Y Lacourciere

Summary

Country: Canada

Publications

  1. doi Telmisartan or valsartan alone or in combination with hydrochlorothiazide: a review
    Yves Lacourciere
    Hypertension Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    Clin Exp Hypertens 35:50-60. 2013
  2. pmc Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
  3. ncbi A multicenter, 14-week study of telmisartan and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure monitoring
    Yves Lacourciere
    Hypertension Research Unit, CHUL, Centre Hospitalier Universitaire de Quebec, 2705 boulevard Laurier S 135, Sainte Foy, Quebec, QC G1V 4G2, Canada
    Am J Hypertens 19:104-12. 2006
  4. ncbi Antihypertensive efficacy and tolerability of two fixed-dose combinations of valsartan and hydrochlorothiazide compared with valsartan monotherapy in patients with stage 2 or 3 systolic hypertension: an 8-week, randomized, double-blind, parallel-group tri
    Yves Lacourciere
    Hypertension Research Unit, Centre Hospitalier de l Université Laval CHUQ, Sainte Foy, Quebec, Canada
    Clin Ther 27:1013-21. 2005
  5. ncbi Sustained antihypertensive activity of telmisartan compared with valsartan
    Yves Lacourciere
    Hypertension Research Unit, Centre Hospitalier l Université de Quebec, Ste Foy, Quebec, Canada
    Blood Press Monit 9:203-10. 2004
  6. ncbi Comparison of a fixed-dose combination of 40 mg telmisartan plus 12.5 mg hydrochlorothiazide with 40 mg telmisartan in the control of mild to moderate hypertension
    Yves Lacourciere
    Hypertension Research Unit, Center Hospitalier Universitaire de Québec, Quebec
    Am J Ther 9:111-7. 2002
  7. ncbi A new fixed-dose combination for added blood pressure control: telmisartan plus hydrochlorothiazide
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Int Med Res 30:366-79. 2002
  8. ncbi Impact of Levovist ultrasonographic contrast agent on the diagnosis and management of hypertensive patients with suspected renal artery stenosis: a Canadian multicentre pilot study
    Yves Lacourciere
    Centre hospitalier de l Université du Québec
    Can Assoc Radiol J 53:219-27. 2002
  9. ncbi Effects of perindopril on elastic and structural properties of large arteries in essential hypertension
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 20:795-9. 2004
  10. ncbi Noninvasive detection of silent coronary artery disease in patients with essential hypertension, alone or associated with type 2 diabetes mellitus, using dipyridamole stress 99mtechnetium-sestamibi myocardial perfusion imaging
    Yves Lacourciere
    Hypertension, Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 22:16A-21A. 2006

