Hans Knecht

Summary

Country: Canada

Publications

  1. doi request reprint The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    H Knecht
    Département de Médicine, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Leukemia 23:565-73. 2009
  2. doi request reprint 3D Telomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres
    Hans Knecht
    Division of Haematology Oncology, CHUS University Hospital, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
    Lab Invest 90:611-9. 2010
  3. doi request reprint 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells
    Hans Knecht
    Division d Hématologie, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Anat 192:302-8. 2010
  4. doi request reprint 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis
    Hans Knecht
    Division of Haematology Oncology, Department of Medicine, CHUS, University of Sherbrooke, Sherbrooke, QC, Canada
    J Cell Physiol 226:859-67. 2011
  5. pmc 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
    Hans Knecht
    CHUS, Universite de Sherbrooke, Quebec, Canada
    BMC Cell Biol 11:99. 2010
  6. pmc Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, Canada
    Transl Oncol 5:269-77. 2012

Collaborators

Detail Information

Publications6

  1. doi request reprint The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    H Knecht
    Département de Médicine, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Leukemia 23:565-73. 2009
    ..Our findings allow a mechanistic 3D understanding of the transition of H to RS cells...
  2. doi request reprint 3D Telomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres
    Hans Knecht
    Division of Haematology Oncology, CHUS University Hospital, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
    Lab Invest 90:611-9. 2010
    ....
  3. doi request reprint 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells
    Hans Knecht
    Division d Hématologie, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Anat 192:302-8. 2010
    ..Our findings are consistent with the hypothesis that distinct 3D telomere changes and shelterin disruption represent a common pathogenetic denominator in the generation of Reed-Sternberg cells...
  4. doi request reprint 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis
    Hans Knecht
    Division of Haematology Oncology, Department of Medicine, CHUS, University of Sherbrooke, Sherbrooke, QC, Canada
    J Cell Physiol 226:859-67. 2011
    ..This article will review current and future avenues in the assessment of diagnostic patient samples...
  5. pmc 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
    Hans Knecht
    CHUS, Universite de Sherbrooke, Quebec, Canada
    BMC Cell Biol 11:99. 2010
    ..In vitro and in vivo formation of RS-cells is associated with the increase of very short telomeres including "t-stumps", telomere loss, telomeric aggregate formation and the generation of "ghost nuclei"...
  6. pmc Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, Canada
    Transl Oncol 5:269-77. 2012
    ..This specific three-dimensional telomere Q-FISH signature identifies these highly aggressive mononuclear H cells at the first diagnostic biopsy and thus may offer a new molecular marker to optimize initial treatment...