Michel Lebel

Summary

Country: Canada

Publications

  1. pmc Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec CHUQ, Quebec, Canada
    Am J Pathol 162:1559-69. 2003
  2. doi request reprint Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseases
    Michel Lebel
    Department of Molecular Biology, Medical Biochemistry, and Pathology, Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec City, Quebec, Canada G1R 2J6
    J Gerontol A Biol Sci Med Sci 67:140-51. 2012
  3. ncbi request reprint Werner syndrome: genetic and molecular basis of a premature aging disorder
    M Lebel
    Centre de recherche en cancérologie de l Université Laval, Pavilion Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Cell Mol Life Sci 58:857-67. 2001
  4. pmc Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Canada
    Ann N Y Acad Sci 1197:40-4. 2010
  5. ncbi request reprint Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, pavillon Hôtel Dieu de Québec, CHUQ, 9 McMahon Street, Quebec City, Quebec G1R 2J6, Canada
    Carcinogenesis 23:213-6. 2002
  6. pmc Vitamin C restores healthy aging in a mouse model for Werner syndrome
    Laurent Massip
    Centre de Recherche en Cancerologie, Hôpital Hôtel Dieu de Québec, 9 McMahon St, Quebec, Quebec, Canada
    FASEB J 24:158-72. 2010
  7. ncbi request reprint The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses
    Ramachander V N Turaga
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, QC, CA
    Cell Cycle 8:2080-92. 2009
  8. pmc Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide
    Adam Labbé
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
    BMC Genomics 11:127. 2010
  9. doi request reprint The strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 breast tumor cells generates several chemoresistance signatures
    David Guay
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec G1R 2J6, Canada
    Int J Biochem Cell Biol 40:2492-507. 2008
  10. ncbi request reprint Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light
    David Guay
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec, 9 McMahon St, Que, Canada G1R 2J6
    Int J Biochem Cell Biol 38:1300-13. 2006

Collaborators

Detail Information

Publications37

  1. pmc Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec CHUQ, Quebec, Canada
    Am J Pathol 162:1559-69. 2003
    ..These results suggest that Wrn and PARP-1 enzymes may be part of a complex involved in the processing of DNA breaks...
  2. doi request reprint Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseases
    Michel Lebel
    Department of Molecular Biology, Medical Biochemistry, and Pathology, Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec City, Quebec, Canada G1R 2J6
    J Gerontol A Biol Sci Med Sci 67:140-51. 2012
    ....
  3. ncbi request reprint Werner syndrome: genetic and molecular basis of a premature aging disorder
    M Lebel
    Centre de recherche en cancérologie de l Université Laval, Pavilion Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Cell Mol Life Sci 58:857-67. 2001
    ..Various mechanisms have evolved to ensure that recombination does not occur promiscuously during these events, and results are consistent with a model in which the WS protein is part of one such mechanism...
  4. pmc Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Canada
    Ann N Y Acad Sci 1197:40-4. 2010
    ..Finally, vitamin C and catechin hydrate did not affect the metabolic status of wild-type mice. These results indicate that vitamin C supplementation could be beneficial for WS patients...
  5. ncbi request reprint Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, pavillon Hôtel Dieu de Québec, CHUQ, 9 McMahon Street, Quebec City, Quebec G1R 2J6, Canada
    Carcinogenesis 23:213-6. 2002
    ....
  6. pmc Vitamin C restores healthy aging in a mouse model for Werner syndrome
    Laurent Massip
    Centre de Recherche en Cancerologie, Hôpital Hôtel Dieu de Québec, 9 McMahon St, Quebec, Quebec, Canada
    FASEB J 24:158-72. 2010
    ..Vitamin C did not have such effect on wild-type mice. These results indicate that vitamin C supplementation could be beneficial for patients with WS...
  7. ncbi request reprint The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses
    Ramachander V N Turaga
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, QC, CA
    Cell Cycle 8:2080-92. 2009
    ..These results are consistent with the pro-inflammatory status and lipid abnormalities observed in WS patients. This approach thus identified new effectors of WRN activity that might contribute to the WS phenotype...
  8. pmc Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide
    Adam Labbé
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
    BMC Genomics 11:127. 2010
    ..In this report, we have examined the impact of exogenous hydrogen peroxide on the expression profile of mouse embryonic fibroblasts lacking part of the helicase domain of the WRN homologue (here referred to as Wrn Delta hel/Delta hel)...
  9. doi request reprint The strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 breast tumor cells generates several chemoresistance signatures
    David Guay
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec G1R 2J6, Canada
    Int J Biochem Cell Biol 40:2492-507. 2008
    ..In contrast, the global expression profiles displayed by both wild type and truncated YB-1(1-205) revealed several chemoresistance signatures which differed depending on the genetic status of the breast cancer cell line used...
  10. ncbi request reprint Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV light
    David Guay
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec, 9 McMahon St, Que, Canada G1R 2J6
    Int J Biochem Cell Biol 38:1300-13. 2006
    ..Such results suggest that an YB-1/p53/WRN complex is formed in response to the emergence of specific DNA lesions in cells...
  11. ncbi request reprint Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
    Laurent Massip
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, CHUQ, 9 McMahon St, Quebec, Que, Canada G1R 2J6
    Exp Gerontol 41:157-68. 2006
    ....
  12. ncbi request reprint Werner syndrome protein prevents DNA breaks upon chromatin structure alteration
    Ramachander V N Turaga
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
    Aging Cell 6:471-81. 2007
    ..We thus describe a novel function for WRN in ensuring genome stability to act in concert with Topol to prevent DNA breaks, following alterations in chromatin topology...
  13. ncbi request reprint Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1
    Josée Lavoie
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, CHUQ, Quebec, Canada
    Cancer Genet Cytogenet 156:134-43. 2005
    ..Moreover, the low number of recurrent rearranged chromosome at any given site suggest a random mutagenesis process in PARP-1 null/Wrn(Deltahel/Deltahel) fibroblasts...
  14. pmc NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines
    Serges P Tsofack
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, G1R 2J6, Canada
    Mol Cancer 10:145. 2011
    ..Recent data have shown that YB-1 is also overexpress in colorectal cancer. In this study, we tested the hypothesis that YB-1 also confers oxaliplatin resistance in colorectal adenocarcinomas...
  15. ncbi request reprint In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1
    François Deschênes
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Canada
    Hum Mol Genet 14:3293-308. 2005
    ..Thus, a major result of this study is that changes in expression of several genes and physiological functions identified in vitro were confirmed in mouse embryonic and adult tissues...
  16. doi request reprint Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver
    Antoine Amaury Lachaud
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, CHUQ, Quebec, Canada
    Biochem Pharmacol 79:463-70. 2010
    ..Taken together, these results suggest that WRN participates in transcription of CYP2B genes in liver and identifies the first physical interaction between a specific promoter sequence and WRN...
  17. doi request reprint Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome
    Adam Labbé
    Department of Molecular Biology, Medical Biochemistry, and Pathology, Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
    J Gerontol A Biol Sci Med Sci 66:264-78. 2011
    ..These results indicate that resveratrol supplementation might exert at least metabolic benefits for Werner syndrome patients...
  18. doi request reprint The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cells
    David Guay
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon St, Quebec, G1R 2J6, Canada
    Cancer Sci 99:762-9. 2008
    ..These data indicate that hNTH1 is a relevant target to potentiate cisplatin cytotoxicity in YB-1 overexpressing tumor cells...
  19. doi request reprint Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples
    Sophie Lachapelle
    Centre de Recherche en Cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Québec City, Québec, G1R 2J6, Canada
    J Proteome Res 10:1216-27. 2011
    ..Our results suggest that the use of nucleases during cell lysis severely restricts interacting protein partners and thus enhances specificity...
