F H Leenen

Summary

Country: Canada

Publications

  1. ncbi Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring
    F H Leenen
    Hypertension Unit H360, University of Ottawa Heart Institute, Ontario
    Can J Cardiol 13:914-20. 1997
  2. ncbi Dietary-sodium-induced cardiac remodeling in spontaneously hypertensive rat versus Wistar-Kyoto rat
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    J Hypertens 16:885-92. 1998
  3. ncbi Catecholamines and heart function in heart transplant patients: effects of beta1- versus nonselective beta-blockade
    F H Leenen
    Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada
    Clin Pharmacol Ther 64:522-35. 1998
  4. ncbi Cardiovascular consequences of sympathetic hyperactivity
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 15:2A-7A. 1999
  5. ncbi Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction
    W Zhang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Am J Physiol 276:H1608-15. 1999
  6. ncbi Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats
    J Tsoporis
    Division of Clinical Pharmacology, Toronto Western Hospital, Ontario, Canada
    Hypertension 11:376-86. 1988
  7. ncbi Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Physiol Heart Circ Physiol 281:H2410-6. 2001
  8. ncbi Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 5:515-9. 1992
  9. ncbi AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline
    J Zhang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7 Canada
    Am J Physiol Heart Circ Physiol 280:H1318-23. 2001
  10. ncbi Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    Am J Physiol Heart Circ Physiol 281:H1881-9. 2001

Collaborators

Detail Information

Publications39

  1. ncbi Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring
    F H Leenen
    Hypertension Unit H360, University of Ottawa Heart Institute, Ontario
    Can J Cardiol 13:914-20. 1997
    ..To evaluate patterns of compliance with once versus twice daily administration of antihypertensive therapy (primary-outcome measure) and relevance of partial compliance for blood pressure control (secondary outcome measure)...
  2. ncbi Dietary-sodium-induced cardiac remodeling in spontaneously hypertensive rat versus Wistar-Kyoto rat
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    J Hypertens 16:885-92. 1998
    ..To study the effects of short-term and long-term high sodium intake on cardiac mass and design in sodium-sensitive spontaneously hypertensive rats versus sodium-resistant Wistar-Kyoto rats...
  3. ncbi Catecholamines and heart function in heart transplant patients: effects of beta1- versus nonselective beta-blockade
    F H Leenen
    Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada
    Clin Pharmacol Ther 64:522-35. 1998
    ....
  4. ncbi Cardiovascular consequences of sympathetic hyperactivity
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 15:2A-7A. 1999
    ..The therapeutic relevance of these CNS effects and differences between lipophilic and hydrophilic compounds provide intriguing new avenues for research in disorders such as hypertension and congestive heart failure...
  5. ncbi Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction
    W Zhang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Am J Physiol 276:H1608-15. 1999
    ....
  6. ncbi Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats
    J Tsoporis
    Division of Clinical Pharmacology, Toronto Western Hospital, Ontario, Canada
    Hypertension 11:376-86. 1988
    ..However, other mechanisms, such as chronic cardiac volume overload, may also play an important role, particularly with minoxidil...
  7. ncbi Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Physiol Heart Circ Physiol 281:H2410-6. 2001
    ..These findings do not support a role for the circulatory or cardiac RAS in the cardiac trophic responses to beta-receptor stimulation...
  8. ncbi Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 5:515-9. 1992
    ..These results indicate that modest increases in sodium intake enhance the blood pressure response to a calcium antagonist possibly by potentiating its inhibitory effects on sympathetic activity...
  9. ncbi AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline
    J Zhang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7 Canada
    Am J Physiol Heart Circ Physiol 280:H1318-23. 2001
    ..We concluded that peripheral administration of losartan as well as embusartan can cause sufficient central effects to prevent the sympathetic hyperactivity and hypertension induced by chronic peripheral ouabain and central sodium...
  10. ncbi Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    Am J Physiol Heart Circ Physiol 281:H1881-9. 2001
    ..These findings indicate that genetic control of mechanisms linking CSF Na+ with brain "ouabain" is altered in Dahl S rats toward sympathetic hyperactivity and hypertension...
  11. ncbi Brain "ouabain," ANG II, and sympathoexcitation by chronic central sodium loading in rats
    B S Huang
    University of Ottawa Heart Institute, Ontario, Canada
    Am J Physiol 274:H1269-76. 1998
    ....
  12. ncbi Brain ouabain and central effects of dietary sodium in spontaneously hypertensive rats
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Circ Res 70:430-7. 1992
    ..In WKY rats, dietary sodium did not change these responses. In contrast, in SHR, HNa significantly enhanced MAP, HR, and RSNA responses to air stress or intracerebroventricular guanabenz.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats
    B S Huang
    Hypertension Unit, University of Ottawa Canada Heart Institute, Ontario, Canada
    Hypertension 28:1005-12. 1996
    ..Brain Ang II receptor stimulation appears to be downstream of "ouabain" in the pathways mediating sympathoexcitatory and pressor effects of high sodium...
  14. ncbi Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 34:107-12. 1999
    ..These results indicate that chronic administration of ouabain activates the brain renin-angiotensin system, resulting in decreased sympathoinhibition and increased sympathoexcitation, impairment of baroreflex function, and hypertension...
  15. ncbi Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake
    B S Huang
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 32:1028-33. 1998
    ....
  16. ncbi Arterial vasodilation and cardiovascular structural changes in normotensive rats
    J Tsoporis
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Physiol 260:H1944-52. 1991
    ....
  17. ncbi Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 37:981-4. 2001
    ....
  18. ncbi Sympathoinhibitory and depressor responses to long-term infusion of nifedipine in spontaneously hypertensive rats on high-salt diet
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    J Cardiovasc Pharmacol 36:704-10. 2000
    ....
  19. ncbi ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR
    A S Budzikowski
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    Am J Physiol Heart Circ Physiol 281:H1210-6. 2001
    ..We conclude that in the MnPO, ANG II via AT(1) receptors mediates cardiovascular responses to an acute increase in CSF sodium as well as the chronic pressor responses to high sodium intake in SHR...
  20. ncbi Dietary sodium restriction and blood pressure response to sympathetic blockade in young versus adolescent spontaneously hypertensive rats
    F H Leenen
    Hypertension Unit, Toronto Western Hospital, Ont, Canada
    Can J Physiol Pharmacol 68:46-50. 1990
    ..We conclude that prevention of development of sympathetic hyperactivity in young SHR represents a major mechanism in the antihypertensive effect of sodium restriction in young SHR...
  21. ncbi Arterial hypertrophy and pressor responsiveness during development of hypertension in spontaneously hypertensive rats
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    J Hypertens 12:23-32. 1994
    ....
  22. ncbi Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 37:209-15. 2001
    ....
  23. ncbi Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Hypertension 23:1087-90. 1994
    ..These data suggest that in normotensive rats exogenous ouabain, regardless of the mode of administration, may act centrally to cause sympathoexcitation and thus hypertension...
  24. ncbi High salt intake and the brain renin--angiotensin system in Dahl salt-sensitive rats
    X Zhao
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    J Hypertens 19:89-98. 2001
    ..Effects of high salt intake on ACE mRNA and activity appear to be secondary to activation of brain 'ouabain'...
  25. ncbi Blockade of brain "ouabain" prevents sympathoexcitatory and pressor responses to high sodium in SHR
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Physiol 271:H103-8. 1996
    ..Brain "ouabain" appears not to be involved in the development of hypertension in SHR on regular sodium intake...
  26. ncbi Brain 'ouabain' mediates sympathetic hyperactivity in congestive heart failure
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Circ Res 77:993-1000. 1995
    ..However, 18 hours after injection of the Fab fragments, resting RSNA levels had significantly decreased compared with the control values, and plasma catecholamine levels had decreased to control values.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. ncbi Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    Am J Physiol 277:H1786-92. 1999
    ..These results indicate that chronic blockade of brain "ouabain" or brain AT(1) receptors substantially inhibits development of LV dilation and dysfunction in rats post-MI...
  28. ncbi Chronic blockade of brain "ouabain" prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failure
    B S Huang
    Hypertension Unit, University of Ottawa Heart Institute, ON, Canada
    Can J Physiol Pharmacol 78:45-53. 2000
    ....
  29. ncbi Intermittent blood pressure control: potential consequences for outcome
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario
    Can J Cardiol 15:13C-18C. 1999
    ..In contrast, drugs with slow onset and long duration of action provide a more consistent effect during actual drug intake and a more persistent effect during short periods of noncompliance...
  30. ncbi alpha- and beta-adrenoceptor blockade fail to prevent high sodium diet-induced left ventricular hypertrophy
    D Song
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 10:913-20. 1997
    ..However, the blockers shifted the LVH from a concentric to an eccentric form, suggesting an involvement of additional trophic factors during adrenoceptor blockade...
  31. ncbi Central sympathoinhibitory effects of calcium channel blockers
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    Curr Hypertens Rep 3:314-21. 2001
    ..This sympathoexcitatory response may be due to activation of the renin-angiotensin system, particularly at higher doses...
  32. ncbi Differential effects of felodipine and nifedipine on 24-h blood pressure and left ventricular mass
    M G Myers
    Division of Cardiology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
    Am J Hypertens 8:712-8. 1995
    ..Once-daily administration of felodipine achieves a more consistent control of blood pressure compared to twice-daily nifedipine and may be associated with a greater reduction in left ventricular mass...
  33. ncbi Responses to central Na(+) and ouabain are attenuated in transgenic rats deficient in brain angiotensinogen
    B S Huang
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 37:683-6. 2001
    ....
  34. ncbi Effects of age and hypertension on cardiac responses to the alpha1-agonist phenylephrine in humans
    M White
    Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 12:151-8. 1999
    ....
  35. ncbi Monotherapy versus combination therapy as first line treatment of uncomplicated arterial hypertension
    M Ruzicka
    Department of Internal Medicine, University of Ottawa, Ontario, Canada
    Drugs 61:943-54. 2001
    ....
  36. ncbi Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium
    J Zhang
    Hypertension Unit, University of Ottawa Heart Institute, ON, Canada
    Can J Physiol Pharmacol 79:861-7. 2001
    ....
  37. ncbi Clinical relevance of 24 h blood pressure control by 1,4-dihydropyridines
    F H Leenen
    Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 9:97S-104S; discussion 108S-109S. 1996
    ..Intermittent hemodynamic responses and the resulting sympathetic hyperactivity with the rapid-acting agents are possible explanations for outcome of treatment as it relates to regression of LVH and cardiac events in patients with CAD...
  38. ncbi Relevance of 24 H blood pressure profile and sympathetic activity for outcome on short- versus long-acting 1,4-dihydropyridines
    M Ruzicka
    University of Ottawa Heart Institute, Ontario, Canada
    Am J Hypertens 9:86-94. 1996
    ..However, the evidence is still missing for patients with unstable CAD. Neither is there evidence that they will reduce cardiovascular morbidity and mortality in patients with CAD when used for the chronic treatment of hypertension...
  39. ncbi Effects of beta-blockade on muscle metabolism during prolonged exercise. A short review
    J Cleroux
    Hypertension Unit, Toronto Western Hospital, Ontario, Canada
    Am J Hypertens 1:290S-294S. 1988
    ..In contrast to what was initially proposed, intramuscular glycogenolysis appears not to be affected by either type of beta-blockade, and a decrease is unlikely to be involved in the reduced exercise capacity...