Douglas S Lee

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. ncbi request reprint Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life
    Douglas S Lee
    Institute for Clinical Evaluative Sciences and University Health Network, University of Toronto, Toronto, Canada
    Hypertension 50:869-76. 2007
  2. ncbi request reprint CCORT/CCS quality indicators for congestive heart failure care
    Douglas S Lee
    University of Toronto, Toronto, Canada
    Can J Cardiol 19:357-64. 2003
  3. doi request reprint Risk stratification in acute heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:312-9. 2014
  4. doi request reprint Survival after implantable cardioverter-defibrillator implantation in the elderly
    Derek Yung
    University of Toronto, Toronto, ON, Canada
    Circulation 127:2383-92. 2013
  5. doi request reprint Administrative hospitalization database validation of cardiac procedure codes
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada M4N3M5
    Med Care 51:e22-6. 2013
  6. doi request reprint Prediction of heart failure mortality in emergent care: a cohort study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 156:767-75, W-261, W-262. 2012
  7. ncbi request reprint Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
  8. doi request reprint Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, ON, M4N 3M5, Canada
    Circulation 122:1806-14. 2010
  9. doi request reprint Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis
    Douglas S Lee
    Division of Cardiology, Institute for Clinical Evaluative Sciences, Toronto General Hospital, Toronto, Ontario, Canada
    Circ Heart Fail 3:228-35. 2010
  10. doi request reprint "Dose-dependent" impact of recurrent cardiac events on mortality in patients with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ont, Canada
    Am J Med 122:162-169.e1. 2009

Detail Information

Publications84

  1. ncbi request reprint Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life
    Douglas S Lee
    Institute for Clinical Evaluative Sciences and University Health Network, University of Toronto, Toronto, Canada
    Hypertension 50:869-76. 2007
    ..Higher blood pressure and BMI in midlife are harbingers of increased risk of heart failure in later life. Early risk factor modification may decrease heart failure burden...
  2. ncbi request reprint CCORT/CCS quality indicators for congestive heart failure care
    Douglas S Lee
    University of Toronto, Toronto, Canada
    Can J Cardiol 19:357-64. 2003
    ..Quality indicators are measurement tools for assessing the structure, processes and outcomes of care. Although quality indicators have been developed in other countries, Canadian cardiovascular disease indicators do not exist...
  3. doi request reprint Risk stratification in acute heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:312-9. 2014
    ....
  4. doi request reprint Survival after implantable cardioverter-defibrillator implantation in the elderly
    Derek Yung
    University of Toronto, Toronto, ON, Canada
    Circulation 127:2383-92. 2013
    ..We examined the impact of age on device-delivered therapies and outcomes after primary or secondary prevention ICD...
  5. doi request reprint Administrative hospitalization database validation of cardiac procedure codes
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada M4N3M5
    Med Care 51:e22-6. 2013
    ..Administrative data sources could be used to track cardiac procedures, but sources of such data have not been validated against clinical registries...
  6. doi request reprint Prediction of heart failure mortality in emergent care: a cohort study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 156:767-75, W-261, W-262. 2012
    ..Heart failure contributes to millions of emergency department (ED) visits, but hospitalization-versus-discharge decisions are often not accompanied by prognostic risk quantification...
  7. ncbi request reprint Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
    ..To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP)...
  8. doi request reprint Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, ON, M4N 3M5, Canada
    Circulation 122:1806-14. 2010
    ..The type of outpatient physician care after an emergency department visit for heart failure may affect patients' outcomes. Methods and..
  9. doi request reprint Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis
    Douglas S Lee
    Division of Cardiology, Institute for Clinical Evaluative Sciences, Toronto General Hospital, Toronto, Ontario, Canada
    Circ Heart Fail 3:228-35. 2010
    ..Although approximately one third of patients with heart failure (HF) visiting the emergency department (ED) are discharged home, little is known about their care and outcomes...
  10. doi request reprint "Dose-dependent" impact of recurrent cardiac events on mortality in patients with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ont, Canada
    Am J Med 122:162-169.e1. 2009
    ..We determined if a "dose-dependent" relationship exists between heart failure events and death, accounting for temporal changes in age, comorbidities, and disease severity...
  11. pmc Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 181:E55-66. 2009
    ..Temporal trends in risk factors for cardiovascular disease and the impact of socio-economic status on these risk factors remain unclear...
  12. doi request reprint Evaluation of early complications related to De Novo cardioverter defibrillator implantation insights from the Ontario ICD database
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 55:774-82. 2010
    ..This study examined the predictors of early complications after defibrillator implantation...
  13. doi request reprint Association of blood pressure at hospital discharge with mortality in patients diagnosed with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Circ Heart Fail 2:616-23. 2009
    ..Higher blood pressure in acute heart failure has been associated with improved survival; however, the relationship between blood pressure and survival in stabilized patients at hospital discharge has not been established...
  14. ncbi request reprint Effect of cardiac and noncardiac conditions on survival after defibrillator implantation
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:2408-15. 2007
    ..We sought to examine outcomes in recipients of implantable cardioverter-defibrillators (ICDs) and the effect of age, gender, and comorbidities on survival...
  15. doi request reprint Cardiovascular outcomes are predicted by exercise-stress myocardial perfusion imaging: Impact on death, myocardial infarction, and coronary revascularization procedures
    Douglas S Lee
    Robert J Burns Nuclear Cardiology Laboratory, Toronto, Canada
    Am Heart J 161:900-7. 2011
    ..The aim of this study was to determine the impact of myocardial perfusion imaging (MPI) on the outcomes of death, myocardial infarction (MI), and late coronary revascularization procedures...
  16. ncbi request reprint Risk-treatment mismatch in the pharmacotherapy of heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 294:1240-7. 2005
    ..Patients with heart failure have a wide spectrum of mortality risks. To maximize the benefit of available pharmacotherapies, patients with high mortality risk should receive high rates of drug therapy...
  17. doi request reprint Lifetime analysis of hospitalizations and survival of patients newly admitted with heart failure
    Soohun Chun
    Institute for Clinical Evaluative Sciences, Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Circ Heart Fail 5:414-21. 2012
    ..Hospital readmissions for heart failure (HF) contribute to increased morbidity and resource burden. Predictors of hospitalization and patterns of cardiovascular events over the lifetime of patients with HF have not been elucidated...
  18. doi request reprint Predictors of short-term complications after implantable cardioverter-defibrillator replacement: results from the Ontario ICD Database
    Andrew D Krahn
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Arrhythm Electrophysiol 4:136-42. 2011
    ..In addition, replacement may be a discretionary decision in the context of an advisory or borderline device performance and patient, device, and implanter factors that predict adverse outcome may assist in clinical decision-making...
  19. ncbi request reprint Care and outcomes of patients newly hospitalized for heart failure in the community treated by cardiologists compared with other specialists
    Philip Jong
    Heart and Stroke Richard Lewar Centre of Excellence, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Circulation 108:184-91. 2003
    ..It is not known whether subspecialty care by cardiologists improves outcomes in heart failure patients from the community over care by other physicians...
  20. doi request reprint Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial
    Jack V Tu
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 302:2330-7. 2009
    ..Publicly released report cards on hospital performance are increasingly common, but whether they are an effective method for improving quality of care remains uncertain...
  21. doi request reprint Outcomes and care of patients with acute heart failure syndromes and cardiac troponin elevation
    Juarez R Braga
    Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada
    Circ Heart Fail 6:193-202. 2013
    ..Cardiac troponins (cTn) may be elevated among patients with acute heart failure syndromes (AHFS). However, the optimal approach to management of AHFS with elevated cTn is unknown...
  22. doi request reprint Life expectancy after an index hospitalization for patients with heart failure: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am Heart J 155:324-31. 2008
    ..However, previous studies have focused on predicting shorter-term mortality and limited data currently exist to predict expected survival among hospitalized patients with HF...
  23. pmc National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004
    Jack V Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 180:E118-25. 2009
    ..We examined recent national trends in mortality and rates of hospital admission for these 3 conditions...
  24. doi request reprint Design and implementation of a population-based registry of Implantable Cardioverter Defibrillators (ICDs) in Ontario
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, M4N 3M5 Canada
    Heart Rhythm 5:1250-6. 2008
    ..There are scarce population-based data on the use, complication rates, and outcomes of patients receiving implantable cardioverter defibrillators (ICDs)...
  25. doi request reprint Statin therapy and clinical outcomes in heart failure: a propensity-matched analysis
    Maral Ouzounian
    Heart and Stroke Richard Lewar Centre for Excellence, University of Toronto, Toronto, Ontario, Canada
    J Card Fail 15:241-8. 2009
    ..The influence of statin therapy in heart failure (HF) has been of considerable interest. The objective of this study was to determine if statins are associated with improved outcomes in patients discharged after hospitalization for HF...
  26. pmc The average lifespan of patients discharged from hospital with heart failure
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Gen Intern Med 27:1171-9. 2012
    ..There are no life-tables quantifying the average life-spans of post-hospitalized heart failure populations across various strata of risk...
  27. ncbi request reprint Comparison of coding of heart failure and comorbidities in administrative and clinical data for use in outcomes research
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Med Care 43:182-8. 2005
    ..Despite the potential usefulness of administrative databases for evaluating outcomes, coding of heart failure and associated comorbidities have not been definitively compared with clinical data...
  28. doi request reprint Sex differences in implantable cardioverter-defibrillator outcomes: findings from a prospective defibrillator database
    Derek R MacFadden
    University of Toronto, Canada
    Ann Intern Med 156:195-203. 2012
    ..Sex differences in the use and outcomes of implantable cardioverter-defibrillators (ICDs) have not been fully studied...
  29. ncbi request reprint Outcome of heart failure with preserved ejection fraction in a population-based study
    R Sacha Bhatia
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, and the Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada
    N Engl J Med 355:260-9. 2006
    ....
  30. ncbi request reprint Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000
    Douglas S Lee
    Faculty of Pharmacy, Toronto, Canada
    Am J Med 116:581-9. 2004
    ..To review trends in drug therapy and concomitant outcomes of elderly heart failure patients in Ontario, Canada...
  31. pmc A systematic assessment of causes of death after heart failure onset in the community: impact of age at death, time period, and left ventricular systolic dysfunction
    Douglas S Lee
    Institute for Clinical Evaluative Sciences and Toronto General Hospital, University of Toronto, Ontario, Canada
    Circ Heart Fail 4:36-43. 2011
    ..Data are limited on the relative contributions of cardiovascular versus noncardiovascular diseases to death in individuals with HF in the community...
  32. doi request reprint Evaluating sex differences in population-based utilization of implantable cardioverter-defibrillators: role of cardiac conditions and noncardiac comorbidities
    Derek R MacFadden
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Heart Rhythm 6:1289-96. 2009
    ..The influence of age and comorbidities on sex-specific implantable cardioverter-defibrillator (ICD) use for primary or secondary prevention is undefined...
  33. doi request reprint Bundle branch block patterns and long-term outcomes in heart failure
    Husam M Abdel-Qadir
    Department of Medicine, University of Toronto, Toronto, Canada
    Int J Cardiol 146:213-8. 2011
    ..We sought to determine the prognostic value of bundle branch blocks in patients hospitalized with heart failure...
  34. doi request reprint Achieving quality indicator benchmarks and potential impact on coronary heart disease mortality
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Can J Cardiol 27:756-62. 2011
    ..Quality indicators in coronary heart disease (CHD) measure the practice gap between optimal care and current clinical practice. However, the potential impact of achieving quality indicator benchmarks remains unknown...
  35. ncbi request reprint Inequitable distribution of implantable cardioverter defibrillators in Ontario
    Jacob A Udell
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, and Department of Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Int J Technol Assess Health Care 23:354-61. 2007
    ..The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death...
  36. doi request reprint Comparison of one-year outcome (death and rehospitalization) in hospitalized heart failure patients with left ventricular ejection fraction >50% versus those with ejection fraction <50%
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Alberta, Edmonton, Canada
    Am J Cardiol 102:79-83. 2008
    ....
  37. doi request reprint A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify important service components
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    Circ Heart Fail 6:68-75. 2013
    ..Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes...
  38. ncbi request reprint Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses
    Louise Emmett
    Robert J Burns Nuclear Cardiology Laboratory, Toronto Western Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 39:991-8. 2002
    ....
  39. doi request reprint Cost-effectiveness of specialized multidisciplinary heart failure clinics in Ontario, Canada
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Value Health 13:915-21. 2010
    ..Specialized multidisciplinary clinics have been shown to reduce mortality in heart failure (HF). Our objective was to evaluate the cost-effectiveness of this model of care delivery...
  40. pmc Regression trees for predicting mortality in patients with cardiovascular disease: what improvement is achieved by using ensemble-based methods?
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Biom J 54:657-73. 2012
    ....
  41. ncbi request reprint Quality of care and outcomes of older patients with heart failure hospitalized in the United States and Canada
    Dennis T Ko
    Department of Cardiology, Schulich Heart Centre, Toronto, Ontario
    Arch Intern Med 165:2486-92. 2005
    ..We compared the process of care and outcomes of patients with heart failure, the most common cause of hospitalization for individuals 65 years and older in both countries...
  42. ncbi request reprint Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis
    Douglas S Lee
    University of Toronto, Department of Health Policy, Management and Evaluation Clinical Epidemiology, Toronto, Canada
    J Am Coll Cardiol 41:1573-82. 2003
    ..The aim of this study was to compare the effectiveness of the implantable cardioverter defibrillator (ICD) and medical strategies for prevention of arrhythmic events and death...
  43. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004
    ..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs...
  44. ncbi request reprint Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model
    Douglas S Lee
    Department of Health Policy, Management, and Evaluation Clinical Epidemiology, Division of Cardiology, University Health Network Toronto General Hospital, Toronto, Ontario
    JAMA 290:2581-7. 2003
    ..A predictive model of mortality in heart failure may be useful for clinicians to improve communication with and care of hospitalized patients...
  45. doi request reprint Patient satisfaction and its relationship with quality and outcomes of care after acute myocardial infarction
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circulation 118:1938-45. 2008
    ....
  46. doi request reprint Diuretic dose and long-term outcomes in elderly patients with heart failure after hospitalization
    Husam M Abdel-Qadir
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 160:264-271.e1. 2010
    ..We examined the relationship of dynamic furosemide dose with mortality and hospitalizations for cardiovascular disease and renal dysfunction...
  47. doi request reprint Association between physician follow-up and outcomes of care after chest pain assessment in high-risk patients
    Andrew Czarnecki
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Circulation 127:1386-94. 2013
    ..Although guidelines recommend primary care physician (PCP) follow-up for patients who are subsequently discharged, little is known about the relationship between physician follow-up and clinical outcomes...
  48. pmc Association of hospital spending intensity with mortality and readmission rates in Ontario hospitals
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 307:1037-45. 2012
    ..The extent to which better spending produces higher-quality care and better patient outcomes in a universal health care system with selective access to medical technology is unknown...
  49. ncbi request reprint Regional outcomes of heart failure in Canada
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Cardiol 20:599-607. 2004
    ..Heart failure is a condition associated with significant mortality and morbidity. However, demographic features and outcomes following hospitalization for heart failure, and associated regional comparisons have not been performed in Canada...
  50. pmc Validation of physician billing and hospitalization data to identify patients with ischemic heart disease using data from the Electronic Medical Record Administrative data Linked Database (EMRALD)
    Karen Tu
    Department of Family and Community Medicine, University of Toronto, Ontario
    Can J Cardiol 26:e225-8. 2010
    ..Reporting of ischemic heart disease (IHD) prevalence in Canada has been based on self-report or patients presenting to hospital. However, IHD often presents and can be managed in the outpatient setting...
  51. doi request reprint Logistic regression had superior performance compared with regression trees for predicting in-hospital mortality in patients hospitalized with heart failure
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Clin Epidemiol 63:1145-55. 2010
    ..To compare the predictive accuracy of regression trees with that of logistic regression models for predicting in-hospital mortality in patients hospitalized with heart failure...
  52. ncbi request reprint Electrocardiographic prediction of the severity of posterior wall perfusion defects on rest technetium-99m Sestamibi myocardial perfusion imaging
    Radu Petrovici
    Robert J Burns Nuclear Cardiology Laboratory, Toronto Western Hospital, Toronto, Ontario, Canada M5T 2S8
    J Electrocardiol 38:195-203. 2005
    ..Established ECG patterns for diagnosis of posterior infarction are insensitive and poor predictors of severity. The SQS and UTV 1 are effective for the diagnosis of posterior infarction and useful for the estimation of infarct severity...
  53. doi request reprint Association of heart rate at hospital discharge with mortality and hospitalizations in patients with heart failure
    Marlena V Habal
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Circ Heart Fail 7:12-20. 2014
    ..Heart failure (HF) is associated with a high burden of morbidity and mortality. Hospital discharge is an opportunity for identification of modifiable prognostic factors in the transition to chronic HF...
  54. doi request reprint Reinitiation of anticoagulation after warfarin-associated intracranial hemorrhage and mortality risk: the Best Practice for Reinitiating Anticoagulation Therapy After Intracranial Bleeding (BRAIN) study
    Derek Yung
    Division of Cardiology, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 28:33-9. 2012
    ..While warfarin-related intracranial hemorrhage (ICH) occurs in 0.25%-1.1% patients per year, little is known about the practice and outcomes of anticoagulant reinitiation...
  55. doi request reprint Percutaneous coronary intervention with vs without on-site cardiac surgery backup: a systematic review and meta-analysis
    Mohammad I Zia
    University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:664.e9-16. 2011
    ..However, variations in outcomes suggest that assurance of optimal outcomes at each PCI centre without on-site surgery is needed...
  56. doi request reprint A comparison of Chinese and non-Chinese Canadian patients hospitalized with heart failure
    Darwin F Yeung
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G250, Toronto ON, Canada
    BMC Cardiovasc Disord 13:114. 2013
    ....
  57. pmc The challenge of heart failure discharge from the emergency department
    Edwin C Ho
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, Room G 106, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada
    Curr Heart Fail Rep 9:252-9. 2012
    ..The use of observation units may also be a cost-effective adjunctive strategy that can assist in determining disposition from the emergency department...
  58. pmc Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction
    David A Alter
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 8:e65130. 2013
    ..To examine the relationship between socio-economic status (SES), functional recovery and long-term mortality following acute myocardial infarction (AMI)...
  59. doi request reprint Using methods from the data-mining and machine-learning literature for disease classification and prediction: a case study examining classification of heart failure subtypes
    Peter C Austin
    Institute for Clinical Evaluative Sciences, G105, 2075 Bayview Ave, Toronto, Ontario, Canada
    J Clin Epidemiol 66:398-407. 2013
    ..In the data-mining and machine-learning literature, alternate classification schemes have been developed. These include bootstrap aggregation (bagging), boosting, random forests, and support vector machines...
  60. pmc Trends in the incidence and outcomes of heart failure in Ontario, Canada: 1997 to 2007
    Darwin F Yeung
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    CMAJ 184:E765-73. 2012
    ..Heart failure is a leading cause of admission to hospital, but whether the incidence of heart failure is increasing or decreasing is uncertain. We examined temporal trends in the incidence and outcomes of heart failure in Ontario, Canada...
  61. ncbi request reprint A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure
    Femida H Gwadry-Sridhar
    Division of Critical Care, Department of Medicine, University of Western Ontario, and London Health Sciences Centre, London, Ontario, Canada
    Arch Intern Med 164:2315-20. 2004
    ..We performed a meta-analysis to evaluate the effectiveness of multidisciplinary heart failure management programs on hospital admission rates...
  62. doi request reprint Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
    ..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
  63. doi request reprint Comparison of processes of care and clinical outcomes for patients newly hospitalized for heart failure attended by different physician specialists
    Nicole K Boom
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 163:252-9. 2012
    ..It remains unclear whether these findings reflect differences in patient characteristics, processes of care, practice setting, or a combination of these factors...
  64. ncbi request reprint Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure
    Douglas S Lee
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Card Fail 9:368-74. 2003
    ..Although an initial study of endothelin receptor blockade reported positive findings, subsequent experiments and clinical trials in humans found little or no benefit...
  65. ncbi request reprint Prophylactic implantable cardioverter-defibrillator therapy in patients with left ventricular systolic dysfunction: a pooled analysis of 10 primary prevention trials
    Kumaraswamy Nanthakumar
    Division of Cardiology, University Health Network, Toronto, Ontario, Canada
    J Am Coll Cardiol 44:2166-72. 2004
    ..In health care settings without unlimited resources, optimal use of this therapy will require better risk stratification methods or lowering of the initial device cost...
  66. ncbi request reprint Anticoagulation in patients with heart failure
    R Sacha Bhatia
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, M4N 3M5 Canada
    Cardiovasc Hematol Agents Med Chem 7:193-7. 2009
    ..Recent clinical trials on anticoagulation and HF are reviewed, including WATCH, WASH, and WARCEF. The absence of compelling clinical trial data leaves many unanswered questions regarding systemic anticoagulation in patients with HF...
  67. doi request reprint Diastolic heart failure: mechanisms and controversies
    Maral Ouzounian
    Institute of Circulatory and Respiratory Health, CIHR, NCSB 11 1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Nat Clin Pract Cardiovasc Med 5:375-86. 2008
    ..New epidemiologic and mechanistic data regarding DHF highlight the urgency with which the scientific community must address this important public health problem...
  68. doi request reprint The concept of the marginally matched subject in propensity-score matched analyses
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:469-82. 2009
    ..The concept of the marginally matched subject can be used as a sensitivity analysis to examine the impact of the matching method on the estimates of treatment effectiveness...
  69. ncbi request reprint Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    David N Juurlink
    Department of Medicine University of Toronto, Toronto
    N Engl J Med 351:543-51. 2004
    ..Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated in these patients. However, life-threatening hyperkalemia can occur when these drugs are used together...
  70. ncbi request reprint CCORT/CCS quality indicators for acute myocardial infarction care
    Chau T T Tran
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Can J Cardiol 19:38-45. 2003
    ..The authors' goal was to develop a set of Canadian quality indicators for AMI care...
  71. ncbi request reprint The contribution of familial and heritable risks in heart failure
    Husam M Abdel-Qadir
    Faculty of Medicine, University Health Network, University of Toronto, Toronto, Canada
    Curr Opin Cardiol 22:214-9. 2007
    ..The purpose of this review is to summarize the recent literature regarding the familial heritability of heart failure and to discuss the possible mechanisms through which this risk is mediated...
  72. ncbi request reprint Do case-generic measures of queue performance for bypass surgery accurately reflect the waiting-list experiences of those most urgent?
    Jason Burstein
    University of Toronto, Toronto, Canada
    J Eval Clin Pract 12:87-93. 2006
    ..The objective of this study was to examine whether case-generic measures of queue performance appropriately reflected the waiting-list experiences of those patients with greatest disease severity...
  73. ncbi request reprint Cardiac encasement by metastatic myxoid liposarcoma
    Douglas S Lee
    Department of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Cardiovasc Pathol 11:322-5. 2002
    ..This case suggests that in clinical and pathological investigation of a cardiac mass, knowledge of previous extracardiac involvement with soft tissue sarcoma is essential...
  74. pmc Improving prognosis estimation in patients with heart failure and the cardiorenal syndrome
    Husam M Abdel-Qadir
    Department of Medicine, University of Toronto, Toronto, ON, Canada M5G 2C4
    Int J Nephrol 2011:351672. 2011
    ....
  75. ncbi request reprint Randomized comparison of T-type versus L-type calcium-channel blockade on exercise duration in stable angina: results of the Posicor Reduction of Ischemia During Exercise (PRIDE) trial
    Douglas S Lee
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 144:60-7. 2002
    ..It is not known if T-type calcium-channel blockade is superior to L-type calcium-channel blockade in patients with stable angina pectoris...
  76. pmc Predict, prevent and personalize: Genomic and proteomic approaches to cardiovascular medicine
    Maral Ouzounian
    Heart and Stroke Richard Lewar Centre for Excellence, University of Toronto
    Can J Cardiol 23:28A-33A. 2007
    ..The present paper reviews the potential contributions of genomic and proteomic approaches in developing a more personalized approach to cardiovascular medicine...
  77. ncbi request reprint How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts
    Finlay A McAlister
    The Division of General Internal Medicine, 2E3 24 Walter Mackenzie Health Sciences Centre, University of Alberta, 8440 112 Street, Edmonton, Alberta T6G 2R7, Canada
    Eur Heart J 27:323-9. 2006
    ..To determine what proportion of patients with heart failure are eligible for cardiac resynchronization therapy (CRT)...
  78. pmc Use of implantable cardioverter defibrillators in Canadian and US survivors of out-of-hospital cardiac arrest
    David H Birnie
    Ottawa Heart Institute, Ottawa, Ont
    CMAJ 177:41-6. 2007
    ..We compared and contrasted the use of implantable cardioverter defibrillator therapy in Canada and the United States among adults who survived a cardiac arrest...
  79. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  80. ncbi request reprint Pharmacological treatment of congestive heart failure in Canada: a description of care in five provinces
    Jafna L Cox
    Department of Medicine, Dalhousie University, Halifax, Canada
    Can J Cardiol 21:337-43. 2005
    ..There have been major advances in the treatment of this condition over the past two decades, yet little information is currently available regarding the current status of CHF management in Canada...
  81. ncbi request reprint Novel markers for heart failure diagnosis and prognosis
    Douglas S Lee
    National Heart, Lung and Blood Institutes, Framingham Heart Study, Framingham, MA 01702 5827, USA
    Curr Opin Cardiol 20:201-10. 2005
    ..This paper reviews recent advances in heart failure biomarkers for identification of disease precursors, subclinical disease, and onset or progression of overt disease...
  82. ncbi request reprint Do Ontario patients with heart failure have equal access to life-saving technology?
    Douglas S Lee
    Canadian Institutes of Health Research, Canada
    Healthc Q 11:20-1. 2008
  83. ncbi request reprint Screening for ventricular remodeling
    Douglas S Lee
    Framingham Heart Study, MA 01702, USA
    Curr Heart Fail Rep 3:5-13. 2006
    ..Additional studies are warranted to confirm these findings...
  84. ncbi request reprint Potential gaps in congestive heart failure management in a rural hospital
    Margaret D Sanborn
    South Bruce Grey Health Care Centre, Chesley, Ont
    Can J Rural Med 10:155-61. 2005
    ..There is a paucity of studies that have evaluated CHF management in a rural setting. We therefore reviewed hospital and outpatient care in this setting as an initial step toward improving CHF care...