  20. doi request reprint An integrative approach to identify YB-1-interacting proteins required for cisplatin resistance in MCF7 and MDA-MB-231 breast cancer cells
    Chantal Garand
    Department of Molecular Biology, Medical Biochemistry, and Pathology, Laval University Quebec City, Quebec, Canada
    Cancer Sci 102:1410-7. 2011
    ..These results suggest that the RPS4X/YB-1 complex is a significant potential target to counteract cisplatin resistance in breast cancer...
  21. doi request reprint The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity
    Adam Labbé
    Centre de recherche en cancérologie de l Université Laval, Centre de recherche du CHUQ, L Hôtel Dieu de Québec, Quebec, QC, Canada G1R 2J6
    Exp Cell Res 318:1620-32. 2012
    ..This work provides a novel mechanistic link between HIF-1 activity and different age-associated pathologies...
  22. doi request reprint The non-synonymous polymorphism at position 114 of the WRN protein affects cholesterol efflux in vitro and correlates with cholesterol levels in vivo
    Julien Bérubé
    Centre de Recherche en Cancérologie de l Université de Laval, Hotel Dieu de Quebec Hospital, 9 McMahon St, Quebec City, Quebec G1R 2J6, Canada
    Exp Gerontol 48:533-8. 2013
    ..These results implicate a functional effect of this WRN polymorphism on cholesterol metabolism...
  23. pmc Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging
    Alexandra Dallaire
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Quebec, Canada
    Aging (Albany NY) 4:636-47. 2012
    ..These results suggest that biological pathways involving WRN and miR-124 are conserved in the aging process across different species...
  24. pmc The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice
    Sophie Lachapelle
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Canada
    Aging (Albany NY) 3:277-90. 2011
    ..These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1-null mice...
  25. ncbi request reprint Increased immunoreactive endothelin-1 levels in blood vessels and glomeruli of rats with reduced renal mass
    R Lariviere
    Department of Pharmacology, Laval University, Quebec, Canada
    Kidney Blood Press Res 20:372-80. 1997
    ..Elevated ET-1 production in blood vessels and glomeruli may thus play a key role in the aggravation of hypertension and the progression of renal insufficiency in this rat remnant kidney model of chronic renal failure...
  26. pmc Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis
    Serges P Tsofack
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, QC, Canada
    BMC Cancer 13:303. 2013
    ..Depletion of RPS4X results in consistent resistance to cisplatin in such cell lines...
  27. ncbi request reprint Mouse telomere analysis using an optimized primed in situ (PRINS) labeling technique
    Josée Lavoie
    Division de Pathologie, Département de Biologie médicale, Université Laval et Unité de Recherche en Génétique Humaine et Moléculaire, Centre de recherché de l hôpital Saint François d Assise, CHUQ, 10 rue de l Espinay, Quebec, QC G1L 3L5, Canada
    Chromosoma 111:438-44. 2003
    ..These advantages may encourage wider use of the PRINS technique for quantitative evaluation of the length of individual telomeres in situ...
  28. pmc YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins
    Isabelle Gaudreault
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec, 9 McMahon Street, Quebec, G1R 2J6, Canada
    Nucleic Acids Res 32:316-27. 2004
    ..These results suggest that YB-1 is involved in base excision and mismatch repair pathways...
  29. ncbi request reprint Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass
    R Lariviere
    Research Centre, CHUQ, L Hôtel Dieu de Québec Hospital, Department of Pharmacology, Laval University, Quebec, Canada
    Am J Hypertens 11:989-97. 1998
    ....
  30. ncbi request reprint Supplementation with a low dose of L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats
    Y Dumont
    Research Center and Division of Nephrology, CHUQ, , and Department of Medicine, Laval University, Quebec, Canada
    Nephrol Dial Transplant 16:746-54. 2001
    ..These protective effects may be mediated in part by the reduction of vascular and renal ET-1 production...
  31. ncbi request reprint Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic rats
    Y Dumont
    Research Center and Division of Nephrology, CHUQ, , Canada
    J Hypertens 19:1479-87. 2001
    ..In contrast, the reduction of renal ET-1 production is mediated by tissue-specific effects of AT1 receptor blockade, and may contribute to the renal protective effects of losartan...
  32. pmc Metabolism, genomics, and DNA repair in the mouse aging liver
    Michel Lebel
    Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street Quebec City, QC, Canada G1R 2J6
    Curr Gerontol Geriatr Res 2011:859415. 2011
    ..This paper covers some of the DNA repair pathways affecting liver homeostasis with age using rodents as model systems...
  33. ncbi request reprint Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase
    M Lebel
    Centre de recherche en cancérologie de l Université Laval, Pavillon H tel Dieu de Québec, Quebec, Canada
    Cancer Res 61:1816-9. 2001
    ..Such data suggest a genetic interaction between p53 and Wrn in which loss of Wrn provokes a more variable p53 response unrelated to its role in the G1-S cell cycle checkpoint...
  34. doi request reprint Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms
    L Massip
    Centre de recherche en cancérologie de l Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Hôpital Hôtel Dieu de Québec, Quebec City, Quebec, Canada G1R 2J6
    Oncogene 29:1486-97. 2010
    ..Overall, our results indicate that a depletion of the WRN protein in normal fibroblasts causes the activation of several PKCs through translocation and association of RACK1 with such kinases...
  35. ncbi request reprint The Ask-Upmark kidney: a curable cause of hypertension in young patients
    J Babin
    Divisions of Nephrology and Pathology, Centre Hospitalier Universitaire, L Hôtel Dieu de Québec Hospital, Quebec, Canada
    J Hum Hypertens 19:315-6. 2005
    ..Her hypertension was renin dependent and the patient was cured following nephrectomy. Controversy on the pathogenesis of this clinical entity is briefly reviewed...
  36. pmc Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    Purnima R Laud
    Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 19:2560-70. 2005
    ....
  37. ncbi request reprint Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis
    Aya Leder
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Ave, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:6657-68. 2002
    ..This work demonstrates a genetic interaction between the instability of the multicopy transgene and the Werner Syndrome gene. From this, we conclude that genetic instability remains a key element in this tumor promoter model...