Massimo Avoli

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Cellular and molecular mechanisms of epilepsy in the human brain
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Canada
    Prog Neurobiol 77:166-200. 2005
  2. ncbi request reprint Mechanisms of epileptiform synchronization in cortical neuronal networks
    M Avoli
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, PQ, Canada, H3A 2B4
    Curr Med Chem 21:653-62. 2014
  3. doi request reprint Does interictal synchronization influence ictogenesis?
    Massimo Avoli
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Montreal, H3A 2B4 Québec, Canada
    Neuropharmacology 69:37-44. 2013
  4. doi request reprint Two different interictal spike patterns anticipate ictal activity in vitro
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and of Physiology, McGill University, 3801 rue University, Montreal, Canada H3A 2B4 PQ
    Neurobiol Dis 52:168-76. 2013
  5. doi request reprint A brief history on the oscillating roles of thalamus and cortex in absence seizures
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:779-89. 2012
  6. ncbi request reprint Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
    Massimo Avoli
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Prog Neurobiol 68:167-207. 2002
  7. doi request reprint GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal H3A 2B4 Quebec, Canada
    Prog Neurobiol 95:104-32. 2011
  8. ncbi request reprint Epileptiform synchronization in the human dysplastic cortex
    Massimo Avoli
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Epileptic Disord 5:S45-50. 2003
  9. doi request reprint Epileptiform synchronization in the cingulate cortex
    Gabriella Panuccio
    Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Epilepsia 50:521-36. 2009
  10. ncbi request reprint Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy
    Philip de Guzman
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 16:843-60. 2006

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Cellular and molecular mechanisms of epilepsy in the human brain
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Canada
    Prog Neurobiol 77:166-200. 2005
    ..Finally, we will address some of the problems that are inherent to this type of experimental approach, in particular the lack of proper controls and possible strategies to obviate this limitation...
  2. ncbi request reprint Mechanisms of epileptiform synchronization in cortical neuronal networks
    M Avoli
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, PQ, Canada, H3A 2B4
    Curr Med Chem 21:653-62. 2014
    ....
  3. doi request reprint Does interictal synchronization influence ictogenesis?
    Massimo Avoli
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Montreal, H3A 2B4 Québec, Canada
    Neuropharmacology 69:37-44. 2013
    ..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  4. doi request reprint Two different interictal spike patterns anticipate ictal activity in vitro
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and of Physiology, McGill University, 3801 rue University, Montreal, Canada H3A 2B4 PQ
    Neurobiol Dis 52:168-76. 2013
    ..We propose a similar condition to occur in vivo in temporal lobe epileptic patients and animal models...
  5. doi request reprint A brief history on the oscillating roles of thalamus and cortex in absence seizures
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:779-89. 2012
    ....
  6. ncbi request reprint Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
    Massimo Avoli
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Prog Neurobiol 68:167-207. 2002
    ....
  7. doi request reprint GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity
    Massimo Avoli
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal H3A 2B4 Quebec, Canada
    Prog Neurobiol 95:104-32. 2011
    ....
  8. ncbi request reprint Epileptiform synchronization in the human dysplastic cortex
    Massimo Avoli
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Epileptic Disord 5:S45-50. 2003
    ..focal cortical dysplastic tissue also generates synchronous potentials that are mainly contributed by GABA(A) receptor-mediated conductances...
  9. doi request reprint Epileptiform synchronization in the cingulate cortex
    Gabriella Panuccio
    Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Epilepsia 50:521-36. 2009
    ..In addition, since the ACC presents with a high density of opioid receptors, we studied the effect of opioid agonism on epileptiform synchronization in this brain region...
  10. ncbi request reprint Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy
    Philip de Guzman
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 16:843-60. 2006
    ..These findings identify an increase in network excitability within the subiculum of pilocarpine-treated, epileptic rats and point at a reduction in inhibition as an underlying mechanism...
