E W Khandjian

Summary

Country: Canada

Publications

  1. ncbi Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Pavillon Saint François d Assise du CHUQ, Département de Biologie médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
    Hum Mol Genet 7:2121-8. 1998
  2. ncbi Disruption of LT-antigen/p53 complex by heat treatment correlates with inhibition of DNA synthesis during transforming infection with SV40
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hôpital Saint François d Assise du CHUQ, Quebec, Canada
    Biochem Cell Biol 78:437-45. 2000
  3. pmc Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles
    Edouard W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada G1L 3L5
    Proc Natl Acad Sci U S A 101:13357-62. 2004
  4. ncbi Biology of the fragile X mental retardation protein, an RNA-binding protein
    E W Khandjian
    Département de Biologie médicale, Faculte de Medecine, Universite Laval, Quebec, QC, Canada
    Biochem Cell Biol 77:331-42. 1999
  5. ncbi The fragile X mental retardation protein is associated with ribosomes
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, Quebec, Canada
    Nat Genet 12:91-3. 1996
  6. ncbi A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, Quebec, Canada
    Hum Mol Genet 4:783-9. 1995
  7. pmc Muscle specific fragile X related protein 1 isoforms are sequestered in the nucleus of undifferentiated myoblast
    M Dube
    Unite de Recherche en Genetique Humaine et Moleculaire, Hôpital Saint François d Assise du CHUQ, Quebec, Canada
    BMC Genet 1:4. 2000
  8. ncbi Expression of dopamine D2 receptor mRNA isoforms in the carotid body of rat, cat and rabbit
    A Bairam
    Unite de Recherche en Néonatologie, Centre de Recherche, CHUQ, Pavillon Saint Francois d Assise, Universite Laval, Quebec, Que, Canada
    Brain Res 760:287-9. 1997
  9. ncbi Differential changes in dopamine D2- and D1-receptor mRNA levels induced by hypoxia in the arterial chemoreflex pathway organs in one-day-old and adult rabbits
    Aida Bairam
    Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Quebec, Hopital Saint Francois d Assise, Universite Laval, Quebec, Canada
    Biol Neonate 84:222-31. 2003
  10. ncbi Fibronectin gene expression in proliferating, quiescent, and SV40-infected mouse kidney cells
    E W Khandjian
    Departement de Biochimie, Faculte de Medecine, Université Laval et Unité de Recherche en Génétique Humaine et Moléculaire, Hôpital St François d Assise, Quebec, Canada
    Exp Cell Res 202:464-70. 1992

Collaborators

Detail Information

Publications25

  1. ncbi Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Pavillon Saint François d Assise du CHUQ, Département de Biologie médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
    Hum Mol Genet 7:2121-8. 1998
    ....
  2. ncbi Disruption of LT-antigen/p53 complex by heat treatment correlates with inhibition of DNA synthesis during transforming infection with SV40
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hôpital Saint François d Assise du CHUQ, Quebec, Canada
    Biochem Cell Biol 78:437-45. 2000
    ..These results suggest that heat treatment had either induced conformational changes in its antigenic sites, or had sequestered the sites through aggregation or binding to insoluble nuclear components...
  3. pmc Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles
    Edouard W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada G1L 3L5
    Proc Natl Acad Sci U S A 101:13357-62. 2004
    ..Our findings highlight the complex roles of FMRP both in actively translating polyribosomes and in repressed trafficking ribonucleoparticle granules...
  4. ncbi Biology of the fragile X mental retardation protein, an RNA-binding protein
    E W Khandjian
    Département de Biologie médicale, Faculte de Medecine, Universite Laval, Quebec, QC, Canada
    Biochem Cell Biol 77:331-42. 1999
    ..The molecular mechanisms altered in cells lacking FMRP still remain to be elucidated as well as the putative role(s) of FXR1P and FXR2P as compensatory molecules...
  5. ncbi The fragile X mental retardation protein is associated with ribosomes
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, Quebec, Canada
    Nat Genet 12:91-3. 1996
  6. ncbi A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture
    E W Khandjian
    Unite de Recherche en Genetique Humaine et Moleculaire, Hopital Saint Francois d Assise, Quebec, Canada
    Hum Mol Genet 4:783-9. 1995
    ..Our results document the widespread expression of the FMR1 gene, and suggest that it is controlled by different mechanisms implicated in cell growth and differentiation...
  7. pmc Muscle specific fragile X related protein 1 isoforms are sequestered in the nucleus of undifferentiated myoblast
    M Dube
    Unite de Recherche en Genetique Humaine et Moleculaire, Hôpital Saint François d Assise du CHUQ, Quebec, Canada
    BMC Genet 1:4. 2000
    ..Great attention has been given to FMRP due to its implication in human hereditary mental retardation while FXR1P and FXR2P have only recently been studied...
  8. ncbi Expression of dopamine D2 receptor mRNA isoforms in the carotid body of rat, cat and rabbit
    A Bairam
    Unite de Recherche en Néonatologie, Centre de Recherche, CHUQ, Pavillon Saint Francois d Assise, Universite Laval, Quebec, Que, Canada
    Brain Res 760:287-9. 1997
    ....
  9. ncbi Differential changes in dopamine D2- and D1-receptor mRNA levels induced by hypoxia in the arterial chemoreflex pathway organs in one-day-old and adult rabbits
    Aida Bairam
    Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Quebec, Hopital Saint Francois d Assise, Universite Laval, Quebec, Canada
    Biol Neonate 84:222-31. 2003
    ..It is concluded that hypoxia affects DA D2- or D1-R mRNA levels in the chemoreflex pathway in an age-dependent and site-specific manner...
  10. ncbi Fibronectin gene expression in proliferating, quiescent, and SV40-infected mouse kidney cells
    E W Khandjian
    Departement de Biochimie, Faculte de Medecine, Université Laval et Unité de Recherche en Génétique Humaine et Moléculaire, Hôpital St François d Assise, Quebec, Canada
    Exp Cell Res 202:464-70. 1992
    ..These changes in FN gene expression suggest that high levels of FN might be indicative in vivo for terminal differentiation and in vitro for cellular senescence...
  11. ncbi Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada
    RNA Biol 2:1-3. 2005
    ..In addition, the data presented in these two reports clearly indicate that FMRP's function resides at the translation control level...
  12. ncbi Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression
    Rachid Mazroui
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, 10 rue de l Espinay, Quebec G1L 3L5, PQ, Canada
    Hum Mol Genet 11:3007-17. 2002
    ..We speculate that, in neurons, FMRP plays a role as a mRNA repressor in incompetent mRNP granules that have to be translocated from the cell body to distal locations such as dendritic spines and synaptosomes...
  13. ncbi Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs
    Rachid Mazroui
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital St François d Assise, le CHUQ, Quebec, QC G1L 3L5, Canada
    Hum Mol Genet 12:3087-96. 2003
    ..Our results indicate that the KH RNA-binding domains and the Protein-Protein Interacting domain are essential for FMRP to associate with polyribosomal mRNPs, while the RGG box and the phosphorylated domains are dispensable...
  14. pmc Physiological and cytogenetic characterization of immortalized human endometriotic cells containing episomal simian virus 40 DNA
    A Akoum
    Laboratoire d endocrinologie de la reproduction, Centre de Recherche, Pavillon Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, Canada
    Am J Pathol 154:1245-57. 1999
    ..In addition, this response was enhanced in interleukin-1-treated cells. Taken together, these findings support the view that this cell line may be an interesting tool for the study of the pathophysiology of endometriosis...
  15. ncbi Expression of dopamine D1-receptor mRNA in the carotid body of adult rabbits, cats and rats
    A Bairam
    Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Quebec, Canada
    Neurosci Res 31:147-54. 1998
    ..The physiological significance of dopamine D1-receptor expression in the carotid body is discussed...
  16. ncbi The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 15:1525-38. 2006
    ..We propose that this novel cellular partner for FMRP escorts FMRP-containing mRNP from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation...
  17. pmc The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis
    Marc Etienne Huot
    Unite de Recherche en Genetique Humaine et Moleculaire, CHUQ St François d Assise, Quebec, Quebec G1L 3L5, Canada
    Mol Biol Cell 16:4350-61. 2005
    ..Microarray analyses showed that xFxr1p depletion affected the expression of 129 known genes of which 50% were implicated in muscle and nervous system formation. These studies shed significant new light on Fxr1p function(s)...
  18. ncbi The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 16:3047-58. 2007
    ....
  19. ncbi Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level
    James Garnon
    McGill University Health Centre, McGill University, Department of Experimental Medicine, Montreal, Quebec H3G 1A4, Canada
    J Biol Chem 280:5750-63. 2005
    ..Finally, complementation of the knock-out macrophages with recombinant FXR1P resulted in decreased TNF protein production, supporting our findings that FXR1P operates as a repressor of TNF translation...
  20. pmc The fragile X mental retardation protein has nucleic acid chaperone properties
    Caroline Gabus
    LaboRetro, Unité INSERM de Virologie Humaine 412, ENS, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Nucleic Acids Res 32:2129-37. 2004
    ..These findings suggest that FMRP may regulate translation by acting on RNA-RNA interactions and thus on the structural status of mRNAs...
  21. ncbi 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization
    Barbara Bardoni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Hum Mol Genet 12:1689-98. 2003
    ..Subcellular distribution of 82-FIP is cell cycle-dependent in cultured cells, suggesting that the composition of some FMRP-containing RNP complexes may be cell cycle-modulated...
  22. pmc On BC1 RNA and the fragile X mental retardation protein
    Anna Iacoangeli
    The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 105:734-9. 2008
    ....
  23. doi RNA-binding proteins in human genetic disease
    Kiven E Lukong
    Terry Fox Molecular Oncology Group, and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    Trends Genet 24:416-25. 2008
    ..Here we review the emerging evidence showing the involvement of RBPs in many disease networks and conclude that defects in RNA metabolism caused by aberrations in RBPs might underlie a broader spectrum of complex human disorders...
  24. ncbi The fragile X syndrome: exploring its molecular basis and seeking a treatment
    Barbara Bardoni
    INSERM, UMR 6543, Faculte de Medecine, 28 Av de Valombrose, Universite de Nice, O6107 Nice, France
    Expert Rev Mol Med 8:1-16. 2006
    ..In this review, we focus on recent insights into the function of FMRP and speculate on how the absence of FMRP might cause the clinical phenotypes seen in FXS patients. Finally, we explore potential therapies for FXS...
  25. pmc Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure
    Elias Bechara
    CNRS UMR 6543, Faculté de Médecine Université de Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107, Nice, France
    Nucleic Acids Res 35:299-306. 2007
    ..In addition, we show that the action of FXR1P is synergistic rather than compensatory for FMRP function...