Research Topics
| Tara GomesSummaryAffiliation: Institute for Clinical Evaluative Sciences Country: Canada Publications
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Detail Information
Publications
Clinical and demographic characteristics of patients receiving different oral hypoglycemic agentsTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Pharmacoepidemiol Drug Saf 18:756-60. 2009....
Rates of hemorrhage during warfarin therapy for atrial fibrillationTara Gomes
The Leslie Dan Faculty of Pharmacy, Universityof Toronto, Canada
CMAJ 185:E121-7. 2013..Our objective was to examine incident hemorrhagic events in a large population-based cohort of patients with atrial fibrillation who were starting treatment with warfarin...- Progression through diabetes therapies among new elderly users of metformin: a population-based studyT Gomes
Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Diabet Med 30:e51-5. 2013..To examine temporal changes in progression to second-line therapies among older patients with diabetes newly treated with metformin... - The impact of federal warnings on publically funded desmopressin utilization among children in OntarioTara Gomes
The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
J Pediatr Urol 8:249-53. 2012..To determine whether safety warnings issued by health regulatory agencies regarding desmopressin treatment influenced treatment rates among children... - Risk of serious falls associated with oxybutynin and tolterodine: a population based studyTara Gomes
Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
J Urol 186:1340-4. 2011..We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence... - Opioid dose and drug-related mortality in patients with nonmalignant painTara Gomes
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Arch Intern Med 171:686-91. 2011..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality... - Trends in opioid use and dosing among socio-economically disadvantaged patientsTara Gomes
Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
Open Med 5:e13-22. 2011..The objective of this study was to examine trends in opioid utilization for nonmalignant pain among recipients of social assistance and to explore the relation between dose of analgesic and mortality... - Comparative adherence to oxybutynin or tolterodine among older patientsTara Gomes
The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Eur J Clin Pharmacol 68:97-9. 2012..To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs... - Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control studyTony Antoniou
University of Toronto, Toronto, ON, Canada
BMJ 343:d5228. 2011..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone... - New fibrate use and acute renal outcomes in elderly adults: a population-based studyYing Y Zhao
Yale University School of Medicine, New Haven, Connecticut, USA
Ann Intern Med 156:560-9. 2012..Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials... - Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort studyDavid N Juurlink
Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
BMJ 339:b2942. 2009..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone... - A population-based study of the drug interaction between proton pump inhibitors and clopidogrelDavid N Juurlink
Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
CMAJ 180:713-8. 2009..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown... - Long-term analgesic use after low-risk surgery: a retrospective cohort studyAsim Alam
Department of Anesthesiology, University of Toronto, Ontario, Canada
Arch Intern Med 172:425-30. 2012..This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics... - Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based studyTony Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 170:1045-9. 2010..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB... - Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, CanadaAbhijat Kitchlu
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Nephrol Dial Transplant 27:1591-8. 2012..Beta-blockers may be cardioprotective in patients receiving chronic dialysis. We examined cardiovascular outcomes among incident dialysis patients receiving beta-blocker therapy... - Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort studyDavid N Juurlink
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Clin Toxicol (Phila) 50:390-5. 2012..To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns... - Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based studyTony Antoniou
University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Br J Clin Pharmacol 71:544-9. 2011..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin... - Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control studyMatthew A Weir
University of Western Ontario, London, Ontario, Canada
Clin J Am Soc Nephrol 5:1544-51. 2010..The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia... - The risk of hip fracture after initiating antihypertensive drugs in the elderlyDebra A Butt
Ellesmere Health Care Centre and The Scarborough Hospital, Scarborough, Ontario, Canada
Arch Intern Med 172:1739-44. 2012.... - Use of other opioids during methadone therapy: a population-based studyPaul Kurdyak
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Addiction 107:776-80. 2012..To determine the extent to which other opioids are prescribed to patients receiving methadone in Ontario, Canada... - Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control studyIrfan A Dhalla
Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
Chest 141:348-53. 2012..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension... 
Thiazolidinediones and cardiovascular outcomes in older patients with diabetesLorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
JAMA 298:2634-43. 2007..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level...- Blood glucose test strips: options to reduce usageTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ont
CMAJ 182:35-8. 2010..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial... - Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort studyCatherine M Kelly
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
BMJ 340:c693. 2010..To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6)... - Risk of acute kidney injury from oral acyclovir: a population-based studyNgan N Lam
Division of Nephrology, Western University, London, Ontario, Canada Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada
Am J Kidney Dis 61:723-9. 2013..Similarly, AKI from oral acyclovir is described in case reports, but the risk in routine practice is unknown... - Opioid dose and risk of road trauma in Canada: a population-based studyTara Gomes
Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
JAMA Intern Med 173:196-201. 2013..Use of opioids may predispose drivers to road trauma, yet the effect of opioid dose on this association is unknown... - Oral bisphosphonate use in the elderly is not associated with acute kidney injuryAndrew W Y Shih
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Kidney Int 82:903-8. 2012..03), and no significant differences in other outcomes or in subgroups of patients with baseline chronic kidney disease. Thus, in this older population-based cohort, oral bisphosphonate use was not associated with acute kidney injury... - Clustering of opioid prescribing and opioid-related mortality among family physicians in OntarioIrfan A Dhalla
Department of Medicine, University of Toronto, Toronto, Ont
Can Fam Physician 57:e92-6. 2011..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality... - Ciprofloxacin-induced theophylline toxicity: a population-based studyTony Antoniou
University of Toronto, Toronto, ON, Canada
Eur J Clin Pharmacol 67:521-6. 2011..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline... - Effects of funding policy changes and health warnings on the use of erythropoiesis-stimulating agentsMatthew A Weir
University of Western Ontario, London University of Waterloo, Waterloo Institute for Clinical Evaluative Sciences University of Toronto Sunnybrook Health Sciences Centre and Applied Health Research Center, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
J Oncol Pract 8:179-83. 2012..To characterize the effects of formulary changes and governmental safety warnings on use of erythropoiesis-stimulating agents (ESAs) in patients with cancer... - Preventing pressure ulcers in long-term care: a cost-effectiveness analysisBa Pham
TorontoHealth Economics and Technology Assessment Collaborative, Department of Health Policy Management andEvaluation, University of Toronto, 144 College Street, Toronto, Ontario, Canada
Arch Intern Med 171:1839-47. 2011..Pressure ulcers are common in many care settings, with adverse health outcomes and high treatment costs. We evaluated the cost-effectiveness of evidence-based strategies to improve current prevention practice in long-term care facilities... - The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockersAlissa J Wright
Department of Medicine, University of Toronto, Ont, Canada
CMAJ 183:303-7. 2011..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics... - The safety of proton pump inhibitors and clopidogrel in patients after strokeDavid N Juurlink
Sunnybrook Research Institute, Toronto, Ontario, Canada
Stroke 42:128-32. 2011..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown... - Health status utilities and the impact of pressure ulcers in long-term care residents in OntarioHla Hla Thein
Toronto General Research Institute, University Health Network, Toronto, ON, Canada
Qual Life Res 19:81-9. 2010..To estimate health status utilities in long-term care (LTC) residents in Ontario, both with and without pressure ulcers (PUs), and to determine the impact of PU on health-related quality of life (HRQOL)... - Adherence to multiple sclerosis disease-modifying therapies in Ontario is lowJanice Wong
Division of Neurology, The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Can J Neurol Sci 38:429-33. 2011..m. IFNβ-1a, Avonex), subcutaneous interferon beta-1a (s.c. IFNβ-1a, Rebif), subcutaneous interferon beta-1b (IFNβ-1b, Betaseron) or glatiramer acetate (Copaxone)... - Relationship of asthma management, socioeconomic status, and medication insurance characteristics to exacerbation frequency in children with asthmaWendy J Ungar
Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Health Policy, Management, and Evaluation, University of Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Ann Allergy Asthma Immunol 106:17-23. 2011..less than 25% of asthmatic children are well controlled... - Antipsychotic therapy and short-term serious events in older adults with dementiaPaula A Rochon
Department of Medicine, University of Toronto, Canada
Arch Intern Med 168:1090-6. 2008.... - Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristicsEric I Benchimol
Division of Gastroenterology, Hepatology and Nutrition, The Hospital of Sick Children, Toronto, Canada
Am J Gastroenterol 103:1524-31. 2008..This study assessed the clinical and radiologic characteristics of TMC in children with IBD...