Tamara Bar-Magen

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Retrovirology 6:103. 2009
  2. pmc Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Virol 84:9210-6. 2010
  3. pmc The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity
    Hong Tao Xu
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Antimicrob Agents Chemother 54:2401-8. 2010
  4. doi request reprint HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Canada
    AIDS 24:2171-9. 2010
  5. doi request reprint Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function
    Hong Tao Xu
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Antimicrob Chemother 65:2291-9. 2010
  6. pmc Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada
    Retrovirology 7:44. 2010
  7. pmc Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2 Canada
    J Virol 85:2828-36. 2011
  8. pmc Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine
    Hongtao Xu
    McGill University AIDS Centre, Lady Davis Institute for Medical Research Jewish General Hospital, 3755 Cote Ste Catherine Rd, Montreal, Quebec, Canada H3T 1E2
    Antimicrob Agents Chemother 53:4667-72. 2009
  9. pmc Tetherin restricts direct cell-to-cell infection of HIV-1
    Björn D Kuhl
    McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
    Retrovirology 7:115. 2010
  10. pmc Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture
    Daniel A Donahue
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 54:1047-54. 2010

Collaborators

Detail Information

Publications11

  1. pmc Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Retrovirology 6:103. 2009
    ..Due to high HIV variability, integrase inhibitor efficacy must be evaluated against a range of integrase enzymes from different subtypes...
  2. pmc Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Virol 84:9210-6. 2010
    ....
  3. pmc The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity
    Hong Tao Xu
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Antimicrob Agents Chemother 54:2401-8. 2010
    ....
  4. doi request reprint HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays
    Tamara Bar-Magen
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Canada
    AIDS 24:2171-9. 2010
    ..Because of high intersubtype HIV-1 genetic variability, it has been shown that subtype-specific patterns of resistance to antiretroviral drugs exist. We wished to ascertain whether this might be true for integrase inhibitors...
  5. doi request reprint Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function
    Hong Tao Xu
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Antimicrob Chemother 65:2291-9. 2010
    ..We wished to study the resistance profile of etravirine, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) active against common human immunodeficiency virus type-1 (HIV-1) drug-resistant strains...
  6. pmc Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada
    Retrovirology 7:44. 2010
    ..Infected cells bearing unintegrated DNA were assayed by flow cytometry in the GFP reporter cell line, Rev-CEM, for cell surface levels of CD4, CXCR4 and CCR5...
  7. pmc Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2 Canada
    J Virol 85:2828-36. 2011
    ..Hence, the capacity of HIV-1 to modulate MHC-I is not linked to its ability to integrate. Thus, Nef-mediated evasion of host immune responsiveness might be attributable, in part at least, to transcription from unintegrated viral DNA...
  8. pmc Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine
    Hongtao Xu
    McGill University AIDS Centre, Lady Davis Institute for Medical Research Jewish General Hospital, 3755 Cote Ste Catherine Rd, Montreal, Quebec, Canada H3T 1E2
    Antimicrob Agents Chemother 53:4667-72. 2009
    ..Both the biochemical and the cell-based phenotypic assays confirmed the susceptibility of G190A-containing enzymes and viruses to ETR. The results of this study indicate that the G190A mutation is not associated with resistance to ETR...
  9. pmc Tetherin restricts direct cell-to-cell infection of HIV-1
    Björn D Kuhl
    McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
    Retrovirology 7:115. 2010
    ..Viral dissemination between T-cells can occur via cell-free transmission or the more efficient direct cell-to-cell route through lipid raft-rich virological synapses, to which tetherin localizes...
  10. pmc Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture
    Daniel A Donahue
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 54:1047-54. 2010
    ..We discuss how stage-dependent inhibition helps to explain the unique viral load decay dynamics observed clinically with RAL...
  11. doi request reprint The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
    Veronique Michaud
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Rd, Montreal, Quebec, H3T 1E2, Canada
    Pharmacol Rev 64:803-33. 2012
    ....