K Krishnan

Summary

Country: Canada

Publications

  1. ncbi Physiologically-based pharmacokinetic and toxicokinetic models in cancer risk assessment
    Kannan Krishnan
    Groupe de Recherche en Toxicologie Humaine, Universite de Montreal, Canada
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 23:31-53. 2005
  2. pmc Modeling the Human Kinetic Adjustment Factor for Inhaled Volatile Organic Chemicals: Whole Population Approach versus Distinct Subpopulation Approach
    M Valcke
    Département de santé environnementale et de santé au travail, Universite de Montreal, Montreal, QC, Canada H3T 1A8
    J Toxicol 2012:404329. 2012
  3. pmc Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans
    Thomas Peyret
    Departement de sante environnementale et sante au travail, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    J Toxicol 2012:286079. 2012
  4. doi The use of exposure source allocation factor in the risk assessment of drinking-water contaminants
    Kannan Krishnan
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health B Crit Rev 16:39-51. 2013
  5. doi Approaches for evaluating the relevance of multiroute exposures in establishing guideline values for drinking water contaminants
    Kannan Krishnan
    GRIS DSEST, Universite de Montreal, Montreal, QC, Canada
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:300-16. 2008
  6. doi Toxicokinetics of p-tert-octylphenol in male and female Sprague-Dawley rats after intravenous, oral, or subcutaneous exposures
    G Hamelin
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec
    J Toxicol Environ Health A 72:541-50. 2009
  7. doi Evaluation of the impact of the exposure route on the human kinetic adjustment factor
    M Valcke
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    Regul Toxicol Pharmacol 59:258-69. 2011
  8. doi An assessment of the impact of physico-chemical and biochemical characteristics on the human kinetic adjustment factor for systemic toxicants
    M Valcke
    Departement de sante environnementale et sante au travail, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C3J7
    Toxicology 286:36-47. 2011
  9. ncbi Physiologically based modeling of p-tert-octylphenol kinetics following intravenous, oral or subcutaneous exposure in male and female Sprague-Dawley rats
    G Hamelin
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Appl Toxicol 30:437-49. 2010
  10. ncbi An integrated QSPR-PBPK modelling approach for in vitro-in vivo extrapolation of pharmacokinetics in rats
    E Kamgang
    Groupe de recherche interdisciplinaire en sante, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    SAR QSAR Environ Res 19:669-80. 2008

Collaborators

Detail Information

Publications38

  1. ncbi Physiologically-based pharmacokinetic and toxicokinetic models in cancer risk assessment
    Kannan Krishnan
    Groupe de Recherche en Toxicologie Humaine, Universite de Montreal, Canada
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 23:31-53. 2005
    ..Overall, the recent advances reviewed in this article point to the continued enhancement of the scientific basis and applicability of PBPK models in cancer risk assessment...
  2. pmc Modeling the Human Kinetic Adjustment Factor for Inhaled Volatile Organic Chemicals: Whole Population Approach versus Distinct Subpopulation Approach
    M Valcke
    Département de santé environnementale et de santé au travail, Universite de Montreal, Montreal, QC, Canada H3T 1A8
    J Toxicol 2012:404329. 2012
    ..6. Overall, this study evaluated for the first time the impact of underlying assumptions with respect to the interindividual variability considered (whole population or each subpopulation taken separately) when determining the HKAF...
  3. pmc Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans
    Thomas Peyret
    Departement de sante environnementale et sante au travail, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    J Toxicol 2012:286079. 2012
    ....
  4. doi The use of exposure source allocation factor in the risk assessment of drinking-water contaminants
    Kannan Krishnan
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health B Crit Rev 16:39-51. 2013
    ....
  5. doi Approaches for evaluating the relevance of multiroute exposures in establishing guideline values for drinking water contaminants
    Kannan Krishnan
    GRIS DSEST, Universite de Montreal, Montreal, QC, Canada
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:300-16. 2008
    ....
  6. doi Toxicokinetics of p-tert-octylphenol in male and female Sprague-Dawley rats after intravenous, oral, or subcutaneous exposures
    G Hamelin
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec
    J Toxicol Environ Health A 72:541-50. 2009
    ..Gender differences in tissue OP concentrations may contribute, in part, to gender differences in the toxicity of OP in rats. The fact that OP was found in all reproductive tissues confirms its potential for direct endocrine-like effects...
  7. doi Evaluation of the impact of the exposure route on the human kinetic adjustment factor
    M Valcke
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    Regul Toxicol Pharmacol 59:258-69. 2011
    ..Overall, this study has pointed out the dependency of the HKAF on the exposure route, dose metrics and subpopulation considered, as well as characteristics of the chemicals investigated...
  8. doi An assessment of the impact of physico-chemical and biochemical characteristics on the human kinetic adjustment factor for systemic toxicants
    M Valcke
    Departement de sante environnementale et sante au travail, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C3J7
    Toxicology 286:36-47. 2011
    ..Overall, this study showed the dependency of the HKAF on the dose metrics, chemical characteristics, metabolic pathways, and subpopulations considered...
  9. ncbi Physiologically based modeling of p-tert-octylphenol kinetics following intravenous, oral or subcutaneous exposure in male and female Sprague-Dawley rats
    G Hamelin
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Appl Toxicol 30:437-49. 2010
    ..77 x) in male than in female rats. Further studies are required to elucidate the mechanism underlying the gender differences and to evaluate whether that is also observed in humans...
  10. ncbi An integrated QSPR-PBPK modelling approach for in vitro-in vivo extrapolation of pharmacokinetics in rats
    E Kamgang
    Groupe de recherche interdisciplinaire en sante, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    SAR QSAR Environ Res 19:669-80. 2008
    ..The integrated QSPR-PBPK model developed in this study is a potentially useful tool for predicting in vivo kinetics and bioaccumulation of chemicals in rats under poor data situations...
  11. ncbi Determination of p-tert-octylphenol in blood and tissues by gas chromatography coupled with mass spectrometry
    G Hamelin
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Anal Toxicol 32:303-7. 2008
    ..This method was applied to the determination of unchanged OP in blood and tissues obtained from Sprague-Dawley rats after oral and IV OP administration...
  12. ncbi Blood:air partition coefficients of individual and mixtures of trihalomethanes
    M Beliveau
    Departement de sante environnementale et sante au travail, Faculte de Medecine, Universite de Montreal, PQ, Canada
    Chemosphere 44:377-81. 2001
    ..The results of this study suggest that an alteration of P(b:a) of the individual THMs is unlikely to occur at the blood concentrations of THMs observed during mixed exposures in rats...
  13. ncbi Quantitative structure-pharmacokinetic relationship modelling
    M O Fouchécourt
    De partement de santé environnementale et santé au travail, Faculte de Medecine, Universite de Montreal, PQ, Canada
    Sci Total Environ 274:125-35. 2001
    ..Integrated QSPR-PBPK modelling should facilitate the identification of chemicals of a family that possess desired properties of bioaccumulation and blood concentration profile in both test animals and humans...
  14. doi QSARs for PBPK modelling of environmental contaminants
    T Peyret
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Canada
    SAR QSAR Environ Res 22:129-69. 2011
    ....
  15. ncbi Physiologically based modeling of the inhalation pharmacokinetics of ethylbenzene in B6C3F1 mice
    A Nong
    Departement de sante environnementale et sante au travail, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health A 70:1838-48. 2007
    ..Overall, the PBPK model developed for the mouse adequately simulated the blood and tissue kinetics of EB by accounting for its high rate of clearance...
  16. ncbi The toxicokinetics of pyrene and its metabolites in rats
    C Viau
    Equipe de Recherche en Surveillance Biologique, Universite de Montreal, Station Centre Ville, Canada
    Toxicol Lett 108:201-7. 1999
    ....
  17. ncbi Molecular structure-based prediction of human abdominal skin permeability coefficients for several organic compounds
    P Poulin
    Groupe de Recherche en Toxicologie Humaine TOXHUM, Universite de Montreal, Canada
    J Toxicol Environ Health A 62:143-59. 2001
    ..The present study is the first initiative that permits prediction of the human Kp of organic compounds by using molecular structure information as the sole chemical-specific input in a mechanistic equation...
  18. ncbi Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans
    S Haddad
    Groupe de Recherche en Toxicologie Humaine (TOXHUM, , , Quebec, Canada
    J Toxicol Environ Health A 64:453-64. 2001
    ..The equations and data on body weight and organ weights presented in this article should be useful for constructing age-specific, physiologically based pharmacokinetic models for children...
  19. doi Quantitative property-property relationships for computing occupational exposure limits and vapour hazard ratios of organic solvents
    M Debia
    Departement de sante environnementale et sante au travail, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    SAR QSAR Environ Res 21:583-601. 2010
    ....
  20. doi Biomonitoring Equivalents for triclosan
    Kannan Krishnan
    Département deSanté Environnementale et Santé au Travail, Universite de Montreal, Montreal, QC, Canada
    Regul Toxicol Pharmacol 58:10-7. 2010
    ..3, 0.9, and 0.4 mg/L, respectively. These values may be used as screening tools for evaluation of population biomonitoring data for triclosan in a risk assessment context...
  21. doi Biomonitoring Equivalents for bisphenol A (BPA)
    Kannan Krishnan
    Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, QC, Canada
    Regul Toxicol Pharmacol 58:18-24. 2010
    ....
  22. ncbi Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children
    Karine Price
    Groupe de recherche en toxicologie humaine TOXHUM Faculté de médecine, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health A 66:417-33. 2003
    ..25. The PBPK model framework developed in this study should be useful for predicting the adult-children differences in internal dose of chemicals for risk assessment applications...
  23. ncbi Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene
    A Nong
    Occupational and Environmental Health, Universite de Montreal, Montreal, QC, Canada
    Toxicol Appl Pharmacol 214:78-87. 2006
    ....
  24. doi An integrated QSAR-PBPK modelling approach for predicting the inhalation toxicokinetics of mixtures of volatile organic chemicals in the rat
    K Price
    Departement de sante environnementale et sante au travail, Faculte de Medecine, Universite de Montreal, PQ, Canada
    SAR QSAR Environ Res 22:107-28. 2011
    ..Overall, the present study indicates the potential usefulness of the QSAR-PBPK modelling approach to provide first-cut evaluations of the kinetics of chemicals in mixtures of increasing complexity, on the basis of chemical structure...
  25. ncbi Physiologically based modeling of the accumulation in plasma and tissue lipids of a mixture of PCB congeners in female Sprague-Dawley rats
    Claude Emond
    Groupe de Recherche en Toxicologie Humaine TOXHUM, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health A 68:1393-412. 2005
    ..The physiologically based pharmacokinetic (PBPK) model developed in this study should be useful as a basis for interpretating blood or plasma lipid concentration data on PCBs collected during biomonitoring studies...
  26. ncbi Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat
    Annie St-Pierre
    TOXHUM Human Toxicology Research Group, Department of Occupational and Environmental Health, University of Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health A 66:2267-80. 2003
    ..7; BDCM, DBCM, and TBM: x3.9) and an increase in the Cmax of CHCl(3) (x1.9). Overall, these results indicate that, at the dose levels tested in this study, TCA alters the blood concentration profiles of THMs...
  27. ncbi Characterization of the metabolic interaction between trihalomethanes and chloroacetic acids using rat liver microsomes
    Annie St-Pierre
    TOXHUM Groupe de Recherche en Toxicologie Humaine, Departement de sante environnementale et sante au travail, Universite de Montreal, Montreal, Quebec, Canada
    J Toxicol Environ Health A 68:287-98. 2005
    ..As for DBCM, results suggest a more complex pattern of inhibition. These results suggest that CYP2E1 is involved in the metabolism of THMs as well as in the metabolic interaction between THMs and TCA...
  28. doi Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats
    Kannan Krishnan
    DSEST, Universite de Montreal, Montreal, Quebec, Canada
    J Appl Toxicol 29:629-37. 2009
    ..Overall, the rat PBPK model for RDX with its parameters adequately simulates the blood and plasma kinetic data, obtained following i.v. doses ranging from 0.77 to 5.5 mg kg(-1) as well as oral doses ranging from 0.2 to 100 mg kg(-1)...
  29. ncbi Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals
    Martin Beliveau
    Groupe de Recherche en Toxicologie Humaine TOXHUM, Universite de Montreal, Case Postale 6128, Succursale Centre Ville, Montreal, PQ, H3C 3J7, Canada
    Chem Res Toxicol 18:475-85. 2005
    ..This study has demonstrated that it is possible to extrapolate the pharmacokinetic behavior of chemicals from rats to humans on the basis of QSPRs and species specific physiological information...
  30. ncbi Deriving uncertainty factors for threshold chemical contaminants in drinking water
    Leonard Ritter
    Department of Environmental Biology, University of Guelph, Guelph, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 10:527-57. 2007
    ....
  31. pmc Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action
    Kenneth T Bogen
    Exponent Health and Environmental, 500 12th Street, Suite 220, Oakland, CA 94607, USA
    Regul Toxicol Pharmacol 51:S27-36. 2008
    ....
  32. doi Approaches for applications of physiologically based pharmacokinetic models in risk assessment
    Chad M Thompson
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
    J Toxicol Environ Health B Crit Rev 11:519-47. 2008
    ....
  33. doi Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop
    Judy S LaKind
    LaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD 21228, USA
    Regul Toxicol Pharmacol 51:S16-26. 2008
    ..Communication of BEs will require outreach, education, and development of communication materials specific to several audiences including the lay public and health care providers...
  34. ncbi Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment
    Rakesh Dixit
    Merck Research Laboratories, West Point, Pennsylvania, USA
    J Toxicol Environ Health B Crit Rev 6:1-40. 2003
    ..The utility of PB-TK models in risk assessment of methylene chloride, vinyl chloride, retinoic acid, dioxin, and inhaled organic esters is discussed...
  35. ncbi Evaluation of physiologically based pharmacokinetic models for use in risk assessment
    Weihsueh A Chiu
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, NW, Washington, DC 20460, USA
    J Appl Toxicol 27:218-37. 2007
    ..Finally, the predictive capacity and sensitivity, variability and uncertainty of the model are analysed so that the applicability of a model for risk assessment can be determined. Published in 2007 by John Wiley & Sons, Ltd...
  36. pmc Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures
    Kannan Krishnan
    Universit de Montréal, Montreal, Canada
    Environ Health Perspect 110:989-94. 2002
    ..The ability to predict the kinetics of chemicals in complex mixtures by accounting for binary interactions alone within a PBPK model is a significant step toward the development of interaction-based risk assessment for chemical mixtures...
  37. ncbi Two generation reproduction study of ethylbenzene by inhalation in Crl-CD rats
    Willem D Faber
    Victor, New York 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 77:10-21. 2006
    ..This study was conducted to evaluate the potential adverse effects of ethylbenzene (EB) on reproductive capability from whole-body inhalation exposure of F0 and F1 parental animals...
  38. doi Guidelines for the derivation of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop
    Sean M Hays
    Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
    Regul Toxicol Pharmacol 51:S4-15. 2008
    ..The findings from this Expert Panel Workshop on BE derivation are presented and provide a set of guidelines and considerations for use in BE derivation...