David A Steinman

Summary

Affiliation: John P. Robarts Research Institute
Country: Canada

Publications

  1. ncbi Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI
    David A Steinman
    Imaging Research Labs, John P Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 47:149-59. 2002
  2. ncbi Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, P O Box 5015, London, Ontario, Canada
    Stroke 36:2450-6. 2005
  3. doi In vitro Doppler ultrasound investigation of turbulence intensity in pulsatile flow with simulated cardiac variability
    Meghan L Thorne
    Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 35:120-8. 2009
  4. ncbi Virtual angiography for visualization and validation of computational models of aneurysm hemodynamics
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute and the Department of Medical Biophysics, The Universty of Western Ontario, 100 Perth Drive, P O Box 5015, London, ON N6A 5K8, Canada
    IEEE Trans Med Imaging 24:1586-92. 2005
  5. doi In vivo Doppler ultrasound quantification of turbulence intensity using a high-pass frequency filter method
    Meghan L Thorne
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    Ultrasound Med Biol 36:761-71. 2010
  6. ncbi Geometry of the carotid bifurcation predicts its exposure to disturbed flow
    Sang Wook Lee
    Biomedical Simulation Laboratory, University of Toronto, Ontario, Canada
    Stroke 39:2341-7. 2008
  7. ncbi On the effect of parent-aneurysm angle on flow patterns in basilar tip aneurysms: towards a surrogate geometric marker of intra-aneurismal hemodynamics
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    J Biomech 41:241-8. 2008
  8. ncbi Reproducibility of image-based computational fluid dynamics models of the human carotid bifurcation
    Jonathan B Thomas
    Imaging Research Labs, Robarts Research Institute and Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Ann Biomed Eng 31:132-41. 2003
  9. pmc Characterization of volumetric flow rate waveforms at the carotid bifurcations of older adults
    Yiemeng Hoi
    Department of Mechanical and Industrial Engineering, Biomedical Simulation Laboratory, University of Toronto, Toronto, Ontario, Canada
    Physiol Meas 31:291-302. 2010
  10. ncbi Path-dependent hemodynamics of the stenosed carotid bifurcation
    Mauro Tambasco
    Imaging Research Laboratories, Robarts Research Institute, Department of Medical Biophysics, The University of Western Ontario, Ontario, Canada
    Ann Biomed Eng 31:1054-65. 2003

Collaborators

Detail Information

Publications31

  1. ncbi Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI
    David A Steinman
    Imaging Research Labs, John P Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 47:149-59. 2002
    ..The noninvasive nature of this image-based modeling approach makes it ideal for carrying out future prospective studies of hemodynamics and plaque development or progression in otherwise healthy subjects...
  2. ncbi Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, P O Box 5015, London, Ontario, Canada
    Stroke 36:2450-6. 2005
    ..On the other hand, anecdotal evidence suggests that vessel geometry is more homogenous in youth, which would tend to undermine this geometric risk hypothesis. The purpose of our study was to test whether the latter is indeed the case...
  3. doi In vitro Doppler ultrasound investigation of turbulence intensity in pulsatile flow with simulated cardiac variability
    Meghan L Thorne
    Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 35:120-8. 2009
    ..Twenty cardiac cycles were required for confidence in TI values. In conclusion, these results indicate that it is possible to quantify TI in vitro, even in the presence of normal and exaggerated cycle-to-cycle cardiac variability...
  4. ncbi Virtual angiography for visualization and validation of computational models of aneurysm hemodynamics
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute and the Department of Medical Biophysics, The Universty of Western Ontario, 100 Perth Drive, P O Box 5015, London, ON N6A 5K8, Canada
    IEEE Trans Med Imaging 24:1586-92. 2005
    ..They also clearly show how the contrast agent injection perturbs the noraml blood flow patterns, further highlighting the potential utility of image-based CFD as a window into the true aneurysmal hemodynamics...
  5. doi In vivo Doppler ultrasound quantification of turbulence intensity using a high-pass frequency filter method
    Meghan L Thorne
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    Ultrasound Med Biol 36:761-71. 2010
    ..05). This investigation demonstrated the ability to precisely quantify TI using a conventional Doppler ultrasound machine in human subjects, without interfering with normal clinical protocols...
  6. ncbi Geometry of the carotid bifurcation predicts its exposure to disturbed flow
    Sang Wook Lee
    Biomedical Simulation Laboratory, University of Toronto, Ontario, Canada
    Stroke 39:2341-7. 2008
    ..In testing these often-implicit assumptions, the present study aimed to determine whether investigations of local risk factors in atherosclerosis can indeed rely on surrogate geometric markers of disturbed flow...
  7. ncbi On the effect of parent-aneurysm angle on flow patterns in basilar tip aneurysms: towards a surrogate geometric marker of intra-aneurismal hemodynamics
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    J Biomech 41:241-8. 2008
    ..That the general features of these flow types may be anticipated by a relatively simple-to-measure geometric parameter could help ease the introduction of hemodynamic information into routine clinical decision-making...
  8. ncbi Reproducibility of image-based computational fluid dynamics models of the human carotid bifurcation
    Jonathan B Thomas
    Imaging Research Labs, Robarts Research Institute and Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Ann Biomed Eng 31:132-41. 2003
    ....
  9. pmc Characterization of volumetric flow rate waveforms at the carotid bifurcations of older adults
    Yiemeng Hoi
    Department of Mechanical and Industrial Engineering, Biomedical Simulation Laboratory, University of Toronto, Toronto, Ontario, Canada
    Physiol Meas 31:291-302. 2010
    ..The characteristic waveforms presented here may serve as a convenient baseline for studies of VFR waveform dynamics or as suitable boundary conditions for models of blood flow in the carotid arteries of older adults...
  10. ncbi Path-dependent hemodynamics of the stenosed carotid bifurcation
    Mauro Tambasco
    Imaging Research Laboratories, Robarts Research Institute, Department of Medical Biophysics, The University of Western Ontario, Ontario, Canada
    Ann Biomed Eng 31:1054-65. 2003
    ..Experimental work is now required to assess the significance of these differences...
  11. ncbi Inlet conditions for image-based CFD models of the carotid bifurcation: is it reasonable to assume fully developed flow?
    Keri R Moyle
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    J Biomech Eng 128:371-9. 2006
    ....
  12. ncbi Template-based finite-element mesh generation from medical images
    Leila Baghdadi
    Imaging Research Laboratories, Robarts Research Institute, London, Ont, N6A 5K8, Canada
    Comput Methods Programs Biomed 77:11-21. 2005
    ..This template-based approach is shown to be as accurate and precise as the previous technique used by our group, while preserving element quality and volume...
  13. ncbi Image-based computational simulation of flow dynamics in a giant intracranial aneurysm
    David A Steinman
    Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Canada
    AJNR Am J Neuroradiol 24:559-66. 2003
    ..This study shows that computational fluid dynamics (CFD) combined with computed rotational angiography can provide such hemodynamic information in a patient-specific and prospective manner...
  14. ncbi Finite-element modeling of the hemodynamics of stented aneurysms
    Gordon R Stuhne
    Imaging Research Labs, Robarts Research Institute, 100 Perth Dr, London, Ontario, Canada N6A 5K8
    J Biomech Eng 126:382-7. 2004
    ..Previous studies of stented aneurysm flows used low mesh resolution, did not include mesh convergence analyses, and depended upon conformal meshing techniques that apply only to very artificial stent geometries...
  15. doi Use of an ultrasound blood-mimicking fluid for Doppler investigations of turbulence in vitro
    Meghan L Thorne
    Robarts Research Institute, London, ON, Canada
    Ultrasound Med Biol 34:1163-73. 2008
    ..005) for both the constrained jet and the constrained grid. Based on our observations, we conclude that a water-glycerol based BMF provides a suitable working fluid during in vitro investigations of turbulence using Doppler ultrasound...
  16. ncbi Flow imaging and computing: large artery hemodynamics
    David A Steinman
    Imaging Research Laboratories, Robarts Research Institute and Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada
    Ann Biomed Eng 33:1704-9. 2005
    ....
  17. ncbi Anthropometric data for magnetic resonance imaging of the carotid bifurcation
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    J Magn Reson Imaging 21:845-9. 2005
    ....
  18. ncbi Characterization of volumetric flow rate waveforms in the normal internal carotid and vertebral arteries
    Matthew D Ford
    Imaging Research Labs, Robarts Research Institute and Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Physiol Meas 26:477-88. 2005
    ..This capability may be of particular utility for studies where cerebrovascular flow dynamics are required, but only average flow rates are available...
  19. ncbi Real-time numerical simulation of Doppler ultrasound in the presence of nonaxial flow
    Mahdieh Khoshniat
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Ultrasound Med Biol 31:519-28. 2005
    ..We conclude that the complex interaction between Doppler ultrasound and complicated clinically relevant blood flow dynamics can be simulated in real time via this relatively straightforward semiempirical approach...
  20. ncbi Robust and objective decomposition and mapping of bifurcating vessels
    Luca Antiga
    Imaging Research Labs, Robarts Research Institute and Bioengineering Department, Mario Negri Institute for Pharmacological Research, London, ON N6A 5K8, Canada
    IEEE Trans Med Imaging 23:704-13. 2004
    ....
  21. ncbi Image-based computational fluid dynamics: a new paradigm for monitoring hemodynamics and atherosclerosis
    David A Steinman
    Imaging Research Labs, Robarts Research Institute and Department of Medical Biophysics, The University of Western Ontario, 100 Perth Dr, P O Box 5015, London, Ontario, N6A 5K8, Canada
    Curr Drug Targets Cardiovasc Haematol Disord 4:183-97. 2004
    ..Current limitations and anticipated future directions for these powerful new tools are discussed...
  22. ncbi Extracorporeal femoral to carotid artery perfusion in selective brain cooling for a giant aneurysm. Case report
    Stephen P Lownie
    Department of Clinical Neurological Sciences, Division of Neurosurgery, University of Western Ontario, Robarts Research Institute, London Health Sciences Centre, London, Ontario, Canada
    J Neurosurg 100:343-7. 2004
    ..This technique of selective brain cooling may be a useful alternative to currently available surgical and endovascular methods of treatment for giant aneurysms...
  23. ncbi Variability of computational fluid dynamics solutions for pressure and flow in a giant aneurysm: the ASME 2012 Summer Bioengineering Conference CFD Challenge
    David A Steinman
    University of Toronto, Toronto, Ontario, Canada
    J Biomech Eng 135:021016. 2013
    ..Future challenges are needed and should focus on hemodynamic quantities thought to be of clinical interest...
  24. ncbi On assessing the quality of particle tracking through computational fluid dynamic models
    Mauro Tambasco
    Imaging Research Labs, The John P Robarts Research Institute, London, Ontario, Canada
    J Biomech Eng 124:166-75. 2002
    ..The VRT maps were found to be useful for identifying regions of a mesh that were under-resolved for such Lagrangian studies, and for guiding the construction of more adequately resolved meshes...
  25. ncbi Image-based computational fluid dynamics modeling in realistic arterial geometries
    David A Steinman
    Imaging Research Laboratories, The John P Robarts Research Institute, The University of Western Ontario, London, Canada
    Ann Biomed Eng 30:483-97. 2002
    ..Issues related to accuracy, precision, and modeling assumptions are also discussed...
  26. doi On the synthesis of sample volumes for real-time spectral Doppler ultrasound simulation
    Luis A Aguilar
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Ultrasound Med Biol 36:2107-16. 2010
    ..Our findings can have direct application on the simulation of spectral Doppler and other ultrasound techniques for the purpose of teaching and training...
  27. ncbi On the relative importance of rheology for image-based CFD models of the carotid bifurcation
    Sang Wook Lee
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada M5S 3G8
    J Biomech Eng 129:273-8. 2007
    ..In this study, we investigated the sensitivity of image-based CFD models of the carotid bifurcation to assumptions regarding the blood rheology...
  28. ncbi Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling
    Akiva Feintuch
    Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada
    Am J Physiol Heart Circ Physiol 292:H884-92. 2007
    ..This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice...
  29. doi PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute, London, Canada N6A 5K8
    J Biomech Eng 130:021015. 2008
    ..Nevertheless, given the various modeling assumptions, this does not prove that they are mimicking the actual in vivo hemodynamics, and so validations against in vivo data are encouraged whenever possible...
  30. ncbi A dual-pressure boundary condition for use in simulations of bifurcating conduits
    Ron Gin
    ICEM CFD Engineering, Livonia, Michigan 48152, USA
    J Biomech Eng 124:617-9. 2002
    ..The dual-pressure condition is suitable for both steady and time-periodic simulations of laminar or turbulent flows...
  31. ncbi On the influence of vessel planarity on local hemodynamics at the human carotid bifurcation
    Jonathan B Thomas
    Imaging Research Labs, The John P Robarts Research Institute, Canada N6A 5K8
    Biorheology 39:443-8. 2002
    ..We conclude that vessel curvature - whether in- or out-of-plane - rather than planarity may deserve further scrutiny as a potential geometric risk for atherogenesis...