  11. ncbi request reprint Thalamocortical oscillations in a genetic model of absence seizures
    Giovanna D'Arcangelo
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801, University St, Montreal, QC, H3A B, Canada
    Eur J Neurosci 16:2383-93. 2002
    ..This activity, which may represent an in vitro hallmark of thalamocortical epileptogenicity, requires the function of reciprocally connected thalamic and cortical networks and depends on cortical NMDA receptor-mediated mechanisms...
  12. pmc Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex
    Philip de Guzman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada
    J Physiol 586:1867-83. 2008
    ..Collectively, these results indicate that reduced inhibition within the pilocarpine-treated EC layer V may promote network epileptic hyperexcitability...
  13. doi request reprint Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsy
    Yugi Inaba
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and Physiology, McGill University, Montreal, Que, Canada
    Neurosignals 17:121-31. 2009
    ..In conclusion, these data highlight a decreased function of presynaptic GABA(B) receptors in the WAG/Rij rat neocortex. We propose that this alteration may contribute to neocortical hyperexcitability and thus to absence seizures...
  14. doi request reprint Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats
    Aleksandra Bortel
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University, Room 794, Montreal, QC, H3A 2B4, Canada
    Eur J Neurosci 31:2014-23. 2010
    ..We propose that this limited degree of hyperexcitability originates from the loss of parvalbumin- and neuropeptide Y-positive interneurons that is compensated by an increased drive for GABA(A) receptor-mediated inhibition...
  15. ncbi request reprint GABA(B) receptor activation and limbic network ictogenesis
    Massimo Avoli
    Departments of Neurology and Neurosurgery, and of Physiology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Neuropharmacology 46:43-51. 2004
    ....
  16. doi request reprint Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro
    Margherita D'Antuono
    Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
    Epilepsia 51:423-31. 2010
    ....
  17. ncbi request reprint Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsy
    Ruba Benini
    Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Canada
    J Neurophysiol 95:2143-54. 2006
    ..Altogether, these findings suggest that alterations in both pre- and postsynaptic inhibitory mechanisms contribute to synaptic hyperexcitability of LA networks in epileptic rats...
  18. ncbi request reprint Masking synchronous GABA-mediated potentials controls limbic seizures
    Michaela Barbarosie
    Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
    Epilepsia 43:1469-79. 2002
    ..We determined how CA3-driven interictal discharges block ictal activity generated in the entorhinal cortex during bath application of 4-aminopyridine (4AP, 50 microM)...
  19. ncbi request reprint Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy
    Margherita D'Antuono
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 87:634-9. 2002
    ..This process is facilitated by a decreased control of EC excitability by hippocampal outputs and possibly sustained by the reverberant activity between EC and CA1/subiculum networks that are excited via the temporoammonic path...
  20. doi request reprint Perirhinal cortex hyperexcitability in pilocarpine-treated epileptic rats
    Ruba Benini
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    Hippocampus 21:702-13. 2011
    ..These findings demonstrate synaptic hyperexcitability that is contributed by attenuated inhibition in the PC of pilocarpine-treated epileptic rats and underscore the role of PC networks in temporal lobe epilepsy...
  21. doi request reprint Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system
    Aleksandra Bortel
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neurobiol Dis 40:478-89. 2010
    ..These findings indicate that convulsive SE duration influences the development of interictal and ictal activity, and that interictal discharges undergo structure-specific changes after seizure appearance...
  22. ncbi request reprint Epileptiform synchronization in the rat insular and perirhinal cortices in vitro
    Jessica R Sudbury
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4 QC, Canada
    Eur J Neurosci 26:3571-82. 2007
    ....
  23. ncbi request reprint The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission
    Yuji Inaba
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    Neuropharmacology 51:681-91. 2006
    ..These data indicate that ZD7288 hampers neocortical epileptiform synchronization, but also suggest that most of this action reflects the ability of ZD7288 to decrease synaptic transmission...
  24. ncbi request reprint NMDA receptor-mediated transmission contributes to network 'hyperexcitability' in the rat insular cortex
    Yuji Inaba
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, QC, Canada H3A 2B4
    Eur J Neurosci 23:1071-6. 2006
    ..This feature may contribute to the role of IC in neurological disorders...
