D A Alter

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. doi request reprint Influence of socioeconomic status on lifestyle behavior modifications among survivors of acute myocardial infarction
    Raymond H M Chan
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1583-8. 2008
  2. pmc Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction
    David A Alter
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 8:e65130. 2013
  3. doi request reprint Ambulatory surveillance of patients referred for cardiac rehabilitation following cardiac hospitalization: a feasibility study
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Cardiol 28:497-501. 2012
  4. pmc Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMC Health Serv Res 12:238. 2012
  5. pmc The average lifespan of patients discharged from hospital with heart failure
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Gen Intern Med 27:1171-9. 2012
  6. pmc Impact of clinical urgency, physician supply and procedural capacity on regional variations in wait times for coronary angiography
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 10:5. 2010
  7. pmc The relationship between depressive symptoms, health service consumption, and prognosis after acute myocardial infarction: a prospective cohort study
    Paul A Kurdyak
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 8:200. 2008
  8. pmc Triage for coronary artery bypass graft surgery in Canada: do patients agree on who should come first?
    Katy Shufelt
    Schulich Heart Program of Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Health Serv Res 7:118. 2007
  9. ncbi request reprint Socioeconomic status and mortality after acute myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, Sunnybrook, Women s College Health Sciences Centre, York University, Institute for Work and Health, and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 144:82-93. 2006
  10. ncbi request reprint The evaluation of a formalized queue management system for coronary angiography waiting lists
    D A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Can J Cardiol 21:1203-9. 2005

Detail Information

Publications83

  1. doi request reprint Influence of socioeconomic status on lifestyle behavior modifications among survivors of acute myocardial infarction
    Raymond H M Chan
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1583-8. 2008
    ..In conclusion, socioeconomically disadvantaged patients were sicker at baseline and less behaviorally responsive to embarking on healthy lifestyle changes after AMI than were those of higher socioeconomic status...
  2. pmc Socioeconomic status, functional recovery, and long-term mortality among patients surviving acute myocardial infarction
    David A Alter
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS ONE 8:e65130. 2013
    ..To examine the relationship between socio-economic status (SES), functional recovery and long-term mortality following acute myocardial infarction (AMI)...
  3. doi request reprint Ambulatory surveillance of patients referred for cardiac rehabilitation following cardiac hospitalization: a feasibility study
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Cardiol 28:497-501. 2012
    ..Our purpose was to examine the feasibility of implementing an ambulatory surveillance system for monitoring patients referred to cardiac rehabilitation following cardiac hospitalizations...
  4. pmc Obesity, lifestyle risk-factors, and health service outcomes among healthy middle-aged adults in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
    BMC Health Serv Res 12:238. 2012
    ..The extent to which uncomplicated obesity among an otherwise healthy middle-aged population is associated with higher longitudinal health-care expenditures remains unclear...
  5. pmc The average lifespan of patients discharged from hospital with heart failure
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Gen Intern Med 27:1171-9. 2012
    ..There are no life-tables quantifying the average life-spans of post-hospitalized heart failure populations across various strata of risk...
  6. pmc Impact of clinical urgency, physician supply and procedural capacity on regional variations in wait times for coronary angiography
    Harindra C Wijeysundera
    Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 10:5. 2010
    ..Our objective was to evaluate the extent to which demand-side factors such as clinical urgency/need, and supply-side factors, as reflected by differences in physician and procedural supply account for these inequalities...
  7. pmc The relationship between depressive symptoms, health service consumption, and prognosis after acute myocardial infarction: a prospective cohort study
    Paul A Kurdyak
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario, Canada
    BMC Health Serv Res 8:200. 2008
    ..This paper explores the relationship between depressive symptoms, health service cardiovascular consumption, and prognosis following acute myocardial infarction (AMI)...
  8. pmc Triage for coronary artery bypass graft surgery in Canada: do patients agree on who should come first?
    Katy Shufelt
    Schulich Heart Program of Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Health Serv Res 7:118. 2007
    ....
  9. ncbi request reprint Socioeconomic status and mortality after acute myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, Sunnybrook, Women s College Health Sciences Centre, York University, Institute for Work and Health, and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 144:82-93. 2006
    ..The intermediary causes of such gradients remain poorly elucidated...
  10. ncbi request reprint The evaluation of a formalized queue management system for coronary angiography waiting lists
    D A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Can J Cardiol 21:1203-9. 2005
    ..The extent to which formal queue management systems may improve the prioritization and survival of patients in the angiography queue is unknown...
  11. ncbi request reprint Influence of education and income on atherogenic risk factor profiles among patients hospitalized with acute myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Cardiol 20:1219-28. 2004
    ..It is unknown whether these differences can be attributed, in part, to variations in the prevalence of atherogenic risk factors preceding the index AMI event...
  12. ncbi request reprint Factors explaining the under-use of reperfusion therapy among ideal patients with ST-segment elevation myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Eur Heart J 27:1539-49. 2006
    ....
  13. ncbi request reprint Community factors, hospital characteristics and inter-regional outcome variations following acute myocardial infarction in Canada
    David A Alter
    University of Toronto, Toronto, Canada
    Can J Cardiol 21:247-55. 2005
    ....
  14. pmc The relationship between physician supply, cardiovascular health service use and cardiac disease burden in Ontario: supply-need mismatch
    David A Alter
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario
    Can J Cardiol 24:187-93. 2008
    ..The objective of the present study was to examine the relationship among cardiovascular evaluation and management intensity, physician supply and cardiovascular disease burden in the Canadian population...
  15. ncbi request reprint The relationship between the supply of fast-food chains and cardiovascular outcomes
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, ON
    Can J Public Health 96:173-7. 2005
    ..To examine the extent to which inter-regional differences in fast-food concentrations account for variations in all-cause mortality and acute coronary syndromes throughout Ontario, Canada...
  16. pmc Therapeutic lifestyle and disease-management interventions: pushing the scientific envelope
    David A Alter
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, Toronto, Ont
    CMAJ 177:887-9. 2007
  17. ncbi request reprint Age, risk-benefit trade-offs, and the projected effects of evidence-based therapies
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am J Med 116:540-5. 2004
    ..We compared the estimated effects of age and efficacy of treatment on survival among patients with acute coronary syndromes...
  18. doi request reprint Relationship between cardiac rehabilitation and survival after acute cardiac hospitalization within a universal health care system
    David A Alter
    Institute for Clinical Evaluative Sciences, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
    Eur J Cardiovasc Prev Rehabil 16:102-13. 2009
    ..The magnitude and mechanisms of survival benefit associated with cardiac rehabilitation services among real-world populations within a universal health care system remain unclear...
  19. ncbi request reprint Factoring socioeconomic status into cardiac performance profiling for hospitals: does it matter?
    David A Alter
    Division of Cardiology, Schulich Heart Centre, University of Toronto, Ontario
    Med Care 40:60-7. 2002
    ....
  20. ncbi request reprint Biology or bias: practice patterns and long-term outcomes for men and women with acute myocardial infarction
    D A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 39:1909-16. 2002
    ..Another objective was to evaluate the association of age, gender and treatment intensity with five-year survival after AMI...
  21. ncbi request reprint Proliferation of cardiac technology in Canada: a challenge to the sustainability of Medicare
    David A Alter
    Institute for Clinical Evaluative Sciences, The University of Toronto Clinical Epidemiology and Health Care Research Program, Toronto, Canada
    Circulation 113:380-7. 2006
    ..The objective of this study was to examine the temporal trends in the utilization and costs of cardiovascular technologies for the evaluation and/or management of patients with ischemic heart disease in Canada...
  22. ncbi request reprint Long-term MI outcomes at hospitals with or without on-site revascularization
    D A Alter
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5
    JAMA 285:2101-8. 2001
    ..Whether such differences are due to invasive procedure rates alone or to other patient, physician, and hospital characteristics is unknown...
  23. pmc Geography and service supply do not explain socioeconomic gradients in angiography use after acute myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    CMAJ 168:261-4. 2003
    ..This study was conducted to determine whether the impact of socioeconomic status on angiography use would be lessened by considering variations in the supply of services...
  24. ncbi request reprint Processes and outcomes of care for diabetic acute myocardial infarction patients in Ontario: do physicians undertreat?
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Diabetes Care 26:1427-34. 2003
    ..To compare the health service utilization and long-term outcomes of acute myocardial infarction (AMI) patients with and without diabetes in Ontario...
  25. ncbi request reprint Waiting times, revascularization modality, and outcomes after acute myocardial infarction at hospitals with and without on-site revascularization facilities in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 42:410-9. 2003
    ..This study was designed to determine whether admission to a Canadian hospital with on-site revascularization (invasive hospital) affected revascularization choice, timing, and outcome compared with community (non-invasive) hospitals...
  26. doi request reprint Lesson from Canada's Universal Care: socially disadvantaged patients use more health services, still have poorer health
    David A Alter
    Institute for Clinical Evaluative Sciences and the research director of theCardiac Rehabilitation and Secondary Prevention Program of the Toronto Rehabilitation Institute, inToronto, Ontario, Canada
    Health Aff (Millwood) 30:274-83. 2011
    ..Universal access can only reduce these disparities. Our findings suggest the need to introduce large-scale preventive strategies early in patients' lives to help change unhealthy behavior...
  27. ncbi request reprint Socioeconomic status, service patterns, and perceptions of care among survivors of acute myocardial infarction in Canada
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 291:1100-7. 2004
    ..The extent to which this theory is a valid representation of Canadian health care is unknown...
  28. ncbi request reprint Comparing hierarchical modeling with traditional logistic regression analysis among patients hospitalized with acute myocardial infarction: should we be analyzing cardiovascular outcomes data differently?
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 145:27-35. 2003
    ..Furthermore, imputing characteristics measured at higher levels of the hierarchy to the patient-level artificially inflates the amount of available information on the effect of higher-level characteristics on outcomes...
  29. ncbi request reprint Evaluating the performance of the Global Registry of Acute Coronary Events risk-adjustment index across socioeconomic strata among patients discharged from the hospital after acute myocardial infarction
    David A Alter
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 151:323-31. 2006
    ..The objective of this study was to validate the Global Registry of Acute Coronary Events (GRACE) risk-adjustment index for 6-month all-cause mortality across socioeconomic strata...
  30. ncbi request reprint Age-social stratification designs had a negligible impact on income-mortality associations
    H C Wijeysundera
    Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    J Clin Epidemiol 60:579-84. 2007
    ..This study was to evaluate whether age-income stratification designs generate comparable income-mortality associations as those whose income rankings are based on absolute thresholds...
  31. pmc Utilisation of coronary angiography after acute myocardial infarction in Ontario over time: have referral patterns changed?
    Y Khaykin
    Division of Cardiology, Schulich Heart Centre, Sunnybrook and Women s College Health Sciences Centre and the University of Toronto, Toronto, Ontario, Canada
    Heart 88:460-6. 2002
    ..To examine how physicians in Ontario, Canada, have altered their referral patterns for coronary angiography after acute myocardial infarction (AMI) over time...
  32. pmc Clinical prognosis, pre-existing conditions and the use of reperfusion therapy for patients with ST segment elevation acute myocardial infarction
    Andrea B Parker
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Cardiol 22:131-9. 2006
    ..The impact of prognostic characteristics and pre-existing conditions on the use of reperfusion therapy among eligible patients with acute ST segment elevation myocardial infarction is examined...
  33. ncbi request reprint Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction
    Jeppe N Rasmussen
    Institute of Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 297:177-86. 2007
    ..The extent to which drug adherence may affect survival remains unclear, in part because mortality differences may be attributable to "healthy adherer" behavioral attributes more so than to pharmacological benefits...
  34. doi request reprint Temporal trends in the use of percutaneous coronary intervention and coronary artery bypass surgery in New York State and Ontario
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Ontario, Canada
    Circulation 121:2635-44. 2010
    ..Although New York State (NYS) historically has had twice as many coronary revascularizations performed as Ontario, the relative evolution of coronary revascularization patterns in both jurisdictions over time is unknown...
  35. doi request reprint Patient satisfaction and its relationship with quality and outcomes of care after acute myocardial infarction
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Circulation 118:1938-45. 2008
    ....
  36. ncbi request reprint Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, and Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    JAMA 291:1864-70. 2004
    ..Ideally, aggressiveness in the use of these beneficial therapies should correlate with baseline cardiovascular risk...
  37. pmc Cardiologists' charting varied by risk factor, and was often discordant with patient report
    Shannon Gravely-Witte
    University Health Network Women s Health Program, 200 Elizabeth St, Toronto, Ontario, Canada
    J Clin Epidemiol 61:1073-9. 2008
    ..To assess the completeness of cardiac risk factor documentation by cardiologists, and agreement with patient report...
  38. ncbi request reprint Risk-treatment mismatch in the pharmacotherapy of heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA 294:1240-7. 2005
    ..Patients with heart failure have a wide spectrum of mortality risks. To maximize the benefit of available pharmacotherapies, patients with high mortality risk should receive high rates of drug therapy...
  39. pmc Secular trends in acute coronary syndrome hospitalization from 1994 to 2005
    Dennis T Ko
    Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Can J Cardiol 26:129-34. 2010
    ..Although substantial advances have been made in the prevention and treatment of coronary artery disease, their impact on the rates of ACS hospitalization is unclear...
  40. doi request reprint Life expectancy after an index hospitalization for patients with heart failure: a population-based study
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Am Heart J 155:324-31. 2008
    ..However, previous studies have focused on predicting shorter-term mortality and limited data currently exist to predict expected survival among hospitalized patients with HF...
  41. ncbi request reprint Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 298:2634-43. 2007
    ..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level...
  42. doi request reprint Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, ON, M4N 3M5, Canada
    Circulation 122:1806-14. 2010
    ..The type of outpatient physician care after an emergency department visit for heart failure may affect patients' outcomes. Methods and..
  43. doi request reprint Association between hospital cardiac management and outcomes for acute myocardial infarction patients
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 48:157-65. 2010
    ..Randomized trials have shown that medical and interventional therapies improve outcomes for acute myocardial infarction (AMI) patients. The extent to which hospital quality improvement translates into better patient outcomes is unclear...
  44. doi request reprint Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis
    Douglas S Lee
    Division of Cardiology, Institute for Clinical Evaluative Sciences, Toronto General Hospital, Toronto, Ontario, Canada
    Circ Heart Fail 3:228-35. 2010
    ..Although approximately one third of patients with heart failure (HF) visiting the emergency department (ED) are discharged home, little is known about their care and outcomes...
  45. ncbi request reprint Outcomes of acute myocardial infarction in Canada
    Jack V Tu
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Can J Cardiol 19:893-901. 2003
    ..Little information is available on recent population-based trends in the outcomes of patients who have had an acute myocardial infarction (AMI) in Canada...
  46. doi request reprint Health impact of hospital restrictions on seriously ill hospitalized patients: lessons from the Toronto SARS outbreak
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Care 46:991-7. 2008
    ..Restrictions on non-urgent hospital care imposed to control the 2003 Toronto severe acute respiratory syndrome outbreak led to substantial disruptions in hospital clinical practice, admission, and transfer patterns...
  47. doi request reprint Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial
    Jack V Tu
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    JAMA 302:2330-7. 2009
    ..Publicly released report cards on hospital performance are increasingly common, but whether they are an effective method for improving quality of care remains uncertain...
  48. pmc Use of evidence-based therapies after discharge among elderly patients with acute myocardial infarction
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 179:895-900. 2008
    ..We examined trends in the use of evidence-based drug therapies after discharge among elderly patients with myocardial infarction...
  49. pmc Factors associated with the use of evidence-based therapies after discharge among elderly patients with myocardial infarction
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 179:901-8. 2008
    ..Our objective was to identify the characteristics of patients, physicians, hospitals and communities associated with differences in the use of these medications after discharge...
  50. doi request reprint "Dose-dependent" impact of recurrent cardiac events on mortality in patients with heart failure
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Ont, Canada
    Am J Med 122:162-169.e1. 2009
    ..We determined if a "dose-dependent" relationship exists between heart failure events and death, accounting for temporal changes in age, comorbidities, and disease severity...
  51. doi request reprint Regional variation in cardiac catheterization appropriateness and baseline risk after acute myocardial infarction
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Am Coll Cardiol 51:716-23. 2008
    ....
  52. ncbi request reprint The use of fixed- and random-effects models for classifying hospitals as mortality outliers: a Monte Carlo assessment
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Decis Making 23:526-39. 2003
    ..There is an increasing movement towards the release of hospital "report-cards. "However, there is a paucity of research into the abilities of the different methods to correctly classify hospitals as performance outliers...
  53. ncbi request reprint Association between lipid testing and statin therapy in acute myocardial infarction patients
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Toronto, Ontario, Canada
    Am Heart J 150:419-25. 2005
    ..We sought to examine rates of inhospital lipid testing and its association with statin therapy at hospital discharge...
  54. pmc The 2003 Canadian recommendations for dyslipidemia management: revisions are needed
    Douglas G Manuel
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 172:1027-31. 2005
  55. ncbi request reprint Socioeconomic status influences care of patients with acne in Ontario, Canada
    Aamir Haider
    Division of Dermatology, University of Toronto, Toronto, Ontario, Canada
    J Am Acad Dermatol 54:331-5. 2006
    ....
  56. ncbi request reprint Impact of the choice of benchmark on the conclusions of hospital report cards
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 148:1041-6. 2004
    ..The objective of the current study was to determine whether the number of hospitals identified as mortality outliers depended upon the benchmark against which hospitals are compared...
  57. pmc Revisiting Rose: strategies for reducing coronary heart disease
    Douglas G Manuel
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 332:659-62. 2006
  58. ncbi request reprint The use of quantile regression in health care research: a case study examining gender differences in the timeliness of thrombolytic therapy
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Canada
    Stat Med 24:791-816. 2005
    ..Investigators who want to determine how a distribution of delays in treatment or of waiting times changes with patient or system characteristics should consider complementing their analyses with the use of quantile regression...
  59. ncbi request reprint The impact of under coding of cardiac severity and comorbid diseases on the accuracy of hospital report cards
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Med Care 43:801-9. 2005
    ..Hospital report cards usually are based on administrative discharge abstracts. However, cardiac severity and comorbidities generally are under-reported in administrative data...
  60. ncbi request reprint Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortality
    Peter C Austin
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Am Heart J 151:969-75. 2006
    ..We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI)...
  61. pmc Analysis of observational studies in the presence of treatment selection bias: effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methods
    Therese A Stukel
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 297:278-85. 2007
    ..Comparisons of outcomes between patients treated and untreated in observational studies may be biased due to differences in patient prognosis between groups, often because of unobserved treatment selection biases...
  62. ncbi request reprint Effect of cardiac and noncardiac conditions on survival after defibrillator implantation
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:2408-15. 2007
    ..We sought to examine outcomes in recipients of implantable cardioverter-defibrillators (ICDs) and the effect of age, gender, and comorbidities on survival...
  63. pmc Effectiveness and efficiency of different guidelines on statin treatment for preventing deaths from coronary heart disease: modelling study
    Douglas G Manuel
    Institute for Clinical Evaluative Sciences G106 2075 Bayview Avenue, Toronto, Ontario M4N 3M5
    BMJ 332:1419. 2006
    ..To examine the potential effectiveness and efficiency of different guidelines for statin treatment to reduce deaths from coronary heart disease in the Canadian population...
  64. ncbi request reprint Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada
    Dennis T Ko
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circulation 115:196-203. 2007
    ....
  65. pmc Effect of widespread restrictions on the use of hospital services during an outbreak of severe acute respiratory syndrome
    Michael J Schull
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 176:1827-32. 2007
    ..We describe the impact of these restrictions on health care utilization and suggest lessons for future epidemics...
  66. ncbi request reprint Influence of socioeconomic status on drug selection for the elderly in Canada
    Muhammad M Mamdani
    Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario M4N 3M5, Canada
    Ann Pharmacother 36:804-8. 2002
    ....
  67. ncbi request reprint Coronary angiography following acute myocardial infarction in Ontario, Canada
    Sheldon M Singh
    Departments of Medicine, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 167:808-13. 2007
    ..The role of scientific evidence in shaping recommendations on capacity targets and cardiovascular technology utilization is unclear...
  68. doi request reprint The economic burden of obesity worldwide: a systematic review of the direct costs of obesity
    D Withrow
    Department of Life Sciences, Queen s University, Toronto, ON, Canada
    Obes Rev 12:131-41. 2011
    ..Accordingly, future studies must better explore how costs accrue among obese populations, in order to best facilitate health and social policy interventions...
  69. doi request reprint The relationship between unprovoked venous thromboembolism, age, and acute myocardial infarction
    F A Spencer
    Department of Medicine, McMaster University Medical Center, Hamilton, ON, Canada
    J Thromb Haemost 6:1507-13. 2008
    ..However, the nature and clinical significance of this association remain unclear, particularly as it relates to age of presentation...
  70. doi request reprint Design and implementation of a population-based registry of Implantable Cardioverter Defibrillators (ICDs) in Ontario
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, M4N 3M5 Canada
    Heart Rhythm 5:1250-6. 2008
    ..There are scarce population-based data on the use, complication rates, and outcomes of patients receiving implantable cardioverter defibrillators (ICDs)...
  71. ncbi request reprint Both clinical epidemiology and population health perspectives can define the role of health care in reducing health disparities
    Geoffrey M Anderson
    Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, McMurrich Building, 2nd Floor, 12 Queen s Park Crescent West, Toronto, Ontario M5S 1A8, Canada
    J Clin Epidemiol 58:757-62. 2005
    ..To compare and contrast clinical epidemiology and population health perspectives on the role of health care in reducing socioeconomic disparities in health...
  72. ncbi request reprint Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis
    Douglas S Lee
    University of Toronto, Department of Health Policy, Management and Evaluation Clinical Epidemiology, Toronto, Canada
    J Am Coll Cardiol 41:1573-82. 2003
    ..The aim of this study was to compare the effectiveness of the implantable cardioverter defibrillator (ICD) and medical strategies for prevention of arrhythmic events and death...
  73. ncbi request reprint Do case-generic measures of queue performance for bypass surgery accurately reflect the waiting-list experiences of those most urgent?
    Jason Burstein
    University of Toronto, Toronto, Canada
    J Eval Clin Pract 12:87-93. 2006
    ..The objective of this study was to examine whether case-generic measures of queue performance appropriately reflected the waiting-list experiences of those patients with greatest disease severity...
  74. pmc Contribution of patient and physician factors to cardiac rehabilitation enrollment: a prospective multilevel study
    Sherry L Grace
    York University, 4700 Keele St, Toronto, Ontario M3J 1P3, Canada
    Eur J Cardiovasc Prev Rehabil 15:548-56. 2008
    ..This is due to both health system and patient-level factors; issues that have yet to be investigated concurrently. This study utilized a hierarchical design to examine physician and patient-level factors affecting verified CR enrollment...
  75. ncbi request reprint The impact of implantable cardiac defibrillators for primary prophylaxis in the community: baseline risk and clinically meaningful benefits
    S Jolly
    St Michael s Hospital, University of Toronto, Ontario, Canada
    J Eval Clin Pract 12:190-5. 2006
    ..To estimate the baseline risk of arrhythmic death required for prophylactic implantable cardiac defibrillators (ICDs) to result in clinically meaningful survival benefits in the population...
  76. ncbi request reprint The importance of echocardiography in physicians' support of endocarditis prophylaxis
    Sheldon M Singh
    Department of Medicine, University of Toronto, Ontario, Canada
    Arch Intern Med 166:549-53. 2006
    ..Our objective was to explore physicians' perspectives regarding the importance of echocardiography in the evaluation and management of endocarditis prophylaxis...
  77. ncbi request reprint Are some patients in Canada treated more equally than others? The Orwell prophecy
    David A Alter
    Am Heart J 146:938-40. 2003
  78. pmc Is routine early invasive management of non-ST-segment elevation myocardial infarction beneficial in elderly patients?
    Sheldon M Singh
    Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, University of Toronto Toronto, Ont
    CMAJ 171:1046-7. 2004
  79. ncbi request reprint Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohort
    Raj Padwal
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Diabetes Care 27:2458-63. 2004
    ..The aim of this study was to determine whether the incidence of type 2 diabetes differed among elderly users of four major antihypertensive drug classes...
  80. ncbi request reprint Where does the waiting list begin? A short review of the dynamics and organization of modern waiting lists
    Dalia L Rotstein
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Soc Sci Med 62:3157-60. 2006
    ..Real-world examples are used to illustrate the infancy of funnel or demand-side reform initiatives targeting the queue, and the suggestion is made that policy needs to address the concept of 'waiting' much earlier in the treatment cycle...
  81. pmc The Smoking Regulatory Index: a new way to measure public health performance
    Daniel Rosenfield
    Canadian Cardiac Outcomes Research Team and Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 174:1403-4. 2006
  82. ncbi request reprint Relation between cardiac troponin I and mortality in acute decompensated heart failure
    John J You
    Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, Canada
    Am Heart J 153:462-70. 2007
    ..Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain...
  83. pmc Addressing the challenges of queues
    Dalia L Rotstein
    CMAJ 166:299-300. 2002