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Genomes and Genes | P BoksaSummaryAffiliation: McGill University Country: Canada Publications
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Publications
Effects of prenatal infection on brain development and behavior: a review of findings from animal modelsPatricia Boksa
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Verdun, Quebec, Canada
Brain Behav Immun 24:881-97. 2010..Directions for further research are discussed...
Animal models of obstetric complications in relation to schizophreniaPatricia Boksa
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
Brain Res Brain Res Rev 45:1-17. 2004..In this way, animal modeling may provide the framework for human studies to ask further more refined questions concerning the role of specific obstetric factors contributing to schizophrenia, and may provide clues to prevention...- Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequencesPatricia Boksa
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
Exp Neurol 175:388-97. 2002..These studies indicate that C-section birth, from either anesthetized or unanesthetized dams, results in postpubertal increases in D1-like receptor binding and enhanced functional responses to D1 receptor activation... - Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the ratPatricia Boksa
Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
Psychopharmacology (Berl) 200:381-91. 2008..Using a rat model, it has been found that C-section birth can produce long-term changes in central nervous system (CNS) dopamine function, compared to vaginal birth... - Global birth hypoxia increases the neonatal testosterone surge in the ratPatricia Boksa
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Que, Canada
Neuroendocrinology 88:266-75. 2008..Birth hypoxia alters levels of several circulating hormones, but it is unknown if it affects neonatal testosterone... - Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disordersP Boksa
Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Que, Canada H4H 1R3
Neurosci Biobehav Rev 27:91-101. 2003..In addition, birth insult alters the manner in which dopaminergic function is regulated by stress at adulthood. The possible relevance of these finding to effects of human birth procedures is discussed... - Effects of prenatal immune activation on hippocampal neurogenesis in the ratKe Cui
Department of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
Schizophr Res 113:288-97. 2009..This indicates that deficits in neurogenesis caused by prenatal LPS are not mediated by LPS-induced fever or eicosanoid induction, but could be mediated by LPS-induced increases in maternal cytokines or corticosterone... - Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspringMarie-Eve Fortier
Department of Psychiatry and Neurology, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
J Psychiatr Res 38:335-45. 2004..It is concluded that maternal LPS exposure during pregnancy in the rat may be a useful model to study mechanisms responsible for effects of maternal infection on behaviors relevant to schizophrenia, in offspring... - Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in ratsH Ashdown
McGill University, Department of Psychiatry, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
Am J Physiol Regul Integr Comp Physiol 292:R1667-74. 2007..This may be an important mechanism that protects the developing fetus from potentially deleterious consequences of maternal fever during pregnancy... - Birth insults involving hypoxia produce long-term increases in hippocampal [125I]insulin-like growth factor-I and -II receptor binding in the ratP Boksa
Department of Psychiatry, McGill University, Douglas Hospital Research Center, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
Neuroscience 139:451-62. 2006.... - Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake siteH Mount
Douglas Hospital Research Center, Department of Pharmacology and Therapeutics, McGill University, Verdun, Quebec, Canada
Can J Physiol Pharmacol 68:1200-6. 1990..It remains conceivable that blocking actions of PCP-like compounds at voltage-regulated K+ channels may at least partly explain the response. These results are discussed in comparison with findings in intact brain... - Caesarean section birth produces long term changes in dopamine D1 receptors and in stress-induced regulation of D3 and D4 receptors in the rat brainB El-Khodor
Department of Psychiatry, McGill University, Douglas Hospital Research Center, Montreal, Quebec, Canada
Neuropsychopharmacology 25:423-39. 2001.... - Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startleRidha Joober
Department of Psychiatry and of Neurology and Neurosurgery, Montreal, Quebec, Canada
Neuropsychopharmacology 27:765-81. 2002..If confirmed, these QTLs may suggest candidate genes directing novel mechanisms for regulation of PPI.. - Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancyMarie Eve Fortier
McGill University, Department of Psychiatry, Douglas Hospital Research Centre, Neuroscience Division, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
Behav Brain Res 181:270-7. 2007..These findings support the idea that maternal infection during critical windows of pregnancy could contribute to sensorimotor gating deficits in schizophrenia... - Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of miceAdam Torkamanzehi
Douglas Hospital Research Centre, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Behav Genet 36:903-13. 2006.... 
