Jacques Lacroix

Summary

Country: Canada

Publications

  1. ncbi request reprint Severity of illness and organ dysfunction scoring in children
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
    Pediatr Crit Care Med 6:S126-34. 2005
  2. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
  3. doi request reprint Red blood cell transfusion: decision making in pediatric intensive care units
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Quebec, Canada
    Semin Perinatol 36:225-31. 2012
  4. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
  5. pmc Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children
    Christopher S Parshuram
    Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Crit Care 15:R184. 2011
  6. ncbi request reprint Transfusion strategies for patients in pediatric intensive care units
    Jacques Lacroix
    Universite de Montreal, Montreal, Canada
    N Engl J Med 356:1609-19. 2007
  7. doi request reprint The Age of Blood Evaluation (ABLE) randomized controlled trial: study design
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Transfus Med Rev 25:197-205. 2011
  8. ncbi request reprint Parental involvement in treatment decisions regarding their critically ill child: a comparative study of France and Quebec
    Franco A Carnevale
    Montreal Children s Hospital, Montreal, Canada
    Pediatr Crit Care Med 8:337-42. 2007
  9. pmc Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks
    Vanessa Turcotte
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C H U Q, Hopital Saint Francois d Assise, Quebec, QC, G1L 3L5, Canada
    J Med Chem 55:6194-208. 2012
  10. doi request reprint Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients
    France Gauvin
    Pediatric Critical Care and the Hematology Oncology Division, Sainte Justine Hospital and Université de Montréal, Montreal, Quebec, Canada
    Transfusion 50:1902-13. 2010

