Dennis T Ko

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. ncbi request reprint Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circulation 115:196-203. 2007
  2. pmc Drug eluting balloons for de novo coronary lesions - a systematic review and meta-analysis
    Georg M Fröhlich
    Heart Hospital, University College London Hospital, 16 18 Westmoreland Street, London, W1G 8PH, UK
    BMC Med 11:123. 2013
  3. doi request reprint Prevalence and extent of obstructive coronary artery disease among patients undergoing elective coronary catheterization in New York State and Ontario
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 310:163-9. 2013
  4. doi request reprint Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 6:315-22. 2013
  5. doi request reprint Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 60:1876-84. 2012
  6. pmc Sodium bicarbonate-based hydration prevents contrast-induced nephropathy: a meta-analysis
    Pascal Meier
    University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    BMC Med 7:23. 2009
  7. doi request reprint Patterns of use of thienopyridine therapy after percutaneous coronary interventions with drug-eluting stents and bare-metal stents
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Am Heart J 158:592-598.e1. 2009
  8. doi request reprint Rescue percutaneous coronary interventions for failed fibrinolytic therapy in ST-segment elevation myocardial infarction: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, University of Toronto, Ontario, Canada
    Am Heart J 161:764-770.e1. 2011
  9. pmc Secular trends in acute coronary syndrome hospitalization from 1994 to 2005
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Can J Cardiol 26:129-34. 2010
  10. pmc Canadian quality indicators for percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Can J Cardiol 24:899-903. 2008

Detail Information

Publications83

  1. ncbi request reprint Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circulation 115:196-203. 2007
    ....
  2. pmc Drug eluting balloons for de novo coronary lesions - a systematic review and meta-analysis
    Georg M Fröhlich
    Heart Hospital, University College London Hospital, 16 18 Westmoreland Street, London, W1G 8PH, UK
    BMC Med 11:123. 2013
    ..Increasing evidence has shown a benefit for the treatment of in-stent restenosis. Its effect on de novo coronary lesions is more controversial. Several smaller randomized trials found conflicting results...
  3. doi request reprint Prevalence and extent of obstructive coronary artery disease among patients undergoing elective coronary catheterization in New York State and Ontario
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 310:163-9. 2013
    ..However, the role of patient selection in these findings and their implications for detection of obstructive coronary artery disease (CAD) are largely unknown...
  4. doi request reprint Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 6:315-22. 2013
    ....
  5. doi request reprint Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 60:1876-84. 2012
    ..The study assessed the appropriateness of coronary revascularization in Ontario, Canada, and examined its association with longer-term outcomes...
  6. pmc Sodium bicarbonate-based hydration prevents contrast-induced nephropathy: a meta-analysis
    Pascal Meier
    University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    BMC Med 7:23. 2009
    ..The objective of this study was to assess the effectiveness of normal saline versus sodium bicarbonate for prevention of contrast-induced nephropathy...
  7. doi request reprint Patterns of use of thienopyridine therapy after percutaneous coronary interventions with drug-eluting stents and bare-metal stents
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Am Heart J 158:592-598.e1. 2009
    ..The objective of the study was to determine the adherence to thienopyridine therapy after stent implantation, factors associated with suboptimal adherence, and association of suboptimal adherence with mortality...
  8. doi request reprint Rescue percutaneous coronary interventions for failed fibrinolytic therapy in ST-segment elevation myocardial infarction: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, University of Toronto, Ontario, Canada
    Am Heart J 161:764-770.e1. 2011
    ..However, limited data exist regarding the pattern of use of rescue percutaneous coronary intervention (PCI) in patients with STEMI who failed fibrinolysis, factors associated with its use, and its impact on long-term outcomes...
  9. pmc Secular trends in acute coronary syndrome hospitalization from 1994 to 2005
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Can J Cardiol 26:129-34. 2010
    ..Although substantial advances have been made in the prevention and treatment of coronary artery disease, their impact on the rates of ACS hospitalization is unclear...
