M Maziade

Summary

Country: Canada

Publications

  1. pmc Young offspring at genetic risk of adult psychoses: the form of the trajectory of IQ or memory may orient to the right dysfunction at the right time
    Michel Maziade
    Laval University and Centre de Recherche Université Laval Robert Giffard, Laval, Quebec, Canada
    PLoS ONE 6:e19153. 2011
  2. ncbi request reprint Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families
    M Maziade
    Department of Psychiatry, Laval University, Quebec G1J 2G3, Canada
    Mol Psychiatry 10:486-99. 2005
  3. ncbi request reprint Chromosome 1q12-q22 linkage results in eastern Québec families affected by schizophrenia
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    Am J Med Genet 114:51-5. 2002
  4. ncbi request reprint A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport Québec G1J 2G3, Canada
    Mol Psychiatry 6:684-93. 2001
  5. pmc Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, QC, Canada
    Acta Psychiatr Scand 117:118-26. 2008
  6. pmc Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern quebec multigenerational families
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, Chemin de Canardiére, F 4500, Québec QC G1J 2G3, Canada
    Schizophr Bull 35:919-30. 2009
  7. ncbi request reprint Prolongation of brainstem auditory-evoked responses in autistic probands and their unaffected relatives
    M Maziade
    or Michel Maziade, MD, FRCP C, Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport, Québec G1J 2G3 Canada
    Arch Gen Psychiatry 57:1077-83. 2000
  8. pmc Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
    Michel Maziade
    Department of Psychiatry, Laval University, Quebec, QC, Canada
    Eur J Hum Genet 17:1034-42. 2009
  9. doi request reprint Atomoxetine and neuropsychological function in children with attention-deficit/hyperactivity disorder: results of a pilot study
    Michel Maziade
    Department of Medicine, Laval University, Centre de Recherche Universite Laval Robert Giffard, Quebec City, Canada
    J Child Adolesc Psychopharmacol 19:709-18. 2009
  10. pmc Verbal and visual memory impairments among young offspring and healthy adult relatives of patients with schizophrenia and bipolar disorder: selective generational patterns indicate different developmental trajectories
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, Quebec, Canada
    Schizophr Bull 37:1218-28. 2011

