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Genomes and Genes | Marek JankowskiSummaryCountry: Canada Publications
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Oxytocin in the heart regenerationMarek Jankowski
Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada
Recent Pat Cardiovasc Drug Discov 7:81-7. 2012..Most of the results are consistent with the postulated cardioprotective role of OT. In this review, new data are discussed in the context of the main points presented in the invention...
Estrogen receptors activate atrial natriuretic peptide in the rat heartM Jankowski
Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, QC, Canada
Proc Natl Acad Sci U S A 98:11765-70. 2001..Changes in plasma ANP correlated with changes in ANP content in the right atrium, as demonstrated by RIA. Increased ANP expression and secretion in response to ERalpha activation may be a protective mechanism in the heart...
Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive ratsMarek Jankowski
Centre de Recherche, CHUM Hôtel Dieu Pav De Boulion, 3840, rue Saint Urbain, Montreal, QC, H2W 1T8, Canada
Am J Physiol Heart Circ Physiol 299:H265-74. 2010..In conclusion, these results demonstrate that cardiac OTRs are involved in the regulation of cardiac function of OVX SHRs. The decreases of OTRs may contribute to cardiac pathology following menopause...- Anti-inflammatory effect of oxytocin in rat myocardial infarctionMarek Jankowski
Centre de Recherche, Centre hospitalier de l Université de Montréal CRCHUM, Hotel Dieu, Pavillon Jeanne Mance 3840, rue Saint Urbain, Montreal, QC H2W 1T8, Canada
Basic Res Cardiol 105:205-18. 2010..These results indicate that continuous OT delivery reduces inflammation and apoptosis in infarcted and remote myocardium, thus improving function in the injured heart... - B-type natriuretic peptide for diagnosis and therapyMarek Jankowski
Department of Medicine, Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, University of Montreal, Montreal, QC, Canada
Recent Pat Cardiovasc Drug Discov 3:77-83. 2008..However, this treatment apparently has safety problems and no proven clinical advantage over existing treatments in terms of improved survival and prevention of subsequent hospitalizations... - Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricleM Jankowski
Laboratory of Cardiovascular Biochemistry, Centre de Recherche, Centre hospitalier de l Université de Montreal CHUM Montreal, Quebec, Canada
J Endocrinol 184:209-17. 2005..We conclude that cGMP concentration in the rat LV is influenced by both NOS and natriuretic peptide systems and may be involved in the changes of LV contractility and hypertrophy that occur during rat gestation... - Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamusMarek Jankowski
Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon de Bullion, 3850 Rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
Brain Res Dev Brain Res 152:39-46. 2004..In conclusion, we have shown that hypothalamic ANP undergoes a dramatic rise after birth, and progresses further until the 3rd postnatal week. ANP and CNP changes in the developing hypothalamus can influence brain maturation... - Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized ratsDonghao Wang
Laboratory of Cardiovascular Biochemistry, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 St Urbain Street, Masson Pavilion, Montreal, Quebec, Canada H2W 1T7
Cardiovasc Res 57:186-94. 2003..In the present study, we localized oxytocin (OT) and its receptor (OTR) in the rat aorta, and investigated whether genistein, an isoflavonic phytoestrogen, influences their expression in ovariectomized (OVX) rats deficient in estrogen... - Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized ratsJolanta Gutkowska
Laboratory of Cardiovascular Biochemistry, CHUM Hôtel Dieu Centre de Recherche, 3850 Rue Saint Urbain, Pavillon Masson, Montreal, Quebec, Canada
Am J Physiol Regul Integr Comp Physiol 293:R267-75. 2007..Altogether, these data indicate that in OVX animals, chronic exercise significantly enhances cardiac OT, NPs, and NOS, thus implicating all three hormonal systems in the beneficial effects of exercise training... - Oxytocin in cardiac ontogenyMarek Jankowski
Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, 3840 rue Saint Urbain, Montreal, QC, Canada H2W 1T8
Proc Natl Acad Sci U S A 101:13074-9. 2004..The results support the hypothesis that RA induces cardiomyogenesis by activation of the cardiac OT system... - Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathyJolanta Gutkowska
Laboratory of Cardiovascular Biochemistry, Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
J Physiol 587:4725-36. 2009..05). In conclusion, downregulation of the OT-NPs-NO system occurs in the heart of the young db/db mouse. Exercise training was not effective in reversing the defect, suggesting impairment of this cardiac protective system in diabetes... - Exercise training decreases hepatic SCD-1 gene expression and protein content in ratsSiham Yasari
Department of Kinesiology, University of Montreal, Montreal, Canada
Mol Cell Biochem 335:291-9. 2010..05) in both SD and HF fed rats. It is concluded that despite an absence of decreased liver TAG, exercise training contributes to the proper regulation of fat metabolism by down-regulating hepatic SCD-1 gene expression and protein content... - Exercise training in ovariectomized rats stimulates estrogenic-like effects on expression of genes involved in lipid accumulation and subclinical inflammation in liverAbdolnaser Pighon
Department of Kinesiology, Universite de Montreal, Montreal, Quebec, Canada
Metabolism 60:629-39. 2011..Exercise training also acts as estrogens in properly regulating the expression of inflammatory biomarkers in liver of Ovx rats... - Specific adaptations of estrogen receptor alpha and beta transcripts in liver and heart after endurance training in ratsAmélie Paquette
Département de Kinésiologie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, QC, Canada H3C 3J7
Mol Cell Biochem 306:179-87. 2007..It is suggested that some of the adaptations to endurance training in liver and heart may be mediated by an ER-dependent mechanism... - Functional arginine vasopressin system in early heart maturationJolanta Gutkowska
Centre de Recherche CHUM, Hotel Dieu, 3850 St Urbain, Montreal, QC, Canada H2W 1T7
Am J Physiol Heart Circ Physiol 293:H2262-70. 2007..Together, it is suggested that the AVP system is implicated in postnatal cardiac maturation... - Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liverAmélie Paquette
Département de Kinésiologie, Universite de Montreal, Montreal, Quebec, Canada
Menopause 15:1169-75. 2008..To investigate whether estrogen deficiency modifies the expression of important genes involved in hepatic lipid regulation, PPAR alpha, SREBP-1c, and SCD-1, in association with fat accumulation in the liver of ovariectomized rats... - Oxytocin increases glucose uptake in neonatal rat cardiomyocytesMaria Florian
Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Pavillon Masson, 3850 Saint Urbain Street, Montreal, Quebec, Canada
Endocrinology 151:482-91. 2010..001), indicating common pathways. Our data suggest that OT and OT-GKR influence glucose uptake in neonatal rat CM and may thus play a role in the maintenance of cardiac function and cell survival during metabolic stress... - Nitric oxide signaling in oxytocin-mediated cardiomyogenesisBogdan A Danalache
Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec a Montreal, Montreal, Quebec, Canada
Stem Cells 25:679-88. 2007..Collectively, our data suggest that the pleiotropic action of NO is involved in the initiation of CM differentiation of P19 cells and maintenance of their undifferentiated state... - Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytesJoanne Paquin
Laboratoire de Neuroendocrinologie Développementale, Département de Chimie et de Biochimie, Universite du Quebec, Montreal, QC, Canada H3C 3P8
Proc Natl Acad Sci U S A 99:9550-5. 2002..These results suggest that the OT/OTR system plays an important role in cardiogenesis by promoting cardiomyocyte differentiation... - Hemodynamic and cardiac effects of chronic eprosartan and moxonidine therapy in stroke-prone spontaneously hypertensive ratsSuhayla Mukaddam-Daher
