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Genomes and GenesSpecies | Jacques LacroixSummaryCountry: Canada Publications
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Publications
Severity of illness and organ dysfunction scoring in childrenJacques Lacroix
Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
Pediatr Crit Care Med 6:S126-34. 2005..To describe predictive and descriptive general scores that can be used to estimate the severity of illness in critically ill children...
Red blood cell transfusion: decision making in pediatric intensive care unitsJacques Lacroix
Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Quebec, Canada
Semin Perinatol 36:225-31. 2012....
Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort studyChristina Katsios
Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
Crit Care 15:R263. 2011..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...- Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised childrenChristopher S Parshuram
Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Crit Care 15:R184. 2011..The objective of this study was to validate the Bedside PEWS score in a large patient population at multiple hospitals... - Transfusion strategies for patients in pediatric intensive care unitsJacques Lacroix
Universite de Montreal, Montreal, Canada
N Engl J Med 356:1609-19. 2007..We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of multiple-organ dysfunction... - The Age of Blood Evaluation (ABLE) randomized controlled trial: study designJacques Lacroix
Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
Transfus Med Rev 25:197-205. 2011.... - Parental involvement in treatment decisions regarding their critically ill child: a comparative study of France and QuebecFranco A Carnevale
Montreal Children s Hospital, Montreal, Canada
Pediatr Crit Care Med 8:337-42. 2007..Anglo-American settings have adopted decision-making models where parents are regarded as responsible for such life-support decisions, while in France physicians are commonly considered the decision makers... - Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaksVanessa Turcotte
Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C H U Q, Hopital Saint Francois d Assise, Quebec, QC, G1L 3L5, Canada
J Med Chem 55:6194-208. 2012..These new compounds are members of a promising new class of anticancer agents... - Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patientsFrance Gauvin
Pediatric Critical Care and the Hematology Oncology Division, Sainte Justine Hospital and Université de Montréal, Montreal, Quebec, Canada
Transfusion 50:1902-13. 2010..The objective was to determine if there is an association between red blood cell (RBC) storage time and development of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children... - Red blood cell transfusion thresholds in pediatric patients with sepsisOliver Karam
Pediatric Critical Care Unit, Sainte Justine Hospital and Université de Montréal, Montreal, Canada
Pediatr Crit Care Med 12:512-8. 2011..We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on clinical outcome... - Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocationAlexandre Patenaude
Unité de Biotechnologie et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Universite Laval, Quebec, QC, Canada
Can J Physiol Pharmacol 88:1102-14. 2010..The importance of TRX1 and the dependence of the cytotoxicity of CEU-025 and CEU-027 on TRX1 intracellular localization are also discussed... - Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysisAriane Willems
Pediatric Intensive Care Unit, Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada
Crit Care Med 38:649-56. 2010..a liberal transfusion strategy on new or progressive multiple organ dysfunction syndrome in children post cardiac surgery. The optimal transfusion threshold after cardiac surgery in children is unknown... - Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocationJessica S Fortin
Unité des Biotechnologies et de Bioingénierie, CRCHUQ, Hopital Saint Francois d Assise, Quebec, QC, Canada
Bioorg Med Chem Lett 18:3526-31. 2008..In addition, the inhibition of Trx-1 nuclear localization also suggests the abrogation of an important chemoresistance mechanism towards a variety of chemotherapeutic agents... - The pediatric multiple organ dysfunction syndromeFrancois Proulx
Division of Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Canada
Pediatr Crit Care Med 10:12-22. 2009..To review the epidemiology of pediatric multiple organ dysfunction syndrome (MODS) and summarize current concepts regarding the pathophysiology of shock, organ dysfunction, and nosocomial infections in this population... - Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational studyOliver Karam
Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
Crit Care 14:R57. 2010..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children... - Acceptable respiratory physiologic limits for children during weaning from mechanical ventilationMiriam Santschi
Pediatric Intensive Care Unit, Hopital Sainte Justine, Universite de Montreal, 3175 Chemin Cote Sainte Catherine, Montreal, Quebec, H3T 1C5, Canada
Intensive Care Med 33:319-25. 2007..The aim of this survey was to characterize the physiological limits considered appropriate during weaning from mechanical ventilation in children... - Diaphragm electrical activity during expiration in mechanically ventilated infantsGuillaume Emeriaud
Department of Pediatrics, , Quebec, Canada, H3T 1C5
Pediatr Res 59:705-10. 2006..This could have potential implications on the management of PEEP in intubated infants... - Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trialJustine Rouette
Pediatric Critical Care Unit, Sainte Justine Hospital, Universite de Montreal, Montreal, QC
Ann Surg 251:421-7. 2010.... - Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological studyDennis Bailey
Service of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
Pediatr Crit Care Med 8:29-35. 2007..The aim of the study was to determine incidence rate, identify risk factors, and describe the clinical outcome of acute renal failure in the pediatric intensive care unit (PICU)... - Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in childrenHelen Trottier
Department of Social and Preventive Medicine, University of Montreal, Sainte Justine Hospital Research Centre, Montreal, Canada
Transfusion 52:2653-63. 2012..The aim of this study was to analyze the incidence of posttransplant EBV infection and its association with administration of blood products in children receiving a hematopoietic stem cell (HSC) graft... - Transfusion in pediatricsLars Desmet
Department of Pediatrics, , , Quebec, Canada
Crit Care Clin 20:299-311. 2004..Other studies must be done on the epidemiology and determinants of RBC transfusion in PICUs, on prevention of transfusion, and on alternatives to RBC transfusion (eg, erythropoietin)... - Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationshipsSebastien Fortin
Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, CHUQ, Hopital Saint Francois d Assise, Quebec, QC, Canada
Eur J Med Chem 46:5327-42. 2011.... - Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methodsFrance Gauvin
, Montreal, Quebec, Canada
Pediatr Crit Care Med 4:437-43. 2003..Further studies should evaluate the validity of all these methods according to the gold standard (autopsy)... - Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding siteSebastien Fortin
Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C, H, U, Q, Hopital Saint Francois d Assise, Quebec, QC, G1L 3L5, Canada
Biol Proced Online 12:113-7. 2010..The occupancy of colchicine-binding site by pertinent antimitotics inhibits the formation of the EBI: β-tubulin adduct, resulting in an assay that allows the screening of new molecules targeting this binding site... - Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serumDouglas D Fraser
Division of Critical Care Medicine, Department of Pediatrics, University of Western Ontario, London, ON, Canada
Pediatr Crit Care Med 12:319-24. 2011.... - Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stabilitySebastien Fortin
Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, Centre Hospitalier Universitaire de Quebec, Hopital Saint Francois d Assise, 10 rue de l Espinay, Quebec, Canada
J Pharmacol Exp Ther 336:460-7. 2011.... - Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological studyRuth Armano
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, , , Canada
Crit Care Med 33:2637-44. 2005..Presence of anemia, cardiac disease, severe critical illness, and multiple organ dysfunction syndrome are the most significant determinants of red blood cell transfusions in PICU... - Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cellsOliver Karam
Pediatric Critical Care Unit, The Division of Hematology Oncology, The Department of Biochemistry, Sainte Justine Hospital and Université de Montréal, Montreal, Canada
Transfusion 49:2326-34. 2009..This study aims to quantify in vitro T-cell activation and cytokine release by white blood cells, after incubation with supernatants from leukoreduced RBCs... - Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescentsJosee Dubois
Department of Radiology, Centre hospitalier universitaire Sainte Justine, Montreal, Que
CMAJ 177:1185-90. 2007..We sought to determine the incidence and characterize risk factors of deep vein thrombosis associated with peripherally inserted central catheters in a pediatric population... - Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trialPhilippe A Jouvet
Pediatric ICU, Soins intensifs pédiatriques, Hopital Sainte Justine, 3175 Chemin Cote Sainte Catherine, Montreal, QC, H3T 1C5, Canada
Intensive Care Med 39:919-25. 2013..Duration of weaning from mechanical ventilation is decreased with the use of written protocols in adults. In children, the use of written protocols has not had such an impact... - The moral experience of parents regarding life-support decisions for their critically-ill children: a preliminary study in FranceFranco A Carnevale
Montreal Children s Hospital, McGill University Health Centre, Montreal, Canada
J Child Health Care 10:69-82. 2006..These findings raise important issues for clinical practice and further research in France... - Risk factors associated with increased length of mechanical ventilation in childrenValérie Payen
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte Justine Hospital, Universite de Montreal, Montreal, Canada
Pediatr Crit Care Med 13:152-7. 2012..Invasive mechanical ventilation, if prolonged, may lead to high morbidity and mortality... - Critical illness in children with influenza A/pH1N1 2009 infection in CanadaPhilippe Jouvet
Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
Pediatr Crit Care Med 11:603-9. 2010..To describe characteristics, treatment, and outcomes of critically ill children with influenza A/pandemic influenza A virus (pH1N1) infection in Canada... - Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trialNancy Robitaille
