Tara Gomes

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. doi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
  2. pmc Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
    Open Med 6:e141-5. 2012
  3. pmc Rates of hemorrhage during warfarin therapy for atrial fibrillation
    Tara Gomes
    The Leslie Dan Faculty of Pharmacy, Universityof Toronto, Canada
    CMAJ 185:E121-7. 2013
  4. doi request reprint Progression through diabetes therapies among new elderly users of metformin: a population-based study
    T Gomes
    Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Diabet Med 30:e51-5. 2013
  5. doi request reprint The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Pediatr Urol 8:249-53. 2012
  6. pmc Trends in opioid use and dosing among socio-economically disadvantaged patients
    Tara Gomes
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Open Med 5:e13-22. 2011
  7. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
  8. doi request reprint Comparative adherence to oxybutynin or tolterodine among older patients
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Eur J Clin Pharmacol 68:97-9. 2012
  9. doi request reprint Risk of serious falls associated with oxybutynin and tolterodine: a population based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    J Urol 186:1340-4. 2011
  10. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011

Detail Information

Publications45

  1. doi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
    ....
  2. pmc Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
    Open Med 6:e141-5. 2012
    ....
  3. pmc Rates of hemorrhage during warfarin therapy for atrial fibrillation
    Tara Gomes
    The Leslie Dan Faculty of Pharmacy, Universityof Toronto, Canada
    CMAJ 185:E121-7. 2013
    ..Our objective was to examine incident hemorrhagic events in a large population-based cohort of patients with atrial fibrillation who were starting treatment with warfarin...
  4. doi request reprint Progression through diabetes therapies among new elderly users of metformin: a population-based study
    T Gomes
    Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Diabet Med 30:e51-5. 2013
    ..To examine temporal changes in progression to second-line therapies among older patients with diabetes newly treated with metformin...
  5. doi request reprint The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Pediatr Urol 8:249-53. 2012
    ..To determine whether safety warnings issued by health regulatory agencies regarding desmopressin treatment influenced treatment rates among children...
  6. pmc Trends in opioid use and dosing among socio-economically disadvantaged patients
    Tara Gomes
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Open Med 5:e13-22. 2011
    ..The objective of this study was to examine trends in opioid utilization for nonmalignant pain among recipients of social assistance and to explore the relation between dose of analgesic and mortality...
  7. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
    ..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality...
  8. doi request reprint Comparative adherence to oxybutynin or tolterodine among older patients
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Eur J Clin Pharmacol 68:97-9. 2012
    ..To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs...
  9. doi request reprint Risk of serious falls associated with oxybutynin and tolterodine: a population based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    J Urol 186:1340-4. 2011
    ..We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence...
  10. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011
    ..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone...
  11. pmc Risk of incident diabetes among patients treated with statins: population based study
    Aleesa A Carter
    Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    BMJ 346:f2610. 2013
    ..To examine the risk of new onset diabetes among patients treated with different HMG-CoA reductase inhibitors (statins)...
  12. doi request reprint No increase in adverse events during aliskiren use among ontario patients receiving Angiotensin-converting enzyme inhibitors or Angiotensin-receptor blockers
    Cameron J Gilbert
    Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:586-91. 2013
    ..The extent to which concomitant treatment increases the risk of these outcomes in routine clinical practice is unknown. We addressed this issue with the use of administrative databases...
  13. doi request reprint Long-term analgesic use after low-risk surgery: a retrospective cohort study
    Asim Alam
    Department of Anesthesiology, University of Toronto, Ontario, Canada
    Arch Intern Med 172:425-30. 2012
    ..This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics...
  14. doi request reprint Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study
    Irfan A Dhalla
    St Michael s Hospital and Institute for Clinical Evaluative Sciences, Toronto, Ontario M5B 1W8, Canada
    Ann Intern Med 158:447-55. 2013
    ..Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension...
  15. doi request reprint New fibrate use and acute renal outcomes in elderly adults: a population-based study
    Ying Y Zhao
    Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Intern Med 156:560-9. 2012
    ..Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials...
  16. pmc Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
    David N Juurlink
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 339:b2942. 2009
    ..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone...
  17. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
    ..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown...
  18. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
    ..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB...
  19. doi request reprint Risk of acute kidney injury from oral acyclovir: a population-based study
    Ngan N Lam
    Division of Nephrology, Western University, London, Ontario, Canada Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada
    Am J Kidney Dis 61:723-9. 2013
    ..Similarly, AKI from oral acyclovir is described in case reports, but the risk in routine practice is unknown...
  20. doi request reprint Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study
    David N Juurlink
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Clin Toxicol (Phila) 50:390-5. 2012
    ..To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns...
  21. doi request reprint Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, Canada
    Abhijat Kitchlu
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Nephrol Dial Transplant 27:1591-8. 2012
    ..Beta-blockers may be cardioprotective in patients receiving chronic dialysis. We examined cardiovascular outcomes among incident dialysis patients receiving beta-blocker therapy...
  22. pmc Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control study
    Matthew A Weir
    University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 5:1544-51. 2010
    ..The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia...
  23. pmc Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Br J Clin Pharmacol 71:544-9. 2011
    ..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin...
  24. doi request reprint Oral bisphosphonate use in the elderly is not associated with acute kidney injury
    Andrew W Y Shih
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 82:903-8. 2012
    ..03), and no significant differences in other outcomes or in subgroups of patients with baseline chronic kidney disease. Thus, in this older population-based cohort, oral bisphosphonate use was not associated with acute kidney injury...
  25. pmc Effect of a course-based intervention and effect of medical regulation on physicians' opioid prescribing
    Meldon Kahan
    Complex Care Clinic, Women s College Hospital, 6th Floor, 76 Grenville St, Toronto, ON M5S 1B2
    Can Fam Physician 59:e231-9. 2013
    ..To examine the effects of an intensive 2-day course on physicians' prescribing of opioids...
  26. doi request reprint The risk of hip fracture after initiating antihypertensive drugs in the elderly
    Debra A Butt
    Ellesmere Health Care Centre and The Scarborough Hospital, Scarborough, Ontario, Canada
    Arch Intern Med 172:1739-44. 2012
    ....
  27. doi request reprint Use of other opioids during methadone therapy: a population-based study
    Paul Kurdyak
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Addiction 107:776-80. 2012
    ..To determine the extent to which other opioids are prescribed to patients receiving methadone in Ontario, Canada...
  28. ncbi request reprint Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 298:2634-43. 2007
    ..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level...
  29. doi request reprint Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study
    Irfan A Dhalla
    Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
    Chest 141:348-53. 2012
    ..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension...
  30. pmc Blood glucose test strips: options to reduce usage
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 182:35-8. 2010
    ..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial...
  31. pmc Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study
    Catherine M Kelly
    Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMJ 340:c693. 2010
    ..To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6)...
  32. doi request reprint Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone
    Jason Lam
    Eli Lilly Canada Inc, Toronto, Canada
    Am J Cardiol 112:420-3. 2013
    ..Physicians should closely monitor patients who initiate amiodarone while receiving warfarin. ..
  33. doi request reprint Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study
    Amit M Patel
    Western University and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Ann Intern Med 158:869-76. 2013
    ..Clarithromycin and erythromycin, but not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by CYP3A4...
  34. doi request reprint Opioid dose and risk of road trauma in Canada: a population-based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    JAMA Intern Med 173:196-201. 2013
    ..Use of opioids may predispose drivers to road trauma, yet the effect of opioid dose on this association is unknown...
  35. pmc Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario
    Irfan A Dhalla
    Department of Medicine, University of Toronto, Toronto, Ont
    Can Fam Physician 57:e92-6. 2011
    ..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality...
  36. doi request reprint Ciprofloxacin-induced theophylline toxicity: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 67:521-6. 2011
    ..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline...
  37. pmc Effects of funding policy changes and health warnings on the use of erythropoiesis-stimulating agents
    Matthew A Weir
    University of Western Ontario, London University of Waterloo, Waterloo Institute for Clinical Evaluative Sciences University of Toronto Sunnybrook Health Sciences Centre and Applied Health Research Center, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    J Oncol Pract 8:179-83. 2012
    ..To characterize the effects of formulary changes and governmental safety warnings on use of erythropoiesis-stimulating agents (ESAs) in patients with cancer...
  38. doi request reprint Preventing pressure ulcers in long-term care: a cost-effectiveness analysis
    Ba Pham
    TorontoHealth Economics and Technology Assessment Collaborative, Department of Health Policy Management andEvaluation, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    Arch Intern Med 171:1839-47. 2011
    ..Pressure ulcers are common in many care settings, with adverse health outcomes and high treatment costs. We evaluated the cost-effectiveness of evidence-based strategies to improve current prevention practice in long-term care facilities...
  39. pmc The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers
    Alissa J Wright
    Department of Medicine, University of Toronto, Ont, Canada
    CMAJ 183:303-7. 2011
    ..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics...
  40. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
    ..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown...
  41. pmc Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
    Hla Hla Thein
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Qual Life Res 19:81-9. 2010
    ..To estimate health status utilities in long-term care (LTC) residents in Ontario, both with and without pressure ulcers (PUs), and to determine the impact of PU on health-related quality of life (HRQOL)...
  42. doi request reprint Relationship of asthma management, socioeconomic status, and medication insurance characteristics to exacerbation frequency in children with asthma
    Wendy J Ungar
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Health Policy, Management, and Evaluation, University of Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Allergy Asthma Immunol 106:17-23. 2011
    ..less than 25% of asthmatic children are well controlled...
  43. ncbi request reprint Adherence to multiple sclerosis disease-modifying therapies in Ontario is low
    Janice Wong
    Division of Neurology, The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Can J Neurol Sci 38:429-33. 2011
    ..m. IFNβ-1a, Avonex), subcutaneous interferon beta-1a (s.c. IFNβ-1a, Rebif), subcutaneous interferon beta-1b (IFNβ-1b, Betaseron) or glatiramer acetate (Copaxone)...
  44. doi request reprint Antipsychotic therapy and short-term serious events in older adults with dementia
    Paula A Rochon
    Department of Medicine, University of Toronto, Canada
    Arch Intern Med 168:1090-6. 2008
    ....
  45. doi request reprint Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics
    Eric I Benchimol
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital of Sick Children, Toronto, Canada
    Am J Gastroenterol 103:1524-31. 2008
    ..This study assessed the clinical and radiologic characteristics of TMC in children with IBD...