Affiliation: Lawson Health Research Institute
- Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurementsMamadou Diop
Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
Opt Lett 37:2358-60. 2012..Combined with the microscopic Beer-Lambert law, the algorithm enables accurate quantification of absorption changes from arbitrary time-of-flight windows, thereby optimizing the depth sensitivity provided by TR measurements...
- A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn pigletsMamadou Diop
Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
Rev Sci Instrum 80:054302. 2009..No significant changes in regional CMRO(2) were observed. The average regional differential pathlength prior to ET-1 injection was 8.4+/-0.2 cm (range of 7.1-9.6 cm) and did not significantly change after the injury...
- Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in pigletsMamadou Diop
Lawson Health Research Institute, Imaging Program, London, Ontario, Canada N6A 4V2
J Biomed Opt 15:057004. 2010..The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements...
- Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopyJonathan T Elliott
University of Western Ontario, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada
J Biomed Opt 15:037014. 2010..The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care...
- Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence dataKenneth M Tichauer
Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
Appl Opt 50:3962-72. 2011....
- Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurementsJonathan T Elliott
Department of Medical Biophysics, Western University, London, Ontario N6A 5C1, Canada Imaging Division, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
Phys Med Biol 57:8285-95. 2012..Considering that determining the AIF is required for performing quantitative tracer kinetics, this method provides a flexible tool for measuring the arterial dye concentration that could be used in a variety of applications...
- Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopyKyle Verdecchia
Lawson Health Research Institute, Imaging Division, London, Ontario, N6A 4V2, Canada
J Biomed Opt 18:27007. 2013..Bland-Altman analysis showed a mean CMRO2 difference of 0.0268 ± 0.8340 mLO2/100 g/min between the two techniques over a range from 0.3 to 4 mL O2/100 g/min...
- Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigsJonathan T Elliott
Department of Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada Imaging Division, Lawson Health Research Institute, St Joseph s Hospital, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
Biomed Opt Express 4:206-18. 2013..Furthermore, when the variance data along with the measured AIF is analyzed using a nonparametric deconvolution method, the recovered change in CBF is in good agreement with CT perfusion values...
- Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosusRohit Arora
Department of Pediatrics, Western University, London, Ontario, Canada
Pediatr Res 73:713-8. 2013....
- Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusionJoel A Cooper
Imaging Division, Lawson Health Research Institute, 268 Grosvenor St, London, ON, Canada N6A 4V2
J Appl Physiol 110:1691-8. 2011..939 (R(2) = 0.907) following middle cerebral artery occlusion. These results suggest that calibrating the HbD signal by baseline hemodynamic measurements provides a clinically feasible method of monitoring CBF changes during neurosurgery...
- Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parametersJonathan T Elliott
Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada
Opt Lett 37:2571-3. 2012..Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios...
- Improving the depth sensitivity of time-resolved measurements by extracting the distribution of times-of-flightMamadou Diop
Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada Department of Medical Biophysics, Western University, London, Ontario N6A 3K7, Canada
Biomed Opt Express 4:447-59. 2013..These results collectively demonstrate that this method improves the depth sensitivity of TR measurements by removing the effects of the IRF...
- Soft trapping and manipulation of cells using a disposable nanoliter biochamberMamadou Diop
Department of Physics, The University of Western Ontario, London, Ontario, Canada
Biophys J 90:3813-22. 2006..These experiments lay the foundation for the use of the microbubble as a mobile, nanoliter-volume disposable biochamber for cellular studies...