Detail Information

Publications55

  1. ncbi request reprint Severity of illness and organ dysfunction scoring in children
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
    Pediatr Crit Care Med 6:S126-34. 2005
    ..To describe predictive and descriptive general scores that can be used to estimate the severity of illness in critically ill children...
  2. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
    ..Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in neurocritically ill patients...
  3. doi request reprint Red blood cell transfusion: decision making in pediatric intensive care units
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Quebec, Canada
    Semin Perinatol 36:225-31. 2012
    ....
  4. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  5. pmc Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children
    Christopher S Parshuram
    Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Crit Care 15:R184. 2011
    ..The objective of this study was to validate the Bedside PEWS score in a large patient population at multiple hospitals...
  6. ncbi request reprint Transfusion strategies for patients in pediatric intensive care units
    Jacques Lacroix
    Universite de Montreal, Montreal, Canada
    N Engl J Med 356:1609-19. 2007
    ..We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of multiple-organ dysfunction...
  7. doi request reprint The Age of Blood Evaluation (ABLE) randomized controlled trial: study design
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Transfus Med Rev 25:197-205. 2011
    ....
  8. ncbi request reprint Parental involvement in treatment decisions regarding their critically ill child: a comparative study of France and Quebec
    Franco A Carnevale
    Montreal Children s Hospital, Montreal, Canada
    Pediatr Crit Care Med 8:337-42. 2007
    ..Anglo-American settings have adopted decision-making models where parents are regarded as responsible for such life-support decisions, while in France physicians are commonly considered the decision makers...
  9. pmc Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks
    Vanessa Turcotte
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C H U Q, Hopital Saint Francois d Assise, Quebec, QC, G1L 3L5, Canada
    J Med Chem 55:6194-208. 2012
    ..These new compounds are members of a promising new class of anticancer agents...
  10. doi request reprint Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients
    France Gauvin
    Pediatric Critical Care and the Hematology Oncology Division, Sainte Justine Hospital and Université de Montréal, Montreal, Quebec, Canada
    Transfusion 50:1902-13. 2010
    ..The objective was to determine if there is an association between red blood cell (RBC) storage time and development of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children...
  11. doi request reprint Red blood cell transfusion thresholds in pediatric patients with sepsis
    Oliver Karam
    Pediatric Critical Care Unit, Sainte Justine Hospital and Université de Montréal, Montreal, Canada
    Pediatr Crit Care Med 12:512-8. 2011
    ..We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on clinical outcome...
  12. doi request reprint Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation
    Alexandre Patenaude
    Unité de Biotechnologie et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Universite Laval, Quebec, QC, Canada
    Can J Physiol Pharmacol 88:1102-14. 2010
    ..The importance of TRX1 and the dependence of the cytotoxicity of CEU-025 and CEU-027 on TRX1 intracellular localization are also discussed...
  13. doi request reprint Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis
    Ariane Willems
    Pediatric Intensive Care Unit, Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada
    Crit Care Med 38:649-56. 2010
    ..a liberal transfusion strategy on new or progressive multiple organ dysfunction syndrome in children post cardiac surgery. The optimal transfusion threshold after cardiac surgery in children is unknown...
  14. ncbi request reprint Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods
    France Gauvin
    Hopital Sainte Justine, Montreal, Quebec, Canada
    Pediatr Crit Care Med 4:437-43. 2003
    ..To compare different methods for diagnosis of ventilator-associated pneumonia in intubated children...
  15. doi request reprint The pediatric multiple organ dysfunction syndrome
    Francois Proulx
    Division of Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Canada
    Pediatr Crit Care Med 10:12-22. 2009
    ..To review the epidemiology of pediatric multiple organ dysfunction syndrome (MODS) and summarize current concepts regarding the pathophysiology of shock, organ dysfunction, and nosocomial infections in this population...
  16. pmc Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
    Oliver Karam
    Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
    Crit Care 14:R57. 2010
    ..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children...
  17. doi request reprint Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial
    Justine Rouette
    Pediatric Critical Care Unit, Sainte Justine Hospital, Universite de Montreal, Montreal, QC
    Ann Surg 251:421-7. 2010
    ....
  18. ncbi request reprint Diaphragm electrical activity during expiration in mechanically ventilated infants
    Guillaume Emeriaud
    Department of Pediatrics, Hopital Sainte Justine, Quebec, Canada, H3T 1C5
    Pediatr Res 59:705-10. 2006
    ..This could have potential implications on the management of PEEP in intubated infants...
  19. ncbi request reprint Acceptable respiratory physiologic limits for children during weaning from mechanical ventilation
    Miriam Santschi
    Pediatric Intensive Care Unit, Hopital Sainte Justine, Universite de Montreal, 3175 Chemin Cote Sainte Catherine, Montreal, Quebec, H3T 1C5, Canada
    Intensive Care Med 33:319-25. 2007
