    ..These results indicate that long-term ovariectomy has persistent effects on the modulation of ASR, and these effects can be at least partly corrected with E(2) replacement therapy...
  22. ncbi request reprint The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
    H Ashdown
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Montreal, Quebec, Canada H4H 1R3
    Mol Psychiatry 11:47-55. 2006
    ..Collectively, these data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta...
  23. ncbi request reprint Effects of the catecholaminergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on adrenal chromaffin cells in culture
    P Boksa
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biochem Pharmacol 38:1491-8. 1989
    ..Longer exposure to DSP-4 resulted in morphological changes in the cells, suggesting that the drug is also toxic to chromaffin cells in culture...
  24. ncbi request reprint Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia
    Cecilia Flores
    Center for Studies in Behavioral Neurobiology Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Biol Psychiatry 52:362-70. 2002
    ....
  25. ncbi request reprint Effects of birth insult and stress at adulthood on excitatory amino acid receptors in adult rat brain
    Bassem F El-Khodor
    Department of Psychiatry, McGill University, Douglas Hospital Research Center, Verdun, Quebec, Canada H4H 1R3
    Synapse 54:138-46. 2004
    ..The possibility that the observed EAA receptor changes contribute to dopaminergic dysfunction in these animal models is discussed, in light of known glutamate-DA interactions...
  26. ncbi request reprint Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring
    Raphael Vartazarmian
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 LaSalle Boulevard, Verdun, QC, Canada, H4H 1R3
    Psychopharmacology (Berl) 178:328-38. 2005
    ..Limitations in previous such studies using rat models may be overcome using a guinea pig model in which fluoxetine is delivered by osmotic pump throughout pregnancy...
  27. ncbi request reprint The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism
    Marie Eve Fortier
    Douglas Hospital Research Centre, McGill Univ, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 287:R759-66. 2004
    ..Finally, poly I:C decreased food intake by 30%, but this response was not altered by pretreatment with IL-1ra. These results suggest that poly I:C induces fever, but not anorexia, through an IL-1 and prostaglandin-dependent mechanism...
  28. doi request reprint Acute brain cytokine responses after global birth hypoxia in the rat
    Helen Ashdown
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Neurosci Res 86:3401-9. 2008
    ....
  29. ncbi request reprint Differential vulnerability of male versus female rats to long-term effects of birth insult on brain catecholamine levels
    Bassem F El-Khodor
    Departments of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    Exp Neurol 182:208-19. 2003
    ..The possible functional significance of the lasting, region-specific changes in brain DA and NE due to birth insult and possible roles of hormones at birth in producing these monoamine changes in the two sexes are discussed...
  30. ncbi request reprint Birth insult and stress interact to alter dopamine transporter binding in rat brain
    Bassem F El-Khodor
    Departments of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
    Neuroreport 13:201-6. 2002
    ..It is concluded that a history of birth complications can alter the manner in which DAT is regulated by stress in the adult rat brain...
  31. ncbi request reprint Effects of clozapine on behavioral and metabolic traits relevant for schizophrenia in two mouse strains
    Jean Mary Zarate
    Department of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, H4H 1R3, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 171:162-72. 2004
    ..In particular, patients with schizophrenia exhibit important variability in their therapeutic and metabolic responses to clozapine, an antipsychotic medication...
  32. ncbi request reprint Psychosis pathways converge via D2high dopamine receptors
    Philip Seeman
    Department of Pharmacology, University of Toronto, and Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5S 1A8
    Synapse 60:319-46. 2006
    ..Dopamine supersensitivity, in turn, correlates with D2High states. The finding that all antipsychotics, traditional and recent ones, act on D2High dopamine receptors further supports the proposition...
  33. pmc Of rats and schizophrenia
    Patricia Boksa
    J Psychiatry Neurosci 32:8-10. 2007
  34. pmc Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
    Philip Seeman
    Pharmacology Department, Medical Science Building, Room 4344, University of Toronto, 1 King s College Circle, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 102:3513-8. 2005
    ..If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted...