Jayadev Raju

Summary

Affiliation: Health Canada
Country: Canada

Publications

  1. doi request reprint Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    Nutr Cancer 61:27-35. 2009
  2. pmc Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, C218 Banting Building, Postal Locator 2202D, Ottawa, K1A 0L2, Ontario, Canada
    World J Gastroenterol 14:6632-5. 2008
  3. doi request reprint Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, K1A 0L2 Ottawa, Ontario
    J Nutr 139:474-81. 2009
  4. pmc Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model
    Sonal Varma
    National Research Council Institute for Biodiagnostics, Winnipeg, Canada
    J Inflamm (Lond) 4:24. 2007
  5. doi request reprint Dietary acrylamide does not increase colon aberrant crypt foci formation in male F344 rats
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, Canada
    Food Chem Toxicol 49:1373-80. 2011
  6. pmc Negligible colon cancer risk from food-borne acrylamide exposure in male F344 rats and nude (nu/nu) mice-bearing human colon tumor xenografts
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 8:e73916. 2013
  7. doi request reprint Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones
    Agnieszka Bielecki
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    Nutr Cancer 63:139-50. 2011
  8. ncbi request reprint Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells
    Jayadev Raju
    Toxicology Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ont, Canada
    Cancer Lett 255:194-204. 2007
  9. doi request reprint Dietary fructooligosaccharides and wheat bran elicit specific and dose-dependent gene expression profiles in the proximal colon epithelia of healthy Fischer 344 rats
    Qixuan Chen
    Nutrition Research Division, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, Canada
    J Nutr 141:790-7. 2011
  10. ncbi request reprint Obese state leads to elevated levels of TGF-beta and COX isoforms in platelets of Zucker rats
    Jayadev Raju
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Mol Cell Biochem 284:19-24. 2006

Collaborators

  • Rekha Mehta
  • Qixuan Chen
  • Jennifer Roberts
  • Agnieszka Bielecki
  • Sonal Varma
  • Judy Green
  • Eleonora Swist
  • Jocelyn Beckstead
  • Fernando Matias
  • Stephen P J Brooks
  • Cunye Qiao
  • Kylie A Scoggan
  • Brion Dolenko
  • Ranjana Bird
  • Tedros Bezabeh
  • Michael Eskin

Detail Information

Publications10

  1. doi request reprint Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    Nutr Cancer 61:27-35. 2009
    ....
  2. pmc Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, C218 Banting Building, Postal Locator 2202D, Ottawa, K1A 0L2, Ontario, Canada
    World J Gastroenterol 14:6632-5. 2008
    ..The role of the dynamics and biological heterogeneity of ACF is critical in understanding them as biomarkers in chemoprevention studies...
  3. doi request reprint Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, K1A 0L2 Ottawa, Ontario
    J Nutr 139:474-81. 2009
    ..The overexpression of ERbeta in both rat colon tumors and DLD-1 cells caused by soy isoflavones suggests that ERbeta is a critical mediator in mitigating its cancer-preventive effects...
  4. pmc Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model
    Sonal Varma
    National Research Council Institute for Biodiagnostics, Winnipeg, Canada
    J Inflamm (Lond) 4:24. 2007
    ..The aim of this study was to analyze the potential of proton magnetic resonance spectroscopy (1H MRS) in diagnosing early inflammatory bowel disease (IBD)...
  5. doi request reprint Dietary acrylamide does not increase colon aberrant crypt foci formation in male F344 rats
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, Canada
    Food Chem Toxicol 49:1373-80. 2011
    ..On the contrary, a high dose of dietary acrylamide decreased the growth of precancerous lesions in both low and high fat diet regimens in this model...
  6. pmc Negligible colon cancer risk from food-borne acrylamide exposure in male F344 rats and nude (nu/nu) mice-bearing human colon tumor xenografts
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 8:e73916. 2013
    ..However, our results characterize a potential hazard of acrylamide as a colon co-carcinogen in association with known and possibly other environmental tumor initiators/promoters. ..
  7. doi request reprint Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones
    Agnieszka Bielecki
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada
    Nutr Cancer 63:139-50. 2011
    ..Thus upregulation of ER-β status by specific food-borne ER-ligands such as soy isoflavones could potentially be a dietary prevention or therapeutic strategy for colon cancer...
  8. ncbi request reprint Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells
    Jayadev Raju
    Toxicology Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ont, Canada
    Cancer Lett 255:194-204. 2007
    ..Importantly, our result identifies that the growth suppressive or apoptotic activity of diosgenin may involve cholesterol homeostasis...
  9. doi request reprint Dietary fructooligosaccharides and wheat bran elicit specific and dose-dependent gene expression profiles in the proximal colon epithelia of healthy Fischer 344 rats
    Qixuan Chen
    Nutrition Research Division, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, Canada
    J Nutr 141:790-7. 2011
    ..These results show that both the amount and source of FM determine proximal colon epithelial gene response patterns in rats...
  10. ncbi request reprint Obese state leads to elevated levels of TGF-beta and COX isoforms in platelets of Zucker rats
    Jayadev Raju
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Mol Cell Biochem 284:19-24. 2006
    ....