Sergio Apuzzo

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding
    Sergio Apuzzo
    Department of Biochemistry and McGill Cancer Center, McGill University, Quebec H1E 1S9, Canada
    J Biol Chem 279:33601-12. 2004
  2. ncbi Cooperative interactions between the two DNA binding domains of Pax3: helix 2 of the paired domain is in the proximity of the amino terminus of the homeodomain
    Sergio Apuzzo
    Department of Biochemistry, McGill University, Montreal, Canada
    Biochemistry 46:2984-93. 2007
  3. ncbi Site-specific modification of single cysteine Pax3 mutants reveals reciprocal regulation of DNA binding activity of the paired and homeo domain
    Sergio Apuzzo
    Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 41:12076-85. 2002
  4. ncbi The paired domain of Pax3 contains a putative homeodomain interaction pocket defined by cysteine scanning mutagenesis
    Sergio Apuzzo
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 45:7154-61. 2006

Detail Information

Publications4

  1. ncbi Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding
    Sergio Apuzzo
    Department of Biochemistry and McGill Cancer Center, McGill University, Quebec H1E 1S9, Canada
    J Biol Chem 279:33601-12. 2004
    ..These results provide a structural basis for the functional interdependence of the two DNA binding domains of Pax3...
  2. ncbi Cooperative interactions between the two DNA binding domains of Pax3: helix 2 of the paired domain is in the proximity of the amino terminus of the homeodomain
    Sergio Apuzzo
    Department of Biochemistry, McGill University, Montreal, Canada
    Biochemistry 46:2984-93. 2007
    ..This arrangement may be important for the noted PD-HD cooperativity in DNA binding...
  3. ncbi Site-specific modification of single cysteine Pax3 mutants reveals reciprocal regulation of DNA binding activity of the paired and homeo domain
    Sergio Apuzzo
    Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 41:12076-85. 2002
    ..Thus, the PD and HD do not function as independent DNA binding modules in Pax3 but seem functionally interdependent.(1)..
  4. ncbi The paired domain of Pax3 contains a putative homeodomain interaction pocket defined by cysteine scanning mutagenesis
    Sergio Apuzzo
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 45:7154-61. 2006
    ..We propose that this hydrophobic pocket may serve as a docking site for the HD during DNA binding by the intact protein...