David N Juurlink

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. doi request reprint Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk population
    D N Juurlink
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabet Med 29:1524-8. 2012
  2. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
  3. pmc Drug interactions with warfarin: what clinicians need to know
    David N Juurlink
    Division of General Internal Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont
    CMAJ 177:369-71. 2007
  4. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
  5. ncbi request reprint Drug-drug interactions: where do we go from here?
    David N Juurlink
    Division of General Internal Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    J Am Pharm Assoc (2003) 44:128, 131-2, 134. 2004
  6. pmc Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
    David N Juurlink
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 339:b2942. 2009
  7. ncbi request reprint Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    David N Juurlink
    Department of Medicine University of Toronto, Toronto
    N Engl J Med 351:543-51. 2004
  8. ncbi request reprint The risk of suicide with selective serotonin reuptake inhibitors in the elderly
    David N Juurlink
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, Ont, Canada M4N 3M5
    Am J Psychiatry 163:813-21. 2006
  9. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004
  10. ncbi request reprint Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors
    Marisa Battistella
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 165:189-92. 2005

Collaborators

Detail Information

Publications98

  1. doi request reprint Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk population
    D N Juurlink
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabet Med 29:1524-8. 2012
    ..Whether this imparts a higher risk of adverse cardiac events is unknown...
  2. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
    ..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown...
  3. pmc Drug interactions with warfarin: what clinicians need to know
    David N Juurlink
    Division of General Internal Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont
    CMAJ 177:369-71. 2007
  4. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
    ..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown...
  5. ncbi request reprint Drug-drug interactions: where do we go from here?
    David N Juurlink
    Division of General Internal Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    J Am Pharm Assoc (2003) 44:128, 131-2, 134. 2004
  6. pmc Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
    David N Juurlink
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 339:b2942. 2009
    ..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone...
  7. ncbi request reprint Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    David N Juurlink
    Department of Medicine University of Toronto, Toronto
    N Engl J Med 351:543-51. 2004
    ..Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated in these patients. However, life-threatening hyperkalemia can occur when these drugs are used together...
  8. ncbi request reprint The risk of suicide with selective serotonin reuptake inhibitors in the elderly
    David N Juurlink
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, Ont, Canada M4N 3M5
    Am J Psychiatry 163:813-21. 2006
    ..The authors explored the relationship between the initiation of therapy with selective serotonin reuptake inhibitor (SSRI) antidepressants and completed suicide in older patients...
  9. ncbi request reprint Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
    Lancet 363:1751-6. 2004
    ..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs...
  10. ncbi request reprint Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors
    Marisa Battistella
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 165:189-92. 2005
    ..We examined the association between the concomitant use of warfarin and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) or selective COX-2 inhibitors in older adults hospitalized for upper GI hemorrhage...
  11. ncbi request reprint Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
    Arch Intern Med 163:481-6. 2003
    ..We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs)...
  12. doi request reprint Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study
    Hadas D Fischer
    Department of Health Policy Management and Evaluation, University of Toronto, Toront, Ontario, Canada
    Arch Intern Med 170:617-21. 2010
    ..We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole...
  13. doi request reprint Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 19:1026-33. 2011
    ..To determine whether current antipsychotic use among older persons without diabetes is associated with a higher risk of hospital visits for hyperglycemia, as previous studies in this population have yielded conflicting results...
  14. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011
    ..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone...
  15. ncbi request reprint Drug-induced lithium toxicity in the elderly: a population-based study
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Am Geriatr Soc 52:794-8. 2004
    ..To study the association between hospital admission for lithium toxicity and the use of diuretics, angiotensin-converting enzyme (ACE) inhibitors, and nonsteroidal antiinflammatory drugs (NSAIDs) in the elderly...
  16. pmc Trends in opioid use and dosing among socio-economically disadvantaged patients
    Tara Gomes
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Open Med 5:e13-22. 2011
    ..The objective of this study was to examine trends in opioid utilization for nonmalignant pain among recipients of social assistance and to explore the relation between dose of analgesic and mortality...
  17. pmc Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological study
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G106, Toronto, ON, Canada M4N 3M5
    BMJ 328:1415-6. 2004
  18. ncbi request reprint Risk-treatment mismatch in the pharmacotherapy of heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 294:1240-7. 2005
    ..Patients with heart failure have a wide spectrum of mortality risks. To maximize the benefit of available pharmacotherapies, patients with high mortality risk should receive high rates of drug therapy...
  19. pmc Risk of incident diabetes among patients treated with statins: population based study
    Aleesa A Carter
    Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    BMJ 346:f2610. 2013
    ..To examine the risk of new onset diabetes among patients treated with different HMG-CoA reductase inhibitors (statins)...
  20. ncbi request reprint Drug-drug interactions among elderly patients hospitalized for drug toxicity
    David N Juurlink
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 289:1652-8. 2003
    ..Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community are not well characterized...
  21. ncbi request reprint Antidepressants, warfarin, and the risk of hemorrhage
    Paul A Kurdyak
    The Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychopharmacol 25:561-4. 2005
    ..We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an increased risk of hospitalization for upper gastrointestinal tract bleeding (UGIB)...
  22. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
    ..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB...
  23. doi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
    ....
  24. ncbi request reprint A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Ann Emerg Med 46:263-71. 2005
    ..We quantitatively estimate the risk of hepatotoxicity based on the degree and duration of pretreatment exposure to supratherapeutic concentrations of acetaminophen...
  25. doi request reprint Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone
    Jason Lam
    Eli Lilly Canada Inc, Toronto, Canada
    Am J Cardiol 112:420-3. 2013
    ..Physicians should closely monitor patients who initiate amiodarone while receiving warfarin. ..
  26. doi request reprint Comparative adherence to oxybutynin or tolterodine among older patients
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Eur J Clin Pharmacol 68:97-9. 2012
    ..To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs...
  27. pmc Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control study
    Matthew A Weir
    University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 5:1544-51. 2010
    ..The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia...
  28. doi request reprint Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study
    Matthew A Weir
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Canada
    Nephrol Dial Transplant 26:1888-94. 2011
    ..Little evidence justifies the avoidance of glyburide in patients with impaired renal function. We aimed to determine if renal function modifies the risk of hypoglycaemia among patients using glyburide...
  29. doi request reprint Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
    JAMA 305:783-9. 2011
    ..Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures...
  30. pmc A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxin
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Br J Clin Pharmacol 59:102-7. 2005
    ..We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting...
  31. doi request reprint No increase in adverse events during aliskiren use among ontario patients receiving angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers
    Cameron J Gilbert
    Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:586-91. 2013
    ..The extent to which concomitant treatment increases the risk of these outcomes in routine clinical practice is unknown. We addressed this issue with the use of administrative databases...
  32. doi request reprint New fibrate use and acute renal outcomes in elderly adults: a population-based study
    Ying Y Zhao
    Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Intern Med 156:560-9. 2012
    ..Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials...
  33. ncbi request reprint Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
    ..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
  34. ncbi request reprint Inequitable distribution of implantable cardioverter defibrillators in Ontario
    Jacob A Udell
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, and Department of Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Int J Technol Assess Health Care 23:354-61. 2007
    ..The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death...
  35. ncbi request reprint Medical illness and the risk of suicide in the elderly
    David N Juurlink
    Clinical Epidemiology and Healthcare Research Program, University of Toronto, and the Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Arch Intern Med 164:1179-84. 2004
    ..We explored the relationship between treatment for several illnesses and the risk of suicide in elderly patients using a population-based approach...
  36. ncbi request reprint How many "Me-Too" drugs are enough? The case of physician preferences for specific statins
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Ann Pharmacother 40:1047-51. 2006
    ..The increasing availability of "Me-Too" drugs has provided considerable treatment options for clinicians. However, the number of such drugs within a class that are actually used by clinicians has not been well studied...
  37. doi request reprint Antipsychotic drugs and hyperglycemia in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Arch Intern Med 169:1282-9. 2009
    ..Evidence suggests that there is an association between antipsychotic drugs and new-onset diabetes, but little is known about the risk of hyperglycemia among persons with preexisting diabetes...
  38. ncbi request reprint Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 298:2634-43. 2007
    ..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level...
  39. doi request reprint The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and other antidepressants
    Erin Salkeld
    Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 28:230-4. 2008
    ....
  40. ncbi request reprint Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortality
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 151:969-75. 2006
    ..We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI)...
  41. doi request reprint Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study
    Amit M Patel
    Western University and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Ann Intern Med 158:869-76. 2013
    ..Clarithromycin and erythromycin, but not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by CYP3A4...
  42. pmc Comparative effectiveness of angiotensin-receptor blockers for preventing macrovascular disease in patients with diabetes: a population-based cohort study
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ont
    CMAJ 185:1035-41. 2013
    ..We sought to explore the risk of myocardial infarction, stroke and heart failure in patients with diabetes who were taking telmisartan relative to the risk of these events occurring in patients taking other angiotensin-receptor blockers...
  43. doi request reprint Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study
    Irfan A Dhalla
    St Michael s Hospital and Institute for Clinical Evaluative Sciences, Toronto, Ontario M5B 1W8, Canada
    Ann Intern Med 158:447-55. 2013
    ..Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension...
  44. pmc Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
    Irfan A Dhalla
    Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
    CMAJ 181:891-6. 2009
    ..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone...
  45. pmc Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study
    Catherine M Kelly
    Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMJ 340:c693. 2010
    ..To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6)...
  46. doi request reprint Colchicine poisoning: the dark side of an ancient drug
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Toxicol (Phila) 48:407-14. 2010
    ..Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome...
  47. ncbi request reprint Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and health
    Peter C Austin
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
    J Clin Epidemiol 59:964-9. 2006
    ..To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility...
  48. ncbi request reprint Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study
    Donna O Lowe
    Department of Pharmacy Services, University Health Network, University of Toronto, ON, M5G 2C4, Canada
    Clin Infect Dis 43:1272-6. 2006
    ..Whether outpatient PPI use influences the risk of hospital admission for CDAD among older patients who have recently been treated with antibiotics is unknown...
  49. ncbi request reprint Appropriateness of spironolactone prescribing in heart failure patients: a population-based study
    Dennis T Ko
    Division of Cardiology, Shulich Heart Centre, Department of Medicine, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
    J Card Fail 12:205-10. 2006
    ..However, recent data have raised concerns regarding hyperkalemia secondary to spironolactone use and suggest it occurs more commonly in routine practice...
  50. doi request reprint Oral bisphosphonate use in the elderly is not associated with acute kidney injury
    Andrew W Y Shih
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 82:903-8. 2012
    ..03), and no significant differences in other outcomes or in subgroups of patients with baseline chronic kidney disease. Thus, in this older population-based cohort, oral bisphosphonate use was not associated with acute kidney injury...
  51. pmc Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study
    J Michael Paterson
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    CMAJ 184:1565-70. 2012
    ..Thus, we examined the risk of idiosyncratic acute liver injury associated with the use of moxifloxacin relative to other selected antibiotic agents...
  52. doi request reprint Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study
    David N Juurlink
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Clin Toxicol (Phila) 50:390-5. 2012
    ..To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns...
  53. doi request reprint Long-term analgesic use after low-risk surgery: a retrospective cohort study
    Asim Alam
    Department of Anesthesiology, University of Toronto, Ontario, Canada
    Arch Intern Med 172:425-30. 2012
    ..This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics...
  54. pmc Blood glucose test strips: options to reduce usage
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 182:35-8. 2010
    ..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial...
  55. pmc Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study
    Laura Y Park-Wyllie
    Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
    PLoS Med 6:e1000157. 2009
    ..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia...
  56. doi request reprint Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns
    Gal Dubnov-Raz
    Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
    Pediatrics 122:e710-5. 2008
    ..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring...
  57. pmc The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers
    Alissa J Wright
    Department of Medicine, University of Toronto, Ont, Canada
    CMAJ 183:303-7. 2011
    ..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics...
  58. pmc Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Br J Clin Pharmacol 71:544-9. 2011
    ..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin...
  59. pmc Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based study
    Claudia Bucci
    Department of Pharmacie, Sunnybook Health Sciences Centre, University of Toronto, Ontario, Canada
    Can J Cardiol 24:629-32. 2008
    ..Despite safety concerns associated with short-acting agents, increasing evidence supports the safety of long-acting dihydropyridines. Although amlodipine is the best studied of these, there are few studies comparing it with nifedipine...
  60. doi request reprint Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based study
    Mohammed Al-Omran
    Division of Vascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Vasc Surg 48:607-12. 2008
    ..However, limited population-based data are available on use of statin therapy in these patients in Canada. We sought to study trends in statin use to treat these patients in Ontario during a 10-year period...
  61. pmc Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
    Open Med 6:e141-5. 2012
    ....
  62. pmc Sex-and age-based differences in the delivery and outcomes of critical care
    Robert A Fowler
    Interdepartmental Division of Critical Care Medicine and Department of Medicine, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ont
    CMAJ 177:1513-9. 2007
    ..Our objective was to determine whether sex and age are associated with differences in admission practices, processes of care and clinical outcomes for critically ill patients...
  63. pmc Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario
    Irfan A Dhalla
    Department of Medicine, University of Toronto, Toronto, Ont
    Can Fam Physician 57:e92-6. 2011
    ..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality...
  64. ncbi request reprint Guillain-Barré syndrome after influenza vaccination in adults: a population-based study
    David N Juurlink
    Institute of Clinical Evaluative Sciences, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    Arch Intern Med 166:2217-21. 2006
    ..Whether influenza vaccination is associated with Guillain-Barré syndrome (GBS) remains uncertain...
  65. pmc Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?
    Irfan A Dhalla
    Department of Medicine, Unversity of Toronto, Ontario M4E 3E9, Canada
    Antimicrob Agents Chemother 50:3216-9. 2006
    ..difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin or moxifloxacin compared to levofloxacin...
  66. pmc Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs
    Muhammad Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
    BMJ 325:624. 2002
    ..To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)...
  67. pmc The effect of antidepressant warnings on prescribing trends in Ontario, Canada
    Paul A Kurdyak
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Public Health 97:750-4. 2007
    ..We studied whether 5 regulatory agency advisories concerning the possible increased risk of suicidal behavior during antidepressant therapy had an effect on antidepressant prescription trends in Ontario...
  68. doi request reprint Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, Canada
    Abhijat Kitchlu
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Nephrol Dial Transplant 27:1591-8. 2012
    ..Beta-blockers may be cardioprotective in patients receiving chronic dialysis. We examined cardiovascular outcomes among incident dialysis patients receiving beta-blocker therapy...
  69. doi request reprint Use of other opioids during methadone therapy: a population-based study
    Paul Kurdyak
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Addiction 107:776-80. 2012
    ..To determine the extent to which other opioids are prescribed to patients receiving methadone in Ontario, Canada...
  70. doi request reprint Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study
    Irfan A Dhalla
    Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
    Chest 141:348-53. 2012
    ..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension...
  71. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
    ..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality...
  72. pmc Does the treatment of dyslipidemia affect the risk of depression or suicidal behaviour?
    David N Juurlink
    Division of General Internal Medicine, Sunnybrook and Women s Health Sciences Centre, Toronto, Ont
    CMAJ 170:192. 2004
  73. doi request reprint Safety of influenza vaccination in patients with myasthenia gravis: a population-based study
    Lorne Zinman
    Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Muscle Nerve 40:947-51. 2009
    ..Vaccination of patients with MG against influenza was not found to be associated with exacerbations of the disease. Our findings do not support the practice of withholding influenza vaccination in patients with MG...
  74. doi request reprint Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis
    Facundo Garcia Bournissen
    Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 50:898-903. 2009
    ....
  75. pmc Iron poisoning in young children: association with the birth of a sibling
    David N Juurlink
    Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 168:1539-42. 2003
    ..We explored the association between iron poisoning in young children and the birth of a sibling...
  76. doi request reprint Ciprofloxacin-induced theophylline toxicity: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 67:521-6. 2011
    ..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline...
  77. ncbi request reprint Discrepant advice from poison centres and their medical directors
    David N Juurlink
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Clin Pharmacol 9:101-5. 2002
    ....
  78. doi request reprint Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study
    Yaron Finkelstein
    Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:2738-43. 2007
    ..However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain...
  79. doi request reprint Risk of serious falls associated with oxybutynin and tolterodine: a population based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    J Urol 186:1340-4. 2011
    ..We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence...
  80. doi request reprint A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journals
    Peter C Austin
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Clin Epidemiol 63:142-53. 2010
    ..Furthermore, some have advocated for the use of regression adjustment to estimate the effect of treatment after adjusting for potential imbalances in prognostically important baseline covariates between treatment groups...
  81. ncbi request reprint Unintended medication discrepancies at the time of hospital admission
    Patricia L Cornish
    Department of Pharmacy, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Arch Intern Med 165:424-9. 2005
    ..These errors are particularly worthy of attention because they are not likely to be detected by computerized physician order entry systems...
  82. ncbi request reprint Recurrent ibuprofen-induced aseptic meningitis
    Huy T V Nguyen
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Ann Pharmacother 38:408-10. 2004
    ..To report a case of recurrent aseptic meningitis temporally associated with the use of ibuprofen...
  83. ncbi request reprint A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Toxicol (Phila) 43:229-34. 2005
    ..We set out to parameterize both the degree and duration of pretreatment exposure into a single, continuous measure of exposure, which will serve as the x-axis of an eventual dose-response curve...
  84. pmc A case of recurrent meningitis
    Erin B Norris
    Department of Medicine, University of Toronto and Sunnybrook and Women s College Health Sciences Centre, Toronto, Ont
    CMAJ 174:1093-4. 2006
  85. ncbi request reprint Drugs and the QT interval - caveat doctor
    Barbara A Liu
    Department of Medicine, University of Toronto
    N Engl J Med 351:1053-6. 2004
  86. ncbi request reprint N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure
    Jeffrey S Eisen
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    J Toxicol Clin Toxicol 42:89-92. 2004
    ..Over the next 72 h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N-AC therapy are reviewed...
  87. ncbi request reprint Clinical consequences of generic warfarin substitution: an ecological study
    J Michael Paterson
    JAMA 296:1969-72. 2006
  88. ncbi request reprint Are selective COX 2 inhibitors superior to traditional NSAIDs? Little is known about COX 2 inhibitors
    Muhammad Mamdani
    BMJ 325:161; author reply 161. 2002
  89. ncbi request reprint Drug safety in patients with heart failure
    David N Juurlink
    Arch Intern Med 165:118. 2005
  90. ncbi request reprint Pseudoephedrine-induced toxic epidermal necrolysis
    Jeffrey J Nagge
    Arch Dermatol 141:907-8. 2005
  91. ncbi request reprint Identifying individuals with a reduced GFR using ambulatory laboratory database surveillance
    Amit X Garg
    Division of Nephrology, University of Western Ontario, London Kidney Clinical Research Unit, Room A01, Westminster Tower, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
    J Am Soc Nephrol 16:1433-9. 2005
    ..Whether such identification leads to improved health outcomes warrants further study...
  92. ncbi request reprint Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001
    Michael E Detsky
    JAMA 294:1900-1. 2005
  93. ncbi request reprint Do Ontario patients with heart failure have equal access to life-saving technology?
    Douglas S Lee
    Canadian Institutes of Health Research, Canada
    Healthc Q 11:20-1. 2008
  94. ncbi request reprint Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestions
    Marco L A Sivilotti
    Acad Emerg Med 12:574-5. 2005
  95. ncbi request reprint Drug-induced hepatotoxicity
    David N Juurlink
    N Engl J Med 349:1974-6; author reply 1974-6. 2003
  96. ncbi request reprint Hyperbaric oxygen for carbon monoxide poisoning : a systematic review and critical analysis of the evidence
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Australian National University Medical School, Canberra, Australian Capital Territory
    Toxicol Rev 24:75-92. 2005
    ..Such research should not exclude patients with severe poisoning, have a primary outcome that is clinically meaningful and have oversight from an independent data monitoring and ethics committee...
  97. pmc Kappa statistic
    David N Juurlink
    CMAJ 173:16; author reply 17. 2005
  98. pmc The effect of publication on Internet-based solicitation of personal-injury litigants
    David N Juurlink
    CMAJ 177:1369-70. 2007
    ..We found that early online release and print publication were associated with an immediate and sustained increase in the number of websites soliciting plaintiffs for legal action...