Detail Information

Publications38

  1. doi Telmisartan or valsartan alone or in combination with hydrochlorothiazide: a review
    Yves Lacourciere
    Hypertension Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    Clin Exp Hypertens 35:50-60. 2013
    ..These findings suggest that pharmacologic differences between telmisartan and valsartan may translate into clinically relevant differences between the two drugs in the management of hypertension...
  2. pmc Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
    ....
  3. ncbi A multicenter, 14-week study of telmisartan and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure monitoring
    Yves Lacourciere
    Hypertension Research Unit, CHUL, Centre Hospitalier Universitaire de Quebec, 2705 boulevard Laurier S 135, Sainte Foy, Quebec, QC G1V 4G2, Canada
    Am J Hypertens 19:104-12. 2006
    ....
  4. ncbi Antihypertensive efficacy and tolerability of two fixed-dose combinations of valsartan and hydrochlorothiazide compared with valsartan monotherapy in patients with stage 2 or 3 systolic hypertension: an 8-week, randomized, double-blind, parallel-group tri
    Yves Lacourciere
    Hypertension Research Unit, Centre Hospitalier de l Université Laval CHUQ, Sainte Foy, Quebec, Canada
    Clin Ther 27:1013-21. 2005
    ..A currently recommended combination is a diuretic added to an angiotensin-receptor blocker...
  5. ncbi Sustained antihypertensive activity of telmisartan compared with valsartan
    Yves Lacourciere
    Hypertension Research Unit, Centre Hospitalier l Université de Quebec, Ste Foy, Quebec, Canada
    Blood Press Monit 9:203-10. 2004
    ..The efficacies of the long half-life telmisartan compared with shorter half-life valsartan in the last 6 h of the dosing interval following active treatment and during 24 h after a missed dose were compared...
  6. ncbi Comparison of a fixed-dose combination of 40 mg telmisartan plus 12.5 mg hydrochlorothiazide with 40 mg telmisartan in the control of mild to moderate hypertension
    Yves Lacourciere
    Hypertension Research Unit, Center Hospitalier Universitaire de Québec, Quebec
    Am J Ther 9:111-7. 2002
    ..5 mg HCTZ is clinically and statistically superior to 40 mg telmisartan in patients with mild to moderate hypertension failing to respond to 40 mg telmisartan alone...
  7. ncbi A new fixed-dose combination for added blood pressure control: telmisartan plus hydrochlorothiazide
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Int Med Res 30:366-79. 2002
    ....
  8. ncbi Impact of Levovist ultrasonographic contrast agent on the diagnosis and management of hypertensive patients with suspected renal artery stenosis: a Canadian multicentre pilot study
    Yves Lacourciere
    Centre hospitalier de l Université du Québec
    Can Assoc Radiol J 53:219-27. 2002
    ....
  9. ncbi Effects of perindopril on elastic and structural properties of large arteries in essential hypertension
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 20:795-9. 2004
    ..It decreases the stiffness of the larger arteries; questions remain as to the mechanisms involved and whether it is blood pressure (BP) control-dependent...
  10. ncbi Noninvasive detection of silent coronary artery disease in patients with essential hypertension, alone or associated with type 2 diabetes mellitus, using dipyridamole stress 99mtechnetium-sestamibi myocardial perfusion imaging
    Yves Lacourciere
    Hypertension, Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 22:16A-21A. 2006
    ..Early diagnosis of CAD and identification of high-risk subgroups, followed by appropriate therapy, may therefore enhance survival...
  11. ncbi Antihypertensive effects of two fixed-dose combinations of losartan and hydrochlorothiazide versus hydrochlorothiazide monotherapy in subjects with ambulatory systolic hypertension
    Yves Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Ste Foy, Quebec, Canada
    Am J Hypertens 16:1036-42. 2003
    ..The aim of this study was to compare the effects of these treatment approaches in patients with ambulatory systolic hypertension...
  12. pmc 24-Hour ambulatory blood pressure control with triple-therapy amlodipine, valsartan and hydrochlorothiazide in patients with moderate to severe hypertension
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Hum Hypertens 25:615-22. 2011
    ..Once-daily treatment with amlodipine/valsartan/hydrochlorothiazide (10/320/25 mg) reduces ABP to a significantly greater extent than component-based dual therapy and maintains its effectiveness over the entire 24-h dosing period...
  13. pmc Increasing the doses of both diuretics and angiotensin receptor blockers is beneficial in subjects with uncontrolled systolic hypertension
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Quebec, Canada
    Can J Cardiol 26:313-9. 2010
    ..Current clinical practice usually limits the daily dose of HCTZ to 25 mg. This often leads to the necessity of using additional antihypertensive agents to control BP in a high proportion of patients...
  14. doi Valsartan plus hydrochlorothiazide for first-line therapy in hypertension
    Yves Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Quebec, QC, G1V 4G2, Canada
    Expert Rev Cardiovasc Ther 7:1491-501. 2009
    ..The focus of this article is on those randomized, double-blind trials in which this combination was administered as first-line therapy in patients with essential hypertension...
  15. doi Effects of force-titrated valsartan/hydrochlorothiazide versus amlodipine/hydrochlorothiazide on ambulatory blood pressure in patients with stage 2 hypertension: the EVALUATE study
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Sainte Foy, Quebec, Canada
    Blood Press Monit 14:112-20. 2009
    ..Previous studies using the combination of angiotensin-receptor blockers and hydrochlorothiazide (HCTZ) have shown superior ambulatory blood pressure (ABP) reduction in study participants with stage 2 hypertension compared with monotherapy...
  16. ncbi Identifying which treated hypertensive patients without known coronary artery disease should be tested for the presence of myocardial ischemia by perfusion imaging
    Yves Lacourciere
    Hypertension Unit, Centre hospitalier de l Universite Laval, Quebec, Canada
    J Clin Hypertens (Greenwich) 9:921-8. 2007
    ..These study data should be clinically helpful in selecting hypertensive patients who are the most suitable candidates to screen for the presence of CAD...
  17. pmc Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension
    Yves Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Sainte Foy, Quebec, Canada
    Can J Cardiol 23:377-82. 2007
    ....
  18. ncbi Antihypertensive effects of amlodipine and hydrochlorothiazide in elderly patients with ambulatory hypertension
    Y Lacourciere
    Hypertension Research Unit, Le Centre Hospitalier de l Université Laval, Sainte Foy, Quebec, Canada
    Am J Hypertens 8:1154-9. 1995
    ..Consequently, the results of the present study suggest that the use of HCTZ in doses of up to 25 mg daily is inadequate for ambulatory BP control in the elderly despite official recommendations...
  19. ncbi The antihypertensive efficacy of the novel calcium antagonist mibefradil in comparison with nifedipine GITS in moderate to severe hypertensives with ambulatory hypertension
    Y Lacourciere
    Hypertension Unit, Le Centre Hospitalier de l Université Laval, Saint Foy, Quebec, Canada
    Am J Hypertens 10:189-96. 1997
    ....
  20. ncbi Efficacy and tolerability of fixed-dose combinations of telmisartan plus HCTZ compared with losartan plus HCTZ in patients with essential hypertension
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    Int J Clin Pract 57:273-9. 2003
    ..5 mmHg and 3.4 mmHg, respectively, during the last six hours of the dosing interval (p < 0.05), and of 2.1 mmHg and 3.4 mmHg, respectively, over the entire 24-hour dosing interval (p < 0.05). All treatments were well tolerated...
  21. ncbi Efficacy and tolerability of a fixed-dose combination of telmisartan plus hydrochlorothiazide in patients uncontrolled with telmisartan monotherapy
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Hum Hypertens 15:763-70. 2001
    ..Our results indicate that a telmisartan 80 mg/HCTZ 12.5 mg fixed-dose combination confers significant additional BP reductions compared with continuation of telmisartan monotherapy in non-responders...
  22. ncbi Antihypertensive and hemodynamic effects of calcium channel blockade with isradipine after acute exercise
    J Cleroux
    Hypertension Research Unit, CHUL Research Center, Canada
    Am J Hypertens 5:84-7. 1992
    ..Thus, isradipine exerts an additional antihypertensive effect during the postexercise period, which appears to be mediated by a further reduction of total peripheral resistance...
  23. ncbi Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients
    L Poirier
    Hypertension Unit, Centre hospitalier universitaire de Québec Pavillon CHUL, Universite Laval, Canada
    J Hypertens 19:1429-35. 2001
    ..To compare the effects of nebivolol and atenolol in 25 ambulatory hypertensive patients with impaired glucose tolerance...
  24. ncbi A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/Lo
    Y Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Quebec, Canada
    Am J Hypertens 12:1181-7. 1999
    ..The differences observed between both agents are most likely attributable to a tighter binding to, and a slower dissociation from, the receptor binding site with candesartan cilexetil...
  25. ncbi A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial of four doses of tasosartan in patients with essential hypertension. Tasosartan Investigator's Group
    Y Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Ste Foy, Quebec, Canada
    Am J Hypertens 11:454-61. 1998
    ..Tasosartan was generally well tolerated...
  26. ncbi Clinical efficacy of force titrated doses of diltiazem extended-release. A placebo controlled study
    Y Lacourciere
    Hypertension Research Unit, Le Centre Hospitalier de l Université Laval, Quebec, Canada
    Am J Hypertens 8:282-6. 1995
    ..The dose escalation forced titration study design appears to be a valuable tool in obtaining rigorous dose-response data of new antihypertensive agents...
  27. ncbi A comparative review of the efficacy of antihypertensive agents on 24 h ambulatory blood pressure
    Y Lacourciere
    Centre hospitalier de l Universite Laval, 2705 Boulevard Laurier S 120, Sainte Foy, Quebec G1V 4G2, Canada
    Can J Cardiol 16:1155-66. 2000
    ..However, most of the published reviews have not focused on the 24 h efficacy of conventional and new antihypertensive agents as measured by ABP monitoring...
  28. ncbi Comparative effects of quinapril, atenolol, and verapamil on blood pressure and forearm hemodynamics during handgrip exercise
    J Cleroux
    Hypertension Research Unit, CHUL Research Center, Universite Laval, Quebec, Canada
    Am J Hypertens 7:566-70. 1994
    ..It is concluded that quinapril and verapamil reduce the pressor response during isometric exercise by quantitatively different effects on the vasoconstrictor response in, as well as outside of, skeletal muscles...
  29. ncbi Treatment of ambulatory hypertensives with nebivolol or hydrochlorothiazide alone and in combination. A randomized, double-blind, placebo-controlled, factorial-design trial
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universite Laval, Quebec, Canada
    Am J Hypertens 7:137-45. 1994
    ..The results provided further evidence for the use of ambulatory blood pressure monitoring and factorial designs when investigating new antihypertensive agents...
  30. ncbi Beneficial effects of the calcium antagonist isradipine on apolipoproteins in hypertensive patients
    Y Lacourciere
    Unit of Hypertension Research, Le Centre Hospitalier de l Université Laval, Sainte Foy, Quebec, Canada
    Am J Hypertens 4:181S-184S. 1991
    ..These data show that the levels of plasma apolipoprotein A-I, a strong predictor of coronary heart disease, are favorably affected by isradipine of either formulation. The mechanisms of this effect remain to be elucidated...
  31. pmc Effects of aerobic exercise training and irbesartan on blood pressure and heart rate variability in patients with chronic obstructive pulmonary disease
    Karine Marquis
    Centre de Recherche de l Hopital Laval, Institut universitaire de cardiologie et de pneumoloigie de L Université Laval, Quebec, Canada
    Can Respir J 15:355-60. 2008
    ....
  32. ncbi Influence of zofenopril and low doses of hydrochlorothiazide on plasma lipoproteins in patients with mild to moderate essential hypertension
    Y Lacourciere
    Hypertension Unit, CHUL, Quebec, Canada
    Am J Hypertens 2:861-4. 1989
    ..Thus, ZOF and small doses of HCT do not cause deleterious effects in lipoprotein composition as reported in previous studies with higher dosage...
  33. ncbi Effect of captopril injection in patients with moderate to severe hypertension
    Y Lacourciere
    Department of Medicine, Universite Laval, Quebec, Canada
    Am J Hypertens 3:769-74. 1990
    ..Short-term intravenous administration seems to predict the response to chronic oral captopril therapy...
  34. ncbi Comparison of fixed-dose combinations of telmisartan/hydrochlorothiazide 40/12.5 mg and 80/12.5 mg and a fixed-dose combination of losartan/hydrochlorothiazide 50/12.5 mg in mild to moderate essential hypertension: pooled analysis of two multicenter, pros
    Yves Lacourciere
    Unité d hypertension, Centre hospitalier de l Universite Laval, Universite Laval, 2705 Boulevard Laurier S 120, Sainte Foy, Quebec G1V 4G2, Quebec, Canada
    Clin Ther 27:1795-805. 2005
    ..Thus, control of BP at this time of day, using oral fixed-dose combinations (FDCs) as required, is important in reducing cardiovascular risk in hypertensive patients...
  35. ncbi A comparison of the efficacy and duration of action of telmisartan, amlodipine and ramipril in patients with confirmed ambulatory hypertension
    Luc Poirier
    Unité d hypertension, Centre hospitalier de l Universite Laval, Universite Laval, 2705 Boulevard Laurier S 120 A, Sainte Foy, Quebec, Canada G1V 4G2
    Blood Press Monit 9:231-6. 2004
    ..The aim of the study was to compare the antihypertensive effects and the duration of action of telmisartan, amlodipine and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure (ABP) monitoring...
  36. pmc Comparative effects of dilevalol and atenolol on lung function and airway response to methacholine in hypertensive subjects
    L P Boulet
    Unité de Recherche en Pneumologie, Hôpital and Université Laval, Sainte Foy, Quebec, Canada
    Br J Clin Pharmacol 29:725-31. 1990
    ..6. Airflow obstruction may develop in normal subjects on dilevalol. Methacholine challenges are safe in subjects with uncomplicated hypertension...
  37. pmc The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension
    Jean Lefebvre
    Hypertension Research Unit, CHUL Research Center, Faculty of Pharmacy, Laval University, Quebec, Canada
    Br J Clin Pharmacol 63:575-82. 2007
    ..The metabolism of the third-generation beta(1)-receptor antagonist nebivolol has been shown to be highly dependent on cytochrome P450 2D6 enzymatic activity in preclinical studies...
  38. ncbi Does QTc interval predict the response to beta-blockers and calcium channel blockers in hypertensives?
    Maxime Lamarre-Cliche
    Department of Clinical Pharmacology, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, QC, Canada
    Heart Dis 5:244-52. 2003
    ..In this study, QTc interval length, pretreatment heart rate, and heart rate change with therapy were not good predictors of the blood pressure response to beta1-selective beta-blockers or DHPCCB in hypertensive subjects...