  25. doi request reprint Adaptive control of epileptiform excitability in an in vitro model of limbic seizures
    Gabriella Panuccio
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Exp Neurol 241:179-83. 2013
    ..Our findings indicate that the adaptive stimulation strategy may represent a novel, promising approach to DBS for individually-tailored epilepsy treatment...
  26. ncbi request reprint Epileptiform synchronization and GABA(B) receptor antagonism in the juvenile rat hippocampus
    Rita Motalli
    Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 303:1102-13. 2002
    ..We propose that the facilitation of ictal activity by CGP 35348 is mainly caused by the blockade of presynaptic GABA(B) receptor, leading to an increase in GABA release and subsequent larger [K+]o elevations...
  27. pmc Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizures
    Ruba Benini
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    J Physiol 566:885-900. 2005
    ..This function depends on GABA(A) receptor-mediated inhibition and controls hippocampal-parahippocampal interactions that are known to modulate limbic seizures...
  28. ncbi request reprint Treating epilepsy via adaptive neurostimulation: a reinforcement learning approach
    Joelle Pineau
    School of Computer Science, McGill University, Montreal, QC, Canada
    Int J Neural Syst 19:227-40. 2009
    ..This work highlights the crucial role that modern machine learning techniques can play in the optimization of treatment strategies for patients with chronic disorders such as epilepsy...
  29. doi request reprint On the ictogenic properties of the piriform cortex in vitro
    Gabriella Panuccio
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:459-68. 2012
    ..Herein, we have characterized some electrophysiologic and pharmacologic properties of the spontaneous epileptiform activity generated by PC networks maintained in vitro...
  30. ncbi request reprint High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes
    Elena Urrestarazu
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 47:1465-76. 2006
    ....
  31. doi request reprint High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsy
    Maxime Levesque
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Neurobiol Dis 42:231-41. 2011
    ..These distinct categories of interictal spikes point at dynamic processes that should bring neuronal networks close to seizure generation...
  32. doi request reprint A comparison between automated detection methods of high-frequency oscillations (80-500 Hz) during seizures
    Pariya Salami
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4 QC, Canada
    J Neurosci Methods 211:265-71. 2012
    ..These findings suggest that method 3 could be used for automated and reliable detection of HFOs on large data sets containing multiple channels during the ictal period...
  33. pmc Cell type-specific properties of subicular GABAergic currents shape hippocampal output firing mode
    Gabriella Panuccio
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e50241. 2012
    ..We propose that GABAergic inhibition may shape hippocampal output activity by providing cell type-specific fine-tuning of subicular excitatory and inhibitory drives...
  34. ncbi request reprint Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy
    Maxime Levesque
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 32:13264-72. 2012
    ..Our findings demonstrate that ripples and fast ripples show distinct time- and region-specific patterns during LVF and HYP seizures, thus suggesting that they play specific roles in ictogenesis...
  35. pmc The pilocarpine model of temporal lobe epilepsy
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
    J Neurosci Methods 172:143-57. 2008
    ....
  36. pmc Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model
    Claude Edouard Chatillon
    Department of Neurosurgery, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Clin Neurophysiol 122:1701-5. 2011
    ..This study assesses the feasibility of HFO detection in a rat epilepsy model using macrocontacts and clinical amplifiers, and the effect of contact size on HFO detection within the macrocontact range...
  37. doi request reprint Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome
    Giulia Curia
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    Cereb Cortex 19:1515-20. 2009
    ..This conclusion is in line with evidence implicating tonic GABA(A) inhibition in learning and memory...
  38. doi request reprint Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats
    Maxime Levesque
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Epilepsia 54:596-604. 2013
    ..We propose that these effects may reflect, at least in part, enhanced GABAA receptor-mediated inhibition as reported in in vitro studies...
