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Genomes and Genes | Michel LebelSummaryCountry: Canada Publications
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Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechinMichel Lebel
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Canada
Ann N Y Acad Sci 1197:40-4. 2010..Finally, vitamin C and catechin hydrate did not affect the metabolic status of wild-type mice. These results indicate that vitamin C supplementation could be beneficial for WS patients...
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in miceMichel Lebel
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec CHUQ, Quebec, Canada
Am J Pathol 162:1559-69. 2003..These results suggest that Wrn and PARP-1 enzymes may be part of a complex involved in the processing of DNA breaks...
Werner syndrome: genetic and molecular basis of a premature aging disorderM Lebel
Centre de recherche en cancérologie de l Université Laval, Pavilion Hôtel Dieu de Québec, CHUQ, Quebec, Canada
Cell Mol Life Sci 58:857-67. 2001..Various mechanisms have evolved to ensure that recombination does not occur promiscuously during these events, and results are consistent with a model in which the WS protein is part of one such mechanism...- Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseasesMichel Lebel
Department of Molecular Biology, Medical Biochemistry, and Pathology, Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec City, Quebec, Canada G1R 2J6
J Gerontol A Biol Sci Med Sci 67:140-51. 2012.... - Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologueMichel Lebel
Centre de recherche en cancérologie de l Université Laval, pavillon Hôtel Dieu de Québec, CHUQ, 9 McMahon Street, Quebec City, Quebec G1R 2J6, Canada
Carcinogenesis 23:213-6. 2002.... - Vitamin C restores healthy aging in a mouse model for Werner syndromeLaurent Massip
Centre de Recherche en Cancerologie, Hôpital Hôtel Dieu de Québec, 9 McMahon St, Quebec, Quebec, Canada
FASEB J 24:158-72. 2010..Vitamin C did not have such effect on wild-type mice. These results indicate that vitamin C supplementation could be beneficial for patients with WS... - The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responsesRamachander V N Turaga
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, QC, CA
Cell Cycle 8:2080-92. 2009..These results are consistent with the pro-inflammatory status and lipid abnormalities observed in WS patients. This approach thus identified new effectors of WRN activity that might contribute to the WS phenotype... - Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxideAdam Labbé
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
BMC Genomics 11:127. 2010..In this report, we have examined the impact of exogenous hydrogen peroxide on the expression profile of mouse embryonic fibroblasts lacking part of the helicase domain of the WRN homologue (here referred to as Wrn Delta hel/Delta hel)... - The strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 breast tumor cells generates several chemoresistance signaturesDavid Guay
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street, Quebec G1R 2J6, Canada
Int J Biochem Cell Biol 40:2492-507. 2008..In contrast, the global expression profiles displayed by both wild type and truncated YB-1(1-205) revealed several chemoresistance signatures which differed depending on the genetic status of the breast cancer cell line used... - Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologueLaurent Massip
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, CHUQ, 9 McMahon St, Quebec, Que, Canada G1R 2J6
Exp Gerontol 41:157-68. 2006.... - Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1Josée Lavoie
Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, CHUQ, Quebec, Canada
Cancer Genet Cytogenet 156:134-43. 2005..Moreover, the low number of recurrent rearranged chromosome at any given site suggest a random mutagenesis process in PARP-1 null/Wrn(Deltahel/Deltahel) fibroblasts... - NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell linesSerges P Tsofack
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, G1R 2J6, Canada
Mol Cancer 10:145. 2011..Recent data have shown that YB-1 is also overexpress in colorectal cancer. In this study, we tested the hypothesis that YB-1 also confers oxaliplatin resistance in colorectal adenocarcinomas... - In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1François Deschênes
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Canada
Hum Mol Genet 14:3293-308. 2005..Thus, a major result of this study is that changes in expression of several genes and physiological functions identified in vitro were confirmed in mouse embryonic and adult tissues... - Werner syndrome protein prevents DNA breaks upon chromatin structure alterationRamachander V N Turaga
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
Aging Cell 6:471-81. 2007..We thus describe a novel function for WRN in ensuring genome stability to act in concert with Topol to prevent DNA breaks, following alterations in chromatin topology... - Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liverAntoine Amaury Lachaud
Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, CHUQ, Quebec, Canada
Biochem Pharmacol 79:463-70. 2010..Taken together, these results suggest that WRN participates in transcription of CYP2B genes in liver and identifies the first physical interaction between a specific promoter sequence and WRN... - Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndromeAdam Labbé
Department of Molecular Biology, Medical Biochemistry, and Pathology, Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec, Canada
J Gerontol A Biol Sci Med Sci 66:264-78. 2011..These results indicate that resveratrol supplementation might exert at least metabolic benefits for Werner syndrome patients... - Formation of a nuclear complex containing the p53 tumor suppressor, YB-1, and the Werner syndrome gene product in cells treated with UV lightDavid Guay
, , , 9 McMahon St, Que, Canada G1R 2J6
Int J Biochem Cell Biol 38:1300-13. 2006..Such results suggest that an YB-1/p53/WRN complex is formed in response to the emergence of specific DNA lesions in cells... - Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samplesSophie Lachapelle
