Jean Legault

Summary

Country: Canada

Publications

  1. ncbi Low-concentration methylene blue maintains energy production and strongly improves survival of Leigh syndrome French Canadian skin fibroblasts
    Jean Legault
    Department of Fundamental Sciences, Universite du Quebec a Chicoutimi, 555 boulevard de l Université, Chicoutimi, Quebec, Canada
    J Pharm Pharm Sci 14:438-49. 2011
  2. doi Antioxidant and anti-inflammatory activities of quercetin 7-O-β-D-glucopyranoside from the leaves of Brasenia schreberi
    Jean Legault
    Laboratory for Analysis and Separation of Plant Species LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    J Med Food 14:1127-34. 2011
  3. ncbi Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action
    Jean Legault
    UMR Institut National de la Santé et de la Recherche Médicale, Clermont Ferrand, France
    Planta Med 69:402-7. 2003
  4. doi Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum
    Jean Legault
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec, Canada
    J Med Food 13:460-8. 2010
  5. ncbi Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel
    Jean Legault
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    J Pharm Pharmacol 59:1643-7. 2007
  6. ncbi Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius
    Dominic Dufour
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, 555, boulevard de l Université, Chicoutimi, Quebec, Canada
    J Ethnopharmacol 111:22-8. 2007
  7. doi Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa
    François Simard
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi Québec, Canada
    Phytother Res 22:919-22. 2008
  8. ncbi Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera
    Vakhtang Mshvildadze
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 555 boul Université, Chicoutimi, Quebec, Canada G7H 2B1
    Phytochemistry 68:2531-6. 2007
  9. ncbi Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter
    Muriel Sylvestre
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
    Phytother Res 21:536-40. 2007
  10. doi Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins
    Charles Gauthier
    Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
    J Nat Prod 72:72-81. 2009

Collaborators

  • C M Barthomeuf
  • André Pichette
  • Eric Debiton
  • Elisabeth Miot-Noirault
  • Patricia Georges
  • Emmanuelle Mounetou
  • Charles Gauthier
  • Serge Lavoie
  • Vakhtang Mshvildadze
  • François Simard
  • Dominic Thibeault
  • Muriel Sylvestre
  • Marianne Piochon
  • Marie Eve Bradette-Hébert
  • Angélique Longtin
  • Chakkrapat Singtothong
  • Jimmy Bouchard
  • Samuel Tremblay
  • Lasha Mskhiladze
  • Dominic Dufour
  • Philippe Dufour
  • Eric Petitclerc
  • Michel J Gagnon
  • Sylvain Mercier
  • Louis Gagné
  • Karl Girard-Lalancette
  • Simon Rondeau
  • Riad Elias
  • Jumber Kuchukhidze
  • Catherine Laprise
  • Maxime Lebrun
  • Francine Nagau
  • Marie France Côté
  • Claude Marquis
  • Richard Janvier
  • Réna G Deschesnes
  • Jean Claude Madelmont
  • René C -Gaudreault
  • Jacques Lacroix

Detail Information

Publications29

  1. ncbi Low-concentration methylene blue maintains energy production and strongly improves survival of Leigh syndrome French Canadian skin fibroblasts
    Jean Legault
    Department of Fundamental Sciences, Universite du Quebec a Chicoutimi, 555 boulevard de l Université, Chicoutimi, Quebec, Canada
    J Pharm Pharm Sci 14:438-49. 2011
    ..Interestingly, MB completely restores ATP content in LSFC-F1 and LSFC-F2 cells. Finally, MB strongly improves the survival of both LSFC cells...
  2. doi Antioxidant and anti-inflammatory activities of quercetin 7-O-β-D-glucopyranoside from the leaves of Brasenia schreberi
    Jean Legault
    Laboratory for Analysis and Separation of Plant Species LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    J Med Food 14:1127-34. 2011
    ..7 macrophages in a dose-dependent manner. Quercetin-7-O-β-D-glucopyranoside also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor...
  3. ncbi Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action
    Jean Legault
    UMR Institut National de la Santé et de la Recherche Médicale, Clermont Ferrand, France
    Planta Med 69:402-7. 2003
    ..These results suggest that GSH depletion and ROS production may be implicated in the cytotoxicity of alpha-humulene and balsam fir oil...
  4. doi Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum
    Jean Legault
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec, Canada
    J Med Food 13:460-8. 2010
    ..Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure maple syrup possess a selective in vitro antiproliferative activity against cancer cells...
  5. ncbi Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel
    Jean Legault
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    J Pharm Pharmacol 59:1643-7. 2007
    ..These results suggest that beta-caryophyllene facilitates the passage of paclitaxel through the membrane and thus potentiates its anticancer activity...
  6. ncbi Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius
    Dominic Dufour
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, 555, boulevard de l Université, Chicoutimi, Quebec, Canada
    J Ethnopharmacol 111:22-8. 2007
    ..Ursolic acid was active against DLD-1 (IC(50): 9.3+/-0.3 microM) and A-549 (IC(50): 8.9+/-0.2 microM), suggesting it is, in part, responsible of the anticancer activity of the twig extract...
  7. doi Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa
    François Simard
    Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi Québec, Canada
    Phytother Res 22:919-22. 2008
    ..Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1...
  8. ncbi Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera
    Vakhtang Mshvildadze
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 555 boul Université, Chicoutimi, Quebec, Canada G7H 2B1
    Phytochemistry 68:2531-6. 2007
    ..Platyphylloside (4) exerted the strongest cytotoxic activity of all isolated compounds with IC(50) values ranging from 10.3 to 13.8 microM...
  9. ncbi Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter
    Muriel Sylvestre
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
    Phytother Res 21:536-40. 2007
    ..Two sesquiterpenes present in the oil, alpha-humulene and (E)-nerolidol, have been found to be cytotoxic against both tumor cell lines...
  10. doi Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins
    Charles Gauthier
    Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
    J Nat Prod 72:72-81. 2009
    ..8-1.9 microM)...
  11. ncbi A new labdane diterpene from the flowers of Solidago canadensis
    Marie Eve Bradette-Hébert
    LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec, Canada
    Chem Pharm Bull (Tokyo) 56:82-4. 2008
    ..Solicanolide (1) showed cytotoxic activity against A549 (IC(50): 13+/-2 microM), DLD-1 (IC(50): 26+/-2 microM) and WS1 (IC(50): 17+/-1 microM) cell lines...
  12. ncbi Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin
    Dominic Thibeault
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 555 boul de l Université, Chicoutimi, Quebec, Canada
    Bioorg Med Chem 15:6144-57. 2007
    ....
  13. ncbi Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins
    Charles Gauthier
    Laboratoire LASEVE, Chaire de Recherche sur les Agents Anticancéreux d Origine Naturelle, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    Bioorg Med Chem 17:2002-8. 2009
    ....
  14. ncbi Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents
    Charles Gauthier
    Laboratoire LASEVE, Departement des Sciences Fondamentales, UQAC, Chicoutimi, Quebec, Canada G7H 2B1
    Bioorg Med Chem 14:6713-25. 2006
    ..6-3.9 microM, 22) than the healthy cells (IC50 31 microM). Thus, this study indicates that 3-O-glycosides of lupane-type triterpenoids represent an interesting class of potent in vitro cytotoxic agents...
  15. doi Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
    Dominic Thibeault
    Universite du Quebec a Chicoutimi, Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, 555 boul de l Université, Chicoutimi Québec, Canada G7H 2B1
    Bioorg Med Chem Lett 22:4735-9. 2012
    ....
  16. doi Diterpenoids from the buds of Pinus banksiana Lamb
    Patricia Georges
    Departement des Sciences Fondamentales, Chaire de Recherche sur les Agents Anticancéreux d Origine Naturelle, Universite du Quebec a Chicoutimi, Quebec G7H 2B1, Canada
