M M Mamdani

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. ncbi request reprint Influence of socioeconomic status on drug selection for the elderly in Canada
    Muhammad M Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario M4N 3M5, Canada
    Ann Pharmacother 36:804-8. 2002
  2. pmc Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
    BMJ 325:624. 2002
  3. ncbi request reprint Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
    Arch Intern Med 163:481-6. 2003
  4. pmc Does socioeconomic status affect mortality subsequent to hospital admission for community acquired pneumonia among older persons?
    Linda Vrbova
    Department of Public Health Sciences, University of Toronto, McMurrich Building, 12 Queen s Park Crescent W, Toronto, ON, M5S 1A8, Canada
    J Negat Results Biomed 4:4. 2005
  5. pmc Time series analysis of age related cataract hospitalizations and phacoemulsification
    Alan M Leong
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, M4N 3M5, Canada
    BMC Ophthalmol 6:2. 2006
  6. pmc Simplicity within complexity: seasonality and predictability of hospital admissions in the province of Ontario 1988-2001, a population-based analysis
    Ross E G Upshur
    Department of Family and Community Medicine, University of Toronto, 263 McCaul Street, Toronto, ON M5T 1W7, Canada
    BMC Health Serv Res 5:13. 2005
  7. pmc Seasonality of service provision in hip and knee surgery: a possible contributor to waiting times? A time series analysis
    Ross E G Upshur
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    BMC Health Serv Res 6:22. 2006
  8. pmc Is there a clinically significant seasonal component to hospital admissions for atrial fibrillation?
    Ross E G Upshur
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, E 349, Toronto, Ontario, Canada M4N 3M5
    BMC Health Serv Res 4:5. 2004
  9. ncbi request reprint The changing landscape for COX-2 inhibitors: a summary of recent events
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, University of Toronto Faculty of Pharmacy, Department of Health Policy, Management, and Evaluation, Ontario
    Healthc Q 8:24, 26. 2005
  10. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004

Detail Information

Publications84

  1. ncbi request reprint Influence of socioeconomic status on drug selection for the elderly in Canada
    Muhammad M Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario M4N 3M5, Canada
    Ann Pharmacother 36:804-8. 2002
    ....
  2. pmc Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
    BMJ 325:624. 2002
    ..To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)...
  3. ncbi request reprint Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
    Arch Intern Med 163:481-6. 2003
    ..We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs)...
  4. pmc Does socioeconomic status affect mortality subsequent to hospital admission for community acquired pneumonia among older persons?
    Linda Vrbova
    Department of Public Health Sciences, University of Toronto, McMurrich Building, 12 Queen s Park Crescent W, Toronto, ON, M5S 1A8, Canada
    J Negat Results Biomed 4:4. 2005
    ....
  5. pmc Time series analysis of age related cataract hospitalizations and phacoemulsification
    Alan M Leong
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, M4N 3M5, Canada
    BMC Ophthalmol 6:2. 2006
    ..The purpose of this study was to utilize time series methodology to determine the temporal and seasonal variations and the strength of the seasonality in age-related (senile) cataract hospitalizations and phacoemulsification surgeries...
  6. pmc Simplicity within complexity: seasonality and predictability of hospital admissions in the province of Ontario 1988-2001, a population-based analysis
    Ross E G Upshur
    Department of Family and Community Medicine, University of Toronto, 263 McCaul Street, Toronto, ON M5T 1W7, Canada
    BMC Health Serv Res 5:13. 2005
    ..Less well understood is whether seasonal patterns occur for non-communicable diseases. The overall effect of seasonal fluctuations on hospital admissions has not been systematically evaluated...
  7. pmc Seasonality of service provision in hip and knee surgery: a possible contributor to waiting times? A time series analysis
    Ross E G Upshur
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    BMC Health Serv Res 6:22. 2006
    ..The objective of this study was to test the hypothesis that significant seasonal variation exists in the performance of hip and knee replacement surgery in the province of Ontario...
  8. pmc Is there a clinically significant seasonal component to hospital admissions for atrial fibrillation?
    Ross E G Upshur
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, E 349, Toronto, Ontario, Canada M4N 3M5
    BMC Health Serv Res 4:5. 2004
    ..Atrial fibrillation is a common cardiac dysrhythmia, particularly in the elderly. Recent studies have indicated a statistically significant seasonal component to atrial fibrillation hospitalizations...
  9. ncbi request reprint The changing landscape for COX-2 inhibitors: a summary of recent events
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, University of Toronto Faculty of Pharmacy, Department of Health Policy, Management, and Evaluation, Ontario
    Healthc Q 8:24, 26. 2005
  10. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004
    ..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs...
  11. pmc Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G106, Toronto, ON, Canada M4N 3M5
    BMJ 328:1415-6. 2004
  12. ncbi request reprint Are rates of gastrointestinal bleeding higher following the introduction of COX-2 inhibitors?
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G215, Toronto, Ontario, Canada
    Expert Opin Drug Saf 4:591-8. 2005
    ....
  13. ncbi request reprint Mental health-related drug utilization among older adults: prevalence, trends, and costs
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, G119, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 13:892-900. 2005
    ..Authors assessed temporal changes in mental health-related drug utilization and costs in an older population...
  14. ncbi request reprint Warfarin therapy and risk of hip fracture among elderly patients
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacotherapy 23:1-4. 2003
    ..To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population...
  15. pmc Initial patterns of use of COX-2 inhibitors by elderly patients in Ontario: findings and implications
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON
    CMAJ 167:1125-6. 2002
  16. ncbi request reprint Use of antidepressants among elderly subjects: trends and contributing factors
    M M Mamdani
    Institute for Clinical Evaluative Sciences, the Center for Addiction and Mental Health, Toronto, Canada
    Am J Psychiatry 157:360-7. 2000
    ..The authors assessed changes over time in antidepressant utilization among elderly subjects regarding the prevalence of antidepressant users, shifts in prescription patterns, and related financial implications...
  17. ncbi request reprint Trends in selection and timing of first-line pharmacotherapy in older patients with type 2 diabetes diagnosed between 1994 and 2006
    P D Foster
    Schulich School of Medicine and Dentistry, University of Western Ontario, London Applied Health Research Centre, St Michael s Hospital, Toronto, ON, Canada
    Diabet Med 30:1209-13. 2013
    ..To characterize temporal trends in the selection and timing of first-line pharmacotherapy among older patients with Type 2 diabetes...
  18. ncbi request reprint Trends in the prescribing of antidepressants following acute myocardial infarction, 1993-2002
    Nili R Benazon
    Centre for Addiction and Mental Healthand Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Psychosom Med 67:916-20. 2005
    ..We examined how the prescribing of antidepressants to patients post-myocardial infarction (MI) changed in the decade 1993 to 2002, including the proportion accounted for by TCAs...
  19. ncbi request reprint Effect of age on the use of evidence-based therapies for acute myocardial infarction
    Chau T T Tran
    University of Toronto, Institute of Medical Sciences, Toronto, Ontario, Canada
    Am Heart J 148:834-41. 2004
    ..The objective of this study was to determine whether elderly patients are less likely than non-elderly patients to receive evidence-based AMI treatments, both before and after the consideration of contraindications to therapy...
  20. ncbi request reprint Antidepressants, warfarin, and the risk of hemorrhage
    Paul A Kurdyak
    The Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychopharmacol 25:561-4. 2005
    ..We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an increased risk of hospitalization for upper gastrointestinal tract bleeding (UGIB)...
  21. ncbi request reprint Does statin therapy decrease the risk for bleeding in patients who are receiving warfarin?
    James D Douketis
    Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Am J Med 120:369.e9-369.e14. 2007
    ..Recent observations in patients with atrial fibrillation who are receiving warfarin suggest that concomitant treatment with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) decreases the risk for bleeding...
  22. ncbi request reprint Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000
    Douglas S Lee
    Faculty of Pharmacy, Toronto, Canada
    Am J Med 116:581-9. 2004
    ..To review trends in drug therapy and concomitant outcomes of elderly heart failure patients in Ontario, Canada...
  23. doi request reprint Progression through diabetes therapies among new elderly users of metformin: a population-based study
    T Gomes
    Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Diabet Med 30:e51-5. 2013
    ..To examine temporal changes in progression to second-line therapies among older patients with diabetes newly treated with metformin...
  24. doi request reprint Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk population
    D N Juurlink
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabet Med 29:1524-8. 2012
    ..Whether this imparts a higher risk of adverse cardiac events is unknown...
  25. pmc A population-based assessment of the drug interaction between levothyroxine and warfarin
    D Pincus
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 92:766-70. 2012
    ..Drug interaction resources that presently characterize this interaction as important should reevaluate this classification...
  26. doi request reprint Chronic dialysis and death among survivors of acute kidney injury requiring dialysis
    Ron Wald
    Division of Nephrology, St Michael s Hospital, 61 Queen St East, 9 140, Toronto, ON M5C 2T2, Canada
    JAMA 302:1179-85. 2009
    ..Severe acute kidney injury among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who survive to hospital discharge...
  27. pmc Proton pump inhibitors. Compliance with a mandated step-up program
    M M Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    Can Fam Physician 47:531-5. 2001
    ..In future, costs and benefits of potential interventions should be carefully considered before implementing new policies...
  28. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
    ..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB...
  29. pmc Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based study
    Claudia Bucci
    Department of Pharmacie, Sunnybook Health Sciences Centre, University of Toronto, Ontario, Canada
    Can J Cardiol 24:629-32. 2008
    ..Despite safety concerns associated with short-acting agents, increasing evidence supports the safety of long-acting dihydropyridines. Although amlodipine is the best studied of these, there are few studies comparing it with nifedipine...
  30. doi request reprint Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study
    Hadas D Fischer
    Department of Health Policy Management and Evaluation, University of Toronto, Toront, Ontario, Canada
    Arch Intern Med 170:617-21. 2010
    ..We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole...
  31. ncbi request reprint Appropriateness of spironolactone prescribing in heart failure patients: a population-based study
    Dennis T Ko
    Division of Cardiology, Shulich Heart Centre, Department of Medicine, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
    J Card Fail 12:205-10. 2006
    ..However, recent data have raised concerns regarding hyperkalemia secondary to spironolactone use and suggest it occurs more commonly in routine practice...
  32. ncbi request reprint Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortality
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 151:969-75. 2006
    ..We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI)...
  33. ncbi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
    ....
  34. ncbi request reprint Inequitable distribution of implantable cardioverter defibrillators in Ontario
    Jacob A Udell
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, and Department of Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Int J Technol Assess Health Care 23:354-61. 2007
    ..The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death...
  35. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
    ..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown...
  36. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
    ..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality...
  37. ncbi request reprint Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based study
    Mohammed Al-Omran
    Division of Vascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Vasc Surg 48:607-12. 2008
    ..However, limited population-based data are available on use of statin therapy in these patients in Canada. We sought to study trends in statin use to treat these patients in Ontario during a 10-year period...
  38. pmc Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
    David N Juurlink
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 339:b2942. 2009
    ..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone...
  39. ncbi request reprint Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and health
    Peter C Austin
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
    J Clin Epidemiol 59:964-9. 2006
    ..To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility...
  40. ncbi request reprint How many "Me-Too" drugs are enough? The case of physician preferences for specific statins
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Ann Pharmacother 40:1047-51. 2006
    ..The increasing availability of "Me-Too" drugs has provided considerable treatment options for clinicians. However, the number of such drugs within a class that are actually used by clinicians has not been well studied...
  41. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
    ..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown...
  42. ncbi request reprint The risk of suicide with selective serotonin reuptake inhibitors in the elderly
    David N Juurlink
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, Ont, Canada M4N 3M5
    Am J Psychiatry 163:813-21. 2006
    ..The authors explored the relationship between the initiation of therapy with selective serotonin reuptake inhibitor (SSRI) antidepressants and completed suicide in older patients...
  43. ncbi request reprint Quantifying the impact of survivor treatment bias in observational studies
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Eval Clin Pract 12:601-12. 2006
    ..Survivor treatment bias can arise when the time dependent nature of treatment exposure is ignored since patients who survived to receive treatment may be healthier than patients who died prior to receipt of treatment...
  44. pmc A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxin
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Br J Clin Pharmacol 59:102-7. 2005
    ..We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting...
  45. ncbi request reprint Hypertension guidelines in elderly patients: is anybody listening?
    Karen Tu
    Institute for Clinical Evaluative Services, G106 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Am J Med 113:52-8. 2002
    ....
  46. ncbi request reprint Community influenza outbreaks and emergency department ambulance diversion
    Michael J Schull
    Institute for Clinical Evaluative Sciences, Department of Medicine, University of Toronto, Ontario, Canada
    Ann Emerg Med 44:61-7. 2004
    ..Influenza has been linked to emergency department (ED) crowding, yet few studies have examined this association. We describe the relationship between ED crowding and influenza outbreaks...
  47. pmc The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario
    Karen Tu
    Institute for Clinical Evaluative Sciences, University Health Network Toronto Western Hospital Family Medicine Center and Department of Family and Community Health Family Health Research Unit, University of Toronto, Toronto, ON
    CMAJ 168:553-7. 2003
    ..We studied whether HOPE affected the prescribing of ACE inhibitors generally, and ramipril specifically, in Ontario, where the trial was coordinated...
  48. ncbi request reprint Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    David N Juurlink
    Department of Medicine University of Toronto, Toronto
    N Engl J Med 351:543-51. 2004
    ..Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated in these patients. However, life-threatening hyperkalemia can occur when these drugs are used together...
  49. ncbi request reprint The impact of the Women's Health Initiative study on incident clonidine use in Ontario, Canada
    Peter C Austin
    Institute of Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto
    Can J Clin Pharmacol 11:e191-4. 2004
    ..There is some evidence that the antihypertensive agent clonidine can reduce the frequency of hot flashes associated with menopause...
  50. ncbi request reprint Potentially inappropriate prescribing in Canada relative to the US
    Paula A Rochon
    Kunin Lunenfeld Applied Research Unit, Department of Medicine, University of Toronto, Baycrest Centre for Geriatric Care, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Drugs Aging 21:939-47. 2004
    ..To explore the prescribing of potentially inappropriate drug therapy in Ontario, Canada where there is a restrictive drug formulary relative to the US where there is no single drug formulary...
  51. ncbi request reprint The use of the propensity score for estimating treatment effects: administrative versus clinical data
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada
    Stat Med 24:1563-78. 2005
    ..Furthermore, measures of treatment effectiveness were attenuated when obtained using clinical data compared to when administrative data were used...
  52. ncbi request reprint A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Stat Med 25:2084-106. 2006
    ..5 per cent, while estimates of the relative risk reduction ranged from 13.3 to 17.0 per cent. Adjusted estimates of the reduction in the odds of 3-year death varied from 15 to 24 per cent across the different propensity score methods...
  53. ncbi request reprint Impact of the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22/Reversal of Atherosclerosis with Aggressive Lipid Lowering trials on trends in intensive versus moderate statin therapy in Ontario, Canada
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Circulation 112:1296-300. 2005
    ..We sought to determine the impact of these 2 trials on trends in intensive versus moderate statin therapy in Ontario, Canada...
  54. ncbi request reprint Influenza and emergency department utilization by elders
    Michael J Schull
    Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Acad Emerg Med 12:338-44. 2005
    ..Influenza outbreaks have been associated with worsened emergency department (ED) crowding. We sought to examine the mechanism behind this association...
  55. ncbi request reprint Anxiety-related visits to Ontario physicians following September 11, 2001
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Department of Public Health Sciences, University of Toronto, Toronto, Ontario
    Can J Psychiatry 48:416-9. 2003
    ..To determine whether the climate of increased anxiety following the terrorist attacks of September 11, 2001, and the subsequent anthrax cases led to increased anxiety-related physician visits...
  56. ncbi request reprint Drug-induced lithium toxicity in the elderly: a population-based study
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Am Geriatr Soc 52:794-8. 2004
    ..To study the association between hospital admission for lithium toxicity and the use of diuretics, angiotensin-converting enzyme (ACE) inhibitors, and nonsteroidal antiinflammatory drugs (NSAIDs) in the elderly...
  57. pmc A population based time series analysis of asthma hospitalisations in Ontario, Canada: 1988 to 2000
    E J Crighton
    Primary Care Research Unit, Room E 354 Sunnybrook and Women s College Health Sciences Centre, Department of Family and Community Medicine and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    BMC Health Serv Res 1:7. 2001
    ..This study set out to examine the seasonal patterns of asthma hospitalisations in relation to age and gender for the province of Ontario over a period of 12 years...
  58. ncbi request reprint Progressive trends in the prevalence of benzodiazepine prescribing in older people in Ontario, Canada
    K Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Geriatr Soc 49:1341-5. 2001
    ..These findings suggest that, without undue regulation, physicians are making progress in the prescribing of benzodiazepine therapy on the basis of current knowledge available...
  59. doi request reprint High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification
    J G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    QJM 101:475-7. 2008
    ..4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered...
  60. pmc Blood glucose test strips: options to reduce usage
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 182:35-8. 2010
    ..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial...
  61. ncbi request reprint Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism
    Joel G Ray
    Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    Thromb Haemost 88:205-9. 2002
    ..Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism...
  62. ncbi request reprint Potentially inappropriate prescribing in Ontario community-dwelling older adults and nursing home residents
    Christopher J Lane
    Department of Medicine, University of Toronto, Toronto, Canada
    J Am Geriatr Soc 52:861-6. 2004
    ..To compare patterns of potentially inappropriate drug therapy prescribing in community-dwelling older adults and nursing home residents in Ontario, Canada...
  63. pmc The effect of antidepressant warnings on prescribing trends in Ontario, Canada
    Paul A Kurdyak
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Public Health 97:750-4. 2007
    ..We studied whether 5 regulatory agency advisories concerning the possible increased risk of suicidal behavior during antidepressant therapy had an effect on antidepressant prescription trends in Ontario...
  64. ncbi request reprint Potentially unintended discontinuation of long-term medication use after elective surgical procedures
    Chaim M Bell
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 166:2525-31. 2006
    ..Transitions between health care settings represent vulnerable periods for medical error. Discontinuation of long-term medication use may occur during discharge from the hospital to the community...
  65. ncbi request reprint Inappropriate prescribing before and after nursing home admission
    Irfan A Dhalla
    Faculty of Medicine, University of Toronto, 2113 40 Gerrard Street East, Toronto, Ontario M5B 2E8, Canada
    J Am Geriatr Soc 50:995-1000. 2002
    ..To compare the prevalence of inappropriate prescribing before and after nursing home admission and to determine which patient and physician characteristics are associated with inappropriate prescribing in the nursing home setting...
  66. ncbi request reprint Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
    ..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
  67. doi request reprint Macrolide-induced digoxin toxicity: a population-based study
    T Gomes
    The Institute for Clinical Evaluative Sciences, Ontario, Canada
    Clin Pharmacol Ther 86:383-6. 2009
    ..7; 95% CI 1.7-7.9; and adjusted OR 3.7; 95% CI 1.1-12.5, respectively). We found no increased risk with a neutral comparator, cefuroxime (adjusted OR 0.8; 95% CI 0.2-3.4)...
  68. ncbi request reprint Outcome of revascularization procedures for peripheral arterial occlusive disease in Ontario between 1991 and 1998: a population-based study
    Mohammed Al-Omran
    Institute for Clinical Evaluative Science, University of Toronto, Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Vasc Surg 38:279-88. 2003
    ..We describe the outcome of revascularization procedures used to treat peripheral arterial occlusive disease (PAOD), using population-based administrative data...
  69. ncbi request reprint Use of interventional procedures for peripheral arterial occlusive disease in Ontario between 1991 and 1998: a population-based study
    Mohammed Al-Omran
    Institute for Clinical Evaluative Science, University of Toronto, Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Vasc Surg 38:289-95. 2003
    ..We describe trends in use of interventional procedures to treat PAOD in Ontario over the past decade...
  70. ncbi request reprint Thresholds for small for gestational age among newborns of East Asian and South Asian ancestry
    Joel G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Obstet Gynaecol Can 31:322-30. 2009
    ..To determine the risk that newborn infants of East Asian and South Asian ancestry may be misclassified as small for gestational age (SGA)...
  71. ncbi request reprint Association between folic acid food fortification and hypertension or preeclampsia in pregnancy
    Joel G Ray
    Toronto, Ontario
    Arch Intern Med 162:1776-7. 2002
  72. doi request reprint Comparative gastrointestinal safety of bisphosphonates in primary osteoporosis: a network meta-analysis
    M Tadrous
    Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada
    Osteoporos Int 25:1225-35. 2014
    ..We found that zoledronic acid had the highest chance of causing gastrointestinal adverse events. Etidronate had the highest chance of discontinuation due to an adverse event. No difference was found for serious adverse events...
  73. pmc Giant cell arteritis and cardiovascular disease in older adults
    J G Ray
    Department of Medicine, Inner City Health, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Heart 91:324-8. 2005
    ..To explore the association between giant cell arteritis (GCA) and subsequent cardiovascular disease in older adults...
  74. doi request reprint New use of rosiglitazone decreased following publication of a meta-analysis suggesting harm
    B R Shah
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Diabet Med 25:871-4. 2008
    ..It is uncertain whether meta-analyses lead to changes in prescribing practices. We studied trends in the prescribing of glucose-lowering therapy before and after the publication of a meta-analysis suggesting harm from rosiglitazone...
  75. pmc Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study
    Laura Y Park-Wyllie
    Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
    PLoS Med 6:e1000157. 2009
    ..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia...
  76. ncbi request reprint Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study
    Donna O Lowe
    Department of Pharmacy Services, University Health Network, University of Toronto, ON, M5G 2C4, Canada
    Clin Infect Dis 43:1272-6. 2006
    ..Whether outpatient PPI use influences the risk of hospital admission for CDAD among older patients who have recently been treated with antibiotics is unknown...
  77. pmc Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
    Irfan A Dhalla
    Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
    CMAJ 181:891-6. 2009
    ..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone...
  78. pmc Health advisories: when good intentions go bad
    Muhammad M Mamdani
    Applied Health Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ont
    CMAJ 178:1025-6. 2008
  79. ncbi request reprint External validity: the neglected dimension in evidence ranking
    Navindra Persaud
    University College, University of Oxford, Oxford, UK
    J Eval Clin Pract 12:450-3. 2006
    ..Ideally, a treatment should only be used when both internally and externally valid evidence indicates that it will be useful for the particular patient...
  80. ncbi request reprint Trends in drug prescriptions among elderly residents of Ontario in the weeks after September 11, 2001
    Peter C Austin
    JAMA 288:575-7. 2002
  81. pmc Statins and the risk of idiopathic venous thromboembolism
    Joel G Ray
    Br J Clin Pharmacol 56:460; author reply 461-2. 2003
  82. ncbi request reprint Changes in prescribing patterns following publication of the ALLHAT trial
    Peter C Austin
    JAMA 291:44-5. 2004
  83. ncbi request reprint Prescriptions for estrogen replacement therapy in Ontario before and after publication of the Women's Health Initiative Study
    Peter C Austin
    JAMA 289:3241-2. 2003
  84. pmc Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?
    Irfan A Dhalla
    Department of Medicine, Unversity of Toronto, Ontario M4E 3E9, Canada
    Antimicrob Agents Chemother 50:3216-9. 2006
    ..difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin or moxifloxacin compared to levofloxacin...