J L Kennedy

Summary

Country: Canada

Publications

  1. ncbi Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene
    E A Billett
    Neurogenetics Section, Clarke Institute of Psychiatry, University of Toronto, Canada
    Mol Psychiatry 2:403-6. 1997
  2. ncbi Chromosome 4 Workshop Summary: Sixth World Congress on Psychiatric Genetics, Bonn, Germany, October 6-10, 1998
    J L Kennedy
    Center for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Am J Med Genet 88:224-8. 1999
  3. doi Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
    A K Tiwari
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:260-6. 2012
  4. doi Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
  5. ncbi Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
  6. doi Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
  7. ncbi Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
  8. ncbi Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
  9. ncbi Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Ontario, Canada
    Am J Med Genet 96:262-7. 2000
  10. ncbi Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006

Collaborators

Detail Information

Publications65

  1. ncbi Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene
    E A Billett
    Neurogenetics Section, Clarke Institute of Psychiatry, University of Toronto, Canada
    Mol Psychiatry 2:403-6. 1997
    ..Given the pharmacological evidence favoring a role for 5-HTT in OCD and SRI response, further genetic evaluation of the serotonin transporter in OCD is indicated...
  2. ncbi Chromosome 4 Workshop Summary: Sixth World Congress on Psychiatric Genetics, Bonn, Germany, October 6-10, 1998
    J L Kennedy
    Center for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Am J Med Genet 88:224-8. 1999
    ....
  3. doi Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
    A K Tiwari
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:260-6. 2012
    ..These results indicate a possible role of CNR1 in the development of TD in our patient population. However, these observations are marginal after correcting for multiple testing and need to be replicated in a larger patient population...
  4. doi Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
    ....
  5. ncbi Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    ....
  6. doi Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
    ..These findings, while preliminary, identify association of ADHD to a gene that potentially plays a role in cell migration and axon growth...
  7. ncbi Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
    ..We did not observe biased transmission of the alleles at either polymorphism to ADHD probands or siblings. Our findings using this sample do not support the role of the MOG gene in ADHD...
  8. ncbi Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
    ..Further, we found no sex-specific relationship. Our results, therefore, do not support the previous evidence for this gene as a major factor contributing to depression...
  9. ncbi Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Ontario, Canada
    Am J Med Genet 96:262-7. 2000
    ..We examined the haplotypes of three polymorphisms of the D4 receptor gene and observed biased transmission of two of these haplotypes. Our findings further support the role of the dopamine D4 gene in ADHD...
  10. ncbi Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006
    ..The results in the present sample indicate that these nine genes are unlikely to be major susceptibility genes contributing to COMD...
  11. ncbi Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle
    V S Basile
    Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
    J Clin Psychiatry 62:45-66. 2001
    ....
  12. ncbi 5'-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
    Am J Med Genet 105:84-90. 2001
    ..We conclude that these three polymorphisms are not related to the ADHD phenotype...
  13. ncbi BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, ON M6S 3R4, Canada
    Neuromolecular Med 5:181-92. 2004
    ..41, df = 4, 58, p = 0.0035) were associated with more optimal performance on the memory tasks. This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes...
  14. doi Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain
    D J Muller
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 12:156-64. 2012
    ..The other genes were primarily negative. We provide evidence that dopamine receptor DRD2 gene variants might be associated with antipsychotic-induced weight gain in chronic schizophrenia patients...
  15. ncbi Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
    Mol Psychiatry 5:548-51. 2000
    ..The number of informative transmissions for these two alleles was small, therefore it would be premature to make any conclusions from our study concerning the role of DRD5 in ADHD...
  16. ncbi The serotonin-1Dbeta receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa
    R D Levitan
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Canada
    Eur Neuropsychopharmacol 16:1-6. 2006
    ..We thus hypothesized that, among a heterogenous group of probands with bulimia nervosa (BN), this same G allele might predict the presence and/or severity of OCD pathology...
  17. ncbi Altered TRPC7 gene expression in bipolar-I disorder
    I S Yoon
    Section of Biochemical Psychiatry, Centre for Addiction and Mental Health-Clarke Site, Toronto, Ontario, Canada
    Biol Psychiatry 50:620-6. 2001
    ..35, p =.027). CONCLUSIONS: Reduced TRPC7 gene expression may be a trait associated with pathophysiological disturbances of Ca(2+) homeostasis in a subgroup of BD-I patients...
  18. pmc Association of the GABRD gene and childhood-onset mood disorders
    Y Feng
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 9:668-72. 2010
    ..These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding...
  19. doi Association of HPA axis genes with suicidal behaviour in schizophrenia
    V De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 24:677-82. 2010
    ..This is to our knowledge the first study on suicidal behaviour investigating the interaction among the HPA axis genes...
  20. ncbi Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 88:710-3. 1999
    ..A total of 77 nuclear families collected from Toronto were genotyped. We find no evidence for linkage of this polymorphism and ADHD in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:710-713, 1999...
  21. ncbi Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 10:861-7. 2005
    ..These results provide evidence that BDNF variants affect liability to juvenile-onset mood disorders, supported by data from two independent samples...
  22. doi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  23. doi Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain
    E J Brandl
    Centre of Addiction and Mental Health, Neurogenetics Section, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 38:134-41. 2012
    ..Thus, we investigated polymorphisms in both genes for an association with AIWG...
  24. ncbi Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder
    K M Dorval
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 6:444-52. 2007
    ..Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait...
  25. doi Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant
    R Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenomics J 10:200-18. 2010
    ..Other DRD3 variants and haplotypes of possible interest were also identified for replication in future studies...
  26. doi Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
    N I Chowdhury
    Neurogenetics Section, Department of Neuroscience, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Pharmacogenomics J 13:272-9. 2013
    ..We performed in vitro electrophoretic mobility-shift assay that suggested that the presence of the A-allele may create a transcription factor-binding site. Further investigation is warranted for both these exploratory findings...
  27. ncbi Human dopamine D5 receptor pseudogenes
    T Nguyen
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Gene 109:211-8. 1991
    ..Thus, the human genome contains at least two DRD5 pseudogenes, consistent with in situ human chromosomal hybridization analysis which reveals the presence of two pseudogenes...
  28. doi Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients
    C C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 9:168-74. 2009
    ..This study suggests that DRD4 may be involved in TD in the Caucasian population, although further replication studies are needed...
  29. ncbi Dopamine system genes not linked to social phobia
    J L Kennedy
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Psychiatr Genet 11:213-7. 2001
    ..Additional studies of dopamine system genes will be necessary to define clearly their role in social phobia...
  30. ncbi Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia
    G Zai
    Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
    Genes Brain Behav 4:2-9. 2005
    ..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene...
  31. ncbi Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, 250 College Str, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 131:16-9. 2004
    ....
  32. ncbi A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia
    V S Basile
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health CAMH, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 5:410-7. 2000
    ..Further studies in independent samples are warranted to evaluate the applicability of our findings to the general patient population receiving antipsychotic medications...
  33. ncbi Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder
    V L Misener
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mol Psychiatry 9:500-9. 2004
    ..DNA from 41 children was analysed, and no sequence variations were identified, indicating that the putative DRD1 risk variant for ADHD resides outside of the coding region of the gene...
  34. ncbi Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mol Psychiatry 6:334-7. 2001
    ..We conclude that the alleles at the polymorphisms tested in these two genes are not linked to the ADHD phenotype in this sample of families...
  35. ncbi Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 96:114-7. 2000
    ..Our findings using this particular sample do not support the role of the dopamine D3 gene in ADHD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:114-117, 2000...
  36. ncbi Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder
    R D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    J Affect Disord 71:229-33. 2002
    ..The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD...
  37. ncbi Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia
    V De Luca
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Acta Psychiatr Scand 114:211-5. 2006
    ..The CHRNA7 gene has a partial duplication that constitutes the alpha7-like nicotinic receptor gene (CHRFAM7A). We hypothesized that major psychoses could affect the expression of both CHRNA7 and CHRFAM7A...
  38. ncbi Untranslated region haplotype in dysbindin gene: analysis in schizophrenia
    V De Luca
    Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont, Canada
    J Neural Transm 112:1263-7. 2005
    ..The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT...
  39. ncbi p75(NTR) gene and suicide attempts in young adults with a history of childhood-onset mood disorder
    S McGregor
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:696-700. 2007
    ..Our results do not support an association of the p75(NTR) S205L polymorphism with risk for COMD or SA in COMD...
  40. doi Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder
    G Novak
    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Genes Brain Behav 9:910-7. 2010
    ..04), providing an important confirmation of the involvement of the NR4A3 gene in nicotine addiction in patients with mental health disease, a population significantly at risk for nicotine addiction...
  41. ncbi Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene
    A H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Psychiatry 8:156-66. 2003
    ....
  42. ncbi Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania
    V De Luca
    Neurogenetics Section, Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Pharmacogenomics J 3:297-9. 2003
    ..No association between antidepressant-induced mania and the MDR1 alleles or genotypes was found (chi2=1.85, 2 df, P=0.39; chi2=0.13, 1 df, P=0.72)...
  43. ncbi Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia
    V S Basile
    Neurogenetics Section, Clarke Institute of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Mol Psychiatry 6:230-4. 2001
    ..Further studies evaluating in tandem multiple candidate genes relevant for the serotonergic system are warranted to dissect the genetic basis of the complex TD phenotype...
  44. doi Opiates, overeating and obesity: a psychogenetic analysis
    C Davis
    Kinesiology and Health Sciences, Faculty of Health Sciences, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Int J Obes (Lond) 35:1347-54. 2011
    ..We also anticipated that these food preferences would be positively associated with binge eating, hedonic eating and emotionally driven eating-patterns of overeating that would, in turn, predict higher body mass index (BMI)...
  45. ncbi The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings
    E Mundo
    Neurogenetics Section, R 31, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 58:539-44. 2001
    ..The 5-HTT gene (SLC6A4) has 2 known polymorphisms. The aim of this study was to investigate the role of the SLC6A4 variants in the pathogenesis of antidepressant-induced mania in BP...
  46. ncbi The 5HT1Dbeta receptor gene in bipolar disorder: a family-based association study
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Site, University of Toronto, ON, Toronto, Canada
    Neuropsychopharmacology 25:608-13. 2001
    ..Further investigations combining genetic and pharmacological strategies are warranted...
  47. doi Association of ethnicity with antipsychotic dosage using STRUCTURE analysis
    A Hassan
    CAMH, Department of Psychiatry, University of Toronto, Toronto, Canada
    Pharmacopsychiatry 46:151-5. 2013
    ..Our preliminary analysis shows that there is no evidence that different ethnic groups receive different dose of antipsychotics...
  48. ncbi CYP1A2 activity as measured by a caffeine test predicts clozapine and active metabolite steady-state concentrationin patients with schizophrenia
    V Ozdemir
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 21:398-407. 2001
    ..CYP1A2 phenotyping with a simple caffeine test may contribute to individualization of clozapine dosage and differentiate between treat ment noncompliance and high CYP1A2 activity...
  49. ncbi Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health CAMH, Department of Psychiatry, University of Toronto, Clarke Site R 31, Toronto, Ontario, Canada M5T 1R8
    Mol Psychiatry 8:241-5. 2003
    ..The role of the gene variants in predicting the response to mood stabilizers in BP should also be investigated...
  50. ncbi PedSplit: pedigree management for stratified analysis
    M B Lanktree
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, Toronto M5T 1R8, Canada
    Bioinformatics 20:2315-6. 2004
    ..PedSplit also provides a simple approach for calculating haplotype relative risk and generating internal 'controls'...
  51. ncbi 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study
    E Mundo
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    Mol Psychiatry 7:805-9. 2002
    ..Further genetic investigations on this marker considering additional polymorphisms and other quantitative phenotypes related to OCD are warranted...
  52. ncbi The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses
    V De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 5:107-10. 2006
    ..These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behaviour...
  53. doi Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications
    T A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:242-66. 2012
    ..More research is required before genetically informed, personalized medicine can be applied to antipsychotic treatment; nevertheless, inroads have been made towards assessing genetic liability and plausible clinical application...
  54. ncbi Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4
    P Muglia
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada M5T 1R8
    Mol Psychiatry 7:860-6. 2002
    ..Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder...
  55. ncbi The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder
    J F Quist
    Neurogentics Section, Centre for Addiction and Mental Health, Clarke Division, and Department of Psychiatry, University of Toronto, Canada
    Mol Psychiatry 8:98-102. 2003
    ..80, P = 0.03) to the affected child. Although preliminary, results from this study provide additional evidence that serotonin genes may be important risk factors for the development of ADHD...
  56. ncbi Investigation of cholecystokinin system genes in panic disorder
    J L Kennedy
    Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Mol Psychiatry 4:284-5. 1999
    ..Our genetic dissection of the CCK system thus far suggests that the CCK-B receptor gene variation may contribute to the neurobiology of panic disorder...
  57. ncbi Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia
    M Masellis
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario M5T 1R8, Canada
    Schizophr Res 47:49-58. 2001
    ..Overall, our findings do not support a role for the T-->C 267 polymorphism of the 5-HT6 receptor gene in response to clozapine, although replication is required to confirm this finding...
  58. ncbi Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa
    R D Levitan
    Depression Clinic, Centre for Addiction and Mental Health, University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada
    Biol Psychiatry 50:640-3. 2001
    ..In the current study, we examined whether genetic variation of the serotonin-1B receptor was associated with minimum and maximum lifetime body mass indices (BMIs) in a sample of women with bulimia nervosa (BN)...
  59. doi Dopamine receptors D1 and D2 are related to observed maternal behavior
    V Mileva-Seitz
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Genes Brain Behav 11:684-94. 2012
    ..The findings also highlight the importance of exploring multiple dimensions of the complex human mothering phenotype...
  60. ncbi An Alu sequence interrupts a human 5-hydroxytryptamine1D receptor pseudogene
    T Nguyen
    Addiction Research Foundation, Toronto, Ontario, Canada
    Gene 124:295-301. 1993
    ..Sequence analysis also revealed that the coding sequence of this pseudogene is disrupted by insertion of a 283-bp Alu repeat sequence...
  61. doi The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia
    T A Lett
    Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 18:443-50. 2013
    ..Finally, the possible consequences of genetic risk factors may be distinct in patients with schizophrenia compared with healthy controls...
  62. ncbi Schizophrenia: an epigenetic puzzle?
    A Petronis
    Department of Psychiatry, University of Toronto, Centre of Addiction and Mental Health, Ontario, Canada
    Schizophr Bull 25:639-55. 1999
    ..In addition, the epigenetic model may lead to experiments investigating the molecular substrates of genetic-environmental interactions...
  63. ncbi Clinical implications of pharmacogenomics for tardive dyskinesia
    D J Muller
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Pharmacogenomics J 4:77-87. 2004
  64. ncbi Long repeat tracts at SCA8 in major psychosis
    J B Vincent
    Neurogenetics Section, Clarke Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Med Genet 96:873-6. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:873-876, 2000...
  65. ncbi Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder
    I S Yoon
    Section of Biochemical Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Psychiatry 6:678-83. 2001
    ..025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD...