Patrick Mathieu

Summary

Country: Canada

Publications

  1. pmc Metabolic syndrome: the danger signal in atherosclerosis
    Patrick Mathieu
    Department of Surgery, Centre de Recherche de l Hôpital Laval Institut de Cardiologie de Québec, Quebec, Canada
    Vasc Health Risk Manag 2:285-302. 2006
  2. pmc The 'valvulo-metabolic' risk in calcific aortic valve disease
    Patrick Mathieu
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Quebec, Quebec
    Can J Cardiol 23:32B-39B. 2007
  3. ncbi request reprint Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity
    Patrick Mathieu
    Department of Cardiac Surgery, Laval Hospital, Sainte Foy, Quebec, Canada
    J Heart Valve Dis 14:353-7. 2005
  4. doi request reprint Pharmacology of ectonucleotidases: relevance for the treatment of cardiovascular disorders
    Patrick Mathieu
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    Eur J Pharmacol 696:1-4. 2012
  5. ncbi request reprint Surgical treatment of commissural prolapse: case report and review of the options
    Patrick Mathieu
    Quebec Heart Institute, Laval Hospital, Sainte Foy, Quebec, Canada
    J Heart Valve Dis 13:142-4. 2004
  6. pmc Abdominal obesity and the metabolic syndrome: a surgeon's perspective
    Patrick Mathieu
    Laval Hospital, Department of Surgery, Laval University, Sainte Foy, Quebec
    Can J Cardiol 24:19D-23D. 2008
  7. doi request reprint Obesity, inflammation, and cardiovascular risk
    P Mathieu
    Quebec Heart and Lung Institute Research Center, Quebec, Quebec, Canada
    Clin Pharmacol Ther 87:407-16. 2010
  8. doi request reprint Visceral obesity and the heart
    Patrick Mathieu
    Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada, G1V 4G5
    Int J Biochem Cell Biol 40:821-36. 2008
  9. doi request reprint Insulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial
    Romain Capoulade
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada
    JACC Cardiovasc Imaging 6:165-74. 2013
  10. doi request reprint Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery
    Nicolas Girerd
    Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada G1V 4G5
    Eur Heart J 30:1270-8. 2009

Collaborators

Detail Information

Publications77

  1. pmc Metabolic syndrome: the danger signal in atherosclerosis
    Patrick Mathieu
    Department of Surgery, Centre de Recherche de l Hôpital Laval Institut de Cardiologie de Québec, Quebec, Canada
    Vasc Health Risk Manag 2:285-302. 2006
    ..Furthermore, therapeutic options that specifically target the metabolic syndrome components are reviewed in light of recent developments...
  2. pmc The 'valvulo-metabolic' risk in calcific aortic valve disease
    Patrick Mathieu
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Quebec, Quebec
    Can J Cardiol 23:32B-39B. 2007
    ....
  3. ncbi request reprint Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity
    Patrick Mathieu
    Department of Cardiac Surgery, Laval Hospital, Sainte Foy, Quebec, Canada
    J Heart Valve Dis 14:353-7. 2005
    ..Since osseous calcification is closely associated with alkaline phosphatase (ALP) activity, it was hypothesized that ALP activity might be implicated in the calcification of isolated leaflet interstitial cells (ICs)...
  4. doi request reprint Pharmacology of ectonucleotidases: relevance for the treatment of cardiovascular disorders
    Patrick Mathieu
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    Eur J Pharmacol 696:1-4. 2012
    ..In this perspective, a short account is given on the role of ectonucleotidases into the pathobiology of some cardiovascular disorders and the need to develop a novel pharmacology based on those recent findings...
  5. ncbi request reprint Surgical treatment of commissural prolapse: case report and review of the options
    Patrick Mathieu
    Quebec Heart Institute, Laval Hospital, Sainte Foy, Quebec, Canada
    J Heart Valve Dis 13:142-4. 2004
    ..An analysis of the options available for surgical treatment of commissural prolapse is included...
  6. pmc Abdominal obesity and the metabolic syndrome: a surgeon's perspective
    Patrick Mathieu
    Laval Hospital, Department of Surgery, Laval University, Sainte Foy, Quebec
    Can J Cardiol 24:19D-23D. 2008
    ..In the present paper, recent concepts surrounding the MetS and its implications in various cardiovascular disorders are reviewed along with the clinical implications...
  7. doi request reprint Obesity, inflammation, and cardiovascular risk
    P Mathieu
    Quebec Heart and Lung Institute Research Center, Quebec, Quebec, Canada
    Clin Pharmacol Ther 87:407-16. 2010
    ..In this review, we provide, in the context of CVD risk, an up-to-date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation...
  8. doi request reprint Visceral obesity and the heart
    Patrick Mathieu
    Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada, G1V 4G5
    Int J Biochem Cell Biol 40:821-36. 2008
    ..Implications and failure of lipid partitioning and some of the potential pathways mediating development of heart diseases are also covered in view of recent development of therapeutic options...
  9. doi request reprint Insulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial
    Romain Capoulade
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada
    JACC Cardiovasc Imaging 6:165-74. 2013
    ....
  10. doi request reprint Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery
    Nicolas Girerd
    Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada G1V 4G5
    Eur Heart J 30:1270-8. 2009
    ..In the present work, we sought to determine which feature of the MetS is associated with POAF...
  11. ncbi request reprint Obesity and metabolic syndrome are independent risk factors for atrial fibrillation after coronary artery bypass graft surgery
    Najmeddine Echahidi
    Department of Medicine, Laval University, Quebec, Canada
    Circulation 116:I213-9. 2007
    ..Previous studies have reported that obesity is a risk factor for POAF after cardiac surgery. However, it is unknown whether the metabolic syndrome (MS) also increases the risk of postoperative atrial fibrillation...
  12. ncbi request reprint Impact of aortic stenosis severity and its interaction with prosthesis-patient mismatch on operative mortality following aortic valve replacement
    Nicolas Girerd
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Department of Cardiology, Laval University, Quebec, Canada
    J Heart Valve Dis 21:158-67. 2012
    ..The study aim was to assess the effect of the preoperative severity of AS and its interaction with PPM with respect to operative mortality after AVR...
  13. doi request reprint Elevated proportion of small, dense low-density lipoprotein particles and lower adiponectin blood levels predict early structural valve degeneration of bioprostheses
    Rahul Shetty
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart Institute Hôpital Laval Research Center, Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, QC, Canada
    Cardiology 121:20-6. 2012
    ..Long-term durability of bioprosthetic heart valves (BPs) are limited by structural valve degeneration (SVD) leading to stenosis and/or regurgitation. In this study, we sought to determine the metabolic markers associated with SVD...
  14. ncbi request reprint Metabolic syndrome is associated with faster degeneration of bioprosthetic valves
    Martin Briand
    Laval Hospital Research Center Quebec Heart Institute, Laval University, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, Canada, G1V 4G5
    Circulation 114:I512-7. 2006
    ..The metabolic syndrome (MS) is associated with a higher risk of vascular atherosclerosis. We thus hypothesized that the atherogenic features of MS could accelerate bioprosthetic valve degeneration...
  15. doi request reprint Validation of conventional and simplified methods to calculate projected valve area at normal flow rate in patients with low flow, low gradient aortic stenosis: the multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) study
    Marie Annick Clavel
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec, Quebec City, Canada
    J Am Soc Echocardiogr 23:380-6. 2010
    ..The objectives of this study were to prospectively validate the diagnostic and prognostic value of AVA(proj) in a large series of patients and to propose a new clinically applicable simplified method to estimate AVA(proj)...
  16. ncbi request reprint NOTCH1 genetic variants in patients with tricuspid calcific aortic valve stenosis
    Valérie Ducharme
    Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, Canada
    J Heart Valve Dis 22:142-9. 2013
    ..Functional DNA variants at the NOTCH1 locus result in bicuspid aortic valve (BAV) and severe valve calcification. The contribution of these variants to AS in the population with tricuspid aortic valve (TAV) remains to be determined...
  17. doi request reprint Statins reduce short- and long-term mortality associated with postoperative atrial fibrillation after coronary artery bypass grafting: impact of postoperative atrial fibrillation and statin therapy on survival
    Nicolas Girerd
    Department of Surgery, Laval University, Quebec, Canada
    Clin Cardiol 35:430-6. 2012
    ..The objective of this study was to determine the impact of POAF on both short- and long-term mortality following isolated CABG...
  18. ncbi request reprint Impact of prosthesis-patient mismatch on survival after mitral valve replacement
    Julien Magne
    Laval Hospital Research Center Quebec Heart Institute, Faculty of Medicine, Laval University, Quebec, Canada
    Circulation 115:1417-25. 2007
    ..Thus, the objective of this study was to evaluate the impact of PPM on mortality in patients undergoing mitral valve replacement...
  19. doi request reprint Does the use of stentless aortic valves in a subcoronary position prevent patient-prosthesis mismatch for small aortic annulus?
    Stephane Lopez
    Department of Surgery, Laval University, Quebec, Canada
    J Card Surg 23:331-5. 2008
    ..85 cm2/m2] after aortic valve replacement (AVR) with 19-mm and 21-mm stentless bioprostheses and to evaluate clinical and hemodynamic outcomes...
  20. doi request reprint Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: influence of age, obesity, and left ventricular dysfunction
    Dania Mohty
    Laval Hospital Research Center Quebec Heart Institute, Laval University, Quebec, Quebec, Canada
    J Am Coll Cardiol 53:39-47. 2009
    ....
  21. doi request reprint Stress echocardiography to assess stenosis severity and predict outcome in patients with paradoxical low-flow, low-gradient aortic stenosis and preserved LVEF
    Marie Annick Clavel
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec, Canada
    JACC Cardiovasc Imaging 6:175-83. 2013
    ..32/0.1 cm(2) decrease in AVA(Proj)). In patients with PLFLG AS, the measurement of AVA(proj) derived from stress echocardiography is helpful to determine the actual severity of the stenosis and predict risk of adverse events...
  22. doi request reprint Outcome of patients with aortic stenosis, small valve area, and low-flow, low-gradient despite preserved left ventricular ejection fraction
    Marie Annick Clavel
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec, Canada
    J Am Coll Cardiol 60:1259-67. 2012
    ..0 cm(2)) and consistent high-gradient (MG ≥40 mm Hg) (HG-SAS group) and with that of patients with a moderate AS (AVA >1.0 cm(2) and MG <40 mm Hg) (MAS group)...
  23. doi request reprint ATP acts as a survival signal and prevents the mineralization of aortic valve
    Nancy Côté
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    J Mol Cell Cardiol 52:1191-202. 2012
    ..Hence, our results show that level of ENPP1 modulates extracellular concentration of ATP, which is an important survival signal for VICs. These findings may help to develop novel pharmacological treatment for CAVD...
  24. ncbi request reprint Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    J Thorac Cardiovasc Surg 132:401-6. 2006
    ..This study evaluates the mechanisms and clinical presentation of structural valve deterioration in the Freestyle stentless bioprosthesis...
  25. doi request reprint Mitral repair versus replacement for ischemic mitral regurgitation: comparison of short-term and long-term survival
    Julien Magne
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Canada
    Circulation 120:S104-11. 2009
    ..The objective of this study was to compare the postoperative outcome of MVRp versus MVR in patients with ischemic MR...
  26. doi request reprint Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study
    Marie Annick Clavel
    Laval Hospital Research Center Quebec Heart Institute, Laval Hospital, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada
    Circulation 118:S234-42. 2008
    ..The objective of this study was to identify the determinants of survival, functional status, and change in left ventricular ejection fraction during follow-up of patients with low-flow, low-gradient aortic stenosis...
  27. doi request reprint Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling
    Ablajan Mahmut
    Department of Surgery, Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart and Lung Institute Research Center, Laval University, Quebec City, QC, Canada
    Eur J Clin Invest 43:570-8. 2013
    ..Lipoprotein lipase (LPL) is implicated in lipid metabolism and may play a role in lipid retention within the aortic valve...
  28. doi request reprint Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats
    Nancy Côté
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    Eur J Pharmacol 689:139-46. 2012
    ..Inhibition of ectonucleotidase activity prevented the development of calcific aortic valve disease in a rat model. On that account, ectonucleotidase may represent a novel target in the treatment of calcific aortic valve disease...
  29. doi request reprint ApoB/ApoA-I ratio is associated with increased risk of bioprosthetic valve degeneration
    Haifa Mahjoub
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Universite Laval, Quebec, Canada
    J Am Coll Cardiol 61:752-61. 2013
    ..This study sought to identify the clinical and metabolic determinants of bioprosthetic valve degeneration...
  30. doi request reprint Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy
    Romain Capoulade
    Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 60:216-23. 2012
    ....
  31. doi request reprint Permanent pacemaker implantation following isolated aortic valve replacement in a large cohort of elderly patients with severe aortic stenosis
    Rodrigo Bagur
    Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    Heart 97:1687-94. 2011
    ....
  32. ncbi request reprint Metabolic syndrome increases operative mortality in patients undergoing coronary artery bypass grafting surgery
    Najmeddine Echahidi
    Department of Medicine, Centre de Recherche de l Hôpital Laval Institut de Cardiologie de Québec, Quebec, Canada
    J Am Coll Cardiol 50:843-51. 2007
    ..The aim of this study was to determine the impact of the metabolic syndrome (MS) on operative mortality after a coronary artery bypass grafting surgery (CABG)...
  33. pmc Recannulation of the right axillary artery for complex aortic surgeries
    Rahul Shetty
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Canada G1V 4G5
    Tex Heart Inst J 32:194-7; discussion 185. 2005
    ..It avoids retrograde perfusion in the often-diseased descending thoracic aorta. Furthermore, sternal reentry may be performed under moderate hypothermia, because antegrade cerebral perfusion can be initiated with ease...
  34. doi request reprint Angiotensin receptor blockers are associated with a lower remodelling score of stenotic aortic valves
    Nancy Côté
    Department of Surgery, Laboratoire d Etudes Moléculaires des Valvulopathies, Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, QC, Canada
    Eur J Clin Invest 41:1172-9. 2011
    ..Experimental and clinical studies have suggested that inhibitors of the renin angiotensin system (RAS) might be useful to slow the progression of valvular calcification in patients with aortic stenosis (AS)...
  35. pmc Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2
    Habib Derbali
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy Québec, Quebec, Canada, G1V 4G5
    Am J Pathol 176:2638-45. 2010
    ..These results suggest that intricate links between valve matrix proteins, inflammation, and lipid retention are involved in the pathobiology of AS...
  36. doi request reprint Age-related differences in the pathogenesis of calcific aortic stenosis: the potential role of resistin
    Dania Mohty
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart Institute Hôpital Laval Research Center, Department of Surgery, Laval University, Quebec, Canada
    Int J Cardiol 142:126-32. 2010
    ..We hypothesized that the metabolic determinants of the valvular inflammatory and calcifying processes occurring in elderly patients are different from those observed earlier in life...
  37. ncbi request reprint Long-term impact of diabetes and its comorbidities in patients undergoing isolated primary coronary artery bypass graft surgery
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, QC, Canada
    Circulation 116:I220-5. 2007
    ....
  38. doi request reprint Age cut-off for the loss of benefit from bilateral internal thoracic artery grafting
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, 2725 Chemin Ste Foy, Quebec City, QC, Canada, G1V 4G5
    Eur J Cardiothorac Surg 33:977-82. 2008
    ..To identify the age-related benefit of single and bilateral internal thoracic artery (ITA) grafting on long-term cardiac-related survival in patients who survived from primary isolated coronary artery bypass grafting (CABG)...
  39. doi request reprint Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis
    Nancy Côté
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec, Canada
    Int J Cardiol 145:444-9. 2010
    ..We sought to determine the relationships between blood pressure, inflammation, oxidative stress and valvular inflammation in a population of normotensive and prehypertensive patients with AS...
  40. doi request reprint Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease
    Nancy Côté
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart and Lung Institute Research Center, Department of Surgery, Quebec, Que, Canada
    Pathobiology 81:15-24. 2014
    ..Calcific aortic valve disease (CAVD) is a chronic disorder characterized by the mineralization of the aortic valve and involving fibrosis...
  41. pmc High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1
    Diala El Husseini
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    PLoS ONE 8:e53393. 2013
    ..These results strongly suggest that overexpression of SLC20A1 promotes apoptosis and mineralization by altering the level of Akt-1...
  42. doi request reprint Restrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosis
    Julien Magne
    Laval Hospital Research Center Quebec Heart Institute, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 51:1692-701. 2008
    ..The purpose of this study was to evaluate mitral valve hemodynamic performance and functional capacity in patients with ischemic mitral regurgitation (MR) who underwent restrictive mitral valve annuloplasty (MVA)...
  43. pmc A pilot study to estimate the feasibility of assessing the relationships between polymorphisms in hKv1.5 and atrial fibrillation in patients following coronary artery bypass graft surgery
    Isabelle Plante
    Quebec Heart Institute, Quebec, Quebec
    Can J Cardiol 24:41-4. 2008
    ..5 in a French-Canadian population. Two of these, R87Q and P307S, modified the gating process and the expression level of the hKv1.5 channel...
  44. ncbi request reprint Extended applications of thoracic aortic stent grafts
    Francois Dagenais
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    Ann Thorac Surg 82:567-72. 2006
    ..Extending TSG applications for arch pathologies or to other yet unproven indications remains to be established. We herein report our experience in 18 patients with extended applications of TSG...
  45. ncbi request reprint Influence of time elapsed between myocardial infarction and coronary artery bypass grafting surgery on operative mortality
    Pierre Voisine
    Division of Cardiac Surgery, Laval Hospital, 2725 Chemin Sainte Foy, Sainte Foy, Que, Canada G1V 4G5
    Eur J Cardiothorac Surg 29:319-23. 2006
    ..Optimal timing for CABG surgery after myocardial infarction (MI) remains controversial. We examined the influence of patient age and time elapsed between MI and isolated CABG surgery on operative mortality...
  46. pmc Relation of mitral valve morphology and motion to mitral regurgitation severity in patients with mitral valve prolapse
    Mario Senechal
    Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Cardiovasc Ultrasound 10:3. 2012
    ..We sought to determine the relation of mitral valve morphology and motion to mitral regurgitation severity in patients with MVP...
  47. doi request reprint Nonrandomized comparison of coronary artery bypass surgery and percutaneous coronary intervention for the treatment of unprotected left main coronary artery disease in octogenarians
    Josep Rodes-Cabau
    Department of Cardiology and Cardiac Surgery, Quebec Heart Institute, Laval Hospital, Quebec, Canada
    Circulation 118:2374-81. 2008
    ....
  48. ncbi request reprint Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis
    Martin Briand
    Laval Hospital Research Center Quebec Heart Institute, Department of Medicine, Laval University, Quebec, Canada
    J Am Coll Cardiol 47:2229-36. 2006
    ..This study sought to examine the association between the metabolic syndrome (MS) and the progression of aortic stenosis (AS)...
  49. doi request reprint Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
    Jean Pierre Despres
    Hôpital Laval Research Centre, 2725 Chemin Ste Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V4G5, Canada
    Arterioscler Thromb Vasc Biol 28:1039-49. 2008
    ....
  50. doi request reprint Moderate aortic stenosis in coronary artery bypass grafting patients more than 70 years of age: to replace or not to replace?
    Francois Dagenais
    Department of Cardiac Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Ontario, Canada
    Ann Thorac Surg 90:1495-9; discussion 1499-500. 2010
    ..To stratify the risk-benefit ratio, we reviewed outcomes of CABG patients more than 70 years old with preoperative moderate aortic stenosis (valve area 1.0 to 1.6 cm(2) or indexed valve area 0.6 to 1.0 cm(2)/m(2))...
  51. doi request reprint Metabolic syndrome is associated with more pronounced impairment of left ventricle geometry and function in patients with calcific aortic stenosis: a substudy of the ASTRONOMER (Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin)
    Anik Pagé
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Universite Laval, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1867-74. 2010
    ..The aim of this study was to examine the relationship between metabolic syndrome (MetS) and left ventricular (LV) geometry and function in patients with asymptomatic aortic stenosis (AS)...
  52. pmc Advances in thoracic aortic surgery: arch replacement with axillary cannulation and thoracic stent grafts
    Francois Dagenais
    Department of Cardiac Surgery, Laval Hospital, 2725 Chemin Ste Foy, Sainte Foy, Quebec
    Can J Cardiol 23:76B-79B. 2007
    ..The importance of establishing dedicated multidisciplinary teams and follow-up clinics to ensure good outcomes in the treatment of these complex diseases is stressed...
  53. pmc Determinants of gastrointestinal complications in cardiac surgery
    Giuseppe D'Ancona
    Department of Cardiovascular Surgery, Laval Hospital, Quebec Heart Institute, Sainte Foy, Quebec, Canada G1V 4G5
    Tex Heart Inst J 30:280-5. 2003
    ....
  54. doi request reprint Inflammation is associated with the remodeling of calcific aortic valve disease
    Nancy Côté
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
    Inflammation 36:573-81. 2013
    ..25, p = 0.05) with the progression rate of aortic stenosis. Dense inflammatory infiltrate within CAVD is associated with an active remodeling process, the severity of aortic stenosis, and the hemodynamic progression rate...
  55. ncbi request reprint Use of the endoclamp device in a patient with a native mitral valve endocarditis and a previous arch replacement with a modified Griepp technique
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec Canada
    J Thorac Cardiovasc Surg 131:1188-90. 2006
  56. doi request reprint Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Pavillon Margeritte d Youville, Y4190, 2725, Chemin Sainte Foy, Quebec City, Quebec, Canada
    Circ Cardiovasc Genet 2:489-98. 2009
    ..However, no genomic approaches were used to identify genes and pathways that are differentially regulated in aortic valves of patients with and without AS...
  57. doi request reprint Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis
    Romain Capoulade
    Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada
    Eur J Clin Invest 43:1262-72. 2013
    ..The objectives of this study were to examine (i) the impact of hypertension on AS progression and clinical events and (ii) the effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs)...
  58. pmc Sirt1 inhibits resistin expression in aortic stenosis
    Sophie Carter
    Quebec Heart and Lung Research Center, Laval University, Quebec, Quebec City, Canada
    PLoS ONE 7:e35110. 2012
    ....
  59. ncbi request reprint Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis
    Dania Mohty
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec, Canada
    Arterioscler Thromb Vasc Biol 28:187-93. 2008
    ....
  60. doi request reprint Replication of genetic association studies in aortic stenosis in adults
    Nathalie Gaudreault
    Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Am J Cardiol 108:1305-10. 2011
    ..05 but did not resist Bonferroni correction. In conclusion, this study suggests that subjects carrying specific polymorphisms in the IL10 and APOB genes are at higher risk for developing AS...
  61. pmc Validation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue
    Kanta Chechi
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    PLoS ONE 7:e32265. 2012
    ..The objective of the current study was to evaluate and identify optimal reference genes for use in the relative quantification of gene expression in human epicardial fat depots of lean, overweight and obese subjects...
  62. doi request reprint Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis
    Yohan Bosse
    Department of Anatomy and Physiology, Laval Hospital Research Center, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 51:1327-36. 2008
    ..We discuss the future utility of these new genomic approaches to improve our understanding of AVS and to refine the management of patients in terms of diagnosis, prevention, and treatment...
  63. ncbi request reprint Impact of valve prosthesis-patient mismatch on pulmonary arterial pressure after mitral valve replacement
    Mingzhou Li
    Research Group in Valvular Heart Diseases, Research Center of Laval Hospital Quebec Heart Institute, Laval University, 2725 Chemin Saint Foy, Sainte Foy, Quebec, Canada G1V 4G5
    J Am Coll Cardiol 45:1034-40. 2005
    ..We sought to determine the impact of valve prosthesis-patient mismatch (PPM) on pulmonary arterial (PA) pressure after mitral valve replacement (MVR)...
  64. pmc The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease
    Sandra Guauque-Olarte
    Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, Canada
    PLoS ONE 6:e19908. 2011
    ....
  65. doi request reprint Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery
    Najmeddine Echahidi
    Department of Medicine, Laval Hospital Research Center Quebec Heart Institute, Laval University, Ste Foy, Quebec, Canada
    J Am Coll Cardiol 51:793-801. 2008
    ..This new knowledge would undoubtedly translate into a more efficient prevention and treatment of this common post-operative complication that is associated with a major health and economic burden...
  66. pmc Complete aortic obstruction owing to a proximal dehiscence of a free-style root bioprosthesis
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    Can J Cardiol 23:633. 2007
  67. pmc Postoperative atrial fibrillation predicts long-term survival after aortic-valve surgery but not after mitral-valve surgery: a retrospective study
    Nicolas Girerd
    Department of Medicine, Laval University, Quebec, Canada
    BMJ Open 1:e000385. 2011
    ..The underlying factors involved in the pathogenesis of POAF after MVR/MVRp may partially account for the lack of association between POAF and survival in these patients...
