Jean Claude Lacaille
Aguilar Valles A, Matta Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille J, et al
. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J Neurosci. 2015;35:11125-32 pubmed publisher
..e., fragile X syndrome). These findings support the use of group I mGluR antagonists as a potential therapy that extends to autism models involving exacerbated mRNA translation initiation. ..
Matos M, Bosson A, Riebe I, Reynell C, Vallée J, Laplante I, et al
. Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells. Nat Commun. 2018;9:4254 pubmed publisher
..Our findings uncover functional interactions between a specific subpopulation of interneurons, astrocytes and pyramidal cells, involved in positive feedback autoregulation of dendritic inhibition of pyramidal cells. ..
Artinian J, Lacaille J. Disinhibition in learning and memory circuits: New vistas for somatostatin interneurons and long-term synaptic plasticity. Brain Res Bull. 2018;141:20-26 pubmed publisher
..Such regulation of network metaplasticity may be important for hippocampal-dependent learning and memory. ..
Riad M, Kobert A, Descarries L, Boye S, Rompré P, Lacaille J. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. 2017;356:78-88 pubmed publisher
..Our findings support the hypothesis that changes in efficacy of serotonergic neurotransmission in this model of depression depends on both activity and density of cell surface-expressed SERT and 5-HT1A auto-receptors. ..