  39. ncbi request reprint A window on the physiopathogenesis of seizures in patients with cortical dysplasia
    Massimo Avoli
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, QC, Canada
    Adv Exp Med Biol 497:123-32. 2002
    ..Cortical dysplasia is found in many cases of intractable epilepsy. Dr. Avoli reports that dysplastic cortex--removed from human brains during seizure surgery--shows abnormal excitability in vitro...
  40. doi request reprint Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Quebec, Canada
    CNS Drugs 23:555-68. 2009
    ..g. interactions with the collapsin-response mediator protein-2) play a contributory role...
  41. ncbi request reprint Volume-conducted epileptiform events between adjacent necortical slices in an interface tissue chamber
    Yuji Inaba
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Que, Canada H3A 2B4
    J Neurosci Methods 151:287-90. 2006
    ..These findings suggest that caution should be taken in assuming that field potential activity seen in an in vitro brain slice is generated within the recorded tissue...
  42. doi request reprint The kainic acid model of temporal lobe epilepsy
    Maxime Levesque
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, QC, Canada H3A 2B4
    Neurosci Biobehav Rev 37:2887-99. 2013
    ..We conclude that the kainic acid model is a reliable tool for understanding temporal lobe epilepsy, provided that the differences existing between methodological procedures are taken into account. ..
  43. doi request reprint "Jasper's Basic Mechanisms of the Epilepsies" Workshop
    Jeffrey L Noebels
    Department of Neurology, Baylor College of Medicine, Houston, Texas, U S A Montreal Neurological Institute, Montreal, Quebec, Canada Department of Neurology, University of California, Davis, California, U S A University of California, Los Angeles, California, U S A VA GLAHS West Los Angeles, California, U S A
    Epilepsia 51:1-5. 2010
    ..ncbi.nlm.nih.gov/books)...
  44. ncbi request reprint Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, 41100 Modena, Italy
    Neuromolecular Med 7:325-42. 2005
    ..These findings indicate that CA3 networks are hypoactive in comparison with other epileptic limbic areas. We propose that this feature may affect the ability of hippocampal outputs to control epileptiform synchronization in EC...
  45. doi request reprint Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
    J Neuropathol Exp Neurol 67:687-701. 2008
    ..These experiments indicate that SE can produce a focal lesion in the perforant path that may affect the roles of the hippocampus in epileptic rats...
  46. ncbi request reprint 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERK
    Daniela Merlo
    Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Roma, Italy
    J Neurochem 89:654-9. 2004
    ..These data demonstrate that activation of ERK1/2 accompanies the appearance of epileptiform activity induced by 4AP and suggest a cause-effect relationship between the ERK pathway and epileptiform synchronization...
  47. ncbi request reprint Ripple activity in the dentate gyrus of dishinibited hippocampus-entorhinal cortex slices
    Margherita D'Antuono
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Roma, Italy
    J Neurosci Res 80:92-103. 2005
    ....
  48. ncbi request reprint Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
    Exp Neurol 201:519-24. 2006
    ..The 5alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic...
  49. ncbi request reprint Neocortical hyperexcitability in a genetic model of absence seizures and its reduction by levetiracetam
    Giovanna D'Arcangelo
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 47:1144-52. 2006
    ....
  50. ncbi request reprint Pierre Gloor (1923-2003): an appreciation
    Massimo Avoli
    Epilepsia 45:882-6. 2004
  51. ncbi request reprint Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine
    Cristina Zona
    Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Roma, Italy
    Epilepsia 43:685-90. 2002
    ....
  52. ncbi request reprint Methodological approaches to exploring epileptic disorders in the human brain in vitro
    Rüdiger Köhling
    Institute of Physiology, University of Rostock, 18055 Rostock, Germany
    J Neurosci Methods 155:1-19. 2006
    ..In addition, we consider the pitfalls and limitations of such studies, in particular regarding the issue of tissue sampling procedures and control experiments...
  53. ncbi request reprint Intractable epilepsies of the neocortex: basic mechanisms
    Peter A Abdelmalik
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Adv Neurol 97:117-27. 2006