  10. pmc Canadian quality indicators for percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Ontario, Canada
    Can J Cardiol 24:899-903. 2008
    ..However, quality indicators for percutaneous coronary intervention (PCI) have not been developed in Canada...
  11. doi request reprint Safety and effectiveness of drug-eluting and bare-metal stents for patients with off- and on-label indications
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 53:1773-82. 2009
    ..Our main objective was to evaluate the longer-term safety and efficacy of drug-eluting stents (DES) in off-label indications as compared with bare-metal stents (BMS)...
  12. doi request reprint Incidence, predictors, and prognostic implications of hospitalization for late bleeding after percutaneous coronary intervention for patients older than 65 years
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circ Cardiovasc Interv 3:140-7. 2010
    ..The incidence of late bleeding after PCI, its independent predictors, and its prognostic importance in clinical practice has not been fully addressed...
  13. doi request reprint Effectiveness of preprocedural statin therapy on clinical outcomes for patients with stable coronary artery disease after percutaneous coronary interventions
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, ON, Canada
    Circ Cardiovasc Qual Outcomes 4:459-66. 2011
    ..We aimed to evaluate the clinical effectiveness of preprocedural statin therapy in patients with stable CAD undergoing PCI...
  14. doi request reprint Long-term safety and effectiveness of drug-eluting stents for the treatment of saphenous vein grafts disease: a population-based study
    Dennis T Ko
    Division of Cardiology, Department of Medicine, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    JACC Cardiovasc Interv 4:965-73. 2011
    ..The purpose of this study was to evaluate the long-term safety and effectiveness of drug-eluting stents (DES) for the treatment of saphenous vein graft (SVG) disease...
  15. doi request reprint Life expectancy after an index hospitalization for patients with heart failure: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am Heart J 155:324-31. 2008
    ..However, previous studies have focused on predicting shorter-term mortality and limited data currently exist to predict expected survival among hospitalized patients with HF...
  16. ncbi request reprint Association between lipid testing and statin therapy in acute myocardial infarction patients
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Toronto, Ontario, Canada
    Am Heart J 150:419-25. 2005
    ..We sought to examine rates of inhospital lipid testing and its association with statin therapy at hospital discharge...
  17. doi request reprint Regional variation in cardiac catheterization appropriateness and baseline risk after acute myocardial infarction
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Coll Cardiol 51:716-23. 2008
    ....
  18. doi request reprint Safety and effectiveness of drug-eluting stents among diabetic patients: a propensity analysis
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am Heart J 156:125-34. 2008
    ..Accordingly, we sought to evaluate the long-term safety and effectiveness of DES in diabetic patients...
  19. pmc A survey of primary percutaneous coronary intervention for patients with ST segment elevation myocardial infarction in Canadian hospitals
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario
    Can J Cardiol 24:839-43. 2008
    ..Recent studies have identified innovative strategies to improve timely access and reduce reperfusion time. Accordingly, the contemporary use of primary PCI treatment in Canada was ascertained...
  20. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
    ..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown...
  21. doi request reprint An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials
    Harindra C Wijeysundera
    Department of Medicine, Division of Cardiology, Schulich Heart Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:564-572, 572.e1-2. 2008
    ....
  22. pmc Determinants of cardiac catheterization use in older Medicare patients with acute myocardial infarction
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 3:54-62. 2010
    ..We sought to determine the importance of anticipated benefit and anticipated harm on the use of cardiac catheterization among older patients with AMI...
  23. doi request reprint Paclitaxel versus sirolimus stents in diabetic and nondiabetic patients
    Maria Chiu
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Circ Cardiovasc Qual Outcomes 2:96-107. 2009
    ..We therefore studied the long-term effectiveness and safety of sirolimus versus paclitaxel stents overall and stratified by the absence or presence of diabetes...
  24. pmc Validation of the Thrombolysis In Myocardial Infarction (TIMI) risk index for predicting early mortality in a population-based cohort of STEMI and non-STEMI patients
    Pamela J Bradshaw
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Can J Cardiol 23:51-6. 2007
    ..It has not been tested in a population outside the United States or among non-STEMI patients...
  25. pmc Is a pattern of increasing biomarker concentrations important for long-term risk stratification in acute coronary syndrome patients presenting early after the onset of symptoms?
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Chem 54:747-51. 2008
    ..It is unknown whether a rising pattern presages a more adverse long-term prognosis than elevations that do not change. The present study assessed whether a rising pattern of cardiac biomarkers was more prognostic than simple elevations...
  26. doi request reprint Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial
    Jack V Tu
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 302:2330-7. 2009
    ..Publicly released report cards on hospital performance are increasingly common, but whether they are an effective method for improving quality of care remains uncertain...
  27. ncbi request reprint Long-term health outcomes associated with detectable troponin I concentrations
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Chem 53:220-7. 2007
    ..We designed this study to extend this observation by examining risk prediction in both men and women presenting to an emergency department with chest discomfort...
  28. ncbi request reprint Quality of care and outcomes of older patients with heart failure hospitalized in the United States and Canada
    Dennis T Ko
    Department of Cardiology, Schulich Heart Centre, Toronto, Ontario
    Arch Intern Med 165:2486-92. 2005
    ..We compared the process of care and outcomes of patients with heart failure, the most common cause of hospitalization for individuals 65 years and older in both countries...
  29. doi request reprint Quality of diabetes and hyperlipidemia screening before a first myocardial infarction
    Peter Lugomirski
    University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:1382-7. 2013
    ..There has been significant attention to the quality of care for acute myocardial infarction (MI). However, little is known about the quality of preventive care before a patient's first MI...
  30. pmc The average lifespan of patients discharged from hospital with heart failure
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Gen Intern Med 27:1171-9. 2012
    ..There are no life-tables quantifying the average life-spans of post-hospitalized heart failure populations across various strata of risk...
  31. ncbi request reprint Risk-treatment mismatch in the pharmacotherapy of heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 294:1240-7. 2005
    ..Patients with heart failure have a wide spectrum of mortality risks. To maximize the benefit of available pharmacotherapies, patients with high mortality risk should receive high rates of drug therapy...
  32. pmc Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Chem 55:1809-15. 2009
    ..The present study was undertaken to determine if a research hs-cTnI assay can be useful for predicting death/myocardial infarction (MI), both short- and long-term, in an emergency department acute coronary syndrome (ACS) population...
  33. doi request reprint Predictors of normal coronary arteries at coronary angiography
    Kevin Levitt
    University of Toronto, Toronto, Ontario, Canada
    Am Heart J 166:694-700. 2013
    ..However, little is known about the clinical predictors of normal angiograms and whether this rate varies across different cardiac centers in Ontario...
  34. doi request reprint Association between hospital cardiac management and outcomes for acute myocardial infarction patients
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 48:157-65. 2010
    ..Randomized trials have shown that medical and interventional therapies improve outcomes for acute myocardial infarction (AMI) patients. The extent to which hospital quality improvement translates into better patient outcomes is unclear...
  35. pmc Determinants of variations in coronary revascularization practices
    Jack V Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 184:179-86. 2012
    ..We conducted a comprehensive study to identify clinical and nonclinical factors associated with variations in the ratio across 17 cardiac centres in the province of Ontario...
  36. pmc Factors associated with the use of evidence-based therapies after discharge among elderly patients with myocardial infarction
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 179:901-8. 2008
    ..Our objective was to identify the characteristics of patients, physicians, hospitals and communities associated with differences in the use of these medications after discharge...
  37. pmc Vascular versus myocardial dysfunction in acute coronary syndrome: are the adhesion molecules as powerful as NT-proBNP for long-term risk stratification?
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 41:436-9. 2008
    ..To determine if elevations of adhesion molecules in acute coronary syndrome (ACS) are useful for risk stratification...
  38. ncbi request reprint Effectiveness and safety of drug-eluting stents in Ontario
    Jack V Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    N Engl J Med 357:1393-402. 2007
    ..However, there is uncertainty about the effectiveness of drug-eluting stents, and increasing concern about their safety, in routine clinical practice...
  39. doi request reprint The effect of multidisciplinary heart failure clinic characteristics on 1-year postdischarge health care costs: a population-based study
    Harindra C Wijeysundera
    Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre Toronto Health Economics and Technology Assessment THETA Collaborative Institute of Health Policy, Management and Evaluation Institute for Clinical Evaluative Sciences ICES Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Med Care 52:272-9. 2014
    ..Although multidisciplinary heart failure (HF) clinics are efficacious, it is not known how patient factors or HF clinic structural indicators and process measures have an impact on the cumulative health care costs...
  40. ncbi request reprint Quality of care of international and Canadian medical graduates in acute myocardial infarction
    Dennis T Ko
    Division of Cardiology and Schulich Heart Centre, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Arch Intern Med 165:458-63. 2005
    ..There are concerns that IMGs may provide inferior medical care compared with locally trained medical graduates, but that has not been established...
  41. pmc Use of evidence-based therapies after discharge among elderly patients with acute myocardial infarction
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 179:895-900. 2008
    ..We examined trends in the use of evidence-based drug therapies after discharge among elderly patients with myocardial infarction...
  42. doi request reprint Temporal trends in the use of percutaneous coronary intervention and coronary artery bypass surgery in New York State and Ontario
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Ontario, Canada
    Circulation 121:2635-44. 2010
    ..Although New York State (NYS) historically has had twice as many coronary revascularizations performed as Ontario, the relative evolution of coronary revascularization patterns in both jurisdictions over time is unknown...
  43. pmc Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 181:E55-66. 2009
    ..Temporal trends in risk factors for cardiovascular disease and the impact of socio-economic status on these risk factors remain unclear...
  44. pmc National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004
    Jack V Tu
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 180:E118-25. 2009
    ..We examined recent national trends in mortality and rates of hospital admission for these 3 conditions...
  45. doi request reprint Association between physician follow-up and outcomes of care after chest pain assessment in high-risk patients
    Andrew Czarnecki
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Circulation 127:1386-94. 2013
    ..Although guidelines recommend primary care physician (PCP) follow-up for patients who are subsequently discharged, little is known about the relationship between physician follow-up and clinical outcomes...
  46. doi request reprint A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify important service components
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada
    Circ Heart Fail 6:68-75. 2013
    ..Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes...
  47. pmc "Upstream markers" provide for early identification of patients at high risk for myocardial necrosis and adverse outcomes
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Chim Acta 387:133-8. 2008
    ..We determined if a panel of biomarkers can be used to identify high risk patients...
  48. ncbi request reprint Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:422-30. 2007
    ....
  49. doi request reprint Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 152:370-9. 2010
    ..Several meta-analyses have evaluated the efficacy of percutaneous coronary intervention (PCI) compared with medical therapy, but none has focused on angina relief...
  50. doi request reprint PAPP-A as a marker of increased long-term risk in patients with chest pain
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 42:1012-8. 2009
    ..The present study examined whether PAPP-A measured in an emergency department (ED) chest pain population in association with conventional and novel high sensitivity cTn (hs-cTnI) assays can predict long-term mortality...
  51. doi request reprint Use of ezetimibe in the United States and Canada
    Cynthia A Jackevicius
    University Health Network, Schulich Heart Centre, Toronto
    N Engl J Med 358:1819-28. 2008
    ..We sought to describe the adoption of ezetimibe relative to that of other lipid-lowering agents and compare its use in the two countries...
  52. doi request reprint Medical therapy v. PCI in stable coronary artery disease: a cost-effectiveness analysis
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada HCW, DTK
    Med Decis Making 33:891-905. 2013
    ..It remains unclear if these benefits are sufficient to offset their increased costs and small increase in adverse events...
  53. doi request reprint Duration of preoperative β-blockade and outcomes after major elective noncardiac surgery
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:217-23. 2014
    ..Although practice guidelines recommend that perioperative β-blockade be initiated at least several days to weeks before noncardiac surgery is performed, the minimum required period of preoperative therapy is unclear...
  54. doi request reprint Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    Circulation 126:1355-62. 2012
    ..Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation...
  55. pmc Association of hospital spending intensity with mortality and readmission rates in Ontario hospitals
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 307:1037-45. 2012
    ..The extent to which better spending produces higher-quality care and better patient outcomes in a universal health care system with selective access to medical technology is unknown...
  56. doi request reprint Percutaneous coronary intervention with vs without on-site cardiac surgery backup: a systematic review and meta-analysis
    Mohammad I Zia
    University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:664.e9-16. 2011
    ..However, variations in outcomes suggest that assurance of optimal outcomes at each PCI centre without on-site surgery is needed...
  57. ncbi request reprint Relation between cardiac troponin I and mortality in acute decompensated heart failure
    John J You
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, Canada
    Am Heart J 153:462-70. 2007
    ..Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain...
  58. doi request reprint Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
    Hance Clarke
    Department of Anesthesia and Pain Management, Toronto General Hospital, 200 Elizabeth Street, Eaton North 3 EB 317, Toronto, ON, Canada, M5G 2C4
    BMJ 348:g1251. 2014
    ..To describe rates and risk factors for prolonged postoperative use of opioids in patients who had not previously used opioids and undergoing major elective surgery...
  59. doi request reprint Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies
    Prateek J Khatri
    University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Ann Intern Med 158:35-46. 2013
    ....
  60. ncbi request reprint Risk stratification for heart failure and death in an acute coronary syndrome population using inflammatory cytokines and N-terminal pro-brain natriuretic peptide
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Chem 53:2112-8. 2007
    ..g., N-terminal pro-brain natriuretic peptide (NT-proBNP)] for predicting HF and death in an ACS population...
  61. pmc The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 43:505-7. 2010
    ..To determine if a cytokine panel could be informative regarding subsequent heart failure(HF)/death...
  62. ncbi request reprint Appropriateness of spironolactone prescribing in heart failure patients: a population-based study
    Dennis T Ko
    Division of Cardiology, Shulich Heart Centre, Department of Medicine, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
    J Card Fail 12:205-10. 2006
    ..However, recent data have raised concerns regarding hyperkalemia secondary to spironolactone use and suggest it occurs more commonly in routine practice...
  63. ncbi request reprint Health outcomes categorized by current and previous definitions of acute myocardial infarction in an unselected cohort of troponin-naïve emergency department patients
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada, and Department of Pathology, Women and Infants Hospital of Rhode Island, Providence, USA
    Clin Chem 52:2028-35. 2006
    ..The health outcomes were based on the WHO definition and occurred in an era that preceded the use of cardiac troponin biomarkers...
  64. ncbi request reprint Factors explaining the under-use of reperfusion therapy among ideal patients with ST-segment elevation myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Eur Heart J 27:1539-49. 2006
    ....
  65. pmc Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction
    David A Alter
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 8:e65130. 2013
    ..To examine the relationship between socio-economic status (SES), functional recovery and long-term mortality following acute myocardial infarction (AMI)...
  66. ncbi request reprint Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, and the Department of Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario
    Arch Intern Med 164:1389-94. 2004
    ..We performed an overview of randomized beta-blocker trials in patients with HF to quantify the risks of these adverse effects...
  67. ncbi request reprint Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, and Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    JAMA 291:1864-70. 2004
    ..Ideally, aggressiveness in the use of these beneficial therapies should correlate with baseline cardiovascular risk...
  68. doi request reprint Coronary artery bypass graft surgery vs percutaneous interventions in coronary revascularization: a systematic review
    Saswata Deb
    Schulich Heart Centre, Division of Cardiology and Cardiac Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada2Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 310:2086-95. 2013
    ..However, the choice of the most appropriate revascularization modality is controversial in some patient subgroups...
  69. pmc Techniques for estimating health care costs with censored data: an overview for the health services researcher
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Clinicoecon Outcomes Res 4:145-55. 2012
    ..The target audience is health service researchers without an advanced statistical background...
  70. doi request reprint Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Med Decis Making 31:481-93. 2011
    ..In its current form, however, it cannot be used in economic evaluations. The investigators sought to create a mapping algorithm that would allow translation of SAQ scores into EQ-5D utility scores...
  71. pmc Indicators of quality of care for patients with acute myocardial infarction
    Jack V Tu
    The Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 179:909-15. 2008
    ..We undertook this initiative to develop an updated set of evidence-based indicators to measure and improve the quality of care for this patient population...
  72. ncbi request reprint Life expectancy gains and cost-effectiveness of implantable cardioverter/defibrillators for the primary prevention of sudden cardiac death in patients with hypertrophic cardiomyopathy
    John J You
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 154:899-907. 2007
    ..Sudden cardiac death (SCD) is a devastating complication of hypertrophic cardiomyopathy (HCM). The optimal strategy for the primary prevention of SCD in HCM remains controversial...
  73. doi request reprint Reporting and representation of ethnic minorities in cardiovascular trials: a systematic review
    Tony Zhang
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 166:52-7. 2013
    ..However, little is known about the reporting and representation of ethnic minorities in major cardiovascular trials...
  74. ncbi request reprint Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction
    Dennis T Ko
    Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    JAMA 288:351-7. 2002
    ..Reluctance to prescribe these agents may derive from concerns about their association with symptoms of depression, fatigue, and sexual dysfunction...
  75. ncbi request reprint The prognostic value of vasodilator myocardial perfusion imaging in octogenarians
    Jeptha P Curtis
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8017, USA
    Am J Geriatr Cardiol 13:239-45, quiz 246-7. 2004
    ..Appropriately selected octogenarians with abnormal vasodilator SPECT imaging may benefit from more aggressive management of their cardiac disease...
  76. ncbi request reprint Exercise capacity and mortality
    Dennis T Ko
    N Engl J Med 347:288-90; author reply 288-90. 2002
  77. ncbi request reprint The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure
    Jeptha P Curtis
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8025, USA
    J Am Coll Cardiol 42:736-42. 2003
    ..The aim of this study was to assess the prognostic importance of left ventricular ejection fraction (LVEF) in stable outpatients with heart failure (HF)...
  78. ncbi request reprint Development of systems of care for ST-elevation myocardial infarction patients: gaps, barriers, and implications
    Brahmajee K Nallamothu
    Circulation 116:e68-72. 2007
  79. ncbi request reprint Risks associated with statin therapy: a systematic overview of randomized clinical trials
    Amir Kashani
    Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 114:2788-97. 2006
    ..We performed a systematic overview of randomized statin trials to quantify the risks of musculoskeletal, renal, and hepatic complications associated with therapy...
  80. ncbi request reprint Authors' response to Apple editorial
    Peter A Kavsak
    Clin Chim Acta 380:245-6. 2007
  81. ncbi request reprint Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University Medical Centre, 1200 Main St W, HSC 2N52, Hamilton, ON, Canada L8N 3Z5
    Clin Chim Acta 380:213-6. 2007
    ....
  82. ncbi request reprint Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, HSC 2N52, Hamilton, ON, Canada L8N 3Z5
    Clin Biochem 40:326-9. 2007
    ..To assess the ability of C-reactive protein (CRP) to predict long-term outcomes in a chest pain population...
  83. ncbi request reprint Review: Beta-blockers increase fatigue and sexual dysfunction but not depression after myocardial infarction
    Dennis T Ko
    ACP J Club 138:30; author reply 30. 2003