Genetics of schizophrenia: from animal models to clinical studiesRidha Joober
Departments of Psychiatry and of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, Montreal, Que
J Psychiatry Neurosci 27:336-47. 2002....- Genetics of developmental psychiatric disorders: pathways to discoveryRidha Joober
Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
J Psychiatry Neurosci 30:349-54. 2005..We also consider the implications of psychiatric genetic research for individual and public health... - The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglionP B Clarke
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Br J Pharmacol 111:397-405. 1994.... - Maternal care is similar for rat pups subjected to birth hypoxia and for controlsYonina Levine
Douglas Hospital Research Center, Department of Psychiatry, McGill University Montreal, Quebec, Canada
Neuroreport 17:45-9. 2006..The results indicate that altered central nervous system function in anoxic animals in this model are not due to differential maternal care, but may be mediated by other mechanisms such as direct hypoxic insult to neurons... - Effects of birth insult and stress at adulthood on in vivo tyrosine hydroxylase and tryptophan hydroxylase activities in rat brainBassem F El-Khodor
Department of Psychiatry, McGill University, and Douglas Hospital Research Centre, Montreal, Quebec, Canada
Synapse 47:87-9. 2003 - Effects of ovariectomy and estradiol on acoustic startle responses in ratsCathy Vaillancourt
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, H4H 1R3, Verdun, , Canada
Pharmacol Biochem Behav 74:103-9. 2002..These results indicate that long-term ovariectomy has persistent effects on the modulation of ASR, and these effects can be at least partly corrected with E(2) replacement therapy... - The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophreniaH Ashdown
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Montreal, Quebec, Canada H4H 1R3
Mol Psychiatry 11:47-55. 2006..Collectively, these data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta... - Effects of the catecholaminergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on adrenal chromaffin cells in cultureP Boksa
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Biochem Pharmacol 38:1491-8. 1989..Longer exposure to DSP-4 resulted in morphological changes in the cells, suggesting that the drug is also toxic to chromaffin cells in culture... - Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxiaCecilia Flores
Center for Studies in Behavioral Neurobiology Department of Psychology, Concordia University, Montreal, Quebec, Canada
Biol Psychiatry 52:362-70. 2002..The mechanisms whereby perinatal anoxia alters dopaminergic function may be similar to those responsible for the development of sensitization to stimulant drugs and may involve bFGF... - Effects of birth insult and stress at adulthood on excitatory amino acid receptors in adult rat brainBassem F El-Khodor
Department of Psychiatry, McGill University, Douglas Hospital Research Center, Verdun, Quebec, Canada H4H 1R3
Synapse 54:138-46. 2004..The possibility that the observed EAA receptor changes contribute to dopaminergic dysfunction in these animal models is discussed, in light of known glutamate-DA interactions... - Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspringRaphael Vartazarmian
Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 LaSalle Boulevard, Verdun, QC, Canada, H4H 1R3
Psychopharmacology (Berl) 178:328-38. 2005..Further studies on long-term effects of prenatal fluoxetine on nociception are warranted... - The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanismMarie-Eve Fortier
Douglas Hospital Research Centre, McGill Univ, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
Am J Physiol Regul Integr Comp Physiol 287:R759-66. 2004..Finally, poly I:C decreased food intake by 30%, but this response was not altered by pretreatment with IL-1ra. These results suggest that poly I:C induces fever, but not anorexia, through an IL-1 and prostaglandin-dependent mechanism... - Acute brain cytokine responses after global birth hypoxia in the ratHelen Ashdown
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
J Neurosci Res 86:3401-9. 2008.... - Differential vulnerability of male versus female rats to long-term effects of birth insult on brain catecholamine levelsBassem F El-Khodor
Departments of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
Exp Neurol 182:208-19. 2003..The possible functional significance of the lasting, region-specific changes in brain DA and NE due to birth insult and possible roles of hormones at birth in producing these monoamine changes in the two sexes are discussed... - Birth insult and stress interact to alter dopamine transporter binding in rat brainBassem F El-Khodor
Departments of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
Neuroreport 13:201-6. 2002..It is concluded that a history of birth complications can alter the manner in which DAT is regulated by stress in the adult rat brain... - Effects of clozapine on behavioral and metabolic traits relevant for schizophrenia in two mouse strainsJean Mary Zarate
Department of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, H4H 1R3, , , Canada
Psychopharmacology (Berl) 171:162-72. 2004..In contrast, enhancement of prepulse inhibition after three days of clozapine treatment and weight gain induced by clozapine are relatively straightforward to quantify, making these trait more amenable to quantitative genetic approaches... - Psychosis pathways converge via D2high dopamine receptorsPhilip Seeman
Department of Pharmacology, University of Toronto, and Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5S 1A8
Synapse 60:319-46. 2006..Dopamine supersensitivity, in turn, correlates with D2High states. The finding that all antipsychotics, traditional and recent ones, act on D2High dopamine receptors further supports the proposition... - Of rats and schizophreniaPatricia Boksa
J Psychiatry Neurosci 32:8-10. 2007 - Dopamine supersensitivity correlates with D2High states, implying many paths to psychosisPhilip Seeman
Pharmacology Department, Medical Science Building, Room 4344, University of Toronto, 1 King s College Circle, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 102:3513-8. 2005..If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted...