Catherine Lemiere

..Although work-exacerbated asthma (WEA) is a prevalent condition likely to have an important societal burden, there are limited data on this condition...

..There is limited information regarding the occupational exposures of subjects with a diagnosis of work-exacerbated asthma (WEA)...

..It also reports examples of occupational agents for which the fabrication processing or use have influenced the outcome of occupational asthma...

..Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS)...

..abstract:..

..Despite being removed from their workplace, the majority of workers with occupational asthma (OA) remain afflicted with asthma...

..Its role in the surveillance of workers at risk to develop occupational asthma remains to be determined...

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..The aim of this study was to assess the respective changes of sputum eosinophil counts and FENO following exposure to occupational agents in the routine practice of two tertiary centers in North America and Europe...

..Asthma is work related when there is an association between symptoms and work. Occupational asthma (OA) is induced by the workplace, whereas work-exacerbated asthma (WEA) is triggered by the workplace but not induced by it...

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..Therefore, further studies investigating the prevalence of WEA, as well as its clinical, functional and inflammatory characteristics, are needed to improve the management of the workers with WEA...

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..Diagnosis of occupational asthma (OA) by specific inhalation challenge (SIC) can be costly and is not always available. The use of sputum testing to avoid this in some patients may be a more cost-effective alternative...

..3% (r 3.1-24.1) depending on the cutoff value in sputum eosinophils chosen (greater than 1 or 2%, respectively). The addition of sputum cell counts to PEF monitoring is useful to improve the diagnosis of occupational asthma...

..The benefits of inhaled corticosteroids (ICS) in reducing the mortality related to chronic obstructive pulmonary disease (COPD) are controversial...

..Isocyanates are a common cause of occupational asthma (OA)...

..To describe changes in inhaled corticosteroid use during pregnancy and markers of uncontrolled asthma, and to evaluate the association between them...

..Experimental studies showed that T cells adhere to ASM through vascular cell adhesion molecule-1 (VCAM-1) and drive ASM growth through direct contact between the T cells and smooth muscle alpha-actin (alpha-SMA)(+) cells...

..These studies must be interpreted with caution because they have insufficient statistical power and a lack of adjustment for potential confounders...

..We still do not know why some subjects with airway hyperresponsiveness (AHR) experience no respiratory symptoms...

..These results can be more easily generalized to women with lower socio-economic status since the cohort under represents women with high socio-economic status...

..In our study, we investigated the effect that the severity of asthma during pregnancy has on the risk of a small for gestational age (SGA) infant, low birth weight (LBW), and preterm birth...

..Compared to inhaled corticosteroids (ICS), better use of leukotriene-receptor antagonists (LTRA) may lead to a greater reduction in exacerbations among asthmatic children in real-life settings...

..The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown...

..Their role in clinical practice has not yet been established. The advantages and limitations of these methods for occupational airway diseases, and more particularly occupational asthma, are discussed in this review...

..This study assessed levels of psychologic distress and a range of disease-relevant emotional and behavioral coping styles in patients with severe vs moderate asthma...

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..In conclusion, compared with nonsmoking asthma patients, smoking asthma patients have features similar to what could be found in early stages of COPD...

..ASMC are a source of the IL-33 cytokine. Our data propose IL-33 as a novel inflammatory marker of severe and refractory asthma...

..To determine the effectiveness of theophyllines in real clinical practice on moderate to severe exacerbations...

..We sought to assess and compare the diurnal variability of PEF during periods at and away from work between subjects with OA and WEA...

..23 to 0.24). Based on the results, we conclude that fetal gender is unlikely to affect maternal asthma during pregnancy to the point where acute care and medications are more often required among women pregnant with a female fetus...

..Genetic susceptibility is explored. New diagnostic means are described. Surveillance programs are conducted and preventive measures are proposed...

..Although reassuring data exist on the use of low-to-moderate doses of inhaled corticosteroids (ICSs) during pregnancy, there are inadequate data for women receiving high doses...

..Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms...

..This study evaluated the prevalence of psychiatric disorders in 406 adult asthma patients, and associations between psychiatric status, levels of asthma control, and asthma-related quality of life...

..Adherence to inhaled corticosteroids (ICSs) has been shown to be low among patients with asthma...

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..The origin of the excess airway smooth muscle in asthma and when in the course of the disease it is acquired are uncertain...

..TPI 1020 is a novel compound with potential for anti-neutrophil effects. TPI 1020 exerts its effects by a dual mechanism of action involving corticosteroid activity and controlled donation of nitric oxide...

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..To examine recent publications on the types of agents involved in occupational asthma, the mechanisms by which they induce asthma, and how best to evaluate and treat workers suspected of this respiratory condition...

..A study was undertaken to develop and validate two database indexes to measure the control and severity of asthma...

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..ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma...

..However, these studies have methodologic limitations, such as lack of adjustment for cigarette smoking, a major risk factor for perinatal mortality...

..Since the last revision of the 1999 Canadian Asthma Consensus Report, important new studies have highlighted the need to incorporate new information into the asthma guidelines...

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..We assessed the changes in airway inflammatory cells following SIC in sensitized workers, and looked at the influence of various factors on the pattern of inflammatory responses to SIC...

..Periodic measurement of disease control is recommended to characterize asthma and monitor treatment...

..A reduced response to inhaled corticosteroids (ICS) has been reported in smoking asthmatic patients but the effects of other medications remain to be evaluated in this population...

..This subject is also examined from a socioeconomic perspective...

..Results tended to be lower for 45-80 years old patients. We conclude that diagnoses recorded in the Medical Services database of Quebec are valid to identify patients with asthma...

..The lack of data might be attributable, at least in part, to the absence of a provincial medication database for patients with private drug insurance...

..These observations emphasize the need for smoking cessation in patients with asthma and for reassessment of current treatment guidelines in this population...

..In this research we investigated the effectiveness of quality control chart as a method to explore the work-relatedness of asthma using peak expiratory flow (PEF) as the variable of interest...

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..This study systematically reviews literature regarding the diagnosis of occupational asthma (OA) and compares specific inhalation challenge (SIC) testing with alternative tests...

..The current Consensus Statement updates the previous one based on additional research that has been published since then, including findings relevant to preventive measures and work-exacerbated asthma (WEA)...

..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..

..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..