Marcel A Behr

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Isolation of the genome sequence strain Mycobacterium avium 104 from multiple patients over a 17-year period
    Kathleen L Horan
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Suite 500, Seattle, Washington 98109, USA
    J Clin Microbiol 44:783-9. 2006
  2. pmc Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis
    Frédéric Veyrier
    Department of Medicine, McGill University, Montreal, QC, H3G 1A4, Canada
    BMC Evol Biol 9:196. 2009
  3. pmc Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
    Joyce Wang
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada
    BMC Genomics 15:415. 2014
  4. pmc The critical role of DNA extraction for detection of mycobacteria in tissues
    Nicolas Radomski
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 8:e78749. 2013
  5. ncbi Is tuberculosis a lymphatic disease with a pulmonary portal?
    Marcel A Behr
    McGill International Tuberculosis Centre, McGill University, Montreal, QC, Canada Electronic address
    Lancet Infect Dis 14:250-5. 2014
  6. pmc Inter- and intra-subtype genotypic differences that differentiate Mycobacterium avium subspecies paratuberculosis strains
    Franck Biet
    INRA, UMR1282, Infectiologie Santé Publique ISP 311, Nouzilly F 37380, France
    BMC Microbiol 12:264. 2012
  7. doi Evolution of Mycobacterium tuberculosis
    Marcel A Behr
    McGill University Health Centre, Montreal General Hospital, Montreal, Canada
    Adv Exp Med Biol 783:81-91. 2013
  8. pmc High yield of culture-based diagnosis in a TB-endemic setting
    Anne Marie Demers
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Infect Dis 12:218. 2012
  9. ncbi Mycobacterium du jour: what's on tomorrow's menu?
    Marcel A Behr
    McGill University Health Centre, Montreal, Quebec, H3G 1A4, Canada
    Microbes Infect 10:968-72. 2008
  10. ncbi Molecular tools for typing and branding the tubercle bacillus
    Marcel A Behr
    McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    Curr Mol Med 7:309-17. 2007

Detail Information

Publications84

  1. pmc Isolation of the genome sequence strain Mycobacterium avium 104 from multiple patients over a 17-year period
    Kathleen L Horan
    Seattle Biomedical Research Institute, 307 Westlake Avenue N, Suite 500, Seattle, Washington 98109, USA
    J Clin Microbiol 44:783-9. 2006
    ..Although M. avium is known for its genetic plasticity, these observations also show that strains of the pathogen can be genotypically stable over extended time periods...
  2. pmc Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis
    Frédéric Veyrier
    Department of Medicine, McGill University, Montreal, QC, H3G 1A4, Canada
    BMC Evol Biol 9:196. 2009
    ..To assign when foreign genes were likely acquired, we designed a bioinformatic program called mycoHIT (mycobacterial homologue investigation tool) to analyze these data in conjunction with the MLSA-based phylogeny...
  3. pmc Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
    Joyce Wang
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada
    BMC Genomics 15:415. 2014
    ..In this study, high-throughput sequencing of MAP transposon libraries were analyzed to qualitatively and quantitatively determine the contribution of individual genes to bacterial survival during infection...
  4. pmc The critical role of DNA extraction for detection of mycobacteria in tissues
    Nicolas Radomski
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 8:e78749. 2013
    ..Specifically, we assessed: 1) tissue disruption procedures; 2) DNA extraction protocols; and 3) inhibition of bacterial PCR by host DNA...
  5. ncbi Is tuberculosis a lymphatic disease with a pulmonary portal?
    Marcel A Behr
    McGill International Tuberculosis Centre, McGill University, Montreal, QC, Canada Electronic address
    Lancet Infect Dis 14:250-5. 2014
    ..More practically, an alternative perspective that classes tuberculosis as a lymphatic disease might affect strategies for preclinical and clinical assessment of novel diagnostics, drugs, and vaccines. ..
  6. pmc Inter- and intra-subtype genotypic differences that differentiate Mycobacterium avium subspecies paratuberculosis strains
    Franck Biet
    INRA, UMR1282, Infectiologie Santé Publique ISP 311, Nouzilly F 37380, France
    BMC Microbiol 12:264. 2012
    ....
  7. doi Evolution of Mycobacterium tuberculosis
    Marcel A Behr
    McGill University Health Centre, Montreal General Hospital, Montreal, Canada
    Adv Exp Med Biol 783:81-91. 2013
    ..Understanding differences within the M. tuberculosis complex and the evolutionary forces shaping these differences is important for investigating the basis of its success as both a symbiont and a pathogen...
  8. pmc High yield of culture-based diagnosis in a TB-endemic setting
    Anne Marie Demers
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Infect Dis 12:218. 2012
    ..In most of the world, microbiologic diagnosis of tuberculosis (TB) is limited to microscopy. Recent guidelines recommend culture-based diagnosis where feasible...
  9. ncbi Mycobacterium du jour: what's on tomorrow's menu?
    Marcel A Behr
    McGill University Health Centre, Montreal, Quebec, H3G 1A4, Canada
    Microbes Infect 10:968-72. 2008
    ..tuberculosis, potentially explaining the sequence of genomic events that originally permitted an environmental mycobacterium to evolve into a host-associated pathogen...
  10. ncbi Molecular tools for typing and branding the tubercle bacillus
    Marcel A Behr
    McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    Curr Mol Med 7:309-17. 2007
    ..Genomic deletions therefore provide a new opportunity to accurately classify organisms for diagnostic and epidemiologic purposes, serving as the basis for further study of the natural variability across MTC organisms...
  11. doi The path to Crohn's disease: is mucosal pathology a secondary event?
    Marcel A Behr
    Department of Medicine, McGill University Health Centre, Montreal, QC, Canada
    Inflamm Bowel Dis 16:896-902. 2010
    ....
  12. ncbi Mycobacteria in Crohn's disease: a persistent hypothesis
    Marcel A Behr
    Department of Medicine, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Inflamm Bowel Dis 12:1000-4. 2006
    ..In this review, we discuss the current understanding of mycobacterial and Crohn's genetic susceptibility and review the evidence that NOD2/CARD15 may mediate host resistance to mycobacterial infection...
  13. ncbi The evidence for Mycobacterium paratuberculosis in Crohn's disease
    Marcel A Behr
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Opin Gastroenterol 24:17-21. 2008
    ..This article reviews published contributions that directly or indirectly address this question...
  14. ncbi BCG--different strains, different vaccines?
    Marcel A Behr
    McGill University Health Centre, Montreal, Canada
    Lancet Infect Dis 2:86-92. 2002
    ..Continuing research is attempting to assess the effect of these genetic alterations on properties of BCG strains, with the goals of suggesting the ideal BCG for vaccination and providing avenues for improvement on existing BCG vaccines...
  15. ncbi Crohn's disease, mycobacteria, and NOD2
    Marcel A Behr
    McGill University Health Centre, Montreal, Canada
    Lancet Infect Dis 4:136-7. 2004
  16. ncbi Molecular epidemiology of nontuberculous mycobacteria
    Marcel A Behr
    Division of Infectious Diseases and Medical Microbiology, McGill University, Montreal General Hospital, Montreal H3G 1A4, Canada
    Future Microbiol 4:1009-20. 2009
    ....
  17. pmc Evolution of the mycobacterial SigK regulon
    Frédéric Veyrier
    Department of Medicine, McGill University, Montreal, Quebec H3G 1A4, Canada
    J Bacteriol 190:1891-9. 2008
    ..tuberculosis delta sigK rskA. Together, our data indicate that the regulatory system SigK/RskA is conserved across the Mycobacterium genus, whereas the regulon under its control varies considerably across species...
  18. pmc Repeat IGRA testing in Canadian health workers: conversions or unexplained variability?
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 8:e54748. 2013
    ....
  19. pmc Mycobacterium avium in the postgenomic era
    Christine Y Turenne
    McGill University Health Centre, A5 156, 1650 Cedar Avenue, Montreal H3G 1A4, Canada
    Clin Microbiol Rev 20:205-29. 2007
    ..avium subsets in isolation, it is expected that attention to the similarities and differences between M. avium organisms will provide greater insight into their fundamental differences, including their propensity to cause disease...
  20. pmc Major Mycobacterium tuberculosis lineages associate with patient country of origin
    Michael B Reed
    Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Microbiol 47:1119-28. 2009
    ..We believe that this independent validation of the LSP method should encourage researchers to adopt this system in investigations aimed at elucidating the role of strain variation in TB...
  21. pmc Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium are independently evolved pathogenic clones of a much broader group of M. avium organisms
    Christine Y Turenne
    McGill University Health Centre, Montreal, Quebec, Canada H3G 1A4
    J Bacteriol 190:2479-87. 2008
    ..In conclusion, M. avium subsp. hominissuis represents a diverse group of organisms from which two pathogenic clones (M. avium subsp. paratuberculosis and M. avium subsp. avium/M. avium subsp. silvaticum) have evolved independently...
  22. ncbi Contact investigation and genotyping to identify tuberculosis transmission to children
    Ivan K T Yeo
    Respiratory Epidemiology Unit, McGill University, Montreal, Quebec, Canada
    Pediatr Infect Dis J 25:1037-43. 2006
    ..We examined contact investigations related to pediatric TB, yield for source case identifications and genotypes for relevant Mycobacterium tuberculosis isolates in a low-incidence setting...
  23. pmc Genetic analysis of Mycobacterium avium complex strains used for producing purified protein derivatives
    Makeda Semret
    McGill University Health Centre, Montreal, Quebec, Canada
    Clin Vaccine Immunol 13:991-6. 2006
    ..These results serve as a baseline for potency studies of different preparations and should aid in comparative studies of newly discovered antigens for the diagnosis of infection and disease by M. avium complex organisms...
  24. pmc Differentiating host-associated variants of Mycobacterium avium by PCR for detection of large sequence polymorphisms
    Makeda Semret
    McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Microbiol 44:881-7. 2006
    ..We propose a simple PCR-based strategy based on these polymorphisms that can rapidly type M. avium isolates into these subgroups...
  25. ncbi The Mycobacterium tuberculosis complex transcriptome of attenuation
    Serge Mostowy
    McGill University Health Centre, Montreal, Canada H3G 1A4
    Tuberculosis (Edinb) 84:197-204. 2004
    ..Furthermore, comparative transcriptomics reveals the concurrent down-regulation of several gene neighborhoods beyond RD1. The potential relevance of these other expression changes towards MTB virulence is discussed...
  26. pmc Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex
    Serge Mostowy
    McGill University Health Centre, Montreal, Canada H3G 1A4
    J Bacteriol 186:104-9. 2004
    ..Newfound deletions from the dassie bacillus are discussed in relation to their evolutionary and biological significance...
  27. ncbi NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
    Maziar Divangahi
    Department of Medicine, McGill University Health Centre, Montreal, Canada
    J Immunol 181:7157-65. 2008
    ..Taken together, these data indicate that NOD2 mediates resistance to mycobacterial infection via both innate and adaptive immunity...
  28. pmc Evaluation of in situ methods used to detect Mycobacterium avium subsp. paratuberculosis in samples from patients with Crohn's disease
    Mangalakumari Jeyanathan
    McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Microbiol 44:2942-50. 2006
    ..paratuberculosis in tissue is governed more by bacterial burden than by staining method...
  29. pmc Strain-specific differences in the genetic control of two closely related mycobacteria
    Tania Di Pietrantonio
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 6:e1001169. 2010
    ..This high degree of adaptation of host genetics to strain-specific pathogenesis is expected to provide a suitable framework for the selection of specific host-mycobacteria combinations during co-evolution of mycobacteria with humans...
  30. pmc Sensitivities and specificities of spoligotyping and mycobacterial interspersed repetitive unit-variable-number tandem repeat typing methods for studying molecular epidemiology of tuberculosis
    Allison N Scott
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Clin Microbiol 43:89-94. 2005
    ....
  31. pmc Extensive genomic polymorphism within Mycobacterium avium
    Makeda Semret
    McGill University Health Center, Montreal, Quebec, Canada
    J Bacteriol 186:6332-4. 2004
    ..avium subsp. paratuberculosis...
