Mamadou Diop

Summary

Affiliation: Lawson Health Research Institute
Country: Canada

Publications

  1. doi request reprint Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
    Opt Lett 37:2358-60. 2012
  2. pmc Improving the depth sensitivity of time-resolved measurements by extracting the distribution of times-of-flight
    Mamadou Diop
    Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Department of Medical Biophysics, Western University, London, Ontario N6A 3K7, Canada
    Biomed Opt Express 4:447-59. 2013
  3. doi request reprint Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
    J Biomed Opt 15:057004. 2010
  4. doi request reprint A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
  5. doi request reprint Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
  6. doi request reprint Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusion
    Joel A Cooper
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, ON, Canada N6A 4V2
    J Appl Physiol (1985) 110:1691-8. 2011
  7. doi request reprint Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
  8. doi request reprint Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy
    Kyle Verdecchia
    Lawson Health Research Institute, Imaging Division, London, Ontario, N6A 4V2, Canada
    J Biomed Opt 18:27007. 2013
  9. doi request reprint Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Phys Med Biol 57:8285-95. 2012
  10. ncbi request reprint Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Electronic address
    Neuroimage 94:303-11. 2014

Collaborators

Detail Information

Publications18

  1. doi request reprint Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
    Opt Lett 37:2358-60. 2012
    ..Combined with the microscopic Beer-Lambert law, the algorithm enables accurate quantification of absorption changes from arbitrary time-of-flight windows, thereby optimizing the depth sensitivity provided by TR measurements...
  2. pmc Improving the depth sensitivity of time-resolved measurements by extracting the distribution of times-of-flight
    Mamadou Diop
    Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Department of Medical Biophysics, Western University, London, Ontario N6A 3K7, Canada
    Biomed Opt Express 4:447-59. 2013
    ..These results collectively demonstrate that this method improves the depth sensitivity of TR measurements by removing the effects of the IRF...
  3. doi request reprint Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
    J Biomed Opt 15:057004. 2010
    ..The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements...
  4. doi request reprint A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets
    Mamadou Diop
    Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Rev Sci Instrum 80:054302. 2009
    ..No significant changes in regional CMRO(2) were observed. The average regional differential pathlength prior to ET-1 injection was 8.4+/-0.2 cm (range of 7.1-9.6 cm) and did not significantly change after the injury...
  5. doi request reprint Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
    Jonathan T Elliott
    University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
    J Biomed Opt 15:037014. 2010
    ..The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care...
  6. doi request reprint Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusion
    Joel A Cooper
    Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, ON, Canada N6A 4V2
    J Appl Physiol (1985) 110:1691-8. 2011
    ..939 (R(2) = 0.907) following middle cerebral artery occlusion. These results suggest that calibrating the HbD signal by baseline hemodynamic measurements provides a clinically feasible method of monitoring CBF changes during neurosurgery...
  7. doi request reprint Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
    ....
  8. doi request reprint Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy
    Kyle Verdecchia
    Lawson Health Research Institute, Imaging Division, London, Ontario, N6A 4V2, Canada
    J Biomed Opt 18:27007. 2013
    ..Bland-Altman analysis showed a mean CMRO2 difference of 0.0268 ± 0.8340 mLO2/100 g/min between the two techniques over a range from 0.3 to 4 mL O2/100 g/min...
  9. doi request reprint Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Phys Med Biol 57:8285-95. 2012
    ..Considering that determining the AIF is required for performing quantitative tracer kinetics, this method provides a flexible tool for measuring the arterial dye concentration that could be used in a variety of applications...
  10. ncbi request reprint Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Electronic address
    Neuroimage 94:303-11. 2014
    ..The findings of this study suggest that the DCE-NIR approach presented is a minimally invasive and portable means of determining absolute hemodynamics in neurocritical care patients...
  11. doi request reprint Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus
    Rohit Arora
    Department of Pediatrics, Western University, London, Ontario, Canada
    Pediatr Res 73:713-8. 2013
    ....
  12. pmc Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs
    Jonathan T Elliott
    Department of Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada Imaging Division, Lawson Health Research Institute, St Joseph s Hospital, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    Biomed Opt Express 4:206-18. 2013
    ..Furthermore, when the variance data along with the measured AIF is analyzed using a nonparametric deconvolution method, the recovered change in CBF is in good agreement with CT perfusion values...
  13. ncbi request reprint Monitoring brain temperature by time-resolved near-infrared spectroscopy: pilot study
    Mohammad Fazel Bakhsheshi
    Lawson Health Research Institute, Imaging Program, London, Ontario N6A 4V2, CanadabRobarts Research Institute, Imaging Research Laboratories, London, Ontario N6A 5B7, CanadacWestern University, Department of Medical Biophysics, London, Ontario N6A 3K7, CA
    J Biomed Opt 19:057005. 2014
    ..66 to temperature measured with a thermometer, respectively. The mean difference between the TR-NIRS and thermometer measurements was 0.15°C ± 1.1°C for the in vitro experiments and 0.5°C ± 1.6°C for the in vivo measurements...
  14. ncbi request reprint Improved light collection and wavelet de-noising enable quantification of cerebral blood flow and oxygen metabolism by a low-cost, off-the-shelf spectrometer
    Mamadou Diop
    Lawson Health Research Institute, Imaging Program, London, Ontario, CanadabWestern University, Department of Medical Biophysics, London, Ontario, Canada
    J Biomed Opt 19:057007. 2014
    ..The ability of this approach to provide reliable cerebral hemodynamics was illustrated in a piglet by measuring CBF and oxygen metabolism under different anesthetic regimens...
  15. doi request reprint Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters
    Jonathan T Elliott
    Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada
    Opt Lett 37:2571-3. 2012
    ..Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios...
  16. pmc Soft trapping and manipulation of cells using a disposable nanoliter biochamber
    Mamadou Diop
    Department of Physics, The University of Western Ontario, London, Ontario, Canada
    Biophys J 90:3813-22. 2006
    ..These experiments lay the foundation for the use of the microbubble as a mobile, nanoliter-volume disposable biochamber for cellular studies...