Sheng-Xiang Lin

Summary

Country: Canada

Publications

  1. request reprint
    Lin S, Han Q, Azzi A, Zhu D, Gangloff A, Campbell R, et al. 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids. J Steroid Biochem Mol Biol. 1999;69:425-9 pubmed
    ..These results give evidence for the structural basis of steroid recognition by 17beta-HSD1 and throw light on the design of new inhibitors for this pivotal steroid enzyme. ..
  2. Thériault J, Lin S. The dual sex hormone specificity for human reductive 17?-hydroxysteroid dehydrogenase type 7: synergistic function in estrogen and androgen control. J Steroid Biochem Mol Biol. 2018;: pubmed publisher
    ..These results strongly support that the inhibition of 17?-HSD7 constitutes the basis of breast cancer cell proliferation decreasing that led to the shrinkage of xenograft ER?+?breast tumor mice model. ..
  3. Sang X, Han H, Poirier D, Lin S. Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism. J Steroid Biochem Mol Biol. 2018;183:80-93 pubmed publisher
    ..This suggests that combined treatment of sulfatase inhibitors with 17?-HSD inhibitors such as the type7 inhibitor could hold promise for hormone-dependent breast cancer. ..
  4. request reprint
    Stephen P, Lin S, Giege R. Interplay between Catalysts and Substrates for Activity of Class Ib Aminoacyl-tRNA Synthetases and Implications for Pharmacology. Curr Top Med Chem. 2016;16:616-33 pubmed
    ..Strategies to inhibit class Ib aaRS:tRNA aminoacylation systems, their dysfunction leading to human diseases, and the implications for pharmacology are outlined. ..
  5. Stephen P, Ye S, Zhou M, Song J, Zhang R, Wang E, et al. Structure of Escherichia coli Arginyl-tRNA Synthetase in Complex with tRNAArg: Pivotal Role of the D-loop. J Mol Biol. 2018;430:1590-1606 pubmed publisher
    ..Functional implications that could be idiosyncratic to the arginine identity of bacterial ArgRSs are discussed. ..
  6. request reprint
    Lin S, Shi R, Qiu W, Azzi A, Zhu D, Dabbagh H, et al. Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5. Mol Cell Endocrinol. 2006;248:38-46 pubmed
    ..The multi-specificity contributes significantly to steroid metabolism in peripheral tissues, due to the high levels of 17beta-HSD5 mRNA in both breast and prostate tissues. ..
  7. Zhang B, Zhu D, Hu X, Zhou M, Shang P, Lin S. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3?-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20?-HSD activity. J Steroid Biochem Mol Biol. 2014;141:135-43 pubmed publisher
    ..The results show that the V54L mutation significantly decreases the 3?-HSD activity for the reduction of DHT, while this mutation enhances the 20?-HSD activity to convert progesterone. ..
  8. Zhang C, Wang W, Chen J, Lin S. Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells. J Steroid Biochem Mol Biol. 2015;150:24-34 pubmed publisher
    ..17β-HSD1 and -7 are principal reductive 17β-HSDs and major players in the viability of estrogen-dependent breast cancer cells. Combined targeting of these enzymes may be potential for molecular therapy of such cancer. ..
  9. Wang X, Gérard C, Thériault J, Poirier D, Doillon C, Lin S. Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer. J Mol Cell Biol. 2015;7:568-79 pubmed publisher
    ..This demonstrates a conceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism. ..

More Information

Publications10

  1. Han H, Thériault J, Chen G, Lin S. Substrate inhibition of 17?-HSD1 in living cells and regulation of 17?-HSD7 by 17?-HSD1 knockdown. J Steroid Biochem Mol Biol. 2017;172:36-45 pubmed publisher
    ..We also demonstrated the central role of 17?-HSD7 in sex-hormone conversion and regulation, supporting it as a novel target for estrogen-dependent (ER+) BC. ..