    Molecules 17:9716-27. 2012
    ..Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line...
  17. ncbi Synthesis and cytotoxicity evaluation of natural alpha-bisabolol beta-D-fucopyranoside and analogues
    Marianne Piochon
    Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Université du Québec à Chicoutimi UQAC, 555 boul de l Université, Chicoutimi, Quebec, Canada G7H 2B1
    Phytochemistry 70:228-36. 2009
    ..According to ADME in silico predictions, this glycoside closely respects physicochemical parameters necessary to cross the blood-brain barrier passively...
  18. ncbi Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion
    Eric Debiton
    UMR INSERM U 484, rue Montalembert, BP 184, 63005, Clermont Ferrand, France
    Cancer Chemother Pharmacol 51:474-82. 2003
    ..The quaternary benzophenanthridine alkaloid sanguinarine exhibits a broad range of activity, including cytotoxicity against various human tumour and normal cell lines. Here, we examined its potency as an anticancer drug...
  19. doi Abibalsamins A and B, two new tetraterpenoids from Abies balsamea oleoresin
    Serge Lavoie
    Universite du Quebec a Chicoutimi, Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, 555 boul de l Université, Chicoutimi Québec, Canada, G7H 2B1
    Org Lett 14:1504-7. 2012
    ..The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines...
  20. doi Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products
    Charles Gauthier
    Laboratoire LASEVE, Chaire de Recherche sur les Agents Anticancéreux d Origine Naturelle, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
    Bioorg Med Chem Lett 19:2310-4. 2009
    ..One important result was that only chacotriosides featuring non-polar functions at the C-28 position (6, 9 and 10) exerted a haemolytic activity against red blood cells...
  21. ncbi Composition and antibacterial activity of Abies balsamea essential oil
    André Pichette
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Canada
    Phytother Res 20:371-3. 2006
    ..However, three constituents of the essential oil were active against S. aureus: alpha-pinene, beta-caryophyllene (0.4%) and alpha-humulene (0.2%) with MIC values of 13.6 microg/mL, 5.1 microg/mL and 2.6 microg/mL, respectively...
  22. ncbi Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance
    Eric Petitclerc
    Centre de Recherche, Unité de Biotechnologie et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Quebec, Canada
    Cancer Res 64:4654-63. 2004
    ....
  23. ncbi Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe
    Muriel Sylvestre
    Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Que, Canada
    J Ethnopharmacol 103:99-102. 2006
    ..Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines...
  24. doi Cytotoxic steroidal saponins from the flowers of Allium leucanthum
    Lasha Mskhiladze
    Tbilisi State Medical University, Departement of Pharmacognosy, 33, Vazha Pshavela Ave, Tbilisi, 0177, Georgia
    Molecules 13:2925-34. 2008
    ..Compounds 1-3 and 5 were found to be the most active, with relatively similar IC50 values ranging from 3.7 to 5.8 microM for a lung cancer cell line (A549) and 5.6 to 8.2 microM for a colon cancer cell line (DLD-1)...
  25. doi Balsacones D-I, dihydrocinnamoyl flavans from Populus balsamifera buds
    François Simard
    Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec G7H 2B1, Canada
    Phytochemistry 100:141-9. 2014
    ..Antibacterial activity and cytotoxicity of all purified enantiomers were evaluated in vitro against Staphylococcus aureus and human skin fibroblast cells, respectively. ..
  26. ncbi New labdane diterpenes from the stem bark of Larix laricina
    André Pichette
    LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, QC, Canada
    Chem Pharm Bull (Tokyo) 54:1429-32. 2006
    ..Compounds 2 and 3 were shown to be moderately cytotoxic against A-549, DLD-1 and normal skin fibroblast cell lines, WS1. Compound 1 was found to be selectively active against colon carcinoma cell lines, DLD-1...
  27. ncbi Chemical composition and biological activity of the essential oil of Amomum biflorum
    Chakkrapat Singtothong
    Departement des Sciences Fondamentales, Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Quebec, Canada G7H 2B1
    Nat Prod Commun 8:265-7. 2013
    ..6 %), alpha-bisabolol (16.0 %), camphene (8.2 %) and alpha-humulene (5.1%). The essential oil was active against Staphylococcus aureus (MIC: 30 microg/mL) and had an antioxidant activity with an ORAC index of 23 +/- 5 micromol Trolox/mg...
  28. ncbi A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics
    Emmanuelle Mounetou
    Centre de Recherche, CHUQ, Hopital Saint Francois d Assise, 10, Rue de l Espinay, Québec G1L3L5, Canada
    J Med Chem 46:5055-63. 2003
    ..In this new series, CEUs 16a and 18a displayed particularly enhanced antiproliferative activity related to a faster reaction with beta-tubulin and merit further investigation as potential antitumor agents...
  29. ncbi Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma
    Elisabeth Miot-Noirault
    UMR 484 INSERM Université d Auvergne Centre Jean Perrin, Rue Montalembert BP 184, 63005 Clermont Ferrand, France
    Invest New Drugs 22:369-78. 2004
    ..These results make CEU-98 a candidate for further investigations with a view to developing an efficacious treatment of colorectal cancer...