R Lalonde

Summary

Country: Canada

Publications

  1. ncbi Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Behav Brain Res 138:71-9. 2003
  2. doi Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice
    R Lalonde
    Universite de Rouen, Faculte de Sciences, Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    J Neurosci Methods 171:48-52. 2008
  3. doi Exploratory activity and motor coordination in old versus middle-aged C57BL/6J mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    Arch Gerontol Geriatr 49:39-42. 2009
  4. ncbi Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Canada
    Brain Res 1188:122-31. 2008
  5. ncbi Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    R Lalonde
    INSERM EPI 9906, Salle 1D18, Bâtiment de Recherche, Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 blvd Gambetta, 76183 Rouen Cedex, France
    Brain Res 956:36-44. 2002
  6. doi The relation between open-field and emergence tests in a hyperactive mouse model
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Canada H2X 3J4
    Neuropharmacology 57:722-4. 2009
  7. ncbi Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordination
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 blvd Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Exp Gerontol 37:1401-12. 2002
  8. ncbi Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degeneration
    R Lalonde
    Universite de Rouen, Faculté des Sciences PSY CO EA 1780, Laboratoire de Neurobiologie de l Apprentissage, 76821 Mont Saint Aignan, Cedex France
    Behav Genet 33:59-66. 2003
  9. doi Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6J and BALB/c mice injected with GABA- and 5HT-anxiolytic agents
    Robert Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    Fundam Clin Pharmacol 24:365-76. 2010
  10. ncbi Neurobehavioral characteristics of mice with modified intermediate filament genes
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM, Rouen, France
    Rev Neurosci 14:369-85. 2003

Collaborators

Detail Information

Publications90

  1. ncbi Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Behav Brain Res 138:71-9. 2003
    ..These results indicate that elevated Abeta(42) levels were insufficient for causing spatial defects but caused disinhibition, psychomotor slowing, and loss of motor skills in this model of familial Alzheimer's disease...
  2. doi Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice
    R Lalonde
    Universite de Rouen, Faculte de Sciences, Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    J Neurosci Methods 171:48-52. 2008
    ..In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests...
  3. doi Exploratory activity and motor coordination in old versus middle-aged C57BL/6J mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    Arch Gerontol Geriatr 49:39-42. 2009
    ..However, there was no significant correlation between open-field measures and emergence latencies, indicating that the two tests of exploratory activity estimate separate aspects of behavior...
  4. ncbi Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Canada
    Brain Res 1188:122-31. 2008
    ..The main effect of this diet restriction was hyperactivity with no change in anxiety, coordination, and memory. It remains to be determined whether severer deficits are demonstrable in older mice...
  5. ncbi Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    R Lalonde
    INSERM EPI 9906, Salle 1D18, Bâtiment de Recherche, Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 blvd Gambetta, 76183 Rouen Cedex, France
    Brain Res 956:36-44. 2002
    ..These results indicate that a learning deficit and hypoactivity, concordant with the early stages of Alzheimer's disease, characterize this mouse model with Abeta accumulation...
  6. doi The relation between open-field and emergence tests in a hyperactive mouse model
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Canada H2X 3J4
    Neuropharmacology 57:722-4. 2009
    ..In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies...
  7. ncbi Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordination
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 blvd Gambetta, INSERM EPI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Exp Gerontol 37:1401-12. 2002
    ....
  8. ncbi Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degeneration
    R Lalonde
    Universite de Rouen, Faculté des Sciences PSY CO EA 1780, Laboratoire de Neurobiologie de l Apprentissage, 76821 Mont Saint Aignan, Cedex France
    Behav Genet 33:59-66. 2003
    ..The deficit in spontaneous alternation rates seen in nervous mutants is accountable by reduced motivation, disinhibition, or spatial disorientation...
  9. doi Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6J and BALB/c mice injected with GABA- and 5HT-anxiolytic agents
    Robert Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, Montreal, Quebec, Canada H2X 3J4
    Fundam Clin Pharmacol 24:365-76. 2010
    ..Though superficially similar, the emergence test seems to tap into a partially separate facet of anxiety...
  10. ncbi Neurobehavioral characteristics of mice with modified intermediate filament genes
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM, Rouen, France
    Rev Neurosci 14:369-85. 2003
    ..In addition, spatial learning was impaired in transgenic mice expressing transgenes for NFH and NFM, similar to the memory deficits reported in patients with ALS...
  11. doi Discrimination learning in Rora(sg) and Grid2(ho) mutant mice
    R Lalonde
    Centre Hospitalier de l Université de Montréal St Luc, Unité de Recherche en Sciences Neurologiques, 1058 St Denis St, Montreal, Que H2X3J4, Canada
    Neurobiol Learn Mem 90:472-4. 2008
    ..In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies...
  12. ncbi The effects of cerebellar damage on maze learning in animals
    R Lalonde
    Hôtel Dieu du Centre hospitalier de l Université de Montréal, Service de Neurologie, 3840 St Urbain, Montreal, Quebec, Canada
    Cerebellum 2:300-9. 2003
    ..The spatial deficits may be ascribed to altered metabolic activity in cerebellar-related pathways...
  13. ncbi Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 Boulevard Gambetta, INSERM EMI 9906, IFRMP 23, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Brain Res 977:38-45. 2003
    ..These measures may be added to cognitive dysfunctions as testing ground for Abeta vaccination and other attempts at experimental therapies...
  14. ncbi Brain regions and genes affecting postural control
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP, 76183 Rouen Cedex
    Prog Neurobiol 81:45-60. 2007
    ..In addition, transgenic mouse models of the synucleinopathies and of Huntington's disease cause deficiencies of motor coordination resembling those of patients with basal ganglia damage...
  15. ncbi Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP23, Bâtiment de Recherche, 76183 Rouen Cedex, France
    Behav Brain Res 157:91-8. 2005
    ..Despite the neurologic signs, APP23 transgenic mice were not deficient in stationary beam, coat-hanger, and rotorod tests, indicating intact motor coordination abilities...
  16. ncbi Neurobehavioral evaluation of Reln-rl-orl mutant mice and correlations with cytochrome oxidase activity
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, INSERM EMI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Neurosci Res 49:297-305. 2004
    ..Conversely, elevated CO activity in the polymorphic layer of primary somatosensory cortex was congruent with higher latencies before falling from the same apparatus, indicating functional compensation...
  17. ncbi Sensorimotor functions in transgenic mice expressing the neurofilament/heavy-LacZ fusion protein on two genetic backgrounds
    M Dubois
    Universite de Rouen, Faculte des Sciences, UPRES PSY CO 1780, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
    Neuroscience 112:447-54. 2002
    ....
  18. ncbi Differential effects of L-trytophan and buspirone on biogenic amine contents and metabolism in Lurcher mice cerebellum
    T A Reader
    Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Canada
    Neurosci Lett 280:171-4. 2000
    ..Catecholamine contents remained unchanged in +/+ mice, but in Lc/+ mutants with higher endogenous NA, L-tryptophan further increased NA and 3,4-dihydroxy-phenylacetic acid (DOPAC), and buspirone augmented NA, DA and DOPAC levels...
  19. ncbi Primary neurologic screening and motor coordination of Dstdt-J mutant mice (dystonia musculorum) with spinocerebellar atrophy
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, Bâtiment de Recherche, Salle 1D18, France
    Physiol Behav 86:46-51. 2005
    ..The neurologic screening battery delineated the functional integrity of some sensorimotor pathways in a spinocerebellar mutant whose severe phenotype prevents a more elaborate evaluation...
  20. ncbi NFH-LacZ transgenic mice: regional brain activity of cytochrome oxidase
    C Strazielle
    Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, UPRES PSY CO EA 1780, 76821, Mont Saint Aignan Cedex, France
    Exp Neurol 177:521-30. 2002
    ..These results indicate regional and age-selective deficits of brain metabolism in a transgenic model with neurofilament maldistribution...
  21. ncbi Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientation
    M Dubois
    Faculte des Sciences, Universite de Rouen, UPRES PSY CO EA 1780, Mont Saint Aignan, France
    J Neurosci Res 80:751-8. 2005
    ..These results indicate that, as early as 6 months, depletion of the NFL protein is sufficient to cause mild sensorimotor dysfunctions and spatial deficits, but without overt signs of paresis...
  22. ncbi Effects of buspirone on brain indoleamines and catecholamines in wild-type mice and Lurcher mutants
    T A Reader
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, H3C 3J7, Montreal, Quebec, Canada
    Eur J Pharmacol 398:41-51. 2000
    ....
  23. ncbi Swimming activity in dystonia musculorum mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Quebec, Canada
    Physiol Behav 54:119-20. 1993
    ..It is not excluded that a measure tracing their path may find a mild deviation from the goal...
  24. ncbi Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP
    M Dumont
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, Rouen, France
    J Neural Transm 113:1225-41. 2006
    ..Because of some similarities in terms of neurochemistry and behavior, this mouse model may be of use for studying prodromal AD...
  25. ncbi Exploration and motor coordination in dystonia musculorum mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Quebec, Canada
    Physiol Behav 56:277-80. 1994
    ....
  26. doi Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease
    M Filali
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada
    Genes Brain Behav 8:143-8. 2009
    ..In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models...
  27. ncbi Biochemical and autoradiographic studies of the central noradrenergic system in dystonia musculorum mutant mice
    C Strazielle
    Departement de Physiologie, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Quebec, H3C 3J7, Montreal, Canada
    J Chem Neuroanat 23:143-55. 2002
    ....
  28. ncbi Treadmill performance of mice with cerebellar lesions: 2. Lurcher mutant mice
    N Le Marec
    Centre Hospitalier de l Universite de Montreal, Pavillon Hôtel Dieu, Service de Neurologie, Unité de Neurologie du Comportement, Neurobiologie et Neuropsychologie, Montreal, Quebec, H2W 1T8, Canada
    Neurobiol Learn Mem 73:195-206. 2000
    ..It is concluded that cerebellar cortical degeneration impaired the time course of acquisition but not long-term retention of the treadmill task...
  29. ncbi Comparisons between C57BL/6J and A/J mice in motor activity and coordination, hole-poking, and spatial learning
    S Thifault
    Laboratoire de médecine moléculaire and Service de neurologie, Centre de Recherche, Hôtel Dieu du Centre hospitalier de l Université de Montréal, Que, Montreal, Canada
    Brain Res Bull 58:213-8. 2002
    ..These results indicate that recombinant inbred or congenic strains derived from B6 and A/J mice offer considerable potential for discerning the genetic basis of several behavioral phenotypes...
  30. doi Brain regions and genes affecting myoclonus in animals
    R Lalonde
    Universite de Rouen, UFR des Sciences Humaines et Sociales, Laboratoire de Psychologie et Neurosciences Intégration COgnitive du NEurone à la Société ICONES, 76821 Mont Saint Aignan Cedex, France
    Neurosci Res 74:69-79. 2012
    ..There is reason to suspect that myoclonic jumping is underreported due to insufficient observations into mouse cages...
  31. ncbi Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, Bâtiment de Recherche, EMI INSERM 9906, IFRMP 23, 76183 Rouen, France
    Physiol Behav 80:333-9. 2003
    ..These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice...
  32. ncbi Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study
    C Strazielle
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neuroscience 94:287-304. 1999
    ..An intense labelling by [3H]idazoxan of the inner third of the molecular layer was a novel, albeit unexplained finding, and could represent a postsynaptic subset of alpha2-adrenergic receptors...
  33. ncbi Behavioral and biochemical effects of L-tryptophan and buspirone in a model of cerebellar atrophy
    N Le Marec
    Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 69:333-42. 2001
    ..The modest test-specific improvements are consistent with some of the clinical data concerning 5-HT pharmacotherapy in patients suffering from cerebellar atrophy...
  34. ncbi Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation
    M Dumont
    Universite de Rouen, INSERM U614, IFRMP23, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Brain Res 1024:113-21. 2004
    ..These results indicate that hyperactivity and impaired learning abilities characterize this mouse model of Alzheimer's disease and cerebral angiopathy...
  35. ncbi Motor coordination and spatial orientation are affected by neurofilament maldistribution: correlations with regional brain activity of cytochrome oxidase
    R Lalonde
    Universite de Rouen, Faculte des Sciences, UPRES PSY CO 1780, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
    Exp Brain Res 126:223-34. 1999
    ..The dramatic cytoskeletal perturbation characterizing NFH-LacZ mice affects only selective neuronal populations and results in selective behavioral deficits, which can be correlated with regional brain metabolic activity...
  36. ncbi Exploratory activity and motor coordination in wild-type SOD1/SOD1 transgenic mice
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, Bâtiment de Recherche, 22 bld Gambetta, Salle 1D18, 76183 Rouen Cedex, France
    Brain Res Bull 66:155-62. 2005
    ....
  37. ncbi Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, 76183 Rouen Cedex, France
    Brain Res 1140:51-74. 2007
    ..We describe neurochemical characteristics of these mutants with respect to regional brain metabolism as well as amino acid and biogenic amine concentrations, uptake sites, and receptors...
  38. ncbi Hole poking and motor coordination in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Quebec, Canada
    Physiol Behav 54:41-4. 1993
    ..In a wooden beam test, although lurchers did not differ from normal mice in terms of the amount of time spent on the beam or in the distance travelled, the mutants were found more often in unstable positions...
  39. ncbi Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, IFRMP, 76183 Rouen Cedex, France
    Behav Brain Res 178:293-304. 2007
    ..Null mutants were lighter than C57BL/6J controls but heavier than 129/SvEv controls, attributable to interactions with strain-dependent genes...
  40. ncbi Motor abnormalities in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Canada
    Physiol Behav 51:523-5. 1992
    ..There was no decrease in rearing responses. These results indicate that in spite of cerebellar degeneration and ataxia, lurcher mutants are not impaired in all tests measuring motor function...
  41. ncbi Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy
    R Lalonde
    Laboratoire de Neurobiologie de l Apprentissage, Universite de Rouen, Faculte des Sciences, UPRES PSY CO EA 1780, 76821 Mont Saint Aignan Cedex, France
    Behav Brain Res 125:103-8. 2001
    ..Altered CO activity in cerebellar-related pathways was linearly correlated with motor performance, indicating that the activity of this enzyme is associated not only with neuronal activity but also with motor performance...
  42. doi Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice
    R Jazi
    INSERM, U724, Vandoeuvre les Nancy, France
    Neurosci Res 63:106-14. 2009
    ..PS1/A246E mice mimic to some extent pre-symptomatic Alzheimer's disease neuropathology, useful for studying early neurochemical changes often inaccessible in clinical studies...
  43. ncbi Effects of L-tryptophan on indoleamines and catecholamines in discrete brain regions of wild type and Lurcher mutant mice
    T A Reader
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neurochem Res 24:1125-34. 1999
    ....
  44. ncbi Beam sensorimotor learning and habituation to motor activity in lurcher mutant mice
    R Lalonde
    Neurology Service, Hotel Dieu Hospital, Montreal, Quebec, Canada
    Behav Brain Res 74:213-6. 1996
    ..Ataxia was not accompanied by hypoactivity, inhibition or disturbances in intrasession habituation...
  45. ncbi Sensorimotor learning and retention during equilibrium tests in Purkinje cell degeneration mutant mice
    N Le Marec
    Unit of Behavioral Neurology, Neurobiology, and Neuropsychology, Hôtel Dieu Hospital Research Center, Montreal, Canada
    Brain Res 768:310-6. 1997
    ..The cerebellar cortex is critically involved in timing whole body movements during postural adjustments to a mobile beam but not to four types of immobile apparatus...
  46. ncbi Brain dopamine and amino acid concentrations in Lurcher mutant mice
    T A Reader
    Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Brain Res Bull 45:489-93. 1998
    ..These results indicate region-selective reductions of neurotransmitter concentrations in a mouse mutant with a defined cerebellar cortical pathology...
  47. ncbi PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, Salle 1D18, 76183 Rouen Cedex, France
    Behav Brain Res 162:182-90. 2005
    ..The dissociation between hidden and visible platform versions in the water maze is consistent with the hypothesis that elevated Abeta42 concentrations cause cognitive disturbances...
  48. ncbi Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Neurosci Lett 369:156-61. 2004
    ..No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease...
  49. ncbi Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxiety
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, INSERM U614, Bâtiment de Recherche, 22 bld Gambetta, Salle 1D18, 76183 Rouen, Cedex, France
    Brain Res Bull 64:251-8. 2004
    ..These results indicate mild deficits in sensorimotor responsiveness in a mouse model expressing human SOD1 and that the overexpressed gene may be responsible for some Down symptoms...
  50. ncbi Absence of an association between motor coordination and spatial orientation in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Quebec, Canada
    Behav Genet 24:497-501. 1994
    ..A similar absence of correlation was noted for lurcher mutants, except for falling latencies in the coat-hanger test during the middle of training...
  51. ncbi Longitudinal analysis of motor activity and coordination, anxiety, and spatial learning in mice with altered blood pressure
    S Thifault
    , , Centre de Recherche, , 3840 rue St-Urbain, , H2W 1T8, , Canada
    Brain Res 910:99-105. 2001
    ..Both groups with abnormal BP values were deficient during visuomotor guidance in the water maze. These results indicate strain-, age-, and test-specific abnormalities in mice with uncontrolled hypertension or hypotension...
  52. ncbi Effects of ventrolateral-ventromedial thalamic lesions on motor coordination and spatial orientation in rats
    M Jeljeli
    Faculté des Sciences UPRES PSY CO EA 1780, Universite de Rouen, 76821 Cedex, Mont Saint Aignan, France
    Neurosci Res 47:309-16. 2003
    ..These results support the hypothesis that thalamic motor nuclei participate in the acquisition of sensorimotor and spatial learning...
  53. ncbi Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, 76183 Rouen Cedex, France
    Neurosci Lett 390:87-92. 2005
    ..These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology...
  54. ncbi Regional variations of cytochrome oxidase activity in the central auditory system of Relnrl-Orl (reeler) mutant mice
    K Hayzoun
    Universite de Rouen, UPRES PSY CO EA 1780 and INSERM U614, France
    Neurosci Res 58:378-85. 2007
    ..These metabolic variations are discussed in terms of their possible relation to morphologic anomalies observed in the mutant...
  55. ncbi Mice with the deleted neurofilament of low-molecular-weight (Nefl) gene: 1. Effects on regional brain metabolism
    M Dubois
    Faculte des Sciences, UPRES PSY CO EA 1780, Universite de Rouen, Mont Saint Aignan, France
    J Neurosci Res 80:741-50. 2005
    ..NFL-disrupted mice displayed functional alterations in brainstem sensorimotor regions affected in amyotrophic lateral sclerosis...
  56. doi Sensorimotor learning in Dab1(scm) (scrambler) mutant mice
    R Lalonde
    Universite de Rouen, Faculte des Sciences, Dept Psychologie, 76821 Mont Saint Aignan, France
    Behav Brain Res 218:350-2. 2011
    ....
  57. ncbi Climbing sensorimotor skills in Lurcher mutant mice
    S Thifault
    Hôtel Dieu Hospital Research Center, Neurology Service, Montreal, Quebec, Canada
    Brain Res Bull 41:385-90. 1996
    ..These results illustrate that massive cerebellar damage does not eliminate the possibility of acquiring climbing skills, but under some conditions limit performance...
  58. ncbi Simultaneous visual discrimination learning in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Que, Canada
    Brain Res 618:19-22. 1993
    ..These results agree with the hypothesis that the cerebellum is involved in the acquisition of visual discrimination tasks in mice...
  59. ncbi Immobility responses in Lurcher mutant mice
    R Lalonde
    Universite de Rouen, Faculte des Sciences, Mont Saint Alignan, France
    Behav Genet 28:309-14. 1998
    ..Moreover, the mutants are able to improve with practice during a task requiring equilibrium that can be solved by the absence of movement, although terminal performance was not so high as that of controls...
  60. ncbi Sensorimotor learning in three cerebellar mutant mice
    R Lalonde
    Universite de Nancy 1, Laboratoire de Biologie et Physiologie du Comportement, Montreal, Quebec, Canada
    Neurobiol Learn Mem 65:113-20. 1996
    ..Cerebellar atrophy in the latter two mutants did not prevent sensorimotor learning, but instead impaired their ability to reach the same level of performance as that of normal mice...
  61. ncbi The effects of unilateral removal of the cerebellar hemispheres on spatial learning and memory in rats
    C Colombel
    UPRES PSY CO EA 1780, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Brain Res 1004:108-15. 2004
    ..Moreover, the operated rats were unable to adapt their behavior to a novel situation, suggesting frontal dysfunctions similar to those demonstrated in human cerebellar syndromes...
  62. ncbi Timed active avoidance learning in lurcher mutant mice
    V Monfort
    Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
    Behav Brain Res 91:165-72. 1998
    ..An alternative explanation is that the cerebellar mutant animals had persevering tendencies acquired during performance of the one-way avoidance task...
  63. ncbi Motor learning in lurcher mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Que, Canada
    Brain Res 639:351-3. 1994
    ..In a test where motor deficits occurred, rapid improvement was seen. Thus, in spite of massive cerebellar degeneration, there was no evidence of a decreased rate in motor learning...
  64. ncbi Early development of synchronized walking on the rotorod in rats. Effects of training and handling
    P Chapillon
    Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
    Behav Brain Res 93:77-81. 1998
    ..These results indicate that the emergence of this postural sensorimotor skill is more dependent on the maturation of sensorimotor brain region than on previous training on the apparatus...
  65. ncbi Distribution of dopamine transporters in basal ganglia of cerebellar ataxic mice by [125I]RTI-121 quantitative autoradiography
    C Strazielle
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neurochem Int 32:61-8. 1998
    ....
  66. ncbi Impaired motor skills on static and mobile beams in lurcher mutant mice
    N Le Marec
    Hotel Dieu Hospital, Neurology Service, University of Montreal, Quebec, Canada
    Exp Brain Res 116:131-8. 1997
    ..These results indicate that, although lurcher mutants are limited in their capacity to execute motor coordination tasks, postural sensorimotor learning is not abolished in the absence of cerebellar cortical output neurons...
  67. ncbi Effects of an ectodermal microceptor preparation on motor coordination in cerebellar mutant mice
    R Lalonde
    Hotel Dieu Hospital, Neurology Service, Montreal, Quebec, Canada
    Pharmacol Biochem Behav 49:777-9. 1994
    ..These results indicate that ectodermal microceptors may improve movement initiation of cerebellar-related disorders in animals, but that these effects are test and disease-specific...
  68. doi Relations between open-field, elevated plus-maze, and emergence tests in C57BL/6JIco and BALB/cAnN@Ico mice injected with ethanol
    R Lalonde
    Universite de Rouen, Dept de Psychologie, 76821 Mont Saint Aignan Cedex, France
    Fundam Clin Pharmacol 26:271-8. 2012
    ..The strain-specific effects may be attributable to differences in GABA(A) -related receptor binding or catalase activity...
  69. doi Treatment durability, effectiveness, and safety with atazanavir/ritonavir-based HAART regimen in treatment-naïve HIV-infected patients
    C Tremblay
    Centre de recherche du Centre hospitalier de I Université de Montréal, Quebec, Canada
    HIV Clin Trials 12:151-60. 2011
    ..To describe the durability of treatment, virological and immunological response, and safety of an atazanavir/ritonavir (ATV/RTV)-based highly active antiretroviral therapy (HAART) regimen in treatment-naïve HIV-infected patients...
  70. doi Computerized testing augments pencil-and-paper tasks in measuring HIV-associated mild cognitive impairment(*)
    L Koski
    The Research Institute of the McGill University Health Centre, Montreal, Quebec
    HIV Med 12:472-80. 2011
    ..Existing tools for rapid cognitive assessment in HIV-positive individuals with mild cognitive deficits lack sensitivity or do not meet psychometric requirements for tracking changes in cognitive ability over time...
  71. ncbi The effects of unilateral removal of the cerebellar hemispheres on motor functions and weight gain in rats
    C Colombel
    UPRES PSY CO 1780, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Universite de Rouen, 76821 Cedex, Mont Saint Aignan, France
    Brain Res 950:231-8. 2002
    ..The motor deficits were more pronounced after left as opposed to right cerebellar damage on the rotorod, implying a certain degree of functional lateralization for this test...
  72. doi Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats
    R F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc, CHUM, Montreal, QC, Canada
    Neurogastroenterol Motil 21:1319-25. 2009
    ..Substitutive therapies with DHEAS or DHEA could represent novel approaches in the management of fatigue due to cholestasis-induced liver failure...
  73. doi Sensitivity of N170 and late positive components to social categorization and emotional valence
    B Montalan
    Universite de Rouen, Faculte des Sciences, Laboratoire de Psychologie et Neurosciences de la Cognition et de l Affectivité PSY NCA EA 4306, 76821 Mont Saint Aignan Cedex, France
    Brain Res 1233:120-8. 2008
    ....
  74. ncbi Spatial navigation of staggerer and normal mice during juvenile and adult stages
    A N Bensoula
    Universite de Nancy 1, Laboratorie de Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre les Nancy, France
    Physiol Behav 58:823-5. 1995
    ..It remains to be determined in this mutant at more advanced stages of aging or in other models of chronic neural disease whether early neuropathology accelerates brain aging...
  75. ncbi Spontaneous alternation, motor activity, and spatial learning in hot-foot mutant mice
    M Filali
    Universite de Nancy 1, Laboratoire Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre les Nancy, France
    J Comp Physiol A 178:101-4. 1996
    ..These results indicate that in addition to motor coordination deficits, these cerebellar mutants have deficits in spatial learning and perseverate choices of maze arms...
  76. ncbi Elevated (+)-maze and hole-board exploration in lurcher mutant mice
    C Monnier
    Lab Biologie et Physiologie du Comportement, Universite de Nancy, France
    Brain Res 702:169-72. 1995
    ..These results may be due to a lesion-induced tendency to explore a more restricted region of a novel spatial environment and to explore it in a more haphazard fashion...
  77. ncbi Spatial learning in a Z-maze by cerebellar mutant mice
    R Lalonde
    Lab Biologie et Physiologie du Comportement, Universite de Nancy 1, Vandoeuvre les Nancy, France
    Physiol Behav 59:83-6. 1996
    ..These results indicate that the cerebellum has a role in spatial learning. Mice with cerebellar dysfunction take a more indirect route toward a goal during the course of swimming, when ataxic symptoms are no longer in evidence...
  78. ncbi Neurobehavioral evaluation of lurcher mutant mice during ontogeny
    F Thullier
    Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Universite Henri Poincare Nancy 1, Vandoeuvre les Nancy, France
    Brain Res Dev Brain Res 100:22-8. 1997
    ..These results indicate test-selective and time-selective neurobehavioral deficits during ontogeny in a spontaneous cerebellar mutant...
  79. ncbi Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation
    C Strazielle
    Laboratoire de Pathologie Moléculaire et Cellulaire en Nutrition and the Service de Microscopie Electronique, Faculte de Medecine, Universite Henri Poincare, 7 Allée de la Forêt de Haye, 54500 Vandoeuvre les Nancy, France
    Neuroscience 118:1151-63. 2003
    ....
  80. ncbi Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on cytochrome oxidase activity in skeletal muscle and brain
    C Strazielle
    Laboratoire de Pathologie Moléculaire et Cellulaire en Nutrition EMI INSERM 0014 and Service de Microscopie Electronique, Faculte de Medecine, Universite Henri Poincare, Nancy I, France
    J Chem Neuroanat 27:237-46. 2004
    ..The overproduction of betaAPP-C99 fragments in brain without (amyloidosis did not appear to affect the metabolic activity of structures particularly vulnerable in Alzheimer's disease...