Collaborators

Detail Information

Publications33

  1. pmc Young offspring at genetic risk of adult psychoses: the form of the trajectory of IQ or memory may orient to the right dysfunction at the right time
    Michel Maziade
    Laval University and Centre de Recherche Université Laval Robert Giffard, Laval, Quebec, Canada
    PLoS ONE 6:e19153. 2011
    ..This led to the following developmental question: Do IQ and memory impairments exhibit different developmental courses from childhood to young adulthood in terms of stability or fluctuations?..
  2. ncbi request reprint Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families
    M Maziade
    Department of Psychiatry, Laval University, Quebec G1J 2G3, Canada
    Mol Psychiatry 10:486-99. 2005
    ..The present results support the relevance of investigating concurrently SZ and BP within the same study and have implications for the modelling of genetic effects...
  3. ncbi request reprint Chromosome 1q12-q22 linkage results in eastern Québec families affected by schizophrenia
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    Am J Med Genet 114:51-5. 2002
    ..The result reported by Brzustowicz et al. cannot be discarded and should probably be considered as a susceptibility locus for a subset of the schizophrenic population...
  4. ncbi request reprint A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport Québec G1J 2G3, Canada
    Mol Psychiatry 6:684-93. 2001
    ..The 6p finding provided confirmatory evidence of linkage for SZ. Our results suggest that both specific and common susceptibility loci must be searched for SZ and BP...
  5. pmc Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, QC, Canada
    Acta Psychiatr Scand 117:118-26. 2008
    ....
  6. pmc Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern quebec multigenerational families
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, Chemin de Canardiére, F 4500, Québec QC G1J 2G3, Canada
    Schizophr Bull 35:919-30. 2009
    ..This study examines the cognitive functioning of high-risk (HR) offspring of parents having schizophrenia (HRSZ) and high-risk offspring of parents having bipolar disorder (HRBP) descending from densely affected kindreds...
  7. ncbi request reprint Prolongation of brainstem auditory-evoked responses in autistic probands and their unaffected relatives
    M Maziade
    or Michel Maziade, MD, FRCP C, Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport, Québec G1J 2G3 Canada
    Arch Gen Psychiatry 57:1077-83. 2000
    ..Autism also has strong genetic determinants, and like all major psychiatric disorders, its complex clinical phenotype renders genetic studies difficult. Innovative strategies focused on alternative biological phenotypes are needed...
  8. pmc Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
    Michel Maziade
    Department of Psychiatry, Laval University, Quebec, QC, Canada
    Eur J Hum Genet 17:1034-42. 2009
    ..Our data suggest a susceptibility locus in 13q13-q14 that is shared by schizophrenia and mood disorder. That locus would be additional to another well documented and more distal 13q locus where the G72/G30 gene is mapped...
  9. doi request reprint Atomoxetine and neuropsychological function in children with attention-deficit/hyperactivity disorder: results of a pilot study
    Michel Maziade
    Department of Medicine, Laval University, Centre de Recherche Universite Laval Robert Giffard, Quebec City, Canada
    J Child Adolesc Psychopharmacol 19:709-18. 2009
    ..These findings suggest that potential benefits of ATX treatment may extend beyond reduction of core ADHD symptoms to amelioration of some neuropsychological and functional deficits...
  10. pmc Verbal and visual memory impairments among young offspring and healthy adult relatives of patients with schizophrenia and bipolar disorder: selective generational patterns indicate different developmental trajectories
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, Quebec, Canada
    Schizophr Bull 37:1218-28. 2011
    ..In multigenerational families densely affected by SZ or BP, our aim was to compare the memory impairments observed in young nonaffected offspring with memory functioning in nonaffected adult relatives and patients...
  11. ncbi request reprint [Genetics of schizophrenia and bipolar disorder: recent success of linkage studies with evidence of specific and shared susceptibility loci]
    Michel Maziade
    Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Beauport, Quebec, G1J 2G3 Canada
    Med Sci (Paris) 19:960-6. 2003
    ..Hence, we report several genomics susceptibility loci for SZ and BP, some of them being probably shared by the two major psychiatric illnesses whereas others could be specific to each...
  12. ncbi request reprint 6p24-22 region and major psychoses in the Eastern Quebec population. Le Groupe IREP
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    Am J Med Genet 74:311-8. 1997
    ....
  13. ncbi request reprint Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine
    Y C Chagnon
    Laval University Robert Giffard Research Center, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:1063-9. 2007
    ..No association was observed for those over 50 years, or for rs11111201. These results suggest that the common allele of PMCH rs7973796 may be associated with a greater BMI in olanzapine-treated SZ patients...
  14. pmc Significant linkage for Tourette syndrome in a large French Canadian family
    C Merette
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, G1J 2G3 Canada
    Am J Hum Genet 67:1008-13. 2000
    ..18. Hence, even after adjustment for multiple testing, the present study shows statistically significant evidence for genetic linkage with TS...
  15. ncbi request reprint A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses
    Y C Chagnon
    Laval University Research Center Robert Giffard, Beauport, Québec G1J 2B3, Canada
    Mol Psychiatry 9:1067-74. 2004
    ..PMCH encodes a neuropeptide involved in the control of food intake, energy expenditure, and in anxiety/depression. This first genome scan targeting the obesity side effect of antipsychotics identified 12q24 as a susceptibility region...
  16. ncbi request reprint Clinical and methodological factors related to reliability of the best-estimate diagnostic procedure
    M A Roy
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    Am J Psychiatry 154:1726-33. 1997
    ..The reliability and accuracy of the best-estimate diagnostic procedure were examined, and factors associated with reliability were determined...
  17. doi request reprint Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
    ..86, respectively), but was slightly repressed by olanzapine in controls (-8%; p=0.008) but not in SZ (+1%; p=0.91). These results are in agreement with those observed in post-mortem brain when the isoforms involved are considered...
