Affiliation: Lawson Health Research Institute
- Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurementsMamadou Diop
Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
Opt Lett 37:2358-60. 2012..Combined with the microscopic Beer-Lambert law, the algorithm enables accurate quantification of absorption changes from arbitrary time-of-flight windows, thereby optimizing the depth sensitivity provided by TR measurements...
- A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn pigletsMamadou Diop
Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
Rev Sci Instrum 80:054302. 2009..No significant changes in regional CMRO(2) were observed. The average regional differential pathlength prior to ET-1 injection was 8.4+/-0.2 cm (range of 7.1-9.6 cm) and did not significantly change after the injury...
- Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in pigletsMamadou Diop
Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
J Biomed Opt 15:057004. 2010..The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements...
- Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopyJonathan T Elliott
University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
J Biomed Opt 15:037014. 2010..The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care...
- Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence dataKenneth M Tichauer
Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
Appl Opt 50:3962-72. 2011....
- Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigsJonathan T Elliott
Department of Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada Imaging Division, Lawson Health Research Institute, St Joseph s Hospital, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
Biomed Opt Express 4:206-18. 2013..Furthermore, when the variance data along with the measured AIF is analyzed using a nonparametric deconvolution method, the recovered change in CBF is in good agreement with CT perfusion values...
- Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurementsJonathan T Elliott
Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
Phys Med Biol 57:8285-95. 2012..Considering that determining the AIF is required for performing quantitative tracer kinetics, this method provides a flexible tool for measuring the arterial dye concentration that could be used in a variety of applications...
- Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusionJoel A Cooper
Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, ON, Canada N6A 4V2
J Appl Physiol 110:1691-8. 2011..939 (R(2) = 0.907) following middle cerebral artery occlusion. These results suggest that calibrating the HbD signal by baseline hemodynamic measurements provides a clinically feasible method of monitoring CBF changes during neurosurgery...
- Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopyKyle Verdecchia
Lawson Health Research Institute, Imaging Division, London, Ontario, N6A 4V2, Canada
J Biomed Opt 18:27007. 2013..Bland-Altman analysis showed a mean CMRO2 difference of 0.0268 ± 0.8340 mLO2/100 g/min between the two techniques over a range from 0.3 to 4 mL O2/100 g/min...
- Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parametersJonathan T Elliott
Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada
Opt Lett 37:2571-3. 2012..Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios...
- Soft trapping and manipulation of cells using a disposable nanoliter biochamberMamadou Diop
Department of Physics, The University of Western Ontario, London, Ontario, Canada
Biophys J 90:3813-22. 2006..These experiments lay the foundation for the use of the microbubble as a mobile, nanoliter-volume disposable biochamber for cellular studies...