  81. ncbi Exploration and motor activity in juvenile and adult rats exposed to hypergravity at 1.8 G during development: a preliminary report
    F Thullier
    Universite de Caen, UPRES EA 2131, Bd du Mal Juin, Campus II, 14032 Caen Cedex, France
    Physiol Behav 76:617-22. 2002
    ..These results indicate that exposure to 1.8 G during development appears to decrease exploratory tendencies in the hole board and fear-related responses in T-maze and social interaction tests...
  82. ncbi The effects of the lurcher mutation on object localization, T-maze discrimination, and radial arm maze tasks
    C Belzung
    Universite de Tours, EA Psychobiologie des émotions, Tours, France
    Behav Genet 31:151-5. 2001
    ..These results indicate that trial-independent tasks and reference memory tasks using cognitive mapping may be particularly vulnerable to cerebellar degeneration...
  83. ncbi Cytochrome oxidase activity in the olfactory system of staggerer mutant mice
    V Deiss
    Laboratoire d Ethologie Experimentale et Comparee, Universite Paris 13, 93430, Villetaneuse, France
    Brain Res 910:126-33. 2001
    ..These results are discussed with regard to the olfactory deficits and changes in social interactions previously observed in this mutant...
  84. ncbi Regional brain variations of cytochrome oxidase activity and motor co-ordination in staggerer mutant mice
    V Deiss
    Université de Paris 13, Laboratoire d Ethologie et d Expérimentation Comparée, Villetaneuse, France
    Neuroscience 95:903-11. 2000
    ..These results indicate that a lack of innervation of Purkinje cells to the deep cerebellar nuclei is in part the cause of motor co-ordination deficits in staggerer mutant mice...
  85. ncbi Regional brain variations of cytochrome oxidase activity and motor coordination in hot-foot mutant mice
    P Kremarik
    Universite de Nancy 1, Laboratoire de Biologie Cellulaire du Developpement, Vandoeuvre les Nancy, France
    Eur J Neurosci 10:2802-9. 1998
    ..These results indicate regionally selective abnormalities of metabolic activity in a cerebellar mutant with defective dendritic arborization of the Purkinje cell...
  86. ncbi Regional brain variations of cytochrome oxidase activity and motor coordination in Lurcher mutant mice
    C Strazielle
    Universite de Nancy 1, Laboratoire de Neuroanatomie Fonctionnelle, Faculté Dentaire, France
    Exp Brain Res 121:35-45. 1998
    ....
  87. ncbi Grooming in Lurcher mutant mice
    C Strazielle
    Laboratoire de Neuroanatomie Fonctionnelle, Universite de Nancy 1, France
    Physiol Behav 64:57-61. 1998
    ..These results indicate that the cerebellar cortex is involved in the appearance of various grooming elements but not in the organization of the cephalocaudal sequence...
  88. ncbi Regional brain variations of cytochrome oxidase activity and motor coordination in Girk2(Wv) (Weaver) mutant mice
    C Strazielle
    INSERM U724 and Laboratoire de Microscopie Electronique, Facultés de Médecine et d Odontologie, 7 avenue de la Forêt de Haye, 54500 Vandoeuvre les Nancy, France
    Neuroscience 142:437-49. 2006
    ..Similarly to the Rora(sg) cerebellar mutant, metabolic alterations in cerebellar and vestibular regions were linearly correlated with poor motor coordination, underlining the sensitivity of these tests to cerebellar dysfunction...
  89. ncbi Effects of dentate nucleus lesions on spatial and postural sensorimotor learning in rats
    C C Joyal
    , , Montreal, Que, Canada H3C 3J7
    Behav Brain Res 122:131-7. 2001
    ....
  90. ncbi Rotorod sensorimotor learning in cerebellar mutant mice
    R Lalonde
    Universite de Nancy 1, Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre les Nancy, France
    Neurosci Res 22:423-6. 1995
    ..However, brain-damaged animals are unable to reach the same level of performance as normal animals. In contrast to the results in lurcher mutants, no sensorimotor learning was displayed by hot-foot mutants and staggerer mutants...