Jack Antel

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    Amit Bar-Or
    Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Neurol 64:1407-15. 2007
  2. doi request reprint Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies
    Jack P Antel
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Clin Neurol Neurosurg 110:951-7. 2008
  3. pmc Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
    Celina Wu
    Montreal Neurological Institute, McGill University, 3801 University St, Montreal QC H3A 2B4, Canada
    J Neuroinflammation 10:41. 2013
  4. doi request reprint Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?
    Jack Antel
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Acta Neuropathol 123:627-38. 2012
  5. ncbi request reprint Multiple sclerosis and immune regulatory cells
    Jack Antel
    Montreal Neurologic Institute Canada
    Brain 127:1915-6. 2004
  6. ncbi request reprint Oligodendrocyte/myelin injury and repair as a function of the central nervous system environment
    Jack Antel
    Department of Neurology and Neurosurgery, Room 111, McGill University, 3801 University Street, Montreal, Que, Canada H3A 2B4
    Clin Neurol Neurosurg 108:245-9. 2006
  7. ncbi request reprint The search for the missing links in multiple sclerosis
    Jack Antel
    Montreal Neurologic Institute, 3801 University Street, Montreal H3A 2T5, Quebec, Canada
    Curr Neurol Neurosci Rep 7:93-4. 2007
  8. ncbi request reprint 8th international congress of neuroimmunology
    Jack Antel
    Neuroimmunology Unit, Montreal Neurologic Institute, McGill University, Montreal H3A2B4, Quebec, Canada
    J Neuroimmunol 185:6-8. 2007
  9. doi request reprint Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis
    Qiao Ling Cui
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Am J Pathol 183:516-25. 2013
  10. doi request reprint Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate
    Qiao Ling Cui
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Stem Cells Dev 21:1831-7. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    Amit Bar-Or
    Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Neurol 64:1407-15. 2007
    ..To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS)...
  2. doi request reprint Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies
    Jack P Antel
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Clin Neurol Neurosurg 110:951-7. 2008
    ..To review the direct and indirect effects on the central nervous system (CNS) of systemically administered immuno-modulatory therapies in use or under evaluation for the relapsing forms of multiple sclerosis (MS)...
  3. pmc Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
    Celina Wu
    Montreal Neurological Institute, McGill University, 3801 University St, Montreal QC H3A 2B4, Canada
    J Neuroinflammation 10:41. 2013
    ..For the function-inducing responses, we measured inhibition of intracellular calcium release stimulated by the proinflammatory cytokine, interleukin (IL)-1β...
  4. doi request reprint Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?
    Jack Antel
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Acta Neuropathol 123:627-38. 2012
    ..In this review, we summarize the knowledge regarding the clinical, epidemiological, imaging, and pathological characteristics of PPMS and compare those characteristics with RRMS and SPMS...
  5. ncbi request reprint Multiple sclerosis and immune regulatory cells
    Jack Antel
    Montreal Neurologic Institute Canada
    Brain 127:1915-6. 2004
  6. ncbi request reprint Oligodendrocyte/myelin injury and repair as a function of the central nervous system environment
    Jack Antel
    Department of Neurology and Neurosurgery, Room 111, McGill University, 3801 University Street, Montreal, Que, Canada H3A 2B4
    Clin Neurol Neurosurg 108:245-9. 2006
    ..Conversely, these interactions also impact on the mechanisms involved in target protection and repair...
  7. ncbi request reprint The search for the missing links in multiple sclerosis
    Jack Antel
    Montreal Neurologic Institute, 3801 University Street, Montreal H3A 2T5, Quebec, Canada
    Curr Neurol Neurosci Rep 7:93-4. 2007
  8. ncbi request reprint 8th international congress of neuroimmunology
    Jack Antel
    Neuroimmunology Unit, Montreal Neurologic Institute, McGill University, Montreal H3A2B4, Quebec, Canada
    J Neuroimmunol 185:6-8. 2007
  9. doi request reprint Oligodendrocyte progenitor cell susceptibility to injury in multiple sclerosis
    Qiao Ling Cui
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Am J Pathol 183:516-25. 2013
    ..Our data suggest that susceptibility of OPCs to injury within the MS lesion environment contributes to the limited remyelination in MS. ..
  10. doi request reprint Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate
    Qiao Ling Cui
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Stem Cells Dev 21:1831-7. 2012
    ..These findings indicate that intrinsic regulatory mechanisms associated with the chronological age of the donor cells are key variables to assess when considering the myelination capacity of OPCs for cellular replacement therapy...
  11. doi request reprint Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients
    Trina A Johnson
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Clin Immunol 137:15-20. 2010
    ..This is relevant for clinical decisions regarding management of patients using this therapy and for introducing alternate therapies...
  12. pmc Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS
    Evelyn Zastepa
    From Neuroscience E Z, L F G, Department of Pathology D G H, and McGill Centre for Bioinformatics M H, McGill University, Montreal Neurology J A, A B O, Y L, Montreal Neurological Hospital, Montreal, Canada and Neurology S B, UCSF, San Francisco, CA
    Neurology 82:681-90. 2014
    ..Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple sclerosis (SPMS)...
  13. pmc Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis
    David Henault
    From the Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Canada
    Neurology 81:1768-72. 2013
    ....
  14. doi request reprint Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation
    Peter J Darlington
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, and Laboratory of Immunology, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada
    Ann Neurol 73:341-54. 2013
    ..To define changes in phenotype and functional responses of reconstituting T cells in patients with aggressive multiple sclerosis (MS) treated with ablative chemotherapy and autologous hematopoietic stem cell transplantation (HSCT)...
  15. ncbi request reprint Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis
    Carolyn Jack
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Glia 55:926-34. 2007
    ..Our results indicate that NO alone is unlikely to induce oligodendrocyte injury, whereas its more potent byproduct peroxynitrite is a potential mediator of injury to oligodendrocytes in MS...
  16. doi request reprint Reduced thymic output and peripheral naïve CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS)
    David G Haegert
    Department of Pathology, McGill University, 3775 Rue University, Montreal, QC, Canada H3A 2B4
    J Neuroimmunol 233:233-9. 2011
    ..We conclude PPMS patients have peripheral immune alterations related to reduced thymic output...
  17. ncbi request reprint Oligodendrocyte injury in multiple sclerosis: a role for p53
    Karolina Wosik
    Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 85:635-44. 2003
    ..In situ analysis of active MS lesions revealed increased p53 expression in oligodendrocytes in lesions that featured oligodendrocyte apoptosis and cell loss. Our data provide evidence for a novel role for p53 in the pathogenesis of MS...
  18. ncbi request reprint New directions in multiple sclerosis therapy: matching therapy with pathogenesis
    Jack Antel
    Neuroimmunnology Unit, Montreal Neurologic Institute, Montreal, Quebec, Canada
    Can J Neurol Sci 37:S42-8. 2010
    ....
  19. ncbi request reprint Pathogenesis of multiple sclerosis
    Alexandre Prat
    Neuroimmunology Laboratory and Multiple Sclerosis Clinic, CHUM Notre Dame Hospital, Montreal, Quebec, Canada
    Curr Opin Neurol 18:225-30. 2005
    ..The aim of this article is to describe recent observations regarding the basis for the initiation and disease evolution of multiple sclerosis...
  20. doi request reprint Response of human oligodendrocyte progenitors to growth factors and axon signals
    Qiao Ling Cui
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 69:930-44. 2010
    ..The distinct properties of fetal and adult OPCs may be related to differences in their chronological age and initial differentiation states...
  21. doi request reprint The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors
    Marcio L De Paula
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada
    Glia 62:64-77. 2014
    ..Thus, our results suggest that a transient suppression of a potential barrier for myelination in combination with other therapeutic approaches including growth factors may be promising to improve the functional recovery of CNS injuries...
  22. doi request reprint Thymic involution and proliferative T-cell responses in multiple sclerosis
    Danielle A Duszczyszyn
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    J Neuroimmunol 221:73-80. 2010
    ..Thus, RRMS patients have early thymic involution with compensatory homeostatic peripheral T-cell proliferative responses that may predispose patients to autoreactivity...
  23. ncbi request reprint Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment
    Jack Antel
    Neuroimmunology Unit, Montreal Neurological Institute and McGill University, 3801 University Street, Room 111, Montreal, Quebec, Canada H3A2B4
    J Neuroimmunol 180:3-8. 2006
    ..This presentation considers what roles Ig and/or B cells can play in mediating or regulating disease-relevant immune responses in MS. A timely corollary is whether B cell/Ig-directed therapeutic strategies can be effective in MS...
  24. doi request reprint Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis
    Trina A Johnson
    Montreal Neurological Institute, QC, Canada
    Arch Neurol 67:1449-55. 2010
    ..To define the capacity of peripheral blood CD8(+) T cells from patients with multiple sclerosis (MS) receiving fingolimod (FTY720) to migrate in response to chemokines that contribute to trafficking into the central nervous system...
  25. ncbi request reprint Extensive cortical remyelination in patients with chronic multiple sclerosis
    Monika Albert
    Institute of Neuropathology, University of Goettingen, Goettingen, Germany
    Brain Pathol 17:129-38. 2007
    ..Our data confirm the high prevalence of cortical demyelination in chronic MS and imply that the propensity to remyelinate is high in cortical MS lesions...
  26. ncbi request reprint Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
    ..This pathway may act as an inhibitory feedback aimed to downregulate the deleterious effects of T-cell infiltration in neuroinflammation...
  27. doi request reprint Cross-reactivity between epidemiology and immunology in multiple sclerosis
    Amit Bar-Or
    Neurology 71:1132-3. 2008
  28. ncbi request reprint Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS
    Tim Magnus
    Department of Neurology, University of Homburg, D 66424 Homburg, Germany
    J Neurosci 25:2537-46. 2005
    ..Together, our data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage...