M Blostein

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Characterization of an ideal amphipathic peptide as a procoagulant agent
    Jorge G Ganopolsky
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Room E 156, SMDB Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada
    Biochem J 412:545-51. 2008
  2. ncbi request reprint The Gla domain of factor IXa binds to factor VIIIa in the tenase complex
    Mark D Blostein
    The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1A4, Canada
    J Biol Chem 278:31297-302. 2003
  3. ncbi request reprint Galectin 3-binding protein is a potential contaminant of recombinantly produced factor IX
    M Blostein
    SMDB Jewish General Hospital, Montreal, Quebec, Canada
    Haemophilia 13:701-6. 2007
  4. doi request reprint The carboxylation efficiency of the vitamin K-dependent clotting factors: studies with factor IX
    M Blostein
    SMDB Jewish General Hospital, Montreal, QC, Canada
    Haemophilia 14:1063-8. 2008
  5. doi request reprint Elevated plasma gas6 levels are associated with venous thromboembolic disease
    Mark D Blostein
    Departments of Medicine and Epidemiology, Lady Davis Institute for Medical Research Jewish General Hospital, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, Canada
    J Thromb Thrombolysis 32:272-8. 2011
  6. doi request reprint Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
    Catherine A Lemarié
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 300:H745-53. 2011
  7. ncbi request reprint The role of gamma-carboxylation in the anti-apoptotic function of gas6
    I Hasanbasic
    The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Thromb Haemost 3:2790-7. 2005

Collaborators

  • Catherine A Lemarié
  • Jorge G Ganopolsky
  • I Hasanbasic
  • Ernesto L Schiffrin
  • Pierre Paradis
  • Marie Eve Deschênes
  • Layla Shbat
  • Orlando J Angulo
  • Chiara Marchesi
  • Henry T Peng
  • Sophie Charbonneau
  • Pang N Shek
  • I Rajotte

Detail Information

Publications7

  1. doi request reprint Characterization of an ideal amphipathic peptide as a procoagulant agent
    Jorge G Ganopolsky
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Room E 156, SMDB Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada
    Biochem J 412:545-51. 2008
    ..In summary, these observations demonstrate that IAP not only enhances essential procoagulant reactions required for fibrin generation, but also inhibits fibrinolysis, suggesting a potential role for IAP as a haemostatic agent...
  2. ncbi request reprint The Gla domain of factor IXa binds to factor VIIIa in the tenase complex
    Mark D Blostein
    The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1A4, Canada
    J Biol Chem 278:31297-302. 2003
    ..These results suggest that the factor IXa Gla domain contacts factor VIIIa in the tenase complex through a contact site that includes phenylalanine 25 and perhaps valine 46...
  3. ncbi request reprint Galectin 3-binding protein is a potential contaminant of recombinantly produced factor IX
    M Blostein
    SMDB Jewish General Hospital, Montreal, Quebec, Canada
    Haemophilia 13:701-6. 2007
    ..The above results raise an important note of caution regarding the production of recombinant FIX and, indeed, other proteins produced recombinantly in mammalian cells...
  4. doi request reprint The carboxylation efficiency of the vitamin K-dependent clotting factors: studies with factor IX
    M Blostein
    SMDB Jewish General Hospital, Montreal, QC, Canada
    Haemophilia 14:1063-8. 2008
    ..These results demonstrate that the nature of the propeptide, per se is not the sole determinant of optimal carboxylation of FIX in our expression system in HEK 293 cells...
  5. doi request reprint Elevated plasma gas6 levels are associated with venous thromboembolic disease
    Mark D Blostein
    Departments of Medicine and Epidemiology, Lady Davis Institute for Medical Research Jewish General Hospital, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, Canada
    J Thromb Thrombolysis 32:272-8. 2011
    ..This constitutes a potential novel mechanism for thrombosis in humans and may aid in the understanding of the pathophysiology of VTE...
  6. doi request reprint Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
    Catherine A Lemarié
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 300:H745-53. 2011
    ..Taken together, these results demonstrate that Mthfr deficiency impairs EPC formation and increases EPC senescence by eNOS uncoupling and downregulation of SIRT1...
  7. ncbi request reprint The role of gamma-carboxylation in the anti-apoptotic function of gas6
    I Hasanbasic
    The Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Thromb Haemost 3:2790-7. 2005
    ..Taken together, these findings demonstrate that gamma-carboxylation is necessary not only for gas6 binding to phospholipid membranes, but also for gas6-mediated endothelial cell survival...