Centre de Recherche en Cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Québec City, Québec, G1R 2J6, Canada
J Proteome Res 10:1216-27. 2011..Our results suggest that the use of nucleases during cell lysis severely restricts interacting protein partners and thus enhances specificity... - The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activityAdam Labbé
Centre de recherche en cancérologie de l Université Laval, Centre de recherche du CHUQ, L Hôtel Dieu de Québec, Quebec, QC, Canada G1R 2J6
Exp Cell Res 318:1620-32. 2012..This work provides a novel mechanistic link between HIF-1 activity and different age-associated pathologies... - An integrative approach to identify YB-1-interacting proteins required for cisplatin resistance in MCF7 and MDA-MB-231 breast cancer cellsChantal Garand
Department of Molecular Biology, Medical Biochemistry, and Pathology, Laval University Quebec City, Quebec, Canada
Cancer Sci 102:1410-7. 2011..These results suggest that the RPS4X/YB-1 complex is a significant potential target to counteract cisplatin resistance in breast cancer... - The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cellsDavid Guay
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon St, Quebec, G1R 2J6, Canada
Cancer Sci 99:762-9. 2008..These data indicate that hNTH1 is a relevant target to potentiate cisplatin cytotoxicity in YB-1 overexpressing tumor cells... - Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated agingAlexandra Dallaire
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Quebec, Canada
Aging (Albany NY) 4:636-47. 2012..These results suggest that biological pathways involving WRN and miR-124 are conserved in the aging process across different species... - The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient miceSophie Lachapelle
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Quebec City, Canada
Aging (Albany NY) 3:277-90. 2011..These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1-null mice... - Increased immunoreactive endothelin-1 levels in blood vessels and glomeruli of rats with reduced renal massR Lariviere
Department of Pharmacology, Laval University, Quebec, Canada
Kidney Blood Press Res 20:372-80. 1997..Elevated ET-1 production in blood vessels and glomeruli may thus play a key role in the aggravation of hypertension and the progression of renal insufficiency in this rat remnant kidney model of chronic renal failure... - Mouse telomere analysis using an optimized primed in situ (PRINS) labeling techniqueJosée Lavoie
Division de Pathologie, Département de Biologie médicale, Université Laval et Unité de Recherche en Génétique Humaine et Moléculaire, Centre de recherché de l hôpital Saint François d Assise, CHUQ, 10 rue de l Espinay, Quebec, QC G1L 3L5, Canada
Chromosoma 111:438-44. 2003..These advantages may encourage wider use of the PRINS technique for quantitative evaluation of the length of individual telomeres in situ... - YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteinsIsabelle Gaudreault
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, Centre Hospitalier Universitaire de Quebec, 9 McMahon Street, Quebec, G1R 2J6, Canada
Nucleic Acids Res 32:316-27. 2004..These results suggest that YB-1 is involved in base excision and mismatch repair pathways... - Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal massR Lariviere
Research Centre, CHUQ, L Hôtel Dieu de Québec Hospital, Department of Pharmacology, Laval University, Quebec, Canada
Am J Hypertens 11:989-97. 1998.... - Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic ratsY Dumont
Research Center and Division of Nephrology, CHUQ, , Canada
J Hypertens 19:1479-87. 2001..In contrast, the reduction of renal ET-1 production is mediated by tissue-specific effects of AT1 receptor blockade, and may contribute to the renal protective effects of losartan... - Supplementation with a low dose of L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic ratsY Dumont
Research Center and Division of Nephrology, CHUQ, , and Department of Medicine, Laval University, Quebec, Canada
Nephrol Dial Transplant 16:746-54. 2001..These protective effects may be mediated in part by the reduction of vascular and renal ET-1 production... - Metabolism, genomics, and DNA repair in the mouse aging liverMichel Lebel
Centre de recherche en cancérologie de l Université Laval, Hôpital Hôtel Dieu de Québec, 9 McMahon Street Quebec City, QC, Canada G1R 2J6
Curr Gerontol Geriatr Res 2011:859415. 2011..This paper covers some of the DNA repair pathways affecting liver homeostasis with age using rodents as model systems... - Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicaseM Lebel
Centre de recherche en cancérologie de l Université Laval, Pavillon H tel Dieu de Québec, Quebec, Canada
Cancer Res 61:1816-9. 2001..Such data suggest a genetic interaction between p53 and Wrn in which loss of Wrn provokes a more variable p53 response unrelated to its role in the G1-S cell cycle checkpoint... - The Ask-Upmark kidney: a curable cause of hypertension in young patientsJ Babin
Divisions of Nephrology and Pathology, Centre Hospitalier Universitaire, , , Canada
J Hum Hypertens 19:315-6. 2005..Her hypertension was renin dependent and the patient was cured following nephrectomy. Controversy on the pathogenesis of this clinical entity is briefly reviewed... - Depletion of WRN protein causes RACK1 to activate several protein kinase C isoformsL Massip
Centre de recherche en cancérologie de l Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Hôpital Hôtel Dieu de Québec, Quebec City, Quebec, Canada G1R 2J6
Oncogene 29:1486-97. 2010..Overall, our results indicate that a depletion of the WRN protein in normal fibroblasts causes the activation of several PKCs through translocation and association of RACK1 with such kinases... - Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesisAya Leder
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Ave, Boston, Massachusetts, MA 02115, USA
Oncogene 21:6657-68. 2002..This work demonstrates a genetic interaction between the instability of the multicopy transgene and the Werner Syndrome gene. From this, we conclude that genetic instability remains a key element in this tumor promoter model... - Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathwayPurnima R Laud
Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 19:2560-70. 2005....