Therese A Stukel

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. pmc The influence of measurement error on calibration, discrimination, and overall estimation of a risk prediction model
    Laura C Rosella
    Public Health Ontario, Toronto, Ontario, Canada
    Popul Health Metr 10:20. 2012
  2. pmc Association of hospital spending intensity with mortality and readmission rates in Ontario hospitals
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 307:1037-45. 2012
  3. pmc Development of a minimization instrument for allocation of a hospital-level performance improvement intervention to reduce waiting times in Ontario emergency departments
    Chad Andrew Leaver
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, Canada
    Implement Sci 4:32. 2009
  4. doi request reprint Association between hospital cardiac management and outcomes for acute myocardial infarction patients
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 48:157-65. 2010
  5. pmc Analysis of observational studies in the presence of treatment selection bias: effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methods
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 297:278-85. 2007
  6. doi request reprint Health impact of hospital restrictions on seriously ill hospitalized patients: lessons from the Toronto SARS outbreak
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Care 46:991-7. 2008
  7. pmc Long-term outcomes of regional variations in intensity of invasive vs medical management of Medicare Patients with acute myocardial infarction
    Therese A Stukel
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, NH, USA
    JAMA 293:1329-37. 2005
  8. doi request reprint The mortality benefit of direct trauma center transport in a regional trauma system: a population-based analysis
    Barbara Haas
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Trauma Acute Care Surg 72:1510-5; discussion 1515-7. 2012
  9. pmc Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMC Health Serv Res 12:238. 2012
  10. doi request reprint Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis
    Douglas S Lee
    Division of Cardiology, Institute for Clinical Evaluative Sciences, Toronto General Hospital, Toronto, Ontario, Canada
    Circ Heart Fail 3:228-35. 2010

Research Grants

  1. TUMOR GROWTH CURVE ANALYSIS
    Therese Stukel; Fiscal Year: 1993
  2. LONGITUDINAL METHODS IN CANCER RESEARCH
    Therese Stukel; Fiscal Year: 2002

Detail Information

Publications78

  1. pmc The influence of measurement error on calibration, discrimination, and overall estimation of a risk prediction model
    Laura C Rosella
    Public Health Ontario, Toronto, Ontario, Canada
    Popul Health Metr 10:20. 2012
    ..abstract:..
  2. pmc Association of hospital spending intensity with mortality and readmission rates in Ontario hospitals
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 307:1037-45. 2012
    ..The extent to which better spending produces higher-quality care and better patient outcomes in a universal health care system with selective access to medical technology is unknown...
  3. pmc Development of a minimization instrument for allocation of a hospital-level performance improvement intervention to reduce waiting times in Ontario emergency departments
    Chad Andrew Leaver
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, Canada
    Implement Sci 4:32. 2009
    ..A minimization algorithm will ensure balanced allocation of the intervention with respect to these factors in study hospitals...
  4. doi request reprint Association between hospital cardiac management and outcomes for acute myocardial infarction patients
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 48:157-65. 2010
    ..Randomized trials have shown that medical and interventional therapies improve outcomes for acute myocardial infarction (AMI) patients. The extent to which hospital quality improvement translates into better patient outcomes is unclear...
  5. pmc Analysis of observational studies in the presence of treatment selection bias: effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methods
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 297:278-85. 2007
    ..Comparisons of outcomes between patients treated and untreated in observational studies may be biased due to differences in patient prognosis between groups, often because of unobserved treatment selection biases...
  6. doi request reprint Health impact of hospital restrictions on seriously ill hospitalized patients: lessons from the Toronto SARS outbreak
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Care 46:991-7. 2008
    ..Restrictions on non-urgent hospital care imposed to control the 2003 Toronto severe acute respiratory syndrome outbreak led to substantial disruptions in hospital clinical practice, admission, and transfer patterns...
  7. pmc Long-term outcomes of regional variations in intensity of invasive vs medical management of Medicare Patients with acute myocardial infarction
    Therese A Stukel
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, NH, USA
    JAMA 293:1329-37. 2005
    ..The health and policy implications of the marked regional variations in intensity of invasive compared with medical management of patients with acute myocardial infarction (AMI) are unknown...
  8. doi request reprint The mortality benefit of direct trauma center transport in a regional trauma system: a population-based analysis
    Barbara Haas
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Trauma Acute Care Surg 72:1510-5; discussion 1515-7. 2012
    ..Taking a novel, population-based approach, we estimated the potential detrimental impact of undertriage to a non-TC (NTC) within a regional system...
  9. pmc Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMC Health Serv Res 12:238. 2012
    ..The extent to which uncomplicated obesity among an otherwise healthy middle-aged population is associated with higher longitudinal health-care expenditures remains unclear...
  10. doi request reprint Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis
    Douglas S Lee
    Division of Cardiology, Institute for Clinical Evaluative Sciences, Toronto General Hospital, Toronto, Ontario, Canada
    Circ Heart Fail 3:228-35. 2010
    ..Although approximately one third of patients with heart failure (HF) visiting the emergency department (ED) are discharged home, little is known about their care and outcomes...
  11. pmc Effect of widespread restrictions on the use of hospital services during an outbreak of severe acute respiratory syndrome
    Michael J Schull
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 176:1827-32. 2007
    ..We describe the impact of these restrictions on health care utilization and suggest lessons for future epidemics...
  12. doi request reprint Disequilibrium between admitted and discharged hospitalized patients affects emergency department length of stay
    Marian J Vermeulen
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ann Emerg Med 54:794-804. 2009
    ..We test whether the balance between daily hospital admissions and discharges affects next-day ED length of stay...
  13. doi request reprint Regional variation in cardiac catheterization appropriateness and baseline risk after acute myocardial infarction
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Coll Cardiol 51:716-23. 2008
    ....
  14. pmc The average lifespan of patients discharged from hospital with heart failure
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Gen Intern Med 27:1171-9. 2012
    ..There are no life-tables quantifying the average life-spans of post-hospitalized heart failure populations across various strata of risk...
  15. doi request reprint Rates of complete colonic evaluation after incomplete colonoscopy and their associated factors: a population-based study
    Randy Rizek
    Department of Medicine, University of Toronto, Toronto, Canada
    Med Care 47:48-52. 2009
    ..With the increasing use of colonoscopy there is growing concern about the quality of these procedures...
  16. doi request reprint Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, ON, M4N 3M5, Canada
    Circulation 122:1806-14. 2010
    ..The type of outpatient physician care after an emergency department visit for heart failure may affect patients' outcomes. Methods and..
  17. pmc Primary care physician workforce and Medicare beneficiaries' health outcomes
    Chiang Hua Chang
    Center for Health Policy Research, Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, NH 03766, USA
    JAMA 305:2096-104. 2011
    ..Despite a widespread interest in increasing the numbers of primary care physicians to improve care and to moderate costs, the relationship of the primary care physician workforce to patient-level outcomes remains poorly understood...
  18. ncbi request reprint Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Epidemiology 18:776-84. 2007
    ..It is also not known whether subgroups of individuals are at greater risk, eg, those with radiation sensitivity or high ultraviolet radiation exposure...
  19. pmc National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004
    Jack V Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 180:E118-25. 2009
    ..We examined recent national trends in mortality and rates of hospital admission for these 3 conditions...
  20. doi request reprint Life expectancy after an index hospitalization for patients with heart failure: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am Heart J 155:324-31. 2008
    ..However, previous studies have focused on predicting shorter-term mortality and limited data currently exist to predict expected survival among hospitalized patients with HF...
  21. ncbi request reprint The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with care
    Elliott S Fisher
    Center for Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Ann Intern Med 138:288-98. 2003
    ..The health implications of regional differences in Medicare spending are unknown...
  22. pmc Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 181:E55-66. 2009
    ..Temporal trends in risk factors for cardiovascular disease and the impact of socio-economic status on these risk factors remain unclear...
  23. ncbi request reprint Risk-treatment mismatch in the pharmacotherapy of heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 294:1240-7. 2005
    ..Patients with heart failure have a wide spectrum of mortality risks. To maximize the benefit of available pharmacotherapies, patients with high mortality risk should receive high rates of drug therapy...
  24. doi request reprint Primary care physician supply and children's health care use, access, and outcomes: findings from Canada
    Astrid Guttmann
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, G106, Toronto, Ontario, Canada M4N 3M5
    Pediatrics 125:1119-26. 2010
    ..To describe the relationship of primary care physician (PCP) supply for children and measures of health care access, use, and outcomes...
  25. doi request reprint Prediction of heart failure mortality in emergent care: a cohort study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 156:767-75, W-261, W-262. 2012
    ..Heart failure contributes to millions of emergency department (ED) visits, but hospitalization-versus-discharge decisions are often not accompanied by prognostic risk quantification...
  26. ncbi request reprint Occupation and keratinocyte cancer risk: a population-based case-control study
    Josh Marehbian
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Dartmouth College, Hanover, NH, USA
    Cancer Causes Control 18:895-908. 2007
    ..The aim of our study was to identify occupations associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)...
  27. doi request reprint Association of blood pressure at hospital discharge with mortality in patients diagnosed with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Circ Heart Fail 2:616-23. 2009
    ..Higher blood pressure in acute heart failure has been associated with improved survival; however, the relationship between blood pressure and survival in stabilized patients at hospital discharge has not been established...
  28. pmc Association between colonoscopy and colorectal cancer mortality in a US cohort according to site of cancer and colonoscopist specialty
    Nancy N Baxter
    Keenan ResearchCentre, Li Ka Shing Knowledge Institute, andDivision of General Surgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    J Clin Oncol 30:2664-9. 2012
    ..We designed this study to evaluate the association of colonoscopy with colorectal cancer (CRC) death in the United States by site of CRC and endoscopist specialty...
  29. ncbi request reprint The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of care
    Elliott S Fisher
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Ann Intern Med 138:273-87. 2003
    ..The health implications of regional differences in Medicare spending are unknown...
  30. doi request reprint Bleeding and perforation after outpatient colonoscopy and their risk factors in usual clinical practice
    Linda Rabeneck
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 135:1899-1906, 1906.e1. 2008
    ..Our objectives were to evaluate the rates of bleeding, perforation, and death associated with outpatient colonoscopy and their risk factors in a population-based study...
  31. ncbi request reprint End-of-life care at academic medical centers: implications for future workforce requirements
    David C Goodman
    Center for the Evaluative Clinical Sciences CECS, Dartmouth Medical School, Hanover, New Hampshire, USA
    Health Aff (Millwood) 25:521-31. 2006
    ....
  32. pmc Association between waiting times and short term mortality and hospital admission after departure from emergency department: population based cohort study from Ontario, Canada
    Astrid Guttmann
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    BMJ 342:d2983. 2011
    ..To determine whether patients who are not admitted to hospital after attending an emergency department during shifts with long waiting times are at risk for adverse events...
  33. pmc How many people have had a myocardial infarction? Prevalence estimated using historical hospital data
    Douglas G Manuel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    BMC Public Health 7:174. 2007
    ..The objective of this study is to estimate the prevalence of people previously hospitalized with an acute myocardial infarction (AMI) using 17 years of hospital data and to create a registry of people with myocardial infarction...
  34. doi request reprint Association between colonoscopy rates and colorectal cancer mortality
    Linda Rabeneck
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 105:1627-32. 2010
    ..Our objective was to evaluate the association between regional colonoscopy rates and death from colorectal cancer (CRC)...
  35. ncbi request reprint Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
    Margaret R Karagas
    Department of Community and Family Medicine, Center for Environmental Health Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Natl Cancer Inst 98:389-95. 2006
    ....
  36. doi request reprint The relationship between variations in antipsychotic prescribing across nursing homes and short-term mortality: quality of care implications
    Susan E Bronskill
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Med Care 47:1000-8. 2009
    ..Determining the extent to which variations in antipsychotic use are a symptom of facility-level quality problems as compared with a drug safety issue is important for selecting the correct interventions to effect change...
  37. doi request reprint "Dose-dependent" impact of recurrent cardiac events on mortality in patients with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ont, Canada
    Am J Med 122:162-169.e1. 2009
    ..We determined if a "dose-dependent" relationship exists between heart failure events and death, accounting for temporal changes in age, comorbidities, and disease severity...
  38. pmc Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study
    Judy R Rees
    Department of Community and Family Medicine Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH, USA
    J Am Acad Dermatol 56:781-5. 2007
    ..Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models...
  39. ncbi request reprint Surge capacity associated with restrictions on nonurgent hospital utilization and expected admissions during an influenza pandemic: lessons from the Toronto severe acute respiratory syndrome outbreak
    Michael J Schull
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Acad Emerg Med 13:1228-31. 2006
    ..One proposed strategy to increase hospital surge capacity is to restrict elective hospitalizations, yet the degree to which this measure would meet the anticipated is unknown...
  40. pmc Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction
    David A Alter
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 8:e65130. 2013
    ..To examine the relationship between socio-economic status (SES), functional recovery and long-term mortality following acute myocardial infarction (AMI)...
  41. pmc The role of ethnicity in predicting diabetes risk at the population level
    Laura C Rosella
    Public Health Ontario, Toronto, Ontario, Canada
    Ethn Health 17:419-37. 2012
    ..Given the importance of ethnicity in influencing diabetes risk and its significance in a multi-ethnic population, it is prudent to determine its influence on a population-based risk prediction tool...
  42. ncbi request reprint Variation in nursing home antipsychotic prescribing rates
    Paula A Rochon
    Kunin Lunenfeld Applied Research Unit, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada
    Arch Intern Med 167:676-83. 2007
    ..We explored variation in the use of antipsychotic therapy across nursing homes in Ontario, Canada, and determined if prescribing decisions were based on clinical indications...
  43. doi request reprint Safety of influenza vaccination in patients with myasthenia gravis: a population-based study
    Lorne Zinman
    Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Muscle Nerve 40:947-51. 2009
    ..Vaccination of patients with MG against influenza was not found to be associated with exacerbations of the disease. Our findings do not support the practice of withholding influenza vaccination in patients with MG...
  44. pmc Impact of clinical urgency, physician supply and procedural capacity on regional variations in wait times for coronary angiography
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 10:5. 2010
    ..Our objective was to evaluate the extent to which demand-side factors such as clinical urgency/need, and supply-side factors, as reflected by differences in physician and procedural supply account for these inequalities...
  45. pmc The effect of universal influenza immunization on mortality and health care use
    Jeffrey C Kwong
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS Med 5:e211. 2008
    ..We evaluated the effect of Ontario's UIIP on influenza-associated mortality, hospitalizations, emergency department (ED) use, and visits to doctors' offices...
  46. doi request reprint Risk of proximal and distal colorectal cancer following flexible sigmoidoscopy: a population-based cohort study
    Linda Rabeneck
    Department of Medicine, Management and Evaluation, University of Toronto, Toronto, Canada
    Am J Gastroenterol 103:2075-82. 2008
    ..Our objective was to estimate the annual incidence of CRC within 7 yr following FS and to identify factors associated with incident CRC in those with a negative FS...
  47. doi request reprint Immunization coverage among young children of urban immigrant mothers: findings from a universal health care system
    Astrid Guttmann
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ambul Pediatr 8:205-9. 2008
    ..To investigate access to effective primary health care services in children of new immigrants to Canada by assessing immunization coverage at age 2...
  48. ncbi request reprint Use of Medicare claims data to monitor provider-specific performance among patients with severe chronic illness
    John E Wennberg
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, New Hampshire, USA
    Health Aff (Millwood) . 2004
    ..We believe that hospital-specific measures can be helpful in identifying providers with acceptable quality indices who are also relatively efficient in managing chronic illness...
  49. ncbi request reprint Guillain-Barré syndrome after influenza vaccination in adults: a population-based study
    David N Juurlink
    Institute of Clinical Evaluative Sciences, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    Arch Intern Med 166:2217-21. 2006
    ..Whether influenza vaccination is associated with Guillain-Barré syndrome (GBS) remains uncertain...
  50. ncbi request reprint Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circulation 115:196-203. 2007
    ....
  51. doi request reprint Risk of Guillain-Barré syndrome after seasonal influenza vaccination and influenza health-care encounters: a self-controlled study
    Jeffrey C Kwong
    Institute for Clinical Evaluative Sciences, Toronto, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Canada Public Health Ontario, Toronto, Canada University Health Network, Toronto, Canada Electronic address
    Lancet Infect Dis 13:769-76. 2013
    ..However, influenza infection might also be associated with Guillain-Barré syndrome. We aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters...
  52. pmc Effectiveness of community-wide and individual high-risk strategies to prevent diabetes: a modelling study
    Douglas G Manuel
    The Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 8:e52963. 2013
    ..Effective population strategies to prevent diabetes have not been determined but two broad strategies have been proposed: "high-risk" and "community-wide" strategies...
  53. ncbi request reprint The risk of missed diagnosis of acute myocardial infarction associated with emergency department volume
    Michael J Schull
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ann Emerg Med 48:647-55. 2006
    ....
  54. pmc The relationship between physician supply, cardiovascular health service use and cardiac disease burden in Ontario: supply-need mismatch
    David A Alter
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario
    Can J Cardiol 24:187-93. 2008
    ..The objective of the present study was to examine the relationship among cardiovascular evaluation and management intensity, physician supply and cardiovascular disease burden in the Canadian population...
  55. ncbi request reprint Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
    ..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
  56. pmc A population-based risk algorithm for the development of diabetes: development and validation of the Diabetes Population Risk Tool (DPoRT)
    Laura C Rosella
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Epidemiol Community Health 65:613-20. 2011
    ..National estimates of the upcoming diabetes epidemic are needed to understand the distribution of diabetes risk in the population and to inform health policy...
  57. doi request reprint Evaluating the effect of clinical decision units on patient flow in seven Canadian emergency departments
    Michael J Schull
    Institute for Clinical Evaluative Sciences, Toronto, Ontario the Institute of Health Policy, Canada
    Acad Emerg Med 19:828-36. 2012
    ..To evaluate the effect of emergency department (ED) clinical decision units (CDUs) on overall ED patient flow in a pilot project funded in 2008 by the Ontario Ministry of Health and Long-Term Care (MOHLTC)...
  58. doi request reprint Influenza vaccination and all-cause mortality in community-dwelling elderly in Ontario, Canada, a cohort study
    Michael A Campitelli
    The Institute for Clinical Evaluative Sciences, Toronto, Canada
    Vaccine 29:240-6. 2010
    ..Since observational studies are prone to bias, future efforts to estimate vaccine effectiveness in the elderly should strive to minimize bias through improved data quality, novel data sources, and/or new analytical techniques...
  59. doi request reprint Survival of the fittest: the hidden cost of undertriage of major trauma
    Barbara Haas
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Surg 211:804-11. 2010
    ..Previous analyses of undertriage focused only on survivors to trauma center care and were potentially subject to survivor bias. Using a novel population-based design, we evaluated the true mortality cost of undertriage...
  60. ncbi request reprint Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Epidemiol 165:719-26. 2007
    ..Findings suggest that cumulative, but not intermittent, measures of sun exposure derived from a personal interview appear to reflect a person's exposure history based on histologic evidence...
  61. doi request reprint Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 117:1175-83. 2012
    ..Nonetheless, unmeasured confounding may unduly influence this comparison. This unmeasured risk may have less influence on comparisons of patients undergoing surgery at hospitals with differing transfusion rates...
  62. doi request reprint Estimating influenza vaccine effectiveness in community-dwelling elderly patients using the instrumental variable analysis method
    Kenny Wong
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, ON, Canada
    Arch Intern Med 172:484-91. 2012
    ..Estimates of influenza vaccine effectiveness in elderly individuals are largely from observational studies, which are susceptible to bias. Instrumental variable (IV) methods control for overt and hidden biases in observational studies...
  63. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004
    ..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs...
  64. pmc Use of hospitals, physician visits, and hospice care during last six months of life among cohorts loyal to highly respected hospitals in the United States
    John E Wennberg
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, 7251 Strasenburgh, Hanover, NH 03755 3863, USA
    BMJ 328:607. 2004
    ..To evaluate the use of healthcare resources during the last six months of life among patients of US hospitals with strong reputations for high quality care in managing chronic illness...
  65. ncbi request reprint The use of the propensity score for estimating treatment effects: administrative versus clinical data
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada
    Stat Med 24:1563-78. 2005
    ..Furthermore, measures of treatment effectiveness were attenuated when obtained using clinical data compared to when administrative data were used...
  66. ncbi request reprint Atypical antipsychotics and parkinsonism
    Paula A Rochon
    Institute for Clinical Evaluative Sciences, Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 165:1882-8. 2005
    ..This has not been well documented. We compared the risk of development of incident parkinsonism among older adults dispensed atypical relative to typical antipsychotics...
  67. ncbi request reprint Regional variation in rates of low birth weight
    Lindsay A Thompson
    Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire, USA
    Pediatrics 116:1114-21. 2005
    ..This study measures regional variation in LBW rates and identifies regions of neonatal health services with significantly high or low adjusted rates...
  68. ncbi request reprint Pregnancy history and incidence of melanoma in women: a pooled analysis
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, 7927 Rubin Bldg, One Medical Center Drive, Hanover, Lebanon, New Hampshire, 03756 0001, USA
    Cancer Causes Control 17:11-9. 2006
    ..g., <5 live births) (pOR 0.33, 95% CI 0.14-0.75). The results are compatible with an effect of reproductive history-related factors on melanoma risk, but also could reflect differences in other factors, such as sun exposure history...
  69. ncbi request reprint Proliferation of cardiac technology in Canada: a challenge to the sustainability of Medicare
    David A Alter
    Institute for Clinical Evaluative Sciences, The University of Toronto Clinical Epidemiology and Health Care Research Program, Toronto, Canada
    Circulation 113:380-7. 2006
    ..The objective of this study was to examine the temporal trends in the utilization and costs of cardiovascular technologies for the evaluation and/or management of patients with ischemic heart disease in Canada...
  70. ncbi request reprint Effect of NSAIDs on the recurrence of nonmelanoma skin cancer
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03766, USA
    Int J Cancer 119:682-6. 2006
    ..There were some indications of a modest, nonsignificant reduction on the number of BCCs and SCCs with NSAID use. Our data suggest a weak and inconsistent chemopreventive effect of NSAIDs on BCC and SCC...
  71. ncbi request reprint Factors associated with incomplete colonoscopy: a population-based study
    Hemant A Shah
    Department of Medicine, University of Toronto, Toronto, Canada
    Gastroenterology 132:2297-303. 2007
    ..We conducted a population-based study to determine the colonoscopy completion rate and to identify factors associated with incomplete procedures...
  72. ncbi request reprint The effect of universal influenza immunization on vaccination rates in Ontario
    Jeff C Kwong
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario
    Health Rep 17:31-40. 2006
    ..This article examines the association between introduction of Ontario's Universal Influenza Immunization Program and changes in vaccination rates over time in Ontario, compared with the other provinces combined...
  73. ncbi request reprint How are volume-outcome associations related to models of health care funding and delivery? A comparison of the United States and Canada
    David R Urbach
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G Wing, Toronto, Ontario M4N 3M5, Canada
    World J Surg 29:1230-3. 2005
    ..By promoting competition between hospitals and providers, market-based models may exacerbate existing variations in the quality of hospital care...
  74. ncbi request reprint The relation between the availability of neonatal intensive care and neonatal mortality
    David C Goodman
    Department of Pediatrics, Dartmouth Medical School, Hanover, NH 03755, USA
    N Engl J Med 346:1538-44. 2002
    ..We conducted a study to determine whether a greater supply of neonatologists or neonatal intensive care beds is associated with lower neonatal mortality...
  75. ncbi request reprint Study design to determine the effects of widespread restrictions on hospital utilization to control an outbreak of SARS in Toronto, Canada
    Michael J Schull
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada
    Expert Rev Pharmacoecon Outcomes Res 6:285-92. 2006
    ..Efforts to control an outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada, led to the imposition of major restrictions on nonurgent use of hospital-based services...
  76. ncbi request reprint Volume matters: physician practice characteristics and immunization coverage among young children insured through a universal health plan
    Astrid Guttmann
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pediatrics 117:595-602. 2006
    ..We studied the association between immunization coverage for a cohort of 2-year-old children covered by a universal health insurance plan and pediatric provider and other health services characteristics...
  77. pmc A controlled trial of methods for managing pain in primary care patients with or without co-occurring psychosocial problems
    Tim A Ahles
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Ann Fam Med 4:341-50. 2006
    ..Pain, a common reason for visits to primary care physicians, is often not well managed. The objective of this study was to determine the effectiveness of pain management interventions suitable for primary care physicians...
  78. ncbi request reprint Influence analysis for linear mixed-effects models
    Eugene Demidenko
    Dartmouth Medical School, Hanover, NH 03755, USA
    Stat Med 24:893-909. 2005
    ..These influence measures are applied to an analysis of 5-year Medicare reimbursements to colon cancer patients to identify the most influential observations and their effects on the fixed-effects coefficients...

Research Grants9

  1. TUMOR GROWTH CURVE ANALYSIS
    Therese Stukel; Fiscal Year: 1993
    ..Future directions include extending these results to multivariate analyses and pulmonary function data...
  2. LONGITUDINAL METHODS IN CANCER RESEARCH
    Therese Stukel; Fiscal Year: 2002
    ..The methods we propose will circumvent many of the above technical difficulties and would not require either special software or high performance computer workstations. ..