Carole L Yauk

Summary

Affiliation: Health Canada
Country: Canada

Publications

  1. pmc NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    Anne Mette Zenner Boisen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Part Fibre Toxicol 9:19. 2012
  2. pmc Identification of thyroid hormone receptor binding sites in developing mouse cerebellum
    Remi Gagne
    Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0L2, Canada
    BMC Genomics 14:341. 2013
  3. pmc Harnessing genomics to identify environmental determinants of heritable disease
    Carole Lyn Yauk
    Health Canada, Canada
    Mutat Res 752:6-9. 2013
  4. pmc Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full-flavor, blonde, and light products
    Carole L Yauk
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 53:281-96. 2012
  5. pmc Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis
    Julie A Bourdon
    Environmental Health Sciences and Research Bureau, Mechanistic Studies Division, Health Canada, Ottawa, Canada, K1A 0K9
    Toxicol Sci 127:474-84. 2012
  6. doi request reprint Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice
    Breanne G Swayne
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Mutat Res 737:1-7. 2012
  7. doi request reprint Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation
    Mainul Husain
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada
    Toxicol Appl Pharmacol 269:250-62. 2013
  8. doi request reprint Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure
    Julie A Bourdon
    Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Drive, Tunney s Pasture, Ottawa, Canada
    Toxicology 303:83-93. 2013
  9. doi request reprint Impact of nose-only exposure system on pulmonary gene expression
    Errol M Thomson
    Hazard Identification Division, Environmental Health Studies and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Canada
    Inhal Toxicol 21:74-82. 2009
  10. doi request reprint Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung
    Julie A Bourdon
    Environmental Health Science and Research Bureau, Health Canada, Tunney s Pasture, Ottawa, Canada K1A 0K9
    Environ Mol Mutagen 53:462-8. 2012

Collaborators

Detail Information

Publications45

  1. pmc NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    Anne Mette Zenner Boisen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Part Fibre Toxicol 9:19. 2012
    ..Here we investigate the effects of nanoparticles on the female germline. Since pulmonary exposure to nanosized titanium dioxide (nanoTiO(2)) produces a long-lasting inflammatory response in mice, it was chosen for the present study...
  2. pmc Identification of thyroid hormone receptor binding sites in developing mouse cerebellum
    Remi Gagne
    Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0L2, Canada
    BMC Genomics 14:341. 2013
    ..We have performed a detailed computational analysis of these data...
  3. pmc Harnessing genomics to identify environmental determinants of heritable disease
    Carole Lyn Yauk
    Health Canada, Canada
    Mutat Res 752:6-9. 2013
    ..Research is urgently needed to establish the health consequences of parental exposures on subsequent generations...
  4. pmc Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full-flavor, blonde, and light products
    Carole L Yauk
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 53:281-96. 2012
    ....
  5. pmc Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis
    Julie A Bourdon
    Environmental Health Sciences and Research Bureau, Mechanistic Studies Division, Health Canada, Ottawa, Canada, K1A 0K9
    Toxicol Sci 127:474-84. 2012
    ..Although further research is needed to establish links between observations and the onset and progression of systemic disorders, the present study demonstrates the ability of NPs to induce systemic effects...
  6. doi request reprint Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice
    Breanne G Swayne
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Mutat Res 737:1-7. 2012
    ..Folic acid supplementation at the level achieved in this study does not improve nor is it detrimental to male germline chromatin integrity...
  7. doi request reprint Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation
    Mainul Husain
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada
    Toxicol Appl Pharmacol 269:250-62. 2013
    ..Our gene expression results imply that retention of nano-TiO2 in the absence of inflammation over time may potentially perturb calcium and ion homeostasis, and affect smooth muscle activities...
  8. doi request reprint Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure
    Julie A Bourdon
    Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Drive, Tunney s Pasture, Ottawa, Canada
    Toxicology 303:83-93. 2013
    ....
  9. doi request reprint Impact of nose-only exposure system on pulmonary gene expression
    Errol M Thomson
    Hazard Identification Division, Environmental Health Studies and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Canada
    Inhal Toxicol 21:74-82. 2009
    ..Observed responses may warrant consideration in the evaluation of materials delivered by nose-only inhalation, and suggest that incorporation of naive animals into nose-only studies should be considered as a best practice...
  10. doi request reprint Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung
    Julie A Bourdon
    Environmental Health Science and Research Bureau, Health Canada, Tunney s Pasture, Ottawa, Canada K1A 0K9
    Environ Mol Mutagen 53:462-8. 2012
    ..We hypothesize that changes in the expression of these miRNAs may be associated with resolution of pulmonary inflammation, but future work will be necessary to precisely identify specific targets of these miRNAs in lungs...
  11. pmc IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation
    Sabina Halappanavar
    Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada
    J Immunol 190:3679-86. 2013
    ..These results suggest that miR-135b expression during cigarette smoke-induced inflammation is regulated by IL-1R1 in a regulatory feedback mechanism to resolve inflammation...
  12. pmc Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Tunney s Pasture, 50 Columbine Driveway, Ottawa, Ontario, Canada
    Inhal Toxicol 21:78-85. 2009
    ..Thus, gene expression profiling of heart tissue revealed a novel cardiovascular mechanism operating in response to MTS. Our results suggest a potential role for PAI-1 in MTS-induced cardiovascular pathology...
  13. pmc Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses
    Martin A Paquette
    Environmental Health Sciences and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, Ontario K1A 0K9, Canada
    BMC Genomics 12:634. 2011
    ..An additional group received only thyroid hormones four hours prior to sacrifice (hyperthyroid). Hepatic mRNA was extracted and hybridized to Agilent mouse microarrays...
  14. pmc Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 52:425-39. 2011
    ..The role of these miRNAs in pulmonary response to inhaled particles is unknown and warrants further research...
  15. doi request reprint No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea
    Jason M O'Brien
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada
    Mutat Res 741:11-7. 2013
    ..These findings suggest that TGI may not extend to all genetic endpoints and that further investigation of this phenomenon and its health relevance will require multiple measures of genomic damage...
  16. doi request reprint Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice
    Jenny L Zheng
    Mechanistic Studies Division, Safe Environments Programme, Health Canada, Ottawa, Ontario K1A0K9, Canada
    Regul Toxicol Pharmacol 60:54-72. 2011
    ....
  17. doi request reprint Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways
    Andrea Rowan-Carroll
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 54:240-9. 2013
    ..Further investigation into the stimulation of lipid droplet synthesis in the lung in response to air pollution and the resulting health implications is warranted. Environ. Mol. Mutagen. 54:240-249, 2013. © 2013 Wiley Periodicals, Inc...
  18. doi request reprint Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 49:26-35. 2008
    ....
  19. pmc Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Program, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Genomics 7:266. 2006
    ..Furthermore, many microarrays lack control features that can be used for quality assurance (QA). Here, we describe a novel external control series integrated with a design feature that addresses the above issues...
  20. ncbi request reprint Mainstream tobacco smoke causes paternal germ-line DNA mutation
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
    Cancer Res 67:5103-6. 2007
    ..Our research suggests that the consequences of smoking extend beyond the smoker to their nonsmoking descendents...
  21. doi request reprint Transcriptional profiles in the cerebral hemisphere of chicken embryos following in ovo perfluorohexane sulfonate exposure
    Cristina G Cassone
    Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Sci 129:380-91. 2012
    ....
  22. pmc Acetaminophen modulates the transcriptional response to recombinant interferon-beta
    Aaron Farnsworth
    Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 5:e11031. 2010
    ..Patients are often advised to use acetaminophen or other over-the-counter pain medications as needed. Little is known regarding the transcriptional changes induced by such co-administration...
  23. pmc Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation
    Amal I Malik
    Environmental Health Sciences and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, Canada K1A 0K9
    Environ Mol Mutagen 53:10-21. 2012
    ..In summary, the validated miRNA and mRNA expression profiles following 28 day BaP exposure reflect a DNA damage response and effects on the cell cycle, consistent with the observed increases in DNA adducts and mutations...
  24. doi request reprint Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways
    Errol M Thomson
    Hazard Identification Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Am J Pathol 180:1413-30. 2012
    ..Impairment of myofibroblast differentiation and extracellular matrix production may underlie resistance to induction of fibrosis...
  25. doi request reprint A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro
    Rebecca M Maertens
    Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada
    Toxicology 308:60-73. 2013
    ..This study shows that in general MSC impacts many of the same molecular processes as TSC. However, subtle pathway differences can provide insight into the differential toxicities of the two complex mixtures...
  26. ncbi request reprint Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
    Vinita Chauhan
    Consumer and Clinical Radiation Protection Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Proteomics 7:3896-905. 2007
    ..However, exposure of both cell-lines to heat-shock conditions (43 degrees C for 1 h) caused an alteration in the expression of a number of well-characterized heat-shock proteins...
  27. doi request reprint Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene
    Amal I Malik
    Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario K1A 0K9, Canada and
    Mutagenesis 28:543-54. 2013
    ..MicroRNA expression was identical for both chemicals, with only miR-34a showing a dose-dependent increase in treated mice. ..
  28. doi request reprint Technical-grade perfluorooctane sulfonate alters the expression of more transcripts in cultured chicken embryonic hepatocytes than linear perfluorooctane sulfonate
    Jason M O'Brien
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Environ Toxicol Chem 30:2846-59. 2011
    ..These data show that T-PFOS elicits a greater transcriptional response in CEH than L-PFOS alone and demonstrates the importance of considering the isomer-specific toxicological properties of PFOS when assessing exposure risk...
  29. pmc Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum
    Hongyan Dong
    Hazard Identification Division, EHSRB, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 4:e4610. 2009
    ..These findings provide mechanistic insight into impaired neurodevelopment resulting from TH deficiency and a rich bioinformatics resource for developing a better understanding of TR binding...
  30. pmc Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver
    Julie A Bourdon
    Health Canada, Environmental and Radiation Health Sciences Directorate, Mechanistic Studies Division, Tunney s Pasture, Ottawa, Canada
    Part Fibre Toxicol 9:5. 2012
    ..Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about their genotoxicity in various organs in vivo...
  31. doi request reprint Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice
    Hongyan Dong
    Hazard Identification Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario, Canada K1A 0K9
    Biochem Biophys Res Commun 415:157-62. 2011
    ..Given the important role of Barhl1 in brain development, we propose that perturbations of TH-mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism...
  32. ncbi request reprint Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element
    Hongyan Dong
    Environmental and Occupational Toxicology Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Columbine Driveway, Ottawa, Ontario, Canada K1A 0L2
    Endocrinology 148:3932-40. 2007
    ....
  33. pmc Cross-platform analysis of global microRNA expression technologies
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada
    BMC Genomics 11:330. 2010
    ..We examined within and between platform reproducibility of four miRNA array technologies alongside TaqMan PCR arrays...
  34. doi request reprint In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA
    Jason M O'Brien
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 20 Marie Curie, Ottawa, ON, Canada K1N 6N5 National Wildlife Research Centre, Environment Canada, 1125 Colonel By Drive, Raven Road, Ottawa, ON, Canada K1A 0H3 Electronic address
    Toxicol In Vitro 27:1649-58. 2013
    ..These findings suggest in ovo exposure of birds to PFUdA may lead to post-hatch developmental deficiencies, such as impaired inflammatory response. ..
  35. pmc Review of the literature examining the correlation among DNA microarray technologies
    Carole L Yauk
    Environmental and Occupational Toxicology Division, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Environ Mol Mutagen 48:380-94. 2007
    ..We suggest several key factors that should be controlled in comparing across technologies, and are good microarray practice in general...
  36. doi request reprint Germ cell mutagens: risk assessment challenges in the 21st century
    Timothy M Singer
    Mechanistic Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 51:919-28. 2010
    ..Appropriate attention to these areas will result in the development of policies that prioritize the protection of the germline and future generations from DNA sequence mutations...
  37. doi request reprint Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform
    A Francina Jackson
    Mechanistic Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa K1A 0K9, Canada Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    J Pharmacol Toxicol Methods 68:260-8. 2013
    ..Gene expression analysis of archival FFPE tissues may advance knowledge of the molecular perturbations contributing to disease. However, formalin causes extensive degradation of RNA...
  38. ncbi request reprint Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays
    Timothy M Singer
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont, Canada K1A 0K9
    Mutat Res 598:164-93. 2006
    ....
  39. pmc Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice
    Breanne G Swayne
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada
    J Nutr 142:813-7. 2012
    ..The results suggest that chronic exposure to folic acid at the levels similar to those achieved through fortification is unlikely to be clastogenic or aneugenic...
  40. ncbi request reprint Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid
    Aris Polyzos
    Environmental Health Centre, Environmental and Occupational Toxicology Division, Health Canada, Tunney s Pasture, P L 0803A, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 598:73-84. 2006
    ..In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in cell culture...
  41. pmc Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Med Genomics 2:56. 2009
    ..Detailed analyses were undertaken for IL-6 and its associated pathways. Our results provide further insight into the role of these pathways in lung injury and inflammation induced by MTS...
  42. doi request reprint Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation
    Caitlin Ritz
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada
    Mutat Res 712:55-8. 2011
    ..05). Thus, maternal exposure to DEP results in increased mutation in sperm during development...
  43. ncbi request reprint A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells
    Carole L Yauk
    Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 578:117-23. 2005
    ..The results indicate that transgene mutations in granulosa cells may provide a sensitive pre-screening tool for potential genotoxic germ cell effects of exposed oocytes...
  44. pmc Comprehensive comparison of six microarray technologies
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division and Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
    Nucleic Acids Res 32:e124. 2004
    ..Most importantly, we show the top four platforms are highly correlated with biological, rather than technological, differences accounting for the majority of variation in the data...
  45. pmc Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation
    Errol M Thomson
    Environment and Occupational Toxicology Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada
    Part Fibre Toxicol 6:6. 2009
    ..abstract:..