    ..The aim of this survey was to characterize the physiological limits considered appropriate during weaning from mechanical ventilation in children...
  20. ncbi request reprint Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study
    Dennis Bailey
    Service of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
    Pediatr Crit Care Med 8:29-35. 2007
    ..The aim of the study was to determine incidence rate, identify risk factors, and describe the clinical outcome of acute renal failure in the pediatric intensive care unit (PICU)...
  21. doi request reprint Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation
    Jessica S Fortin
    Unité des Biotechnologies et de Bioingénierie, CRCHUQ, Hopital Saint Francois d Assise, Quebec, QC, Canada
    Bioorg Med Chem Lett 18:3526-31. 2008
    ..In addition, the inhibition of Trx-1 nuclear localization also suggests the abrogation of an important chemoresistance mechanism towards a variety of chemotherapeutic agents...
  22. doi request reprint Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children
    Helen Trottier
    Department of Social and Preventive Medicine, University of Montreal, Sainte Justine Hospital Research Centre, Montreal, Canada
    Transfusion 52:2653-63. 2012
    ..The aim of this study was to analyze the incidence of posttransplant EBV infection and its association with administration of blood products in children receiving a hematopoietic stem cell (HSC) graft...
  23. ncbi request reprint Transfusion in pediatrics
    Lars Desmet
    Department of Pediatrics, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Crit Care Clin 20:299-311. 2004
    ..Other studies must be done on the epidemiology and determinants of RBC transfusion in PICUs, on prevention of transfusion, and on alternatives to RBC transfusion (eg, erythropoietin)...
  24. doi request reprint Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships
    Sebastien Fortin
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, CHUQ, Hopital Saint Francois d Assise, Quebec, QC, Canada
    Eur J Med Chem 46:5327-42. 2011
    ....
  25. pmc Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding site
    Sebastien Fortin
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C, H, U, Q, Hopital Saint Francois d Assise, Quebec, QC, G1L 3L5, Canada
    Biol Proced Online 12:113-7. 2010
    ..The occupancy of colchicine-binding site by pertinent antimitotics inhibits the formation of the EBI: β-tubulin adduct, resulting in an assay that allows the screening of new molecules targeting this binding site...
  26. doi request reprint Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trial
    Nancy Robitaille
    Service d hématologie oncologie, Centre de cancérologie Charles Bruneau, Departement de Pediatrie, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    Biol Blood Marrow Transplant 19:468-73. 2013
    ..No major imbalance between groups was seen with regard to risk factors for veno-occlusive disease. Therefore, maintaining the hemoglobin at higher levels should be avoided after hematopoietic stem cell transplantation...
  27. ncbi request reprint Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological study
    Ruth Armano
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
    Crit Care Med 33:2637-44. 2005
    ..To determine the incidence and to characterize the determinants of red blood cell transfusions in critically ill children...
  28. doi request reprint Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability
    Sebastien Fortin
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, Centre Hospitalier Universitaire de Quebec, Hopital Saint Francois d Assise, 10 rue de l Espinay, Quebec, Canada
    J Pharmacol Exp Ther 336:460-7. 2011
    ....
  29. doi request reprint Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum
    Douglas D Fraser
    Division of Critical Care Medicine, Department of Pediatrics, University of Western Ontario, London, ON, Canada
    Pediatr Crit Care Med 12:319-24. 2011
    ....
  30. doi request reprint Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells
    Oliver Karam
    Pediatric Critical Care Unit, The Division of Hematology Oncology, The Department of Biochemistry, Sainte Justine Hospital and Université de Montréal, Montreal, Canada
    Transfusion 49:2326-34. 2009
    ..This study aims to quantify in vitro T-cell activation and cytokine release by white blood cells, after incubation with supernatants from leukoreduced RBCs...
  31. pmc Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescents
    Josee Dubois
    Department of Radiology, Centre hospitalier universitaire Sainte Justine, Montreal, Que
    CMAJ 177:1185-90. 2007
    ..We sought to determine the incidence and characterize risk factors of deep vein thrombosis associated with peripherally inserted central catheters in a pediatric population...
  32. ncbi request reprint Acute transfusion reactions in the pediatric intensive care unit
    France Gauvin
    Intensive Care Unit, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Transfusion 46:1899-908. 2006
    ..This study was undertaken to determine the incidence, type, imputability, and severity of ATRs observed in a tertiary care pediatric intensive care unit (PICU)...
  33. doi request reprint Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial
    Philippe A Jouvet
    Pediatric ICU, Soins intensifs pédiatriques, Hopital Sainte Justine, 3175 Chemin Cote Sainte Catherine, Montreal, QC, H3T 1C5, Canada
    Intensive Care Med 39:919-25. 2013
    ..Duration of weaning from mechanical ventilation is decreased with the use of written protocols in adults. In children, the use of written protocols has not had such an impact...
  34. ncbi request reprint The moral experience of parents regarding life-support decisions for their critically-ill children: a preliminary study in France
    Franco A Carnevale
    Montreal Children s Hospital, McGill University Health Centre, Montreal, Canada
    J Child Health Care 10:69-82. 2006
    ..These findings raise important issues for clinical practice and further research in France...
  35. doi request reprint Risk factors associated with increased length of mechanical ventilation in children
    Valérie Payen
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
    Pediatr Crit Care Med 13:152-7. 2012
    ..Invasive mechanical ventilation, if prolonged, may lead to high morbidity and mortality...
  36. doi request reprint Critical illness in children with influenza A/pH1N1 2009 infection in Canada
    Philippe Jouvet
    Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
    Pediatr Crit Care Med 11:603-9. 2010
    ..To describe characteristics, treatment, and outcomes of critically ill children with influenza A/pandemic influenza A virus (pH1N1) infection in Canada...
  37. ncbi request reprint Prolonged neural expiratory time induced by mechanical ventilation in infants
    Jennifer Beck
    Pediatric Intensive Care Unit, Department of Pediatrics and Hôpital Sainte Justine Research Center, Universite de Montreal, Quebec, Canada
    Pediatr Res 55:747-54. 2004
    ..Infant-ventilator asynchrony (both inspiratory and expiratory asynchrony) was present in every mandatory breath and constituted 53.4 +/- 26.2% of the total breath duration...
  38. ncbi request reprint New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia
    Alexandre Patenaude
    Unité de Biotechnologie et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Universite Laval, Quebec, Canada
    Cancer Res 67:2306-16. 2007
    ..The role of mitochondria in these mechanisms and the potential of N-betaTAC as a new therapeutic approach for targeting hypoxia-resistant cells are discussed...
  39. ncbi request reprint Reproducibility of blind protected bronchoalveolar lavage in mechanically ventilated children
    France Gauvin
    Division of Pediatric Intensive Care, Department of Pediatrics, Sainte Justine Hospital, Quebec, Canada
    Am J Respir Crit Care Med 165:1618-23. 2002
    ..Overall, blind protected BAL is a reproducible test in mechanically ventilated children, is easily feasible, and is usually well tolerated...
  40. ncbi request reprint Evaluation of the pediatric risk of admission score in a pediatric emergency department
    Jocelyn Gravel
    Division of Emergency Medicine, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Ann Emerg Med 41:630-8. 2003
    ..We sought to evaluate prospectively the predictive value of the PRISA score with respect to the risk for hospitalization in a pediatric ED...
  41. ncbi request reprint Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy
    Macha Bourdages
    Department of Pediatrics, Division of Pediatric Intensive Care Medicine, Centre Mère Enfant du CHUQ, Universite Laval, Quebec, Canada
    Pediatr Crit Care Med 11:408-14. 2010
    ....
  42. doi request reprint Developmental outcome after a single episode of status epilepticus
    Hélène Roy
    University Hospital Mother Child Sainte Justine Hospital, Montreal, QC, Canada
    Epilepsy Behav 21:430-6. 2011
    ..A single episode of SE can interfere with psychomotor and cognitive development in children without previous developmental delay, and it seems that the functions that are emerging at the time of insult are most vulnerable...
  43. ncbi request reprint Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study
    Stephane Leteurtre
    Paediatric Intensive Care Unit, Jeanne de Flandre University Hospital, Lille, France
    Lancet 362:192-7. 2003
    ..We aimed to validate the paediatric logistic organ dysfunction (PELOD) score and estimate its validity when recorded daily (dPELOD)...
  44. ncbi request reprint Bronchiolitis: what's next?
    Anne Marie Guerguerian
    Pediatr Crit Care Med 5:498-500. 2004
  45. ncbi request reprint Paediatric logistic organ dysfunction (PELOD) score
    Stephane Leteurtre
    Lancet 367:897; author reply 900-2. 2006
  46. ncbi request reprint Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children
    Francis Leclerc
    Service de Réanimation Pédiatrique, Hopital Jeanne de Flandre, 59037 Lille, France
    Am J Respir Crit Care Med 171:348-53. 2005
    ..We conclude that there is a cumulative accrual of the risk of death both with an increasing severity of organ dysfunction and an increasing severity of the diagnostic category of septic state...
  47. doi request reprint Anemia, blood loss, and blood transfusions in North American children in the intensive care unit
    Scot T Bateman
    Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Crit Care Med 178:26-33. 2008
    ..Minimizing exposure of children to blood products is desirable...
  48. ncbi request reprint What tests can help diagnose and estimate the severity of sepsis?
    Jacques Lacroix
    J Pediatr (Rio J) 83:297-8. 2007
  49. ncbi request reprint Noninvasive therapy with helium-oxygen for severe bronchiolitis
    Jean Michel Liet
    Service de Réanimation Pédiatrique, Centre Hospitalier Universitaire de Nantes, Nantes, France
    J Pediatr 147:812-7. 2005
    ..To determine whether noninvasive therapy using a helium-oxygen mixture reduces the use of positive-pressure ventilation in the treatment of respiratory failure caused by severe bronchiolitis...
  50. ncbi request reprint Erythropoietin for critically ill children
    Jacques Lacroix
    Pediatr Crit Care Med 4:123-4. 2003
  51. ncbi request reprint Erthropoietin in PICU: Is it appropriate therapy?
    Marisa Tucci
    Pediatr Crit Care Med 7:607-8. 2006
  52. ncbi request reprint Habit and the hub
    Jacques Lacroix
    Crit Care Med 31:1583-4. 2003
  53. ncbi request reprint PICU mortality: is it better 9 to 5?
    Marisa Tucci
    Pediatr Crit Care Med 6:608-9. 2005
  54. ncbi request reprint When the brain is injured, the body suffers
    Jacques Lacroix
    Crit Care Med 33:697-8. 2005
  55. ncbi request reprint Acute lung injury: is volume the question?
    Philippe Jouvet
    Pediatr Crit Care Med 8:397-8. 2007