  68. ncbi request reprint [New insight into the treatment of aortic stenosis]
    Philippe Pibarot
    Centre de Recherche de l Hopital Laval, Institut de Cardiologie de Quebec, Universite Laval, 2725, Chemin Sainte Foy, Sainte Foy, Quebec, G1V 4G5 Canada
    Med Sci (Paris) 23:81-7. 2007
    ....
  69. ncbi request reprint Aortic valve-sparing procedure with cusp elongation and free edge reinforcement for bicuspid aortic valve
    Francois Dagenais
    Department of Cardiovascular Surgery, Quebec Heart Institute, Laval Hospital, Sainte Foy, Quebec, Canada
    Ann Thorac Surg 79:1393-5. 2005
    ..This procedure includes raphe excision, pericardial patch elongation, free edge leaflet reinforcement, and a root reimplantation valve-sparing procedure...
  70. ncbi request reprint Giant pseudoaneurysm after proximal aortic surgery treated by means of redo axillary artery cannulation and use of an Endoclamp device
    Francois Dagenais
    Department of Cardiac Surgery, Laval Hospital, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, Canada G1V 4G5
    J Thorac Cardiovasc Surg 130:208-9. 2005
  71. ncbi request reprint Electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (R87Q, A251T, and P307S) found in hKv1.5
    Isabelle Plante
    Quebec Heart Institute, Laval Hospital Research Centre, and Faculty of Pharmacy, Laval University, Sainte Foy, Quebec, G1V 4G5, Canada
    Pflugers Arch 452:316-23. 2006
    ..SNPs properties were not reproduced when expressed in the HEK293 cell line, suggesting that the regulatory beta-subunit present in CHO cells (and the human heart) is essential for the SNPs effects that we have observed...
  72. ncbi request reprint Changing trends in management of thoracic aortic disease: where do we stand with thoracic endovascular stent grafts?
    Francois Dagenais
    Department of Cardiac Surgery, Laval Hospital, Sainte Foy, Quebec G1V 4G5
    Can J Cardiol 21:173-8. 2005
    ..Thoracic endovascular stent grafts were designed to decrease perioperative risks, especially in patients with severe comorbidities. However, procedure-related complications and clinical outcomes remain ill-defined...
  73. ncbi request reprint Determinants of stroke after coronary artery bypass grafting
    Giuseppe D'Ancona
    Department of Cardiovascular Surgery, Laval Hospital, Quebec Heart Institute, 2725 Chemin Ste Foy, Sainte Foy, QC, Canada G1V 4G5
    Eur J Cardiothorac Surg 24:552-6. 2003
    ..Cerebrovascular accidents (CVA) after CABG are deleterious complications whose prevention remains poorly defined. The aim of this study was to identify the determinants for CVA after CABG...
  74. ncbi request reprint Myocardial infarction in a young woman secondary to a rupture of a noncoronary sinus of Valsalva aneurysm without coronary artery disease
    Alexis F Turgeon
    Division of Cardiac Surgery and Cardiology, Quebec Heart Institute, Laval University, Ste Foy, Canada
    Can J Cardiol 19:723-4. 2003
    ....
  75. pmc [Abdominal complications associated with cardiac surgery. Review of a contemporary surgical experience and of a series done without extracorporeal circulation]
    Brigitte Poirier
    Département de chirurgie cardiaque, Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, Ste Foy, Quebec
    Can J Surg 46:176-82. 2003
    ....
  76. ncbi request reprint Rescue therapy with methylene blue in systemic inflammatory response syndrome after cardiac surgery
    Francois Dagenais
    Quebec Heart Institute Laval Hospital, Ste Foy
    Can J Cardiol 19:167-9. 2003
    ..A single intravenous bolus (2 mg/kg) of methylene blue was administered with normalization of the peripheral resistance. The use of methylene blue as rescue therapy in severe vasoplegia syndrome is discussed...
  77. pmc Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels
    Delphine Bouchet
    Institut National de la Sante et de la Recherche Medicale U437, Nantes, France
    Mol Med 8:612-23. 2002
    ..In human ECs, levels of FLICE/caspase 8-inhibitory protein (FLIP) have been shown to control apoptosis mediated by Fas...