Francois Maltais

Summary

Country: Canada

Publications

  1. pmc Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD
    Philippe Gagnon
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Respir Res 15:4. 2014
  2. doi request reprint The potential for aclidinium bromide, a new anticholinergic, in the management of chronic obstructive pulmonary disease
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Ther Adv Respir Dis 6:345-61. 2012
  3. doi request reprint Tiotropium improves walking endurance in COPD
    M E Bédard
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, Quebec, G1V 4G5 Canada
    Eur Respir J 39:265-71. 2012
  4. pmc CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, 3626 rue St, Urbain, Montreal, QC, H2X 2P2 Canada
    Respir Res 12:43. 2011
  5. doi request reprint Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Respir Med 105:580-7. 2011
  6. ncbi request reprint [Loco-motor muscles in chronic respiratory diseases: the example of COPD]
    F Maltais
    Pneumologue, Hopital Laval, Faculte de Medecine, Universite Laval, Quebec, Canada
    Rev Mal Respir 22:2S53-61. 2005
  7. ncbi request reprint Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 725 Chemin Ste Foy, Quebec, QC, G1V 4G5, Canada
    Chest 128:1168-78. 2005
  8. ncbi request reprint A Canadian, multicentre, randomized clinical trial of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease: rationale and methods
    Francois Maltais
    Centre de rechereche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Canada
    Can Respir J 12:193-8. 2005
  9. ncbi request reprint Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial
    Francois Maltais
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Université Laval and Centre Hospitalier Universitaire Associé, Quebec City, Quebec, Canada
    Ann Intern Med 149:869-78. 2008
  10. doi request reprint Locus of symptom limitation and exercise response to bronchodilation in chronic obstructive pulmonary disease
    Dominic Deschênes
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Cardiopulm Rehabil Prev 28:208-14. 2008

Detail Information

Publications99

  1. pmc Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD
    Philippe Gagnon
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Respir Res 15:4. 2014
    ....
  2. doi request reprint The potential for aclidinium bromide, a new anticholinergic, in the management of chronic obstructive pulmonary disease
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Ther Adv Respir Dis 6:345-61. 2012
    ..The approved therapeutic dose of aclidinium 400 µg BID is thus an effective new treatment option for patients with COPD...
  3. doi request reprint Tiotropium improves walking endurance in COPD
    M E Bédard
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, Quebec, G1V 4G5 Canada
    Eur Respir J 39:265-71. 2012
    ..3 weeks of tiotropium resulted in a greater walking endurance in patients with COPD. Improvements in FEV(1), maximal ventilation and tidal volume may contribute to this enhanced exercise capacity...
  4. pmc CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, 3626 rue St, Urbain, Montreal, QC, H2X 2P2 Canada
    Respir Res 12:43. 2011
    ..This study analyzed the expression of IL-17A and IL-17F as well as the phenotype of cells producing them in bronchial biopsies from COPD patients...
  5. doi request reprint Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Respir Med 105:580-7. 2011
    ..Static and dynamic lung hyperinflation are associated with exercise impairment and poor outcomes in COPD patients. Aclidinium bromide is a novel, long-acting inhaled muscarinic antagonist currently in development for COPD treatment...
  6. ncbi request reprint [Loco-motor muscles in chronic respiratory diseases: the example of COPD]
    F Maltais
    Pneumologue, Hopital Laval, Faculte de Medecine, Universite Laval, Quebec, Canada
    Rev Mal Respir 22:2S53-61. 2005
  7. ncbi request reprint Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 725 Chemin Ste Foy, Quebec, QC, G1V 4G5, Canada
    Chest 128:1168-78. 2005
    ..The present study was designed to gain further insight into the duration of improvements...
  8. ncbi request reprint A Canadian, multicentre, randomized clinical trial of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease: rationale and methods
    Francois Maltais
    Centre de rechereche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Canada
    Can Respir J 12:193-8. 2005
    ..Pulmonary rehabilitation remains largely underused. Self-monitored, home-based rehabilitation is a promising approach to improving the availability of pulmonary rehabilitation...
  9. ncbi request reprint Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial
    Francois Maltais
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Université Laval and Centre Hospitalier Universitaire Associé, Quebec City, Quebec, Canada
    Ann Intern Med 149:869-78. 2008
    ..Home-based rehabilitation is a promising approach to improve access to pulmonary rehabilitation...
  10. doi request reprint Locus of symptom limitation and exercise response to bronchodilation in chronic obstructive pulmonary disease
    Dominic Deschênes
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Cardiopulm Rehabil Prev 28:208-14. 2008
    ....
  11. ncbi request reprint Assessment of muscle fatigue during exercise in chronic obstructive pulmonary disease
    Didier Saey
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725 Chemin Ste Foy, Quebec G1V 4G5, Canada
    Muscle Nerve 34:62-71. 2006
    ..We conclude that contractile fatigue commonly occurs during cycling exercise in COPD. The electromyographic median frequency appears to be a valuable indirect marker to predict contractile leg fatigue...
  12. ncbi request reprint Impact of preinduced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjects
    Philippe Gagnon
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Quebec G1V 4G5 Canada
    J Appl Physiol (1985) 107:832-40. 2009
    ..Our findings demonstrate that peripheral muscle fatigue is an additional important factor, besides intense dyspnea, that limits exercise tolerance in COPD...
  13. ncbi request reprint Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease
    Karine Marquis
    Centre de Recherche, Hopital Laval, Institut Universtaire de Cardiologie et de Pneumologie de L Université Laval, Quebec, Canada
    Am J Respir Crit Care Med 166:809-13. 2002
    ..These findings suggest that the assessment of body composition may be useful in the clinical evaluation of these patients...
  14. doi request reprint Walking exercise response to bronchodilation in mild COPD: a randomized trial
    Philippe Gagnon
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy Québec, Universite Laval, Quebec G1V 4G5, Canada
    Respir Med 106:1695-705. 2012
    ..However, bronchodilation does not enhance cycling exercise tolerance in these patients whereas walking may be more sensitive to the effects of bronchodilation...
  15. ncbi request reprint Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial
    Isabelle Vivodtzev
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Chest 141:716-25. 2012
    ..We investigated the functional and muscular effects of NMES in advanced COPD...
  16. pmc Effect of obesity on constant workrate exercise in hyperinflated men with COPD
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:33. 2010
    ..The aim of this study was to investigate the effects of increased BMI during constant workrate cycle ergometry in patients with COPD...
  17. doi request reprint Distal leg muscle function in patients with COPD
    Philippe Gagnon
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    COPD 10:235-42. 2013
    ..In addition, when exposed to the same absolute walking task, the fatigability of the distal leg muscles was higher in patients with COPD...
  18. pmc Physiological correlates of endurance time variability during constant-workrate cycling exercise in patients with COPD
    Isabelle Vivodtzev
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    PLoS ONE 6:e17007. 2011
    ..The endurance time (T(end)) during constant-workrate cycling exercise (CET) is highly variable in COPD. We investigated pulmonary and physiological variables that may contribute to these variations in T(end)...
  19. doi request reprint Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD
    Mariève Doucet
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Thorax 65:963-70. 2010
    ....
  20. ncbi request reprint Contractile fatigue, muscle morphometry, and blood lactate in chronic obstructive pulmonary disease
    Didier Saey
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Am J Respir Crit Care Med 171:1109-15. 2005
    ..We conclude that changes in muscle enzymatic profile and capillarization with a greater reliance on glycolytic metabolism during exercise are associated with contractile fatigue in patients with chronic obstructive pulmonary disease...
  21. ncbi request reprint Use of facemask and mouthpiece to assess constant-workrate exercise capacity in COPD
    Didier Saey
    Centre de Recherche, Hopital Laval, Institut de Cardiologie et de Pneumologie de Québec, Departement de Medecine, Universite Laval, Quebec, Canada
    Med Sci Sports Exerc 38:223-30. 2006
    ..To compare the response to constant-workrate cycling exercise between the mouthpiece and the facemask in patients with chronic obstructive pulmonary disease (COPD)...
  22. pmc Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses
    Patrice Brassard
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec
    Can J Cardiol 23:89B-96B. 2007
    ....
  23. doi request reprint Detecting improvements in dyspnea in COPD using a three-minute constant rate shuttle walking protocol
    Francesco Sava
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Canada
    COPD 9:395-400. 2012
    ..Our hypothesis was that the 3-minute constant rate shuttle walking protocol would be able to adequately put forth improvements in exertional dyspnea following acute bronchodilation in this population...
  24. doi request reprint Effect of bisoprolol on respiratory function and exercise capacity in chronic obstructive pulmonary disease
    Vincent Mainguy
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada
    Am J Cardiol 110:258-63. 2012
    ..The magnitude of these effects was small and should not contraindicate the use of bisoprolol in patients with COPD...
  25. pmc The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD
    Francesco Sava
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:55. 2010
    ..We examined the influence of overweight and obesity on pulmonary function, exercise tolerance, quality of life and response to pulmonary rehabilitation in COPD...
  26. ncbi request reprint Lipofuscin accumulation in the vastus lateralis muscle in patients with chronic obstructive pulmonary disease
    Joakim Allaire
    Centre de Recherche, Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5 Canada
    Muscle Nerve 25:383-9. 2002
    ..Oxidative damage of muscle tissue may thus be involved in skeletal muscle dysfunction and wasting in COPD...
  27. ncbi request reprint Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease
    Miriam Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Que, Canada
    Respir Med 99:877-86. 2005
    ..12, 95% CI [1.54-17.00]). In conclusion, COPD patients have a lower HRR than healthy subjects, and have a worse prognosis when presenting abnormal HRR...
  28. pmc Six-minute walking versus shuttle walking: responsiveness to bronchodilation in chronic obstructive pulmonary disease
    Veronique Pepin
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Thorax 62:291-8. 2007
    ..The current literature suggests that the 6 min walking test (6MWT) is less responsive to bronchodilation than the endurance shuttle walk...
  29. ncbi request reprint Catabolic/anabolic balance and muscle wasting in patients with COPD
    Richard Debigare
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Sainte Foy, QC, Canada
    Chest 124:83-9. 2003
    ....
  30. ncbi request reprint Performance during constant workrate cycling exercise in women with COPD and hyperinflation
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    COPD 6:340-51. 2009
    ..Compared to men, women with COPD were disadvantaged during exercise as they reached a critical inspiratory reserve volume earlier, leading to a steep increase in dyspnoea and to exercise termination...
  31. ncbi request reprint Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    J Med Food 13:589-98. 2010
    ..Thus dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD...
  32. doi request reprint Quadriceps metabolism during constant workrate cycling exercise in chronic obstructive pulmonary disease
    Didier Saey
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Sainte Foy, Quebec, Canada
    J Appl Physiol (1985) 110:116-24. 2011
    ..These intramuscular events required a much lower exercise work load and time to occur in COPD. Our data suggest a greater reliance on glycolysis during exercise in COPD, which may contribute to exercise intolerance in COPD...
  33. ncbi request reprint Synergetic interactions between rehabilitation and pharmacotherapy in COPD
    Veronique Pepin
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Clin Invest Med 29:170-7. 2006
    ..It is also becoming evident that it is the concomitant use of appropriate pharmacotherapy and non-pharmacological approaches, such as exercise training and pulmonary rehabilitation, that offers the best hope for an optimal status...
  34. doi request reprint MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease
    Bruno B Lemire
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    J Appl Physiol (1985) 113:159-66. 2012
    ..47; P < 0.05) were negatively associated with the mid-thigh muscle cross-sectional area. These data support the hypothesis that the MAPKs might play a role in the development of muscle atrophy in COPD...
  35. doi request reprint Neuromuscular electrical stimulation of the lower limbs in patients with chronic obstructive pulmonary disease
    Isabelle Vivodtzev
    Centre de Recherche, de l Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Universite Laval, Quebec, Canada
    J Cardiopulm Rehabil Prev 28:79-91. 2008
    ..In this review, the technical aspects of electrostimulation, its clinical benefits in COPD, and the potential mechanisms of action have been discussed...
  36. ncbi request reprint Paced-walk and step tests to assess exertional dyspnea in COPD
    Helene Perrault
    Respiratory Epidemiology and Clinical Research Unit of the Montreal Chest Institute, McGill University Health Center, Montreal, Quebec, Canada
    COPD 6:330-9. 2009
    ..5 to 4.0 km x h(- 1) and the 3-min of step testing at rates between 18 and 26 steps x min(- 1). Both field tests were highly reproducible in patients with COPD...
  37. doi request reprint Repeatability and responsiveness of exercise tests in pulmonary arterial hypertension
    Vincent Mainguy
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, QC, Canada
    Eur Respir J 42:425-34. 2013
    ..The 6MWT had the best ability to capture changes in exercise capacity when sildenafil citrate was combined with patients' baseline monotherapy, supporting its use as an outcome measure in PAH. ..
  38. pmc The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies
    Magali Poulain
    Division de kinesiologie, Departement de Medecine sociale et preventive, Universite Laval, Quebec, Que
    CMAJ 174:1293-9. 2006
    ....
  39. doi request reprint Evaluating nocturnal oxygen desaturation in COPD--revised
    Yves Lacasse
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy, Quebec, Quebec G1V 4G5, Canada
    Respir Med 105:1331-7. 2011
    ..An understanding of the prevalence of nocturnal desaturation in COPD, in the absence of other respiratory co-morbidities, is an important step towards its standardized management...
  40. ncbi request reprint Exercise capacity in chronic obstructive pulmonary disease: mechanisms of limitation
    Veronique Pepin
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    COPD 4:195-204. 2007
    ..The objective of this paper is to review the mechanisms of exercise limitation in COPD and discuss their relative contribution to exercise intolerance in patients suffering from this disease...
  41. doi request reprint Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease
    Richard Debigare
    P T, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, PQ, G1V 4G5 Canada
    Proc Am Thorac Soc 7:84-90. 2010
    ..Based on this information, the reader should be able to understand the essential role of this pathway in the context of muscle homeostasis and to picture the coming research in this area...
  42. doi request reprint Angiogenesis-related factors in skeletal muscles of COPD patients: roles of angiopoietin-2
    Mahroo Mofarrahi
    Department of Critical Care, McGill University Health Centre, Montreal, Quebec, Canada
    J Appl Physiol (1985) 114:1309-18. 2013
    ..We conclude that upregulation of ANGPT2 expression in vastus lateralis muscles of COPD patients is likely due to oxidative stress and represents a positive adaptive response aimed at facilitating myogenesis and angiogenesis...
  43. doi request reprint Profiling of mRNA expression in quadriceps of patients with COPD and muscle wasting
    Richard Debigare
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    COPD 5:75-84. 2008
    ..This study provides for the first time evidence that genes are selectively expressed in limb muscles of COPD patients and further research need to focus on their functional roles in the pathogenesis of muscle dysfunction...
  44. doi request reprint Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation
    Richard Debigare
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Appl Physiol 105:764. 2008
  45. doi request reprint Physiology of walking in patients with moderate to severe chronic obstructive pulmonary disease
    Nicole Marquis
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec, Canada
    Med Sci Sports Exerc 41:1540-8. 2009
    ..Our objective was to evaluate the cardiac and respiratory responses as well as the electrical activity of lower limb muscles during walking in patients with COPD compared with healthy controls...
  46. doi request reprint Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension
    Vincent Mainguy
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Service de Pneumologie, 2725, Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Thorax 65:113-7. 2010
    ..The hypothesis that the muscles of patients with IPAH are weaker and display morphological changes compared with those of control subjects and that those changes partly correlate with their exercise capacity was tested...
  47. pmc Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial
    Jean Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Thorax 62:938-43. 2007
    ..A study was therefore undertaken to evaluate combined salmeterol/fluticasone propionate (SFC) and fluticasone propionate (FP) alone on inflammatory cells in the airways of patients with COPD...
  48. pmc Alternatives to the six-minute walk test in pulmonary arterial hypertension
    Vincent Mainguy
    Pulmonary Hypertension Research Group, Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Québec Québec, Canada
    PLoS ONE 9:e103626. 2014
    ..We also hypothesized that differences in respiratory response during exercise would be related to the characteristics of the exercise tests...
  49. ncbi request reprint Chronic obstructive pulmonary disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes, prognostic markers, and functional status changes
    Michael Mok
    Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    JACC Cardiovasc Interv 6:1072-84. 2013
    ....
  50. doi request reprint Should all patients with COPD be exercise trained?
    Fernanda Ribeiro
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    J Appl Physiol (1985) 114:1300-8. 2013
    ..Strategies to optimize the gains achievable with exercise training will be presented. Whether exercise training may exert deleterious effects in some patients will also be discussed...
  51. doi request reprint The major limitation to exercise performance in COPD is lower limb muscle dysfunction
    Richard Debigare
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Appl Physiol 105:751-3; discussion 755-7. 2008
  52. doi request reprint Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease
    Philippe Gagnon
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy, Quebec, QC, Canada
    Am J Respir Crit Care Med 186:606-15. 2012
    ..We hypothesized that signaling from lower limb muscle group III/IV sensory afferents to the central motor command could be involved in premature cycling exercise termination in COPD...
  53. pmc Assessment of daily life physical activities in pulmonary arterial hypertension
    Vincent Mainguy
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    PLoS ONE 6:e27993. 2011
    ..Whether DL(PA) are decreased in PAH and whether the 6MWT is representative of patient's DL(PA) remain unknown...
  54. pmc Postoperative outcome after coronary artery bypass grafting in chronic obstructive pulmonary disease
    Hélène Manganas
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Quebec
    Can Respir J 14:19-24. 2007
    ..It is uncertain if the presence and severity of airflow obstruction in chronic obstructive pulmonary disease (COPD) is predictive of surgical morbidity and mortality after coronary artery bypass grafting (CABG)...
  55. doi request reprint Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy
    Sabah N A Hussain
    McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 182:1377-86. 2010
    ..The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but its contribution to diaphragmatic protein degradation in mechanically ventilated patients is unknown...
  56. ncbi request reprint Contractile leg fatigue after cycle exercise: a factor limiting exercise in patients with chronic obstructive pulmonary disease
    Didier Saey
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, PQ, G1V 4G5 Canada
    Am J Respir Crit Care Med 168:425-30. 2003
    ..59, p = 0.01). The occurrence of contractile fatigue during exercise may explain why bronchodilation fails to improve exercise tolerance in some COPD patients...
  57. ncbi request reprint Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension
    François Potus
    Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Center, Laval University, Quebec City, Canada
    Am J Respir Crit Care Med 190:318-28. 2014
    ..Pulmonary arterial hypertension (PAH) is characterized by significant exercise intolerance, which is multifactorial and involves skeletal muscle alterations. There is growing evidence that microRNAs (miRs) are involved in PAH pathogenesis...
  58. pmc Tolerance and physiological correlates of neuromuscular electrical stimulation in COPD: a pilot study
    Isabelle Vivodtzev
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada Univ Grenoble Alpes, HP2 Hypoxia respiratory and cardiovascular physiopathology, Grenoble, France Inserm HP2 Hypoxia respiratory and cardiovascular physiopathology, Grenoble, France Centre Hospitalier de Grenoble, Grenoble, France
    PLoS ONE 9:e94850. 2014
    ..Our goal was to find potential physiological predictors of the tolerance to increasing NMES stimulation intensity in patients with mild to severe COPD...
  59. pmc Pathogenesis of hyperinflation in chronic obstructive pulmonary disease
    Philippe Gagnon
    Faculte de Medecine, Universite Laval, Quebec, QC, Canada Centre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, QC, Canada
    Int J Chron Obstruct Pulmon Dis 9:187-201. 2014
    ..We also address the influence of biological sex and obesity and new developments in our understanding of hyperinflation in patients with mild COPD and its evolution during progression of the disease. ..
  60. pmc Chronic obstructive pulmonary disease in women
    Louis Laviolette
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Can Respir J 14:93-8. 2007
    ..Little is known about the comparative impact of chronic obstructive pulmonary disease (COPD) between women and men and about women's response to pulmonary rehabilitation...
  61. ncbi request reprint Exercise and COPD: therapeutic responses, disease-related outcomes, and activity-promotion strategies
    Francois Maltais
    Universite Laval, Quebec, Canada
    Phys Sportsmed 41:66-80. 2013
    ..Notably, it appears that even mild COPD reduces exercise capacity and daily physical activity, indicating the need for early intervention...
  62. doi request reprint Hypoxia alters contractile protein homeostasis in L6 myotubes
    Marc André Caron
    Centre de recherche de l Institut Universitaire de Cardiologie et de Pneumologie de l Université Laval, 2725 Chemin Ste Foy, Quebec City, QC, Canada, G1V 4G5
    FEBS Lett 583:1528-34. 2009
    ..These results are comparable to the cellular adaptation seen during development of muscle atrophy...
  63. ncbi request reprint Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2275 Chemin Ste Foy, Ste Foy, Quebec G1V 4G5, Canada
    Am J Respir Crit Care Med 165:698-703. 2002
    ....
  64. ncbi request reprint Comparative assessment of the quadriceps and the diaphragm in patients with COPD
    Marc André Caron
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada G1V 4G5
    J Appl Physiol (1985) 107:952-61. 2009
    ....
  65. doi request reprint Home-based pulmonary rehabilitation in chronic obstructive pulmonary disease patients
    Danielle S R Vieira
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Opin Pulm Med 16:134-43. 2010
    ....
  66. doi request reprint The Oort structural equation modeling approach detected a response shift after a COPD self-management program not detected by the Schmitt technique
    Sara Ahmed
    Faculty of Medicine, McGill University, School of Physical and Occupational Therapy, 3654 Prom Sir William Osler, Montreal, Quebec, Canada
    J Clin Epidemiol 62:1165-72. 2009
    ..The second objective was to compare the Oort and Schmitt structural equation modeling (SEM) approaches...
  67. doi request reprint Significance of changes in endurance shuttle walking performance
    Veronique Pepin
    Axe de recherche en santé respiratoire, Hôpital du Sacré Cœur de Montréal, Montreal, Canada
    Thorax 66:115-20. 2011
    ..However, the minimal important difference (MID) for this test remains unknown, therefore limiting its interpretability...
  68. ncbi request reprint Endurance shuttle walking test: responsiveness to salmeterol in COPD
    C Brouillard
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Quebec, QC, G1V 4G5, Canada
    Eur Respir J 31:579-84. 2008
    ..These findings provide further support for the use of the endurance shuttle walking test as an evaluative tool in chronic obstructive pulmonary disease...
  69. ncbi request reprint Canadian Cohort Obstructive Lung Disease (CanCOLD): Fulfilling the need for longitudinal observational studies in COPD
    Jean Bourbeau
    1McGill University, Montreal, Quebec, Canada
    COPD 11:125-32. 2014
    ....
  70. ncbi request reprint Rationale for earlier treatment in COPD: a systematic review of published literature in mild-to-moderate COPD
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    COPD 10:79-103. 2013
    ....
  71. pmc Unusual respiratory manifestations in two young adults with Duchenne muscular dystrophy
    Julie Lemay
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec
    Can Respir J 19:37-40. 2012
    ....
  72. ncbi request reprint Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention
    Jean Bourbeau
    Montreal Chest Institute of the Royal Victoria Hospital, McGill University Health Centre, and Respiratory Epidemiology Unit, McGill University, Montreal, Quebec, Canada
    Arch Intern Med 163:585-91. 2003
    ..We evaluated the effect of a continuum of self-management, specific to COPD, on the use of hospital services and health status among patients with moderate to severe disease...
  73. ncbi request reprint Smoking cessation in pulmonary rehabilitation: goal or prerequisite?
    Yves Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Cardiopulm Rehabil 22:148-53. 2002
    ....
  74. ncbi request reprint Pulmonary rehabilitation: an integral part of the long-term management of COPD
    Yves Lacasse
    Centre de Recherche, Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec G1V 4G5, Canada
    Swiss Med Wkly 134:601-5. 2004
    ..The value of various components of rehabilitation, programme length, the required degree of supervision, the intensity of training and the best approach to maintaining programme adherence represent issues that remain to be explored...
  75. ncbi request reprint Randomized trial of paroxetine in end-stage COPD
    Y Lacasse
    Centre de Recherche, Centre de Pneumologie, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Monaldi Arch Chest Dis 61:140-7. 2004
    ..The objective of this study was to examine the effect of an antidepressant drug on disease-specific quality of life in patients with end-stage COPD who present significant depressive symptoms...
  76. ncbi request reprint Biology of muscle impairment in COPD
    F Maltais
    Centre De Pneumologie Hôpital Laval 2725 Chemin Ste Foy Glv 4g5 Ste Foy, Quebec Canada
    Monaldi Arch Chest Dis 59:338-41. 2003
  77. pmc Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD
    J Allaire
    Centre de Recherches Cliniques, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, QC, Canada G1V 4G5
    Thorax 59:673-8. 2004
    ....
  78. ncbi request reprint Prevalence of depressive symptoms and depression in patients with severe oxygen-dependent chronic obstructive pulmonary disease
    Y Lacasse
    Centre de Recherche, , , , Canada
    J Cardiopulm Rehabil 21:80-6. 2001
    ..CONCLUSION: Significant depressive symptoms and depression are highly prevalent in patients with severe COPD on LTOT. There is strong evidence that depression is under-recognized and under-treated in this group of patients...
  79. ncbi request reprint [Peripheral muscle dysfunction in chronic obstructive pulmonary disease]
    F Maltais
    Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, Universite Laval, Quebec, Canada
    Rev Mal Respir 19:444-53. 2002
    ..Lastly, the available therapeutic options to improve peripheral muscle function in COPD will be reviewed...
  80. ncbi request reprint Effects of oxygen on lower limb blood flow and O2 uptake during exercise in COPD
    F Maltais
    Centre de Recherche, Institut de Cardiologie et de Pneumologie de Québec, Departement de Medecine, Universite Laval, Quebec, Canada
    Med Sci Sports Exerc 33:916-22. 2001
    ....
  81. ncbi request reprint Randomised trial of ambulatory oxygen in oxygen-dependent COPD
    Y Lacasse
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 25:1032-8. 2005
    ..Ambulatory oxygen had no effect on any of the outcomes. In conclusion, the current results do not support the widespread provision of ambulatory oxygen to patients with oxygen-dependent chronic obstructive pulmonary disease...
  82. ncbi request reprint Pulmonary rehabilitation in chronic obstructive pulmonary disease
    D Saey
    Research Centre, Quebec Cardiology and Pneumology Institute, Quebec City, QC, Canada
    Panminerva Med 51:95-114. 2009
    ..Among the main challenges of pulmonary rehabilitation, efforts have to be devoted to improve accessibility to early rehabilitation strategies, not only to patients with COPD but to those with other chronic respiratory diseases...
  83. ncbi request reprint Clinical, physiological and radiological features of asthma with incomplete reversibility of airflow obstruction compared with those of COPD
    L P Boulet
    Universite Laval, Sainte Foy, Canada
    Can Respir J 5:270-7. 1998
    ....
  84. pmc Validity of chronic obstructive pulmonary disease diagnoses in a large administrative database
    Yves Lacasse
    Centre de Recherche, Institut universitaire de cardiologie et de pneumologie de Québec Hospital Laval, Quebec
    Can Respir J 19:e5-9. 2012
    ..Administrative databases are often used for research purposes, with minimal attention devoted to the validity of the included diagnoses...
  85. pmc Satellite cells senescence in limb muscle of severe patients with COPD
    Marie Eve Thériault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    PLoS ONE 7:e39124. 2012
    ..The maintenance of peripheral muscle mass may be compromised in chronic obstructive pulmonary disease (COPD) due to premature cellular senescence and exhaustion of the regenerative potential of the muscles...
  86. ncbi request reprint Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease
    Mariève Doucet
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Laval, Quebec, Canada
    Am J Respir Crit Care Med 176:261-9. 2007
    ..The molecular mechanisms of muscle atrophy in chronic obstructive pulmonary disease (COPD) are poorly understood. In wasted animals, muscle mass is regulated by several AKT-related signaling pathways...
  87. doi request reprint Pleural effusions following cardiac surgery: prevalence, risk factors, and clinical features
    Moujahed Labidi
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, QC, Canada
    Chest 136:1604-11. 2009
    ..Our objective was to determine the prevalence, characteristics, and determinants of clinically significant pleural effusions, defined as those requiring therapeutic pleural drainage according to clinical assessment...
  88. pmc Nocturnal oxygen therapy in patients with chronic obstructive pulmonary disease: a survey of Canadian respirologists
    Yves Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Quebec
    Can Respir J 14:343-8. 2007
    ....
  89. ncbi request reprint Assessing the impact of pulmonary rehabilitation on functional status in COPD
    L Laviolette
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Thorax 63:115-21. 2008
    ....
  90. ncbi request reprint Adaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPD
    M Doucet
    Centre de Pneumologie, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5, Canada
    Eur Respir J 24:971-9. 2004
    ....
  91. pmc Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD
    Benoit Borel
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, QC, Canada
    Pulm Med 2013:410748. 2013
    ....
  92. ncbi request reprint Clinical management of chronic obstructive pulmonary disease and asthma in an obese patient
    Andréa Lessard
    Universite Laval, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725 Chemin Sainte Foy, G1V 4G5 Quebec, Canada
    Expert Opin Pharmacother 9:83-93. 2008
    ..The influence of weight loss, response to present therapies as well as new targets for the treatment of COPD and asthma in obese subjects are also discussed, in addition to future directions for research...
  93. pmc Variability of protein level and phosphorylation status caused by biopsy protocol design in human skeletal muscle analyses
    Marc André Caron
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Res Notes 4:488. 2011
    ..abstract:..
  94. pmc Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease
    Jessica Nadigel
    Meakins Christie Laboratories, Faculty of Medicine, McGill University, Montreal, QC, Canada
    Respir Res 12:149. 2011
    ..We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor (TLR) expression compared to control subjects due to the exposure of cigarette smoke in the airways...
  95. ncbi request reprint In vitro and in vivo contractile properties of the vastus lateralis muscle in males with COPD
    R Debigare
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, QC, Canada
    Eur Respir J 21:273-8. 2003
    ..Therefore, the reduction in the quadriceps strength in patients with chronic obstructive pulmonary disease cannot be explained on the basis of an alteration of the contractile apparatus...
  96. ncbi request reprint Self-management reduces both short- and long-term hospitalisation in COPD
    M A Gadoury
    Respiratory Epidemiology and Clinical Research Unit, 3650 St Urbain Street, Montreal, Quebec, H2X 2P4, Canada
    Eur Respir J 26:853-7. 2005
    ....
  97. pmc Skeletal muscle endurance and muscle metabolism in patients with chronic heart failure
    Patrice Brassard
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Ste Foy, Quebec, Canada
    Can J Cardiol 22:387-92. 2006
    ..Alterations in skeletal muscle function are known to contribute to exercise intolerance in patients with chronic heart failure (CHF)...
  98. ncbi request reprint [Cardiovascular manifestations in patients with COPD]
    K Marquis
    Centre de Recherche de l Hopital Laval, Institut universitaire de cardiologie et pneumologie de l Université Laval, Quebec, Canada
    Rev Mal Respir 25:663-73. 2008
    ..In addition, COPD is frequently associated with other health problems with serious systemic manifestations. In particular, COPD patients are at increased risk of cardiovascular disease...
  99. ncbi request reprint Self-administered prescriptions of oral steroids and antibiotics in chronic obstructive pulmonary disease: are we doing more harm than good?
    L Beaulieu-Genest
    Centre de Recherche, Centre de Pneumologie, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Chron Respir Dis 4:143-7. 2007
    ..005). Self-administered prescriptions may increase steroids and antibiotics utilization in patients with moderate to severe COPD, without reducing the number of unplanned medical visits...