Research Topics
| M M MamdaniSummaryAffiliation: Institute for Clinical Evaluative Sciences Country: Canada Publications
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Detail Information
Publications
Influence of socioeconomic status on drug selection for the elderly in CanadaMuhammad M Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario M4N 3M5, Canada
Ann Pharmacother 36:804-8. 2002....
Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
BMJ 325:624. 2002..To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)...- Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderlyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
Arch Intern Med 163:481-6. 2003..We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs)... 
Does socioeconomic status affect mortality subsequent to hospital admission for community acquired pneumonia among older persons?Linda Vrbova
Department of Public Health Sciences, University of Toronto, McMurrich Building, 12 Queen s Park Crescent W, Toronto, ON, M5S 1A8, Canada
J Negat Results Biomed 4:4. 2005....- Time series analysis of age related cataract hospitalizations and phacoemulsificationAlan M Leong
Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, M4N 3M5, Canada
BMC Ophthalmol 6:2. 2006..The purpose of this study was to utilize time series methodology to determine the temporal and seasonal variations and the strength of the seasonality in age-related (senile) cataract hospitalizations and phacoemulsification surgeries... - Simplicity within complexity: seasonality and predictability of hospital admissions in the province of Ontario 1988-2001, a population-based analysisRoss E G Upshur
Department of Family and Community Medicine, University of Toronto, 263 McCaul Street, Toronto, ON M5T 1W7, Canada
BMC Health Serv Res 5:13. 2005..Less well understood is whether seasonal patterns occur for non-communicable diseases. The overall effect of seasonal fluctuations on hospital admissions has not been systematically evaluated... - Seasonality of service provision in hip and knee surgery: a possible contributor to waiting times? A time series analysisRoss E G Upshur
Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
BMC Health Serv Res 6:22. 2006..The objective of this study was to test the hypothesis that significant seasonal variation exists in the performance of hip and knee replacement surgery in the province of Ontario... - Is there a clinically significant seasonal component to hospital admissions for atrial fibrillation?Ross E G Upshur
Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, E 349, Toronto, Ontario, Canada M4N 3M5
BMC Health Serv Res 4:5. 2004..Atrial fibrillation is a common cardiac dysrhythmia, particularly in the elderly. Recent studies have indicated a statistically significant seasonal component to atrial fibrillation hospitalizations... - Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort studyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
Lancet 363:1751-6. 2004..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs... - Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological studyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G106, Toronto, ON, Canada M4N 3M5
BMJ 328:1415-6. 2004 - Warfarin therapy and risk of hip fracture among elderly patientsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Pharmacotherapy 23:1-4. 2003..To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population... - Initial patterns of use of COX-2 inhibitors by elderly patients in Ontario: findings and implicationsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, Toronto, ON
CMAJ 167:1125-6. 2002 - Use of antidepressants among elderly subjects: trends and contributing factorsM M Mamdani
Institute for Clinical Evaluative Sciences, the Center for Addiction and Mental Health, Toronto, Canada
Am J Psychiatry 157:360-7. 2000..The authors assessed changes over time in antidepressant utilization among elderly subjects regarding the prevalence of antidepressant users, shifts in prescription patterns, and related financial implications... - Mental health-related drug utilization among older adults: prevalence, trends, and costsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G119, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 13:892-900. 2005..Authors assessed temporal changes in mental health-related drug utilization and costs in an older population... - The changing landscape for COX-2 inhibitors: a summary of recent eventsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, University of Toronto Faculty of Pharmacy, Department of Health Policy, Management, and Evaluation, Ontario
Healthc Q 8:24, 26. 2005 - Are rates of gastrointestinal bleeding higher following the introduction of COX-2 inhibitors?Muhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G215, Toronto, Ontario, Canada
Expert Opin Drug Saf 4:591-8. 2005.... - Trends in the prescribing of antidepressants following acute myocardial infarction, 1993-2002Nili R Benazon
Centre for Addiction and Mental Healthand Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Psychosom Med 67:916-20. 2005..We examined how the prescribing of antidepressants to patients post-myocardial infarction (MI) changed in the decade 1993 to 2002, including the proportion accounted for by TCAs... - Effect of age on the use of evidence-based therapies for acute myocardial infarctionChau T T Tran
University of Toronto, Institute of Medical Sciences, Toronto, Ontario, Canada
Am Heart J 148:834-41. 2004..46; 95% CI, 1.22-1.74). CONCLUSIONS: Despite adjustments for contraindications to therapy, the underuse of AMI treatments, particularly in elderly patients, was found... - Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000Douglas S Lee
Faculty of Pharmacy, Toronto, Canada
Am J Med 116:581-9. 2004..CONCLUSION: During 1992 to 2000, mortality and morbidity improved among elderly patients with heart failure, with increased utilization of beta-blockers contributing most to the beneficial trends in outcomes... - Antidepressants, warfarin, and the risk of hemorrhagePaul A Kurdyak
The Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychopharmacol 25:561-4. 2005..We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an increased risk of hospitalization for upper gastrointestinal tract bleeding (UGIB)... - Does statin therapy decrease the risk for bleeding in patients who are receiving warfarin?James D Douketis
Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
Am J Med 120:369.e9-369.e14. 2007..Recent observations in patients with atrial fibrillation who are receiving warfarin suggest that concomitant treatment with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) decreases the risk for bleeding... 
A population-based assessment of the drug interaction between levothyroxine and warfarinD Pincus
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Clin Pharmacol Ther 92:766-70. 2012..Drug interaction resources that presently characterize this interaction as important should reevaluate this classification...- Chronic dialysis and death among survivors of acute kidney injury requiring dialysisRon Wald
Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
JAMA 302:1179-85. 2009..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge... - Proton pump inhibitors. Compliance with a mandated step-up programM M Mamdani
Institute for Clinical Evaluative Sciences, Toronto, Ont
Can Fam Physician 47:531-5. 2001..In future, costs and benefits of potential interventions should be carefully considered before implementing new policies... - Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based studyClaudia Bucci
Department of Pharmacie, Sunnybook Health Sciences Centre, University of Toronto, Ontario, Canada
Can J Cardiol 24:629-32. 2008..Despite safety concerns associated with short-acting agents, increasing evidence supports the safety of long-acting dihydropyridines. Although amlodipine is the best studied of these, there are few studies comparing it with nifedipine... - Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based studyTony Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 170:1045-9. 2010..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB... - Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based studyHadas D Fischer
Department of Health Policy Management and Evaluation, University of Toronto, Toront, Ontario, Canada
Arch Intern Med 170:617-21. 2010..We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole... - Quantifying the impact of survivor treatment bias in observational studiesPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
J Eval Clin Pract 12:601-12. 2006..Survivor treatment bias can arise when the time dependent nature of treatment exposure is ignored since patients who survived to receive treatment may be healthier than patients who died prior to receipt of treatment... - Opioid dose and drug-related mortality in patients with nonmalignant painTara Gomes
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Arch Intern Med 171:686-91. 2011..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality... - Inequitable distribution of implantable cardioverter defibrillators in OntarioJacob A Udell
Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, and Department of Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
Int J Technol Assess Health Care 23:354-61. 2007..The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death... - Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort studyDavid N Juurlink
Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
BMJ 339:b2942. 2009..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone... - The safety of proton pump inhibitors and clopidogrel in patients after strokeDavid N Juurlink
Sunnybrook Research Institute, Toronto, Ontario, Canada
Stroke 42:128-32. 2011..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown... - Clinical and demographic characteristics of patients receiving different oral hypoglycemic agentsTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Pharmacoepidemiol Drug Saf 18:756-60. 2009.... - Appropriateness of spironolactone prescribing in heart failure patients: a population-based studyDennis T Ko
Division of Cardiology, Shulich Heart Centre, Department of Medicine, Sunnybrook and Women's Health Sciences Centre, Toronto, Ontario, Canada
J Card Fail 12:205-10. 2006..These findings highlight the need for more careful patient selection when prescribing spironolactone to minimize potential life-threatening hyperkalemia... - Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortalityPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Am Heart J 151:969-75. 2006..We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI)... - The risk of suicide with selective serotonin reuptake inhibitors in the elderlyDavid N Juurlink
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, Ont, Canada M4N 3M5
Am J Psychiatry 163:813-21. 2006..The authors explored the relationship between the initiation of therapy with selective serotonin reuptake inhibitor (SSRI) antidepressants and completed suicide in older patients... - A population-based study of the drug interaction between proton pump inhibitors and clopidogrelDavid N Juurlink
Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
CMAJ 180:713-8. 2009..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown... - How many "Me-Too" drugs are enough? The case of physician preferences for specific statinsPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Canada
Ann Pharmacother 40:1047-51. 2006..The increasing availability of "Me-Too" drugs has provided considerable treatment options for clinicians. However, the number of such drugs within a class that are actually used by clinicians has not been well studied... - Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based studyMohammed Al-Omran
Division of Vascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Vasc Surg 48:607-12. 2008..However, limited population-based data are available on use of statin therapy in these patients in Canada. We sought to study trends in statin use to treat these patients in Ontario during a 10-year period... - Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and healthPeter C Austin
Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
J Clin Epidemiol 59:964-9. 2006..To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility... - A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin usePeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Stat Med 25:2084-106. 2006..5 per cent, while estimates of the relative risk reduction ranged from 13.3 to 17.0 per cent. Adjusted estimates of the reduction in the odds of 3-year death varied from 15 to 24 per cent across the different propensity score methods... - Impact of the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22/Reversal of Atherosclerosis with Aggressive Lipid Lowering trials on trends in intensive versus moderate statin therapy in Ontario, CanadaPeter C Austin
Institute for Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
Circulation 112:1296-300. 2005..We sought to determine the impact of these 2 trials on trends in intensive versus moderate statin therapy in Ontario, Canada... - Drug-induced lithium toxicity in the elderly: a population-based studyDavid N Juurlink
Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Am Geriatr Soc 52:794-8. 2004..To study the association between hospital admission for lithium toxicity and the use of diuretics, angiotensin-converting enzyme (ACE) inhibitors, and nonsteroidal antiinflammatory drugs (NSAIDs) in the elderly... - The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in OntarioKaren Tu
Institute for Clinical Evaluative Sciences, University Health Network Toronto Western Hospital Family Medicine Center and Department of Family and Community Health Family Health Research Unit, University of Toronto, Toronto, ON
CMAJ 168:553-7. 2003..We studied whether HOPE affected the prescribing of ACE inhibitors generally, and ramipril specifically, in Ontario, where the trial was coordinated... - Community influenza outbreaks and emergency department ambulance diversionMichael J Schull
Institute for Clinical Evaluative Sciences, Department of Medicine, University of Toronto, Ontario, Canada
Ann Emerg Med 44:61-7. 2004..Influenza has been linked to emergency department (ED) crowding, yet few studies have examined this association. We describe the relationship between ED crowding and influenza outbreaks... - Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation StudyDavid N Juurlink
Department of Medicine University of Toronto, Toronto
N Engl J Med 351:543-51. 2004..Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated in these patients. However, life-threatening hyperkalemia can occur when these drugs are used together... - The impact of the Women's Health Initiative study on incident clonidine use in Ontario, CanadaPeter C Austin
Institute of Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto
Can J Clin Pharmacol 11:e191-4. 2004..There is some evidence that the antihypertensive agent clonidine can reduce the frequency of hot flashes associated with menopause... - Hypertension guidelines in elderly patients: is anybody listening?Karen Tu
Institute for Clinical Evaluative Services, G106 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Am J Med 113:52-8. 2002.... - Potentially inappropriate prescribing in Canada relative to the USPaula A Rochon
Kunin Lunenfeld Applied Research Unit, Department of Medicine, University of Toronto, Baycrest Centre for Geriatric Care, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Drugs Aging 21:939-47. 2004..To explore the prescribing of potentially inappropriate drug therapy in Ontario, Canada where there is a restrictive drug formulary relative to the US where there is no single drug formulary... - A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxinDavid N Juurlink
Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Br J Clin Pharmacol 59:102-7. 2005..We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting... - The use of the propensity score for estimating treatment effects: administrative versus clinical dataPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada
Stat Med 24:1563-78. 2005..Furthermore, measures of treatment effectiveness were attenuated when obtained using clinical data compared to when administrative data were used... - Influenza and emergency department utilization by eldersMichael J Schull
Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
Acad Emerg Med 12:338-44. 2005..Influenza outbreaks have been associated with worsened emergency department (ED) crowding. We sought to examine the mechanism behind this association... - Anxiety-related visits to Ontario physicians following September 11, 2001Peter C Austin
Institute for Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto, Toronto, Ontario
Can J Psychiatry 48:416-9. 2003..To determine whether the climate of increased anxiety following the terrorist attacks of September 11, 2001, and the subsequent anthrax cases led to increased anxiety-related physician visits... - Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk populationD N Juurlink
The Sunnybrook Research Institute, Departments of Medicine Pediatrics Health Policy, Management and Evaluation at the University of Toronto The Institute for Clinical Evaluative Sciences Department of Pharmacy at the University of Toronto the Li Ka Shing Knowledge Institute, Toronto, ON, Canada
Diabet Med 29:1524-8. 2012.... - A population based time series analysis of asthma hospitalisations in Ontario, Canada: 1988 to 2000E J Crighton
Primary Care Research Unit, Room E 354 Sunnybrook and Women s College Health Sciences Centre, Department of Family and Community Medicine and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
BMC Health Serv Res 1:7. 2001..This study set out to examine the seasonal patterns of asthma hospitalisations in relation to age and gender for the province of Ontario over a period of 12 years... - High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortificationJ G Ray
Department of Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
QJM 101:475-7. 2008..4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered... - Progressive trends in the prevalence of benzodiazepine prescribing in older people in Ontario, CanadaK Tu
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
J Am Geriatr Soc 49:1341-5. 2001..These findings suggest that, without undue regulation, physicians are making progress in the prescribing of benzodiazepine therapy on the basis of current knowledge available... - Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolismJoel G Ray
Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
Thromb Haemost 88:205-9. 2002..Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism... - Blood glucose test strips: options to reduce usageTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ont
CMAJ 182:35-8. 2010..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial... - Outpatient gatifloxacin therapy and dysglycemia in older adultsLaura Y Park-Wyllie
Institute for Clinical Evaluative Sciences, St. Michael's Hospital, Toronto
N Engl J Med 354:1352-61. 2006.... - Inappropriate prescribing before and after nursing home admissionIrfan A Dhalla
Faculty of Medicine, University of Toronto, 2113 40 Gerrard Street East, Toronto, Ontario M5B 2E8, Canada
J Am Geriatr Soc 50:995-1000. 2002..To compare the prevalence of inappropriate prescribing before and after nursing home admission and to determine which patient and physician characteristics are associated with inappropriate prescribing in the nursing home setting... - The effect of antidepressant warnings on prescribing trends in Ontario, CanadaPaul A Kurdyak
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Am J Public Health 97:750-4. 2007..We studied whether 5 regulatory agency advisories concerning the possible increased risk of suicidal behavior during antidepressant therapy had an effect on antidepressant prescription trends in Ontario... - Potentially unintended discontinuation of long-term medication use after elective surgical proceduresChaim M Bell
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 166:2525-31. 2006..Transitions between health care settings represent vulnerable periods for medical error. Discontinuation of long-term medication use may occur during discharge from the hospital to the community... - Potentially inappropriate prescribing in Ontario community-dwelling older adults and nursing home residentsChristopher J Lane
Department of Medicine, University of Toronto, Toronto, Canada
J Am Geriatr Soc 52:861-6. 2004..Clinical pharmacist services, which are mandated in the nursing home setting, may be responsible for these differences in Ontario, Canada... - Macrolide-induced digoxin toxicity: a population-based studyT Gomes
The Institute for Clinical Evaluative Sciences, Ontario, Canada
Clin Pharmacol Ther 86:383-6. 2009..7; 95% CI 1.7-7.9; and adjusted OR 3.7; 95% CI 1.1-12.5, respectively). We found no increased risk with a neutral comparator, cefuroxime (adjusted OR 0.8; 95% CI 0.2-3.4)... - Association between folic acid food fortification and hypertension or preeclampsia in pregnancyJoel G Ray
Toronto, Ontario
Arch Intern Med 162:1776-7. 2002 - Thresholds for small for gestational age among newborns of East Asian and South Asian ancestryJoel G Ray
Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
J Obstet Gynaecol Can 31:322-30. 2009..To determine the risk that newborn infants of East Asian and South Asian ancestry may be misclassified as small for gestational age (SGA)... - Outcome of revascularization procedures for peripheral arterial occlusive disease in Ontario between 1991 and 1998: a population-based studyMohammed Al-Omran
Institute for Clinical Evaluative Science, University of Toronto, Sunnybrook and Women's College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
J Vasc Surg 38:279-88. 2003.... - Use of interventional procedures for peripheral arterial occlusive disease in Ontario between 1991 and 1998: a population-based studyMohammed Al-Omran
Institute for Clinical Evaluative Science, University of Toronto, Sunnybrook and Women's College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
J Vasc Surg 38:289-95. 2003..The slight reduction in overall major amputation rate, driven by decreased rate in patients aged 85 years or older, may reflect a trend toward a more aggressive revascularization approach in this age group... - New use of rosiglitazone decreased following publication of a meta-analysis suggesting harmB R Shah
Institute for Clinical Evaluative Sciences, Toronto, Canada
Diabet Med 25:871-4. 2008..It is uncertain whether meta-analyses lead to changes in prescribing practices. We studied trends in the prescribing of glucose-lowering therapy before and after the publication of a meta-analysis suggesting harm from rosiglitazone... - Giant cell arteritis and cardiovascular disease in older adultsJ G Ray
Department of Medicine, Inner City Health, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
Heart 91:324-8. 2005..To explore the association between giant cell arteritis (GCA) and subsequent cardiovascular disease in older adults... - Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based studyDonna O Lowe
Department of Pharmacy Services, University Health Network, University of Toronto, ON, M5G 2C4, Canada
Clin Infect Dis 43:1272-6. 2006..Whether outpatient PPI use influences the risk of hospital admission for CDAD among older patients who have recently been treated with antibiotics is unknown... - Cholinesterase inhibitors and hospitalization for bradycardia: a population-based studyLaura Y Park-Wyllie
Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
PLoS Med 6:e1000157. 2009..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia... - Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodoneIrfan A Dhalla
Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
CMAJ 181:891-6. 2009..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone... - Trends in drug prescriptions among elderly residents of Ontario in the weeks after September 11, 2001Peter C Austin
JAMA 288:575-7. 2002 - External validity: the neglected dimension in evidence rankingNavindra Persaud
University College, University of Oxford, Oxford, UK
J Eval Clin Pract 12:450-3. 2006..Ideally, a treatment should only be used when both internally and externally valid evidence indicates that it will be useful for the particular patient... - Health advisories: when good intentions go badMuhammad M Mamdani
Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont
CMAJ 178:1025-6. 2008 - Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?Irfan A Dhalla
Department of Medicine, Unversity of Toronto, Ontario M4E 3E9, Canada
Antimicrob Agents Chemother 50:3216-9. 2006..difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin or moxifloxacin compared to levofloxacin... - Statins and the risk of idiopathic venous thromboembolismJoel G Ray
Br J Clin Pharmacol 56:460; author reply 461-2. 2003 - Changes in prescribing patterns following publication of the ALLHAT trialPeter C Austin
JAMA 291:44-5. 2004 - Prescriptions for estrogen replacement therapy in Ontario before and after publication of the Women's Health Initiative StudyPeter C Austin
JAMA 289:3241-2. 2003