Research Topics
| Jayadev RajuSummaryAffiliation: Health Canada Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Cancer chemopreventive and therapeutic effects of diosgenin, a food saponinJayadev Raju
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
Nutr Cancer 61:27-35. 2009....
Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancerJayadev Raju
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, C218 Banting Building, Postal Locator 2202D, Ottawa, K1A 0L2, Ontario, Canada
World J Gastroenterol 14:6632-5. 2008..The role of the dynamics and biological heterogeneity of ACF is critical in understanding them as biomarkers in chemoprevention studies...- Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-betaJayadev Raju
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, K1A 0L2 Ottawa, Ontario
J Nutr 139:474-81. 2009..The overexpression of ERbeta in both rat colon tumors and DLD-1 cells caused by soy isoflavones suggests that ERbeta is a critical mediator in mitigating its cancer-preventive effects... - Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal modelSonal Varma
National Research Council Institute for Biodiagnostics, Winnipeg, Canada
J Inflamm (Lond) 4:24. 2007..The aim of this study was to analyze the potential of proton magnetic resonance spectroscopy (1H MRS) in diagnosing early inflammatory bowel disease (IBD)... - Dietary acrylamide does not increase colon aberrant crypt foci formation in male F344 ratsJayadev Raju
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, Canada
Food Chem Toxicol 49:1373-80. 2011..On the contrary, a high dose of dietary acrylamide decreased the growth of precancerous lesions in both low and high fat diet regimens in this model... - Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavonesAgnieszka Bielecki
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
Nutr Cancer 63:139-50. 2011..Thus upregulation of ER-β status by specific food-borne ER-ligands such as soy isoflavones could potentially be a dietary prevention or therapeutic strategy for colon cancer... 
Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cellsJayadev Raju
Toxicology Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ont, Canada
Cancer Lett 255:194-204. 2007..Importantly, our result identifies that the growth suppressive or apoptotic activity of diosgenin may involve cholesterol homeostasis...- Dietary fructooligosaccharides and wheat bran elicit specific and dose-dependent gene expression profiles in the proximal colon epithelia of healthy Fischer 344 ratsQixuan Chen
Nutrition Research Division, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, Canada
J Nutr 141:790-7. 2011..These results show that both the amount and source of FM determine proximal colon epithelial gene response patterns in rats... - Obese state leads to elevated levels of TGF-beta and COX isoforms in platelets of Zucker ratsJayadev Raju
Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
Mol Cell Biochem 284:19-24. 2006....