Research Topics
Species | Massimo AvoliSummaryAffiliation: McGill University Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Cellular and molecular mechanisms of epilepsy in the human brainMassimo Avoli
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Canada
Prog Neurobiol 77:166-200. 2005..Finally, we will address some of the problems that are inherent to this type of experimental approach, in particular the lack of proper controls and possible strategies to obviate this limitation...
Does interictal synchronization influence ictogenesis?Massimo Avoli
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Montreal, H3A 2B4 Québec, Canada
Neuropharmacology 69:37-44. 2013..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...- Two different interictal spike patterns anticipate ictal activity in vitroMassimo Avoli
Montreal Neurological Institute and Departments of Neurology and Neurosurgery and of Physiology, McGill University, 3801 rue University, Montreal, Canada H3A 2B4 PQ
Neurobiol Dis 52:168-76. 2013..We propose a similar condition to occur in vivo in temporal lobe epileptic patients and animal models... - A brief history on the oscillating roles of thalamus and cortex in absence seizuresMassimo Avoli
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Quebec, Canada
Epilepsia 53:779-89. 2012.... - Epileptiform synchronization in the human dysplastic cortexMassimo Avoli
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada
Epileptic Disord 5:S45-50. 2003..focal cortical dysplastic tissue also generates synchronous potentials that are mainly contributed by GABA(A) receptor-mediated conductances... - Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitroMassimo Avoli
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
Prog Neurobiol 68:167-207. 2002.... - GABAergic synchronization in the limbic system and its role in the generation of epileptiform activityMassimo Avoli
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal H3A 2B4 Quebec, Canada
Prog Neurobiol 95:104-32. 2011.... - Epileptiform synchronization in the cingulate cortexGabriella Panuccio
Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Epilepsia 50:521-36. 2009..In addition, since the ACC presents with a high density of opioid receptors, we studied the effect of opioid agonism on epileptiform synchronization in this brain region... - Subiculum network excitability is increased in a rodent model of temporal lobe epilepsyPhilip de Guzman
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Hippocampus 16:843-60. 2006..These findings identify an increase in network excitability within the subiculum of pilocarpine-treated, epileptic rats and point at a reduction in inhibition as an underlying mechanism... 
Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortexPhilip de Guzman
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada
J Physiol 586:1867-83. 2008..Collectively, these results indicate that reduced inhibition within the pilocarpine-treated EC layer V may promote network epileptic hyperexcitability...- Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsyYugi Inaba
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and Physiology, McGill University, Montreal, Que, Canada
Neurosignals 17:121-31. 2009..In conclusion, these data highlight a decreased function of presynaptic GABA(B) receptors in the WAG/Rij rat neocortex. We propose that this alteration may contribute to neocortical hyperexcitability and thus to absence seizures... - Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic ratsAleksandra Bortel
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University, Room 794, Montreal, QC, H3A 2B4, Canada
Eur J Neurosci 31:2014-23. 2010..We propose that this limited degree of hyperexcitability originates from the loss of parvalbumin- and neuropeptide Y-positive interneurons that is compensated by an increased drive for GABA(A) receptor-mediated inhibition... - GABA(B) receptor activation and limbic network ictogenesisMassimo Avoli
Departments of Neurology and Neurosurgery, and of Physiology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
Neuropharmacology 46:43-51. 2004.... - Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitroMargherita D'Antuono
Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
Epilepsia 51:423-31. 2010.... - Thalamocortical oscillations in a genetic model of absence seizuresGiuseppe Biagini
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801, University St, , QC, H3A B, Canada
Eur J Neurosci 16:2383-93. 2002..This activity, which may represent an in vitro hallmark of thalamocortical epileptogenicity, requires the function of reciprocally connected thalamic and cortical networks and depends on cortical NMDA receptor-mediated mechanisms... - Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsyRuba Benini
Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Canada
J Neurophysiol 95:2143-54. 2006..Altogether, these findings suggest that alterations in both pre- and postsynaptic inhibitory mechanisms contribute to synaptic hyperexcitability of LA networks in epileptic rats... - Perirhinal cortex hyperexcitability in pilocarpine-treated epileptic ratsRuba Benini
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
Hippocampus 21:702-13. 2011..These findings demonstrate synaptic hyperexcitability that is contributed by attenuated inhibition in the PC of pilocarpine-treated epileptic rats and underscore the role of PC networks in temporal lobe epilepsy... - Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic systemAleksandra Bortel
Montreal Neurological Institute, McGill University, Montreal, QC, Canada
Neurobiol Dis 40:478-89. 2010..These findings indicate that convulsive SE duration influences the development of interictal and ictal activity, and that interictal discharges undergo structure-specific changes after seizure appearance... - Masking synchronous GABA-mediated potentials controls limbic seizuresMichaela Barbarosie
Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
Epilepsia 43:1469-79. 2002.... - NMDA receptor-mediated transmission contributes to network 'hyperexcitability' in the rat insular cortexYuji Inaba
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, , QC, Canada H3A 2B4
Eur J Neurosci 23:1071-6. 2006..This feature may contribute to the role of IC in neurological disorders... - Epileptiform synchronization in the rat insular and perirhinal cortices in vitroJessica R Sudbury
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4 QC, Canada
Eur J Neurosci 26:3571-82. 2007.... - The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmissionYuji Inaba
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, , , Canada
Neuropharmacology 51:681-91. 2006..These data indicate that ZD7288 hampers neocortical epileptiform synchronization, but also suggest that most of this action reflects the ability of ZD7288 to decrease synaptic transmission... - Adaptive control of epileptiform excitability in an in vitro model of limbic seizuresGabriella Panuccio
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
Exp Neurol 241:179-83. 2013..Our findings indicate that the adaptive stimulation strategy may represent a novel, promising approach to DBS for individually-tailored epilepsy treatment... - Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsyRuba Benini
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
J Neurophysiol 87:634-9. 2002..This process is facilitated by a decreased control of EC excitability by hippocampal outputs and possibly sustained by the reverberant activity between EC and CA1/subiculum networks that are excited via the temporoammonic path... - Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizuresRuba Benini
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
J Physiol 566:885-900. 2005..This function depends on GABA(A) receptor-mediated inhibition and controls hippocampal-parahippocampal interactions that are known to modulate limbic seizures... - Treating epilepsy via adaptive neurostimulation: a reinforcement learning approachJoelle Pineau
School of Computer Science, McGill University, Montreal, QC, Canada
Int J Neural Syst 19:227-40. 2009..This work highlights the crucial role that modern machine learning techniques can play in the optimization of treatment strategies for patients with chronic disorders such as epilepsy... - On the ictogenic properties of the piriform cortex in vitroGabriella Panuccio
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Epilepsia 53:459-68. 2012..Herein, we have characterized some electrophysiologic and pharmacologic properties of the spontaneous epileptiform activity generated by PC networks maintained in vitro... - High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikesElena Urrestarazu
Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
Epilepsia 47:1465-76. 2006..We propose that the reduction in high frequencies reflects a postspike depression in neuronal activity that is more pronounced in the region of spike generation. This depression is almost always seen in hippocampus but less in amygdala... - High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsyMaxime Levesque
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
Neurobiol Dis 42:231-41. 2011..These distinct categories of interictal spikes point at dynamic processes that should bring neuronal networks close to seizure generation... - Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsyMaxime Levesque
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4
J Neurosci 32:13264-72. 2012..Our findings demonstrate that ripples and fast ripples show distinct time- and region-specific patterns during LVF and HYP seizures, thus suggesting that they play specific roles in ictogenesis... - The pilocarpine model of temporal lobe epilepsyGiulia Curia
Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
J Neurosci Methods 172:143-57. 2008.... - Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndromeGiulia Curia
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
Cereb Cortex 19:1515-20. 2009..This conclusion is in line with evidence implicating tonic GABA(A) inhibition in learning and memory... - Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy modelClaude Edouard Chatillon
Department of Neurosurgery, Montreal Neurological Hospital, McGill University, Montreal, Canada
Clin Neurophysiol 122:1701-5. 2011..This study assesses the feasibility of HFO detection in a rat epilepsy model using macrocontacts and clinical amplifiers, and the effect of contact size on HFO detection within the macrocontact range... - Epileptiform synchronization and GABA(B) receptor antagonism in the juvenile rat hippocampusRita Motalli
Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
J Pharmacol Exp Ther 303:1102-13. 2002..We propose that the facilitation of ictal activity by CGP 35348 is mainly caused by the blockade of presynaptic GABA(B) receptor, leading to an increase in GABA release and subsequent larger [K+]o elevations... - A window on the physiopathogenesis of seizures in patients with cortical dysplasiaMassimo Avoli
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, QC, Canada
Adv Exp Med Biol 497:123-32. 2002..Cortical dysplasia is found in many cases of intractable epilepsy. Dr. Avoli reports that dysplastic cortex--removed from human brains during seizure surgery--shows abnormal excitability in vitro... - Volume-conducted epileptiform events between adjacent necortical slices in an interface tissue chamberYuji Inaba
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, , Que, Canada H3A 2B4
J Neurosci Methods 151:287-90. 2006..These findings suggest that caution should be taken in assuming that field potential activity seen in an in vitro brain slice is generated within the recorded tissue... - Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disordersGiulia Curia
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Quebec, Canada
CNS Drugs 23:555-68. 2009..g. interactions with the collapsin-response mediator protein-2) play a contributory role... - A comparison between automated detection methods of high-frequency oscillations (80-500Hz) during seizuresPariya Salami
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4 QC, Canada
J Neurosci Methods 211:265-71. 2012..These findings suggest that method 3 could be used for automated and reliable detection of HFOs on large data sets containing multiple channels during the ictal period... - Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in ratsMaxime Levesque
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Epilepsia 54:596-604. 2013..We propose that these effects may reflect, at least in part, enhanced GABAA receptor-mediated inhibition as reported in in vitro studies... - Cell type-specific properties of subicular GABAergic currents shape hippocampal output firing modeGabriella Panuccio
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
PLoS ONE 7:e50241. 2012..We propose that GABAergic inhibition may shape hippocampal output activity by providing cell type-specific fine-tuning of subicular excitatory and inhibitory drives... - "Jasper's Basic Mechanisms of the Epilepsies" WorkshopJeffrey L Noebels
Department of Neurology, Baylor College of Medicine, Houston, Texas, U S A Montreal Neurological Institute, Montreal, Quebec, Canada Department of Neurology, University of California, Davis, California, U S A University of California, Los Angeles, California, U S A VA GLAHS West Los Angeles, California, U S A
Epilepsia 51:1-5. 2010..ncbi.nlm.nih.gov/books)... - Ripple activity in the dentate gyrus of dishinibited hippocampus-entorhinal cortex slicesPhilip de Guzman
Dipartimento di Fisiologia Umana e Farmacologia, , Roma, Italy
J Neurosci Res 80:92-103. 2005.... - Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsyGiuseppe Biagini
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
Exp Neurol 201:519-24. 2006..The 5alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic... - Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticusGiuseppe Biagini
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
J Neuropathol Exp Neurol 67:687-701. 2008..These experiments indicate that SE can produce a focal lesion in the perforant path that may affect the roles of the hippocampus in epileptic rats... - Impaired activation of CA3 pyramidal neurons in the epileptic hippocampusGiuseppe Biagini
Dipartimento di Scienze Biomediche, , 41100 Modena, Italy
Neuromolecular Med 7:325-42. 2005..These findings indicate that CA3 networks are hypoactive in comparison with other epileptic limbic areas. We propose that this feature may affect the ability of hippocampal outputs to control epileptiform synchronization in EC... - 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERKDaniela Merlo
Dipartimento di Neuroscienze, , Roma, Italy
J Neurochem 89:654-9. 2004..These data demonstrate that activation of ERK1/2 accompanies the appearance of epileptiform activity induced by 4AP and suggest a cause-effect relationship between the ERK pathway and epileptiform synchronization... - Methodological approaches to exploring epileptic disorders in the human brain in vitroRüdiger Köhling
Institute of Physiology, University of Rostock, 18055 Rostock, Germany
J Neurosci Methods 155:1-19. 2006..In addition, we consider the pitfalls and limitations of such studies, in particular regarding the issue of tissue sampling procedures and control experiments... - Intractable epilepsies of the neocortex: basic mechanismsPeter A Abdelmalik
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Adv Neurol 97:117-27. 2006 - Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigineCristina Zona
Dipartimento di Neuroscienze, , Roma, Italy
Epilepsia 43:685-90. 2002..This mechanism of action contributes to the anticonvulsant effects exerted by LTG in experimental models of epileptiform discharge, and presumably in clinical practice... - Neocortical hyperexcitability in a genetic model of absence seizures and its reduction by levetiracetamVirginia Tancredi
Dipartimento di Neuroscienze, , Rome, Italy
Epilepsia 47:1144-52. 2006..The ability of LEV to reduce these patterns of network hyperexcitability supports the potential use of this new antiepileptic drug in primary generalized epileptic disorders... - Pierre Gloor (1923-2003): an appreciationMassimo Avoli
Epilepsia 45:882-6. 2004