  32. pmc Insertion sequence IS900 revisited
    Makeda Semret
    McGill University Health Center, Montreal, Quebec, Canada
    J Clin Microbiol 44:1081-3. 2006
    ..paratuberculosis isolates revealed that IS900 is highly conserved, with only two sequevars distinguishing sheep and cattle lineages. Amplification of IS900-like sequences is not sufficient as a proxy for M. avium subsp. paratuberculosis...
  33. pmc Reduced transmissibility of East African Indian strains of Mycobacterium tuberculosis
    Amr S Albanna
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e25075. 2011
    ..Some reports have associated certain lineages with particular clinical phenotypes, but there is still insufficient information regarding the clinical and epidemiologic implications of MTB lineage variation...
  34. ncbi How close is close enough? Exploring matching criteria in the estimation of recent transmission of tuberculosis
    Andrea Benedetti
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 172:318-26. 2010
    ....
  35. pmc Sequencing of hsp65 distinguishes among subsets of the Mycobacterium avium complex
    Christine Y Turenne
    Division of Infectious Diseases and Medical Microbiology, A5 156, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4 Canada
    J Clin Microbiol 44:433-40. 2006
    ..A unique profile for M. avium subsp. silvaticum was not obtained. These results indicate that sequencing the 3' region of the hsp65 gene can simply and unambiguously distinguish species and subspecies of the M. avium complex...
  36. ncbi Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK
    Danielle Charlet
    Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada
    Mol Microbiol 56:1302-13. 2005
    ..These data demonstrate that a mutation of sigK is responsible for decreased expression of MPB70 and MPB83 in low-producing BCG strains and provide clues into the role of Mycobacterium tuberculosis SigK...
  37. pmc Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection
    Mark Verway
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003407. 2013
    ..These data provide evidence that the anti-microbial actions of vitamin D extend beyond the macrophage by modulating paracrine signaling, reinforcing its role in innate immune regulation in humans...
  38. pmc Tuberculosis and homelessness in Montreal: a retrospective cohort study
    Jason Tan de Bibiana
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    BMC Public Health 11:833. 2011
    ..9/100,000. The objectives of this study were to describe the epidemiology of TB among homeless persons in Montreal and assess patterns of transmission and sharing of key locations...
  39. ncbi Visualization of Mycobacterium avium in Crohn's tissue by oil-immersion microscopy
    Mangalakumari Jeyanathan
    Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    Microbes Infect 9:1567-73. 2007
    ..Using two assays in two settings, presence of M. avium organisms was strongly associated with Crohn's disease...
  40. ncbi Rv1773 is a transcriptional repressor deleted from BCG-Pasteur
    David C Alexander
    McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Tuberculosis (Edinb) 87:421-5. 2007
    ..We show that these genes form a bicistronic operon regulated by Rv1773, a transcriptional repressor deleted during the in vitro evolution of BCG...
  41. pmc Insertion and deletion events that define the pathogen Mycobacterium avium subsp. paratuberculosis
    David C Alexander
    McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Bacteriol 191:1018-25. 2009
    ..avium subsp. paratuberculosis and may serve as a general model for the origin of pathogenic mycobacteria...
  42. ncbi Bayesian modelling of tuberculosis clustering from DNA fingerprint data
    Allison N Scott
    Department of Epidemiology and Biostatistics, McGill University, 1020 Pine Avenue West, Montreal, Que, Canada H3A 1A2
    Stat Med 27:140-56. 2008
    ..We also discuss how one must carefully interpret any inferences that arise from a combination of continuous and dichotomous tests...
  43. pmc Region of difference 2 contributes to virulence of Mycobacterium tuberculosis
    Robert A Kozak
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Infect Immun 79:59-66. 2011
    ....
  44. pmc Joint effects of host genetic background and mycobacterial pathogen on susceptibility to infection
    Tania Di Pietrantonio
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Infect Immun 79:2372-8. 2011
    ..Overall, the results demonstrated the importance of considering the joint effects of the mycobacterial and host genetic backgrounds on susceptibility to mycobacterial infections...
