Bernard Le Foll

Summary

Country: Canada

Publications

  1. ncbi Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, Pharmacology and Toxicology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada Electronic address
    Prog Brain Res 211:255-75. 2014
  2. pmc Translational strategies for therapeutic development in nicotine addiction: rethinking the conventional bench to bedside approach
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada Department of Psychiatry and Institute of Medical Sciences, University of Toronto, Toronto, Canada Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 52:86-93. 2014
  3. pmc Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study
    Lina Chiuccariello
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 8:e60382. 2013
  4. pmc Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Curr Drug Targets 14:768-76. 2013
  5. doi Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Med Hypotheses 80:564-7. 2013
  6. pmc Varenicline decreases nicotine self-administration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 15:1265-74. 2012
  7. pmc Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 35:1751-60. 2010
  8. doi Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Canada
    Addict Biol 17:47-61. 2012
  9. pmc AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychopharmacol 27:564-71. 2013
  10. ncbi Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada
    Biol Psychiatry 68:265-71. 2010

Collaborators

Detail Information

Publications49

  1. ncbi Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, Pharmacology and Toxicology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada Electronic address
    Prog Brain Res 211:255-75. 2014
    ..The first results of clinical investigations are now being provided. Overall, those recent findings support further exploration of D3 ligands to treat drug addiction. ..
  2. pmc Translational strategies for therapeutic development in nicotine addiction: rethinking the conventional bench to bedside approach
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada Department of Psychiatry and Institute of Medical Sciences, University of Toronto, Toronto, Canada Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 52:86-93. 2014
    ....
  3. pmc Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study
    Lina Chiuccariello
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 8:e60382. 2013
    ....
  4. pmc Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Curr Drug Targets 14:768-76. 2013
    ..Finally, studies that investigated the effects of PPAR agonists on neural pathways of addiction are reviewed. Taken together these preclinical data indicate that PPAR agonists are promising new medications for drug addiction treatment...
  5. doi Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Med Hypotheses 80:564-7. 2013
    ..We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications...
  6. pmc Varenicline decreases nicotine self-administration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 15:1265-74. 2012
    ..The ability of varenicline to reduce both nicotine-taking and nicotine-seeking behaviour can contribute to its relatively high efficacy in treating human smokers...
  7. pmc Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 35:1751-60. 2010
    ..The findings point to alpha(1) adrenoceptor blockade as a potential new approach to the treatment of tobacco dependence in humans...
  8. doi Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Canada
    Addict Biol 17:47-61. 2012
    ..Thus, modulating CB1-receptor signalling might have therapeutic value for treating nicotine dependence...
  9. pmc AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychopharmacol 27:564-71. 2013
    ..Our results indicate that AM404 could be a potential promising therapeutic option for the prevention of relapse to nicotine-seeking in abstinent smokers...
  10. ncbi Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada
    Biol Psychiatry 68:265-71. 2010
    ..However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated...
  11. doi Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:582-5. 2010
    ..We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication...
  12. doi Cannabis use and mental health-related quality of life among individuals with anxiety disorders
    Shaul Lev-Ran
    Social Aetiology of Mental Illness SAMI CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Anxiety Disord 26:799-810. 2012
    ..Out results highlight the importance of taking into account direct functional and emotional outcomes, as well as frequency of cannabis used, when assessing the impact of cannabis use among individuals with anxiety disorders...
  13. ncbi Bipolar disorder and co-occurring cannabis use disorders: characteristics, co-morbidities and clinical correlates
    Shaul Lev-Ran
    Social Aetiology of Mental Illness SAMI CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Psychiatry Res 209:459-65. 2013
    ..Comprehensive evaluation of patients with bipolar disorder should include a systematic assessment of CUD. ..
  14. doi Cannabis use and cannabis use disorders among individuals with mental illness
    Shaul Lev-Ran
    Social Aetiology of Mental Illness CIHR Training Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Compr Psychiatry 54:589-98. 2013
    ..However, this subject has not been sufficiently investigated, particularly given limitations in diagnostic tools used and lack of data pertaining to frequency of cannabis used...
  15. pmc Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction
    Yijin Yan
    Translational Addiction Research Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Behav Brain Res 230:34-9. 2012
    ..Future work will utilize these models to evaluate nicotine-taking and relapsing behavior in genetically-altered mice...
  16. doi Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
    Gabriela Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Ann Hum Genet 74:291-8. 2010
    ..01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour...
  17. doi Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes
    Celine Teo
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Toronto, Canada
    Pharmacogenet Genomics 22:807-11. 2012
    ..However, this phenotype can be assessed retrospectively in cross-sectional studies and these preliminary results point out the importance of choosing alternative phenotypes in psychiatric pharmacogenetics...
  18. pmc Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats
    Yijin Yan
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health Addiction CAMH, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 37:685-96. 2012
    ....
  19. pmc The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Br J Pharmacol 164:1652-60. 2011
    ..In this study, we have tested the selective anadamide uptake inhibitor, VDM11, which elevates anandamide levels without affecting levels of OEA/PEA, on nicotine-taking and nicotine-seeking behaviour...
  20. pmc Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking
    Islam Gamaleddin
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 7:e29900. 2012
    ..Administration of the CB2 ligands did not affect either nicotine-taking nicotine-seeking behavior. Our results do not support the involvement of CB2 receptors in nicotine-taking or nicotine-seeking behavior...
  21. pmc Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Addict Biol 13:239-52. 2008
    ..Rimonabant also appears to decrease relapse rates in smokers. These findings indicate significant, but limited, utility of rimonabant for smoking cessation...
  22. doi The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking
    Maram A T M Khaled
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neuropsychopharmacol 13:181-90. 2010
    ..These findings validate the role of DRD3 on reactivity to drug-associated stimuli and suggest that the DRD3 antagonist, but perhaps not the DRD3 partial agonist, could be used to prevent relapse in tobacco smokers...
  23. pmc Elevation of dopamine induced by cigarette smoking: novel insights from a [(11)C]-(+)-PHNO PET study in humans
    Bernard Le Foll
    1 Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada 4 Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada 5 Department of Pharmacology, University of Toronto, Toronto, ON, Canada 6 Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada 7 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:415-24. 2014
    ..We propose that due to the robust effect of smoking on [(11)C]-(+)-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission. ..
  24. doi Obesity and cannabis use: results from 2 representative national surveys
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Epidemiol 174:929-33. 2011
    ..Additionally, after adjustment for sex and age, the use of cannabis was associated with body mass index differences in both samples. The authors conclude that the prevalence of obesity is lower in cannabis users than in nonusers...
  25. doi Gender differences in health-related quality of life among cannabis users: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Drug Alcohol Depend 123:190-200. 2012
    ..Cannabis is the most widely used illicit substance worldwide. The aim of the present study was to assess self-reported Quality of Life (QoL) among cannabis users in a large representative sample...
  26. doi Self-reported psychotic disorders among Individuals with substance use disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 21:531-5. 2012
    ..Most reports to-date focus on the prevalence of SUDs among clinical populations of patients with PDs, and there is a lack of data pertaining to rates of PDs among individuals with substance use and SUDs...
  27. ncbi Gender differences in prevalence of substance use disorders among individuals with lifetime exposure to substances: results from a large representative sample
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 22:7-13. 2013
    ..In this study, we explored gender differences in prevalence of SUDs among individuals with lifetime exposure to substances using a single diagnostic category (abuse or dependence)...
  28. ncbi Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health CAMH, Toronto, Canada, M5S 2S1
    Psychopharmacology (Berl) 205:613-24. 2009
    ..Therefore, there is a great need to develop alternative ways of modulating the cannabinoid system that will be better tolerated...
  29. doi Analysis of CpG SNPs in 34 genes: association test with suicide attempt in schizophrenia
    Ali Bani-Fatemi
    CAMH, Department of Psychiatry, University of Toronto, Canada
    Schizophr Res 147:262-8. 2013
    ..To date, there are no robust genetic or epigenetic predictors of suicide or suicide attempt in this specific population...
  30. doi Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia
    Gabriela Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatr Genet 20:39-43. 2010
    ..Although the results of this study are limited by a small sample size, it presents important pilot data and warrants further investigation of the involvement of NR4A1 variants in TD...
  31. ncbi Pharmacotherapy of alcohol use disorders and concurrent psychiatric disorders: a review
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Can J Psychiatry 57:342-9. 2012
    ..Several prevalent psychiatric disorders have not been studied when co-occurring with AUDs. Further research of pharmacological treatments for concurrent AUDs and psychiatric diagnoses is urgently needed...
  32. doi Child marriage in the United States and its association with mental health in women
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pediatrics 128:524-30. 2011
    ..This article presents nationally representative data on the prevalence, sociodemographic correlates, and psychiatric comorbidity of child marriage among women in the United States...
  33. doi Exploring the association between lifetime prevalence of mental illness and transition from substance use to substance use disorders: results from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC)
    Shaul Lev-Ran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Addict 22:93-8. 2013
    ..This may be important as increased prevalence of substance use among individuals with MI may partially explain the strong association between SUDs and MI...
  34. pmc Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors
    Abhiram Pushparaj
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, ON, Canada
    Neuropsychopharmacology 38:690-8. 2013
    ..Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored...
  35. doi Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity
    Gabriela Novak
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Neurosci 120:691-7. 2010
    ..We suggest that nicotine-induced elevation in D2(High) levels could be participating in hypersensitivity to dopamine following nicotine exposure...
  36. ncbi How generalisable to community samples are clinical trial results for treatment of nicotine dependence: a comparison of common eligibility criteria with respondents of a large representative general population survey
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Tob Control 20:338-43. 2011
    ..To examine the generalisability of findings from clinical trials of individuals with nicotine dependence to a large general population sample...
  37. pmc The potential role of dopamine D₃ receptor neurotransmission in cognition
    Shinichiro Nakajima
    Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Canada M5T 1R8
    Eur Neuropsychopharmacol 23:799-813. 2013
    ..Clinical trials are needed to confirm these effects...
  38. pmc Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 3E1
    Proc Natl Acad Sci U S A 109:3101-6. 2012
    ....
  39. pmc Extinction bursts in rats trained to self-administer nicotine or food in 1-h daily sessions
    Abhiram Pushparaj
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto, Canada
    Am J Transl Res 4:422-31. 2012
    ..This study supports the presence of a loading phase in rats trained to self-administer nicotine in 1-r daily sessions and the presence of a transient extinction burst...
  40. pmc Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 65:714-6. 2009
    ..However, no study has been performed evaluating the impact of interindividual differences in midbrain nAChR levels on motivation to self-administer nicotine...
  41. pmc The future of endocannabinoid-oriented clinical research after CB1 antagonists
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, ON, Canada
    Psychopharmacology (Berl) 205:171-4. 2009
    ..Great interest has been shown by the medical community and the public in the cannabinoid CB(1) receptor antagonists, such as rimonabant, for treatment of obesity, metabolic syndrome, and possibly drug addiction...
  42. doi Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:1412-8. 2010
    ..We did not find a statistically significant association with the other DRD3 and BDNF polymorphisms. Taken together, the results from the present study suggest that BDNF and DRD3 may not be involved in SCZ susceptibility...
  43. ncbi Dopamine D3 receptor ligands for the treatment of tobacco dependence
    Bernard Le Foll
    Center for Addiction and Mental Health, Department of Family and Community Medicine, Psychiatry and Pharmacology, University of Toronto, 33 Russell Street, Toronto, ON M5S 2S1, Ontario, Canada
    Expert Opin Investig Drugs 16:45-57. 2007
    ..These preclinical studies suggest that the clinical evaluation of DRD3 ligands should be performed with clinical trials designed specifically to evaluate the relapse phenomena...
  44. doi Genetics of dopamine receptors and drug addiction: a comprehensive review
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Behav Pharmacol 20:1-17. 2009
    ..Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans...
  45. doi Prevalence and correlates of major depressive episode in pregnant and postpartum women in the United States
    Yann Le Strat
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Affect Disord 135:128-38. 2011
    ..This study presents nationally representative data on the prevalence, correlates, and psychiatric comorbidities of depression in women during pregnancy and postpartum in the United States...
  46. doi Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study
    Gabriela Novak
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health and the University of Toronto, Toronto, Ontario, Canada
    World J Biol Psychiatry 10:929-35. 2009
    ....
  47. pmc [Future medications for tobacco and cannabis dependence]
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Bull Acad Natl Med 192:45-56; discussion 56-7. 2008
    ..These promising approaches warrant clinical trials in the treatment of tobacco and marijuana dependence...
  48. doi Dopamine D4 receptors in psychostimulant addiction
    Patricia Di Ciano
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Adv Pharmacol 69:301-21. 2014
    ..The data summarized here suggest a role for D4 receptors in relapse to stimulant use. Therefore, treatments based on antagonism of the D4 receptor may be useful treatments for relapse to nicotine, cocaine, and amphetamine use. ..
  49. pmc Treatment of tobacco dependence: integrating recent progress into practice
    Bernard Le Foll
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    CMAJ 177:1373-80. 2007
    ..Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings...