C L Yauk

Summary

Affiliation: Health Canada
Country: Canada

Publications

  1. ncbi request reprint A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus
    Carole L Yauk
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Mutat Res 500:147-56. 2002
  2. doi request reprint Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 49:26-35. 2008
  3. ncbi request reprint Mainstream tobacco smoke causes paternal germ-line DNA mutation
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
    Cancer Res 67:5103-6. 2007
  4. ncbi request reprint Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
    Vinita Chauhan
    Consumer and Clinical Radiation Protection Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Proteomics 7:3896-905. 2007
  5. pmc Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
  6. pmc Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation
    Errol M Thomson
    Environment and Occupational Toxicology Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada
    Part Fibre Toxicol 6:6. 2009
  7. pmc Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation
    Anne T Saber
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Part Fibre Toxicol 6:12. 2009
  8. pmc Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Med Genomics 2:56. 2009
  9. pmc Testing for mean and correlation changes in microarray experiments: an application for pathway analysis
    Mayer Alvo
    Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, Ontario, Canada
    BMC Bioinformatics 11:60. 2010
  10. pmc Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Program, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Genomics 7:266. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus
    Carole L Yauk
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Mutat Res 500:147-56. 2002
    ....
  2. doi request reprint Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 49:26-35. 2008
    ....
  3. ncbi request reprint Mainstream tobacco smoke causes paternal germ-line DNA mutation
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
    Cancer Res 67:5103-6. 2007
    ..Our research suggests that the consequences of smoking extend beyond the smoker to their nonsmoking descendents...
  4. ncbi request reprint Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
    Vinita Chauhan
    Consumer and Clinical Radiation Protection Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Proteomics 7:3896-905. 2007
    ..However, exposure of both cell-lines to heat-shock conditions (43 degrees C for 1 h) caused an alteration in the expression of a number of well-characterized heat-shock proteins...
  5. pmc Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
    ..Changes in methylation can have widespread repercussions for chromatin structure, gene expression and genome stability. Potential health effects warrant extensive further investigation...
  6. pmc Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation
    Errol M Thomson
    Environment and Occupational Toxicology Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada
    Part Fibre Toxicol 6:6. 2009
    ..abstract:..
  7. pmc Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation
    Anne T Saber
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Part Fibre Toxicol 6:12. 2009
    ..abstract:..
  8. pmc Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Med Genomics 2:56. 2009
    ..Detailed analyses were undertaken for IL-6 and its associated pathways. Our results provide further insight into the role of these pathways in lung injury and inflammation induced by MTS...
  9. pmc Testing for mean and correlation changes in microarray experiments: an application for pathway analysis
    Mayer Alvo
    Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, Ontario, Canada
    BMC Bioinformatics 11:60. 2010
    ..The issue of how to incorporate the influence of correlation among the genes is not generally addressed...
  10. pmc Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Program, Health Canada, Ottawa, Ontario, K1A 0L2, Canada
    BMC Genomics 7:266. 2006
    ..Furthermore, many microarrays lack control features that can be used for quality assurance (QA). Here, we describe a novel external control series integrated with a design feature that addresses the above issues...
  11. pmc Cross-platform analysis of global microRNA expression technologies
    Carole L Yauk
    Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada
    BMC Genomics 11:330. 2010
    ..We examined within and between platform reproducibility of four miRNA array technologies alongside TaqMan PCR arrays...
  12. ncbi request reprint Automation of cDNA microarray hybridization and washing yields improved data quality
    Carole Yauk
    Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
    J Biochem Biophys Methods 64:69-75. 2005
    ..This decreased variation led to improved correlation among technical replicates across slides in both the Cy3 and Cy5 channels...
  13. pmc Comprehensive comparison of six microarray technologies
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division and Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
    Nucleic Acids Res 32:e124. 2004
    ..Most importantly, we show the top four platforms are highly correlated with biological, rather than technological, differences accounting for the majority of variation in the data...
  14. ncbi request reprint Advances in the application of germline tandem repeat instability for in situ monitoring
    Carole L Yauk
    Environmental Health Centre, Health Canada, Tunney s Pasture, 0803A, Ottawa, Ont, Canada, K1A 0L2
    Mutat Res 566:169-82. 2004
    ....
  15. pmc High-resolution sperm typing of meiotic recombination in the mouse MHC Ebeta gene
    C L Yauk
    Department of Genetics, University of Leicester, Leicester, LE1 7RH, UK
    EMBO J 22:1389-97. 2003
    ..The detailed behaviour of the E(beta) hotspot, including evidence for highly localized recombination initiation, is strikingly similar to human hotspots...
  16. doi request reprint Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response
    Carole Lyn Yauk
    Environmental Health Sciences and Research Bureau, Health Canada, ON, Canada
    Mutat Res 722:131-9. 2011
    ..Our results are consistent with the lack of response of miRNA in rodent liver to dioxin, another potent AHR-agonist. We conclude that hepatic miRNA in vivo is not directly responsive to BaP exposure...
  17. ncbi request reprint Microarray gene expression profiling of a human glioblastoma cell line exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
    S S Qutob
    Consumer and Clinical Radiation Protection Bureau, Healthy Environment and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada, K1A 1C1
    Radiat Res 165:636-44. 2006
    ..Future studies will assess the effect of RF fields on other cell lines and on gene expression in the mouse brain after in vivo exposure...
  18. ncbi request reprint Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element
    Hongyan Dong
    Environmental and Occupational Toxicology Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Columbine Driveway, Ottawa, Ontario, Canada K1A 0L2
    Endocrinology 148:3932-40. 2007
    ....
  19. ncbi request reprint Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid
    Aris Polyzos
    Environmental Health Centre, Environmental and Occupational Toxicology Division, Health Canada, Tunney s Pasture, P L 0803A, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 598:73-84. 2006
    ..In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in cell culture...
  20. pmc Air pollution induces heritable DNA mutations
    Christopher M Somers
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Proc Natl Acad Sci U S A 99:15904-7. 2002
    ..Our results indicate that human and wildlife populations in proximity to integrated steel mills may be at risk of developing germline mutations more frequently because of the inhalation of airborne chemical mutagens...
  21. ncbi request reprint Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays
    Timothy M Singer
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont, Canada K1A 0K9
    Mutat Res 598:164-93. 2006
    ....
  22. ncbi request reprint A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells
    Carole L Yauk
    Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 578:117-23. 2005
    ..The results indicate that transgene mutations in granulosa cells may provide a sensitive pre-screening tool for potential genotoxic germ cell effects of exposed oocytes...
  23. pmc Review of the literature examining the correlation among DNA microarray technologies
    Carole L Yauk
    Environmental and Occupational Toxicology Division, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Environ Mol Mutagen 48:380-94. 2007
    ..We suggest several key factors that should be controlled in comparing across technologies, and are good microarray practice in general...