  45. ncbi Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis
    Battouli Said-Salim
    McGill University Health Centre, Montreal, QC, Canada
    Mol Microbiol 62:1251-63. 2006
    ..Together these findings indicate that Rv0444c encodes the regulator of SigK (RskA) and mutations in this gene explain high-level MPT70/MPT83 expression by certain MTC members...
  46. ncbi N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis
    Jesse M Hansen
    Department of Medicine, Research Institute of the McGill University Health Center, Montreal, Canada
    J Infect Dis 209:1045-54. 2014
    ..These results indicate that the modified MDP is an important contributor to the unusual immunogenicity of mycobacteria but has a limited role in the pathogenesis of M. tuberculosis infection. ..
  47. pmc Impact of methoxymycolic acid production by Mycobacterium bovis BCG vaccines
    Adam Belley
    Centre for the Study of Host Resistance, McGill University, Montreal H3G 1A4, Canada
    Infect Immun 72:2803-9. 2004
    ..Our results demonstrate that the loss of methoxymycolic acid production did not apparently affect the virulence of BCG strains...
  48. pmc TB screening in Canadian health care workers using interferon-gamma release assays
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 7:e43014. 2012
    ....
  49. doi Mycobacterium africanum is not a major cause of human tuberculosis in Cape Town, South Africa
    Anne Marie Demers
    Departement de Microbiologie et Immunologie, CHU Sainte Justine, Universite de Montreal, Montreal, QC, Canada
    Tuberculosis (Edinb) 90:143-4. 2010
    ..As none of these strains was marked by the deletion of RD9, we conclude that M. africanum and other atypical members of the M. tuberculosis complex are decidedly uncommon in this part of Africa...
  50. pmc Genomic polymorphisms for Mycobacterium avium subsp. paratuberculosis diagnostics
    Makeda Semret
    McGill University Health Centre, Montreal, Quebec, Canada H3G 1A4
    J Clin Microbiol 43:3704-12. 2005
    ..These data highlight the need to evaluate these regions across a diverse panel of clinical and environmental isolates and indicate the LSPs best suited for M. avium subsp. paratuberculosis diagnostics...
  51. pmc Revisiting the evolution of Mycobacterium bovis
    Serge Mostowy
    McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 187:6386-95. 2005
    ..From this, a phylogenetic stratification of genotypes offers a predictive framework upon which to base future genetic and phenotypic studies of the MTC...
  52. ncbi Tuberculosis in the Inuit community of Quebec, Canada
    Dao Nguyen
    Department of Medicine and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 168:1353-7. 2003
    ..In a resource-rich country such as Canada, these communities illustrate some of the persistent challenges of TB control and elimination...
  53. pmc Extraction of Mycobacterium tuberculosis DNA: a question of containment
    Wendy Somerville
    McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    J Clin Microbiol 43:2996-7. 2005
    ..tuberculosis remained viable during this process. These data suggest that the extraction of M. tuberculosis DNA should be performed within containment until complete...
  54. ncbi The in vitro evolution of BCG vaccines
    Serge Mostowy
    McGill University Health Centre, Montreal, Que, Canada H3G 1A4
    Vaccine 21:4270-4. 2003
    ..tuberculosis complex subspecies. The contrast between the two modes of evolution are discussed in its relevance towards TB pathogenicity...
  55. ncbi Origins of a 350-Kilobase Genomic Duplication in Mycobacterium tuberculosis and Its Impact on Virulence
    Pilar Domenech
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Infect Immun 82:2902-12. 2014
    ....
  56. doi Mycobacteria in Crohn's disease: how innate immune deficiency may result in chronic inflammation
    Jean Daniel Lalande
    Department of Medicine, McGill University Health Centre, A5 156, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Expert Rev Clin Immunol 6:633-41. 2010
    ....
  57. doi Accuracy of prospective space-time surveillance in detecting tuberculosis transmission
    Aman Verma
    Department of Epidemiology and Biostatistics, McGill University, 1140 Pine Avenue West, Montreal, Quebec H3A 1A3, Canada Electronic address
    Spat Spatiotemporal Epidemiol 8:47-54. 2014
    ..We found evidence that prospective space-time surveillance for TB leads to a high false alarm rate, limiting its practical utility in settings with TB epidemiology similar to Montreal...
  58. pmc An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria
    Silayuv E Bongfen
    Department of Biochemistry, McGill University, Montreal, Canada
    PLoS ONE 7:e31012. 2012
    ..CM resistance in Jak3(W81R/+) heterozygotes occurs in presence of normal T, B and NK cell numbers. These findings highlight the pathological role of CD8(+) T cells and Jak3-dependent IFN-γ-mediated Th1 responses in CM pathogenesis...
  59. pmc Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease
    Tian Tian Wang
    Department of Physiology, Montreal General Hospital, Canada
    J Biol Chem 285:2227-31. 2010
    ....
  60. ncbi Comparative metagenomic study of alterations to the intestinal microbiota and risk of nosocomial Clostridum difficile-associated disease
    Amee R Manges
    Department of Epidemiology, Biostatistics, and Occupational Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    J Infect Dis 202:1877-84. 2010
    ..Hospital exposures were associated with changes in the intestinal microbiota and risk of CDAD, and these changes were not driven exclusively by antimicrobial use...
  61. pmc Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
    Francois Coulombe
    Department of Medicine, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Exp Med 206:1709-16. 2009
    ..Our findings indicate that N-glycolyl MDP has a greater NOD2-stimulating activity than N-acetyl MDP, consistent with the historical observation attributing exceptional immunogenic activity to the mycobacterial cell wall...
  62. ncbi Comparative genomics in the fight against tuberculosis: diagnostics, epidemiology, and BCG vaccination
    Serge Mostowy
    Division of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Pharmacogenomics 2:189-96. 2002
    ..Attention is drawn towards the impact of comparative genomics in generating several exciting hypotheses towards diagnosis, epidemiology, and prevention of tuberculosis disease...
  63. ncbi Genomic deletions suggest a phylogeny for the Mycobacterium tuberculosis complex
    Serge Mostowy
    McGill University Health Centre, Montreal, Quebec, Canada
    J Infect Dis 186:74-80. 2002
    ..The data provide compelling evidence that human tuberculosis did not originate from the present-day bovine form. Genomic deletions present themselves as an attractive modality to study the evolution of the M. tuberculosis complex...
  64. ncbi The origin and evolution of Mycobacterium tuberculosis
    Serge Mostowy
    McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada
    Clin Chest Med 26:207-16, v-vi. 2005
    ..Finally, it discusses the current genomic evidence regarding the origin and evolution of M. tuberculosis in the context of its relevance for tuberculosis control in humans and other mammalian hosts...
  65. doi Crohn's as an immune deficiency: from apparent paradox to evolving paradigm
    Donald C Vinh
    Department of Medicine, McGill University Health Centre, Montreal, QC, H3G 1A4, Canada
    Expert Rev Clin Immunol 9:17-30. 2013
    ..Finally, we outline potential clinical implications of this model, from immunologic assessment of patients to the selection of therapeutic interventions...
  66. pmc The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS Med 8:e1001012. 2011
    ..Madhu Pai and colleagues introduce the BCG World Atlas, an open access, user friendly Web site for TB clinicians to discern global BCG vaccination policies and practices and improve the care of their patients...
  67. doi Causality and gastrointestinal infections: Koch, Hill, and Crohn's
    Anne Marie Lowe
    Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Lancet Infect Dis 8:720-6. 2008
    ..We also identify crucial research questions required to advance towards assessing the causal role of candidate microbes in the aetiopathogenesis of Crohn's disease...
  68. pmc Widespread pyrazinamide-resistant Mycobacterium tuberculosis family in a low-incidence setting
    Dao Nguyen
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Microbiol 41:2878-83. 2003
    ..We conclude that a clonally related family of PZA-monoresistant M. tuberculosis isolates in Quebec represents historic rather than recent transmission...
  69. pmc Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guérin attenuation
    Kaeryn N Lewis
    Department of Pediatrics, University of Washington, Seattle 98195, USA
    J Infect Dis 187:117-23. 2003
    ..Therefore, it was concluded that genes within or controlled by RD1 are essential for MTB virulence and that loss of RD1 was important in BCG attenuation...