Service d hématologie oncologie, Centre de cancérologie Charles Bruneau, Departement de Pediatrie, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
Biol Blood Marrow Transplant 19:468-73. 2013..No major imbalance between groups was seen with regard to risk factors for veno-occlusive disease. Therefore, maintaining the hemoglobin at higher levels should be avoided after hematopoietic stem cell transplantation... - Acute transfusion reactions in the pediatric intensive care unitFrance Gauvin
Intensive Care Unit, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
Transfusion 46:1899-908. 2006..This study was undertaken to determine the incidence, type, imputability, and severity of ATRs observed in a tertiary care pediatric intensive care unit (PICU)... - Prolonged neural expiratory time induced by mechanical ventilation in infantsJennifer Beck
Pediatric Intensive Care Unit, Department of Pediatrics and Hôpital Sainte Justine Research Center, Universite de Montreal, Quebec, Canada
Pediatr Res 55:747-54. 2004..Infant-ventilator asynchrony (both inspiratory and expiratory asynchrony) was present in every mandatory breath and constituted 53.4 +/- 26.2% of the total breath duration... - Developmental outcome after a single episode of status epilepticusHélène Roy
University Hospital Mother Child Sainte Justine Hospital, Montreal, QC, Canada
Epilepsy Behav 21:430-6. 2011..A single episode of SE can interfere with psychomotor and cognitive development in children without previous developmental delay, and it seems that the functions that are emerging at the time of insult are most vulnerable... - Reproducibility of blind protected bronchoalveolar lavage in mechanically ventilated childrenFrance Gauvin
Division of Pediatric Intensive Care, Department of Pediatrics, Sainte Justine Hospital, Quebec, Canada
Am J Respir Crit Care Med 165:1618-23. 2002..Overall, blind protected BAL is a reproducible test in mechanically ventilated children, is easily feasible, and is usually well tolerated... - Evaluation of the pediatric risk of admission score in a pediatric emergency departmentJocelyn Gravel
Division of Emergency Medicine, Department of Pediatrics, Sainte Justine Hospital, University of Montreal, Montreal, Quebec, Canada
Ann Emerg Med 41:630-8. 2003..We sought to evaluate prospectively the predictive value of the PRISA score with respect to the risk for hospitalization in a pediatric ED... - New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxiaAlexandre Patenaude
Unité de Biotechnologie et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Universite Laval, Quebec, Canada
Cancer Res 67:2306-16. 2007..The role of mitochondria in these mechanisms and the potential of N-betaTAC as a new therapeutic approach for targeting hypoxia-resistant cells are discussed... - Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapyMacha Bourdages
Department of Pediatrics, Division of Pediatric Intensive Care Medicine, Centre Mère Enfant du CHUQ, Universite Laval, Quebec, Canada
Pediatr Crit Care Med 11:408-14. 2010.... - Cumulative influence of organ dysfunctions and septic state on mortality of critically ill childrenFrancis Leclerc
Service de Réanimation Pédiatrique, Hopital Jeanne de Flandre, 59037 Lille, France
Am J Respir Crit Care Med 171:348-53. 2005..We conclude that there is a cumulative accrual of the risk of death both with an increasing severity of organ dysfunction and an increasing severity of the diagnostic category of septic state... - Bronchiolitis: what's next?Anne Marie Guerguerian
Pediatr Crit Care Med 5:498-500. 2004 - Anemia, blood loss, and blood transfusions in North American children in the intensive care unitScot T Bateman
Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
Am J Respir Crit Care Med 178:26-33. 2008..Minimizing exposure of children to blood products is desirable... - Paediatric logistic organ dysfunction (PELOD) scoreStephane Leteurtre
Lancet 367:897; author reply 900-2. 2006 - Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre studyStephane Leteurtre
Paediatric Intensive Care Unit, Jeanne de Flandre University Hospital, Lille, France
Lancet 362:192-7. 2003..We aimed to validate the paediatric logistic organ dysfunction (PELOD) score and estimate its validity when recorded daily (dPELOD)... - Erythropoietin for critically ill childrenJacques Lacroix
Pediatr Crit Care Med 4:123-4. 2003 - PICU mortality: is it better 9 to 5?Marisa Tucci
Pediatr Crit Care Med 6:608-9. 2005 - Habit and the hubJacques Lacroix
Crit Care Med 31:1583-4. 2003 - When the brain is injured, the body suffersJacques Lacroix
Crit Care Med 33:697-8. 2005 - What tests can help diagnose and estimate the severity of sepsis?Jacques Lacroix
J Pediatr (Rio J) 83:297-8. 2007 - Erthropoietin in PICU: Is it appropriate therapy?Marisa Tucci
Pediatr Crit Care Med 7:607-8. 2006 - Acute lung injury: is volume the question?Philippe Jouvet
Pediatr Crit Care Med 8:397-8. 2007 - Noninvasive therapy with helium-oxygen for severe bronchiolitisJean Michel Liet
Service de Réanimation Pédiatrique, Centre Hospitalier Universitaire de Nantes, Nantes, France
J Pediatr 147:812-7. 2005..To determine whether noninvasive therapy using a helium-oxygen mixture reduces the use of positive-pressure ventilation in the treatment of respiratory failure caused by severe bronchiolitis...