University of Montreal Hospital Research Center CRCHUM, Montreal, Quebec, Canada
Hypertension 53:775-81. 2009.... - Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: effect of tumor necrosis factor blockadeJolanta Gutkowska
Laboratory of Cardiovascular Biochemistry, Research Centre, Centre hospitalier de l Université de Montréal CRCHUM Hôtel Dieu, Montreal, Quebec, Canada
J Hypertens 29:1203-12. 2011..In this study we investigated the hypothesis that placental ischemia in pregnant rat, a model of preeclampsia, stimulates cardiac hypertrophy and fibrosis via a TNF-α-dependent mechanism... - Exercise training decreases plasma leptin levels and the expression of hepatic leptin receptor-a, -b, and, -e in ratsSiham Yasari
Department of Kinesiology, University of Montreal, Montreal, Canada
Mol Cell Biochem 324:13-20. 2009..The present findings indicate that exercise training-induced decrease in plasma leptin levels is accompanied by a reduction in gene expression of three different isoforms of leptin receptors in liver... - Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptideBogdan A Danalache
Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
PLoS ONE 5:e13643. 2010.... - Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulationSiham Yasari
Department of Kinesiology, University of Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
J Nutr Metab 2012:181687. 2012.... - Preconditioning of stem cells by oxytocin to improve their therapeutic potentialNicolas Noiseux
M Sc, Centre Hospitalier de l Universite de Montreal, 3840 Saint Urbain street, Montreal, Quebec, Canada H2W 1T8
Endocrinology 153:5361-72. 2012..Ex vivo cellular treatment with OT represents an attractive strategy aimed to maximize the biological and functional properties of effector cells... - Oxytocin revisited: It is also a cardiovascular hormoneJolanta Gutkowska
Laboratory of Cardiovascular Biochemistry, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu and Department of Medicine, Université of Montréal, Montreal, Quebec, Canada
J Am Soc Hypertens 2:318-25. 2008..Therefore, in pathological conditions, OT plays an anti-inflammatory and cardioprotective role, improving vascular and metabolic functions; it has potential for therapeutic use... - Chronic imidazoline receptor activation in spontaneously hypertensive ratsAhmed Menaouar
Am J Hypertens 15:803-8. 2002..Accordingly, natriuretic peptides may contribute to the sympatholytic and cardioprotective effects of chronic activation of imidazoline I1-receptors... - Oxytocin, vasopressin and atrial natriuretic peptide control body fluid homeostasis by action on their receptors in brain, cardiovascular system and kidneySamuel M McCann
Pennington Biomedical Research Center (LSU, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA
Prog Brain Res 139:309-28. 2002 - Functional activity of the carboxyl-terminally extended oxytocin precursor Peptide during cardiac differentiation of embryonic stem cellsNatig Gassanov
Department of Internal Medicine III, University of Cologne, Cologne, Germany
Stem Cells 26:45-54. 2008..In conclusion, this report provides new evidence of the biological activity of OT-X, notably OT-GKR, during cardiomyogenic differentiation... - Arginine vasopressin-mediated cardiac differentiation: insights into the role of its receptors and nitric oxide signalingNatig Gassanov
Department of Internal Medicine III, University of Cologne, 50924 Cologne, Germany
J Biol Chem 282:11255-65. 2007..In conclusion, this report provides new evidence for the essential role of the AVP system in ES cell-derived cardiomyogenesis... - The cardiovascular and renal effects of a highly potent mu-opioid receptor agonist, cyclo[N epsilon,N beta-carbonyl-D-Lys2,Dap5]enkephalinamideJolanta Gutkowska
Laboratory of Peptides, Department of Chemistry, University of Warsaw, Warsaw, Poland
Eur J Pharmacol 496:167-74. 2004..192+/-21 pg/ml, P<0.005), and was associated with augmented ANP mRNA levels in right atria and left ventricles. Thus, cUENK6 evokes renal effects by enhancing activity of the renal natriuretic peptide system...