  70. ncbi Genetic characterization of the Guinea-Bissau family of Mycobacterium tuberculosis complex strains
    Tuija Koivula
    Swedish Institute for Infectious Disease Control, 17182 Solna, Sweden
    Microbes Infect 6:272-8. 2004
    ..tuberculosis complex tree in between classical M. tuberculosis and classical M. bovis. These observations are discussed in their significance in M. tuberculosis complex classification...
  71. ncbi Tuberculosis due to multiple strains: a concern for the patient? A concern for tuberculosis control?
    Marcel A Behr
    Am J Respir Crit Care Med 169:554-5. 2004
  72. ncbi Polyclonal tuberculosis and the emergence of drug resistance
    Marcel A Behr
    Am J Respir Crit Care Med 172:521-2. 2005
  73. ncbi Evidence for local transmission and reactivation of tuberculosis in the Toronto Somali community
    Camille Achonu
    Toronto Public Health, Toronto, Ontario, Canada
    Scand J Infect Dis 38:778-81. 2006
    ..We recommend that ongoing surveillance and treatment programmes be directed towards this community...
  74. pmc Genome plasticity of BCG and impact on vaccine efficacy
    Roland Brosch
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 104:5596-601. 2007
    ..Furthermore, the combined findings suggest that early BCG vaccines may even be superior to the later ones that are more widely used...
  75. doi Antimycobacterial therapy for Crohn's disease: a reanalysis
    Marcel A Behr
    Lancet Infect Dis 8:344. 2008
  76. pmc Evaluation of a semi-automated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa
    Niaz Banaiee
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Tuberculosis (Edinb) 88:64-8. 2008
    ..tuberculosis cultures in diagnostic laboratories with limited financial resources, but with competent technologists...
  77. pmc T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data
    Anandharaman Veerapathran
    Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India
    PLoS ONE 3:e1850. 2008
    ..A logical start is to determine the within-person variability of T-cell responses during serial testing...
  78. pmc Mycobacterium bovis BCG vaccines exhibit defects in alanine and serine catabolism
    Jeffrey M Chen
    Department of Medical Genetics and Microbiology, University of Toronto, Ontario M5S 1A8, Canada
    Infect Immun 71:708-16. 2003
    ..These results suggest that BCG strains are limited in nitrogen metabolic capacity and predict defects that may restrict multiplication and persistence of the live vaccine within the host...
  79. ncbi Proportion of tuberculosis transmission that takes place in households in a high-incidence area
    Suzanne Verver
    Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
    Lancet 363:212-4. 2004
    ..The proportion of transmission in the community that took place in the household was 19%, and therefore, in this high-incidence area, tuberculosis transmission occurs mainly outside the household...
  80. ncbi Mycobacterial virulence and specialized secretion: same story, different ending
    Marcel A Behr
    Nat Med 13:286-7. 2007
  81. ncbi Transmission of tuberculosis in a high incidence urban community in South Africa
    Suzanne Verver
    Department of Paediatrics and Child Health, Stellenbosch University, South Africa
    Int J Epidemiol 33:351-7. 2004
    ..The objective of this study was to identify risk factors for ongoing community transmission of tuberculosis (TB) in two densely populated urban communities with a high incidence rate of TB in Cape Town, South Africa...
  82. ncbi Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG: implications for the inactivation of a global regulator and strain attenuation
    Claire L Spreadbury
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Microbiology 151:547-56. 2005
    ..bovis BCG strains. This raises the possibility that a contributing factor to the attenuation of BCG strains may be an inability of this global regulator to control the expression of genes required for in vivo survival and persistence...
  83. ncbi Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis
    Suzanne Verver
    Desmond Tutu TB Center, Department of Pediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
    Am J Respir Crit Care Med 171:1430-5. 2005
    ..In a high-tuberculosis (TB) incidence area of Cape Town, South Africa, there is a very high rate of unexplained recurrent TB. The incidence of new bacteriologically confirmed disease in the area is 313 per 100,000 individuals...
  84. doi Global rates of Crohn's disease
    Marcel A Behr
    Inflamm Bowel Dis 14:1170-2. 2008