Marek Jankowski

Summary

Country: Canada

Publications

  1. pmc Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide
    Bogdan A Danalache
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    PLoS ONE 5:e13643. 2010
  2. ncbi Oxytocin in the heart regeneration
    Marek Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada
    Recent Pat Cardiovasc Drug Discov 7:81-7. 2012
  3. pmc Estrogen receptors activate atrial natriuretic peptide in the rat heart
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 98:11765-70. 2001
  4. ncbi B-type natriuretic peptide for diagnosis and therapy
    Marek Jankowski
    Department of Medicine, Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, University of Montreal, Montreal, QC, Canada
    Recent Pat Cardiovasc Drug Discov 3:77-83. 2008
  5. doi Anti-inflammatory effect of oxytocin in rat myocardial infarction
    Marek Jankowski
    Centre de Recherche, Centre hospitalier de l Université de Montréal CRCHUM, Hotel Dieu, Pavillon Jeanne Mance 3840, rue Saint Urbain, Montreal, QC H2W 1T8, Canada
    Basic Res Cardiol 105:205-18. 2010
  6. ncbi Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats
    Marek Jankowski
    Centre de Recherche, CHUM Hôtel Dieu Pav De Boulion, 3840, rue Saint Urbain, Montreal, QC, H2W 1T8, Canada
    Am J Physiol Heart Circ Physiol 299:H265-74. 2010
  7. ncbi Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montreal CHUM Montreal, Quebec, Canada
    J Endocrinol 184:209-17. 2005
  8. ncbi Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon de Bullion, 3850 Rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
    Brain Res Dev Brain Res 152:39-46. 2004
  9. ncbi Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats
    Donghao Wang
    Laboratory of Cardiovascular Biochemistry, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 St Urbain Street, Masson Pavilion, Montreal, Quebec, Canada H2W 1T7
    Cardiovasc Res 57:186-94. 2003
  10. ncbi Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, CHUM Hôtel Dieu Centre de Recherche, 3850 Rue Saint Urbain, Pavillon Masson, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R267-75. 2007

Collaborators

Detail Information

Publications34

  1. pmc Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide
    Bogdan A Danalache
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    PLoS ONE 5:e13643. 2010
    ....
  2. ncbi Oxytocin in the heart regeneration
    Marek Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada
    Recent Pat Cardiovasc Drug Discov 7:81-7. 2012
    ..Most of the results are consistent with the postulated cardioprotective role of OT. In this review, new data are discussed in the context of the main points presented in the invention...
  3. pmc Estrogen receptors activate atrial natriuretic peptide in the rat heart
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 98:11765-70. 2001
    ..Changes in plasma ANP correlated with changes in ANP content in the right atrium, as demonstrated by RIA. Increased ANP expression and secretion in response to ERalpha activation may be a protective mechanism in the heart...
  4. ncbi B-type natriuretic peptide for diagnosis and therapy
    Marek Jankowski
    Department of Medicine, Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, University of Montreal, Montreal, QC, Canada
    Recent Pat Cardiovasc Drug Discov 3:77-83. 2008
    ..However, this treatment apparently has safety problems and no proven clinical advantage over existing treatments in terms of improved survival and prevention of subsequent hospitalizations...
  5. doi Anti-inflammatory effect of oxytocin in rat myocardial infarction
    Marek Jankowski
    Centre de Recherche, Centre hospitalier de l Université de Montréal CRCHUM, Hotel Dieu, Pavillon Jeanne Mance 3840, rue Saint Urbain, Montreal, QC H2W 1T8, Canada
    Basic Res Cardiol 105:205-18. 2010
    ..These results indicate that continuous OT delivery reduces inflammation and apoptosis in infarcted and remote myocardium, thus improving function in the injured heart...
  6. ncbi Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats
    Marek Jankowski
    Centre de Recherche, CHUM Hôtel Dieu Pav De Boulion, 3840, rue Saint Urbain, Montreal, QC, H2W 1T8, Canada
    Am J Physiol Heart Circ Physiol 299:H265-74. 2010
    ..In conclusion, these results demonstrate that cardiac OTRs are involved in the regulation of cardiac function of OVX SHRs. The decreases of OTRs may contribute to cardiac pathology following menopause...
  7. ncbi Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle
    M Jankowski
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montreal CHUM Montreal, Quebec, Canada
    J Endocrinol 184:209-17. 2005
    ..We conclude that cGMP concentration in the rat LV is influenced by both NOS and natriuretic peptide systems and may be involved in the changes of LV contractility and hypertrophy that occur during rat gestation...
  8. ncbi Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon de Bullion, 3850 Rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
    Brain Res Dev Brain Res 152:39-46. 2004
    ..In conclusion, we have shown that hypothalamic ANP undergoes a dramatic rise after birth, and progresses further until the 3rd postnatal week. ANP and CNP changes in the developing hypothalamus can influence brain maturation...
  9. ncbi Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats
    Donghao Wang
    Laboratory of Cardiovascular Biochemistry, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 St Urbain Street, Masson Pavilion, Montreal, Quebec, Canada H2W 1T7
    Cardiovasc Res 57:186-94. 2003
    ..In the present study, we localized oxytocin (OT) and its receptor (OTR) in the rat aorta, and investigated whether genistein, an isoflavonic phytoestrogen, influences their expression in ovariectomized (OVX) rats deficient in estrogen...
  10. ncbi Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, CHUM Hôtel Dieu Centre de Recherche, 3850 Rue Saint Urbain, Pavillon Masson, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R267-75. 2007
    ..Altogether, these data indicate that in OVX animals, chronic exercise significantly enhances cardiac OT, NPs, and NOS, thus implicating all three hormonal systems in the beneficial effects of exercise training...
  11. pmc Oxytocin in cardiac ontogeny
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, 3840 rue Saint Urbain, Montreal, QC, Canada H2W 1T8
    Proc Natl Acad Sci U S A 101:13074-9. 2004
    ..The results support the hypothesis that RA induces cardiomyogenesis by activation of the cardiac OT system...
  12. pmc Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    J Physiol 587:4725-36. 2009
    ..05). In conclusion, downregulation of the OT-NPs-NO system occurs in the heart of the young db/db mouse. Exercise training was not effective in reversing the defect, suggesting impairment of this cardiac protective system in diabetes...
  13. pmc Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes
    Joanne Paquin
    Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec, Montreal, QC, Canada H3C 3P8
    Proc Natl Acad Sci U S A 99:9550-5. 2002
    ..These results suggest that the OT/OTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation...
  14. ncbi Functional arginine vasopressin system in early heart maturation
    Jolanta Gutkowska
    Centre de Recherche CHUM, Hotel Dieu, 3850 St Urbain, Montreal, QC, Canada H2W 1T7
    Am J Physiol Heart Circ Physiol 293:H2262-70. 2007
    ..Together, it is suggested that the AVP system is implicated in postnatal cardiac maturation...
  15. doi Exercise training in ovariectomized rats stimulates estrogenic-like effects on expression of genes involved in lipid accumulation and subclinical inflammation in liver
    Abdolnaser Pighon
    Department of Kinesiology, Universite de Montreal, Montreal, Quebec, Canada
    Metabolism 60:629-39. 2011
    ..Exercise training also acts as estrogens in properly regulating the expression of inflammatory biomarkers in liver of Ovx rats...
  16. doi Exercise training decreases hepatic SCD-1 gene expression and protein content in rats
    Siham Yasari
    Department of Kinesiology, University of Montreal, Montreal, Canada
    Mol Cell Biochem 335:291-9. 2010
    ..05) in both SD and HF fed rats. It is concluded that despite an absence of decreased liver TAG, exercise training contributes to the proper regulation of fat metabolism by down-regulating hepatic SCD-1 gene expression and protein content...
  17. ncbi Specific adaptations of estrogen receptor alpha and beta transcripts in liver and heart after endurance training in rats
    Amélie Paquette
    Département de Kinésiologie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, QC, Canada H3C 3J7
    Mol Cell Biochem 306:179-87. 2007
    ..It is suggested that some of the adaptations to endurance training in liver and heart may be mediated by an ER-dependent mechanism...
  18. doi Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liver
    Amélie Paquette
    Département de Kinésiologie, Universite de Montreal, Montreal, Quebec, Canada
    Menopause 15:1169-75. 2008
    ..To investigate whether estrogen deficiency modifies the expression of important genes involved in hepatic lipid regulation, PPAR alpha, SREBP-1c, and SCD-1, in association with fat accumulation in the liver of ovariectomized rats...
  19. ncbi Nitric oxide signaling in oxytocin-mediated cardiomyogenesis
    Bogdan A Danalache
    Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Stem Cells 25:679-88. 2007
    ..Collectively, our data suggest that the pleiotropic action of NO is involved in the initiation of CM differentiation of P19 cells and maintenance of their undifferentiated state...
  20. doi Oxytocin increases glucose uptake in neonatal rat cardiomyocytes
    Maria Florian
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Pavillon Masson, 3850 Saint Urbain Street, Montreal, Quebec, Canada
    Endocrinology 151:482-91. 2010
    ..001), indicating common pathways. Our data suggest that OT and OT-GKR influence glucose uptake in neonatal rat CM and may thus play a role in the maintenance of cardiac function and cell survival during metabolic stress...
  21. ncbi Exercise training decreases plasma leptin levels and the expression of hepatic leptin receptor-a, -b, and, -e in rats
    Siham Yasari
    Department of Kinesiology, University of Montreal, Montreal, Canada
    Mol Cell Biochem 324:13-20. 2009
    ..The present findings indicate that exercise training-induced decrease in plasma leptin levels is accompanied by a reduction in gene expression of three different isoforms of leptin receptors in liver...
  22. doi Preconditioning of stem cells by oxytocin to improve their therapeutic potential
    Nicolas Noiseux
    Centre de Recherche, Department of Medicine, Universite de Montreal, Quebec, Canada
    Endocrinology 153:5361-72. 2012
    ..Ex vivo cellular treatment with OT represents an attractive strategy aimed to maximize the biological and functional properties of effector cells...
  23. doi Hemodynamic and cardiac effects of chronic eprosartan and moxonidine therapy in stroke-prone spontaneously hypertensive rats
    Suhayla Mukaddam-Daher
    University of Montreal Hospital Research Center CRCHUM, Montreal, Quebec, Canada
    Hypertension 53:775-81. 2009
    ....
  24. doi Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: effect of tumor necrosis factor blockade
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, Research Centre, Centre hospitalier de l Université de Montréal CRCHUM Hôtel Dieu, Montreal, Quebec, Canada
    J Hypertens 29:1203-12. 2011
    ..In this study we investigated the hypothesis that placental ischemia in pregnant rat, a model of preeclampsia, stimulates cardiac hypertrophy and fibrosis via a TNF-α-dependent mechanism...
  25. doi Oxytocin-Gly-Lys-Arg stimulates cardiomyogenesis by targeting cardiac side population cells
    Bogdan A Danalache
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    J Endocrinol 220:277-89. 2014
    ..Finally, SP cells stimulated by OT-GKR induced endothelial phenotype. These results suggest that the C-terminally extended OT molecule stimulates cardiac differentiation of SP CD31- cells and is involved in heart growth. ..
  26. ncbi Anti-hypertrophic effects of oxytocin in rat ventricular myocytes
    Ahmed Menaouar
    Cardiovascular Biochemistry Laboratory, CRCHUM, Department of Medicine, University of Montreal Quebec, Canada
    Int J Cardiol 175:38-49. 2014
    ..During the synthesis of OT, its precursor, termed OT-Gly-Lys-Arg (OT-GKR), is accumulated in the developing rat heart. Consequently, we hypothesized that an OT-related mechanism of ANP controls cardiomyocyte (CM) hypertrophy...
  27. pmc Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation
    Siham Yasari
    Department of Kinesiology, University of Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    J Nutr Metab 2012:181687. 2012
    ....
  28. ncbi Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice
    Eric Plante
    Cardiovascular Biochemistry Laboratory, CRCHUM 7 134, Tour Viger, 900 St Denis St, Montreal, Quebec, H2X 0A9, Canada
    Diabetologia 57:1257-67. 2014
    ..Since brain natriuretic peptide (BNP) is known to influence metabolism and cardioprotection, we investigated the effect of chronic exogenous BNP treatment on adverse myocardial consequences related to obesity and diabetes...
  29. doi Oxytocin revisited: It is also a cardiovascular hormone
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu and Department of Medicine, Université of Montréal, Montreal, Quebec, Canada
    J Am Soc Hypertens 2:318-25. 2008
    ..Therefore, in pathological conditions, OT plays an anti-inflammatory and cardioprotective role, improving vascular and metabolic functions; it has potential for therapeutic use...
  30. ncbi Functional activity of the carboxyl-terminally extended oxytocin precursor Peptide during cardiac differentiation of embryonic stem cells
    Natig Gassanov
    Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Stem Cells 26:45-54. 2008
    ..In conclusion, this report provides new evidence of the biological activity of OT-X, notably OT-GKR, during cardiomyogenic differentiation...
  31. ncbi Chronic imidazoline receptor activation in spontaneously hypertensive rats
    Ahmed Menaouar
    Am J Hypertens 15:803-8. 2002
    ..In these studies we investigated the involvement of natriuretic peptides (ANP and brain natriuretic peptide) in the effects of chronic activation of imidazoline receptors...
  32. ncbi Oxytocin, vasopressin and atrial natriuretic peptide control body fluid homeostasis by action on their receptors in brain, cardiovascular system and kidney
    Samuel M McCann
    Pennington Biomedical Research Center LSU, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Prog Brain Res 139:309-28. 2002
  33. ncbi Arginine vasopressin-mediated cardiac differentiation: insights into the role of its receptors and nitric oxide signaling
    Natig Gassanov
    Department of Internal Medicine III, University of Cologne, 50924 Cologne, Germany
    J Biol Chem 282:11255-65. 2007
    ..In conclusion, this report provides new evidence for the essential role of the AVP system in ES cell-derived cardiomyogenesis...
  34. ncbi The cardiovascular and renal effects of a highly potent mu-opioid receptor agonist, cyclo[N epsilon,N beta-carbonyl-D-Lys2,Dap5]enkephalinamide
    Jolanta Gutkowska
    Laboratory of Peptides, Department of Chemistry, University of Warsaw, Warsaw, Poland
    Eur J Pharmacol 496:167-74. 2004
    ..192+/-21 pg/ml, P<0.005), and was associated with augmented ANP mRNA levels in right atria and left ventricles. Thus, cUENK6 evokes renal effects by enhancing activity of the renal natriuretic peptide system...