Jonathan T Elliott

Summary

Affiliation: Lawson Health Research Institute
Country: Canada

Publications

  1. doi request reprint Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters
    Jonathan T Elliott
    Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada
    Opt Lett 37:2571-3. 2012
  2. doi request reprint Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
  3. doi request reprint Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 106:1506-12. 2009
  4. doi request reprint A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
  5. doi request reprint Using near-infrared spectroscopy to measure cerebral metabolic rate of oxygen under multiple levels of arterial oxygenation in piglets
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor St, London, ON N6A 4V2, Canada
    J Appl Physiol (1985) 109:878-85. 2010
  6. doi request reprint Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
    J Biomed Opt 15:057004. 2010
  7. doi request reprint Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Phys Med Biol 57:8285-95. 2012
  8. doi request reprint Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
  9. ncbi request reprint Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Electronic address
    Neuroimage 94:303-11. 2014
  10. pmc Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada Imaging Division, Lawson Health Research Institute, St Joseph s Hospital, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    Biomed Opt Express 4:206-18. 2013

Detail Information

Publications10

  1. doi request reprint Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters
    Jonathan T Elliott
    Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada
    Opt Lett 37:2571-3. 2012
    ..Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios...
  2. doi request reprint Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
    ..The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care...
  3. doi request reprint Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets
    Kenneth M Tichauer
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 106:1506-12. 2009
    ..This study highlights the potential for combining NIRS measures of CMRO(2) with EEG in the neonatal intensive care unit to improve early detection of perinatal hypoxia-ischemia...
  4. doi request reprint A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
    ..No significant changes in regional CMRO(2) were observed. The average regional differential pathlength prior to ET-1 injection was 8.4+/-0.2 cm (range of 7.1-9.6 cm) and did not significantly change after the injury...
  5. doi request reprint Using near-infrared spectroscopy to measure cerebral metabolic rate of oxygen under multiple levels of arterial oxygenation in piglets
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor St, London, ON N6A 4V2, Canada
    J Appl Physiol (1985) 109:878-85. 2010
    ..In conclusion, the bolus-tracking technique of measuring CSvO2, and therefore CMRO2, is accurate and robust for an SaO2>50% but provides reduced accuracy under more severe hypoxic levels...
  6. doi request reprint Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
    J Biomed Opt 15:057004. 2010
    ..The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements...
  7. doi request reprint Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Phys Med Biol 57:8285-95. 2012
    ..Considering that determining the AIF is required for performing quantitative tracer kinetics, this method provides a flexible tool for measuring the arterial dye concentration that could be used in a variety of applications...
  8. doi request reprint Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
    ....
  9. ncbi request reprint Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Electronic address
    Neuroimage 94:303-11. 2014
    ..The findings of this study suggest that the DCE-NIR approach presented is a minimally invasive and portable means of determining absolute hemodynamics in neurocritical care patients...
  10. pmc Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada Imaging Division, Lawson Health Research Institute, St Joseph s Hospital, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    Biomed Opt Express 4:206-18. 2013
    ..Furthermore, when the variance data along with the measured AIF is analyzed using a nonparametric deconvolution method, the recovered change in CBF is in good agreement with CT perfusion values...