Affiliation: McGill University
- Treatment of hospitalized adult patients with severe ulcerative colitis: Toronto consensus statementsAlain Bitton
McGill University Health Centre, Montreal, Quebec, Canada
Am J Gastroenterol 107:179-94; author reply 195. 2012..The objective of this study was to provide updated explicit and relevant consensus statements for clinicians to refer to when managing hospitalized adult patients with acute severe ulcerative colitis (UC)...
- Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitisA Bitton
Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Gastroenterology 120:13-20. 2001..Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. We aimed to assess whether clinical, biological, and histologic parameters in quiescent UC predict time to clinical relapse...
- Medical management of ulcerative proctitis, proctosigmoiditis, and left-sided colitisA Bitton
Department of Medicine, McGill University Health Centre, Montreal, Canada
Semin Gastrointest Dis 12:263-74. 2001..This article reviews the clinical diagnosis and current medical management of ulcerative proctitis, proctosigmoiditis, and left-sided ulcerative colitis, including patients resistant to conventional medical therapy...
- Predicting relapse in Crohn's disease: a biopsychosocial modelA Bitton
McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A1
Gut 57:1386-92. 2008..Crohn's disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience...
- Psychological distress, social support, and disease activity in patients with inflammatory bowel diseaseM J Sewitch
Department of Epidemiology, McGill University, Montreal, Quebec, Canada
Am J Gastroenterol 96:1470-9. 2001..CONCLUSIONS: These findings suggest that strategies aimed at improving social support can have a favorable impact on psychological distress and, ultimately, can improve health outcomes in patients with IBD...
- The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseasesP L De Jager
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Genes Immun 8:387-97. 2007..16, 95% CI: 1.04-1.30; P=0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway - in this case, TLR4 and its signaling molecule TIRAP - plays a role in susceptibility to IBD...
- Association between genetic variants in the HNF4A gene and childhood-onset Crohn's diseaseV Marcil
Departments of Medicine and Pediatrics, Research Institute, McGill University, Montreal, Quebec, Canada
Genes Immun 13:556-65. 2012..This is the first report showing that the HNF4A locus may be a common genetic determinant of childhood-onset CD. These findings highlight the importance of the intestinal epithelium and oxidative protection in the pathogenesis of CD...
- The mechanisms of prednisone inhibition of inflammation in Crohn's disease involve changes in intestinal permeability, mucosal TNFalpha production and nuclear factor kappa B expressionG E Wild
Department of Medicine, Division of Gastroenterology, McGill University, Montreal, Canada
Aliment Pharmacol Ther 18:309-17. 2003..The clinical course of Crohn's disease after the induction of remission with medical therapy is characterized by unpredictable relapse...
- L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammationG Fortin
Department of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada
Clin Exp Immunol 156:161-71. 2009..LCAR therapy may therefore represent a novel alternative therapeutic strategy and highlights the role of diet in CD...
- Rectal tissue, plasma and urine concentrations of mesalazine after single and multiple administrations of 500 mg suppositories to healthy volunteers and ulcerative proctitis patientsG Aumais
Algorithme Pharma Inc, , Quebec, Canada
Aliment Pharmacol Ther 17:93-7. 2003..9 (0.5) h for half-life. CONCLUSION: Mesalazine is released in the rectum of patients, with a bioavailability of about 40%. Tissue distribution is also appreciable. Both parameters appear higher than in healthy volunteers...
- Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseJ D Rioux
Whitehead Institute/Massachusetts Institute of Technology, Center for Genome Research, Cambridge, Massachusetts, USA
Nat Genet 29:223-8. 2001..These results have important implications for Crohn disease in particular and LD mapping in general...
- Occult dysplasia in a localized giant pseudopolyp in Crohn's colitis: a case reportJ Wyse
McGill University Health Centre, Montreal, Canada
Can J Gastroenterol 23:477-8. 2009..Occult dysplasia without superficial dysplasia may exist in these lesions and further studies are needed to examine risk factors that make a giant pseudopolyp more likely to harbour dysplasia and/or carcinoma...
- An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29Y Y Shugart
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21231, USA
Genes Immun 9:161-7. 2008..67). This study demonstrates the ability of high information content adequately powered SNP genome-wide linkage studies to identify loci not observed in multiple microsatellite-based studies in smaller cohorts...