Andrew Bateman

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model
    Huishi Toh
    Division of Endocrinology and Metabolism, Department of Medicine, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada
    PLoS ONE 8:e64989. 2013
  2. pmc Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1
    Babykumari P Chitramuthu
    Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada
    Mol Neurodegener 5:41. 2010
  3. pmc Growing a tumor stroma: a role for granulin and the bone marrow
    Andrew Bateman
    Endocrine Research Laboratory, Room H 5 21 Royal Victoria Hospital, Research Institute of the McGill University Health Centre, 687 Pine Ave West, Montreal, Quebec H3A1A1, Canada
    J Clin Invest 121:516-9. 2011
  4. doi request reprint The granulin gene family: from cancer to dementia
    Andrew Bateman
    Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
    Bioessays 31:1245-54. 2009
  5. doi request reprint Structure, function, and mechanism of progranulin; the brain and beyond
    Huishi Toh
    Endocrine Research Laboratory, Royal Victoria Hospital, McGill University Health Centre Research Institute, 687 Pine Ave West, Montreal, QC, H3A 1A1, Canada
    J Mol Neurosci 45:538-48. 2011
  6. pmc Progranulin is expressed within motor neurons and promotes neuronal cell survival
    Cara L Ryan
    Royal Victoria Hospital and Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    BMC Neurosci 10:130. 2009
  7. ncbi request reprint Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development
    Rachael Daniel
    Endocrine Research Laboratory, Royal Victoria Hospital, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Dev Dyn 227:593-9. 2003
  8. doi request reprint Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models
    Arnaud Tauffenberger
    CRCHUM, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 22:782-94. 2013
  9. pmc Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
    Dmitri Tolkatchev
    Bio NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 17:711-24. 2008
  10. ncbi request reprint Regulation of progranulin expression in myeloid cells
    Colin H P Ong
    Endocrine Research Laboratories, Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 291:R1602-12. 2006

Collaborators

Detail Information

Publications13

  1. pmc Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model
    Huishi Toh
    Division of Endocrinology and Metabolism, Department of Medicine, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada
    PLoS ONE 8:e64989. 2013
    ..These results demonstrate that overexpression of progranulin in endothelial cells influences normal angiogenesis in vivo...
  2. pmc Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1
    Babykumari P Chitramuthu
    Endocrine Research Laboratory and Department of Medicine, Royal Victoria Hospital and McGill University Health Centre Research Institute, Montreal, Quebec, H3A 1A1, Canada
    Mol Neurodegener 5:41. 2010
    ..Here we document the neuronal expression and functions of PGRN in spinal cord motoneuron (MN) maturation and branching in vivo using zebrafish, a well established model of vertebrate embryonic development...
  3. pmc Growing a tumor stroma: a role for granulin and the bone marrow
    Andrew Bateman
    Endocrine Research Laboratory, Room H 5 21 Royal Victoria Hospital, Research Institute of the McGill University Health Centre, 687 Pine Ave West, Montreal, Quebec H3A1A1, Canada
    J Clin Invest 121:516-9. 2011
    ..These data shed new light on the importance of the bone marrow in tumor growth and the role of granulin in carcinogenesis...
  4. doi request reprint The granulin gene family: from cancer to dementia
    Andrew Bateman
    Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
    Bioessays 31:1245-54. 2009
    ..In this review we will discuss current knowledge of the multifaceted biology of PGRN...
  5. doi request reprint Structure, function, and mechanism of progranulin; the brain and beyond
    Huishi Toh
    Endocrine Research Laboratory, Royal Victoria Hospital, McGill University Health Centre Research Institute, 687 Pine Ave West, Montreal, QC, H3A 1A1, Canada
    J Mol Neurosci 45:538-48. 2011
    ..Here we review the structure, biology, and mechanism of progranulin action. By understanding PGRN in a wider context, we may be better able to delineate its roles in the normal brain and in neurodegenerative disease...
  6. pmc Progranulin is expressed within motor neurons and promotes neuronal cell survival
    Cara L Ryan
    Royal Victoria Hospital and Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    BMC Neurosci 10:130. 2009
    ....
  7. ncbi request reprint Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development
    Rachael Daniel
    Endocrine Research Laboratory, Royal Victoria Hospital, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Dev Dyn 227:593-9. 2003
    ....
  8. doi request reprint Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models
    Arnaud Tauffenberger
    CRCHUM, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 22:782-94. 2013
    ..elegans and mammalian cells. Altogether our data point towards a conserved function for TDP-43 and FUS in promoting polyglutamine toxicity and that delivery of PGRN may have therapeutic benefits...
  9. pmc Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
    Dmitri Tolkatchev
    Bio NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 17:711-24. 2008
    ..The functionally active and structurally well-characterized human hGrnA offers a unique opportunity for detailed structure-function studies of these important GEM proteins as novel members of mammalian growth factors...
  10. ncbi request reprint Regulation of progranulin expression in myeloid cells
    Colin H P Ong
    Endocrine Research Laboratories, Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 291:R1602-12. 2006
    ....
  11. doi request reprint Expression of TBX2 promotes anchorage-independent growth and survival in the p53-negative SW13 adrenocortical carcinoma
    Amin Ismail
    Endocrine Research Laboratory, Division of Experimental Medicine, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada
    Cancer Lett 278:230-40. 2009
    ..Our findings identify TBX2 as a cell type-dependent survival factor under a p53-negative background, and are indicative of a potentially wider role for TBX2 in carcinogenesis than hitherto described...
  12. ncbi request reprint Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival
    Zhiheng He
    Endocrine Research Laboratory, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada H3A 1A1
    Cancer Res 62:5590-6. 2002
    ..The ability of pgrn to stimulate cell division, invasion, and survival demonstrates that pgrn regulates multiple steps in carcinomal progression, and suggests that the pgrn system may be a possible future therapeutic target...
  13. ncbi request reprint Progranulin is a mediator of the wound response
    Zhiheng He
    Division of Experimental Medicine, McGill University, and Endocrine Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada
    Nat Med 9:225-9. 2003
    ..It acts directly on isolated dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Progranulin is, therefore, a probable wound-related growth factor...