Genomes and Genes


Jean Claude Lacaille


Country: Canada


  1. Aguilar Valles A, Matta Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille J, et al. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J Neurosci. 2015;35:11125-32 pubmed publisher
    ..e., fragile X syndrome). These findings support the use of group I mGluR antagonists as a potential therapy that extends to autism models involving exacerbated mRNA translation initiation. ..
  2. Matos M, Bosson A, Riebe I, Reynell C, Vallée J, Laplante I, et al. Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells. Nat Commun. 2018;9:4254 pubmed publisher
    ..Our findings uncover functional interactions between a specific subpopulation of interneurons, astrocytes and pyramidal cells, involved in positive feedback autoregulation of dendritic inhibition of pyramidal cells. ..
  3. Artinian J, Lacaille J. Disinhibition in learning and memory circuits: New vistas for somatostatin interneurons and long-term synaptic plasticity. Brain Res Bull. 2018;141:20-26 pubmed publisher
    ..Such regulation of network metaplasticity may be important for hippocampal-dependent learning and memory. ..
  4. Riad M, Kobert A, Descarries L, Boye S, Rompré P, Lacaille J. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. 2017;356:78-88 pubmed publisher
    ..Our findings support the hypothesis that changes in efficacy of serotonergic neurotransmission in this model of depression depends on both activity and density of cell surface-expressed SERT and 5-HT1A auto-receptors. ..