  18. ncbi request reprint Anticipation in schizophrenia and bipolar disorder controlling for an information bias
    C Merette
    Centre de Recherche Universite Laval Robert Giffard, Quebec, Canada
    Am J Med Genet 96:61-8. 2000
    ..Findings suggest that future anticipation studies should also control for QOI. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:61-68, 2000...
  19. ncbi request reprint Subtyping schizophrenia according to outcome or severity: a search for homogeneous subgroups
    M A Roy
    Department of Psychiatry, Universite Laval, Quebec, Canada
    Schizophr Bull 27:115-38. 2001
    ..We propose ten methodological and conceptual recommendations for future studies aimed at the identification of valid SZ subtypes according to outcome or severity...
  20. ncbi request reprint Male gender is associated with deficit schizophrenia: a meta-analysis
    M A Roy
    Centre de Recherche Universite Laval Robert Giffard, département de Psychiatrie de la faculté de Médecine de l Université Laval, Robert Giffard, 2601 de la Canardiere, Beauport, G1J 2G3, Quebec, Canada
    Schizophr Res 47:141-7. 2001
    ..g. sexual hormones) or gender differences in the liability to different etiologies of schizophrenia. The role of gender as a potential confounder must be closely examined in studies comparing deficit and non-deficit SZ...
  21. doi request reprint Schizophrenia patients with polydipsia and water intoxication are characterized by greater severity of psychotic illness and a more frequent history of alcohol abuse
    Simon Poirier
    Centre de Recherche Universite Laval Robert Giffard, Beauport, QC, Canada
    Schizophr Res 118:285-91. 2010
    ..Thus, our data suggest that a greater severity of illness and a prior history of alcohol use disorders interact in increasing the risk of developing PWI in chronic schizophrenic patients...
  22. ncbi request reprint A pilot feasibility study of an extension of the acquaintanceship recruitment procedure in recent-onset psychosis
    Catherine Lehoux
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    J Nerv Ment Dis 193:560-3. 2005
    ..This pilot study suggests that several obstacles prevent the use of this procedure to recruit controls in this research focusing on recent-onset psychotic disorders...
  23. doi request reprint Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population
    Chantal Mérette
    Department of Psychiatry, Laval University, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:737-44. 2008
    ....
  24. ncbi request reprint Fine motor dexterity is correlated to social functioning in schizophrenia
    Catherine Lehoux
    Centre de Recherche Universite Laval Robert Giffard, H 4100, 2601 chemin de la Canardière, G1J 2G3 Beauport, Quebec, Canada
    Schizophr Res 62:269-73. 2003
    ..To identify neuropsychological domains, including fine motor dexterity, that are related to social functioning in schizophrenia...
  25. doi request reprint An examination of the relative contribution of saturation and selective attention to memory deficits in patients with recent-onset schizophrenia and their unaffected parents
    Caroline Cellard
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    J Abnorm Psychol 119:60-70. 2010
    ..The methodological strategy adopted here allowed us to show that the dysfunction of STM is genuine, can be aggravated by deficits in selective attention, and is a good candidate for further research on genetic epidemiology...
  26. ncbi request reprint A factor analysis of the Strauss and Carpenter revised outcome criteria scale: a validation of the French translation
    Simon Poirier
    Centre de Recherche Universite Laval Robert Giffard, Beauport, Quebec, Canada
    J Nerv Ment Dis 192:864-7. 2004
    ..This article supports the relevance of the SCOCS-R to assess the dimensions of outcome in schizophrenic subjects...
  27. doi request reprint Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents
    Andrée Anne Lefèbvre
    Centre de Recherche Universite Laval Robert Giffard, F 4500, Quebec, Quebec, Canada
    Psychiatry Res 175:15-21. 2010
    ..The results also suggest that use of experimental tasks represents a promising method in the search of cognitive endophenotypes in SZ...
  28. doi request reprint Retinal response to light in young nonaffected offspring at high genetic risk of neuropsychiatric brain disorders
    Marc Hebert
    Centre de Recherche Universite Laval Robert Giffard, Quebec G1J 2G3, Canada
    Biol Psychiatry 67:270-4. 2010
    ..Here, we report a specific electroretinographic (ERG) anomaly in young nonaffected and nonmedicated offspring at high genetic risk (HR) of these disorders...
  29. doi request reprint A new strategy for linkage analysis under epistasis taking into account genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche, Université Laval Robert Giffard, Quebec, Que, Canada
    Hum Hered 68:231-42. 2009
    ..We propose a complete three-step strategy for parametric linkage analysis under epistasis and heterogeneity in extended pedigrees...
  30. ncbi request reprint A pilot neuropsychological study of Kraepelinian and non-Kraepelinian schizophrenia
    Marc Andre Roy
    Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Beauport, P Quebec, Canada G1J 2G3
    Schizophr Res 62:155-63. 2003
    ..This is the first study to report a direct comparison of neuropsychological performance in Kraepelinian vs. non-Kraepelinian schizophrenia (SZ)...
  31. doi request reprint Effects of phonological and semantic cuing on encoding and retrieval processes in adolescent psychosis
    Marie Claire Dore
    Ecole de Psychologie, Pavillon FA Savard, Universite Laval, Quebec, QC, Canada
    J Clin Exp Neuropsychol 31:533-44. 2009
    ..Patients' performance improved from free to cued recall, but this was not sufficient to normalize their performance. Impaired strategic processes may lead to encoding and retrieval difficulties in patients...
  32. ncbi request reprint Informative phenotypes for genetic studies of psychiatric disorders
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:581-8. 2007
    ..This is a conceptual review with a focus on methodological issues that may arise in psychiatric genetics and examples are taken from the literature on autism, schizophrenia, bipolar disorder, and alcoholism...
  33. ncbi request reprint Decomposing the autism phenotype into familial dimensions
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:3-9. 2008
    ..These findings suggest that non-verbal IQ and language in PDD may arise from independent genetic mechanisms. The implications of this finding for linkage analysis and for identifying genetically informative phenotypes are discussed...