Research Topics
| Mohamed A KarmaliSummaryAffiliation: Health Canada Country: Canada Publications
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Detail Information
Publications
Infection by Shiga toxin-producing Escherichia coli: an overviewMohamed A Karmali
Laboratory for Foodborne Zoonoses, Health Canada, 110 Stone Road West, Guelph, Ontario, Canada, N1G 3W4
Mol Biotechnol 26:117-22. 2004..The recent sequencing of genomes of two epidemic E. coli O157 strains has revealed novel pathogenicity islands which will likely provide new insights into the virulence of these bacteria...
Genomic O island 122, locus for enterocyte effacement, and the evolution of virulent verocytotoxin-producing Escherichia coliPaulina Konczy
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, 110 Stone Rd West, Guelph, Ontario, Canada N1G 3W4
J Bacteriol 190:5832-40. 2008..Correlations between clonal group, seropathotype, and LEE and OI-122 content provide insight into the role of genomic islands in VTEC evolution...- Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypesJohn He Nash
Public Health Agency of Canada, Toronto, Ontario, Canada
BMC Genomics 11:667. 2010..To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated E. coli pathotype... - Evidence for a hybrid genomic island in verocytotoxin-producing Escherichia coli CL3 (serotype O113:H21) containing segments of EDL933 (serotype O157:H7) O islands 122 and 48Songhai Shen
Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario N1G 3W4, Canada
Infect Immun 72:1496-503. 2004..In contrast, fragmented Z1640 was seen in strains of nonepidemic serotypes, such as O91:H21 and O113:H21, and in animal serotypes that have not been associated with human disease, indicating that Z1640 might be a virulence gene... - Identification of four fimbria-encoding genomic islands that are highly specific for verocytotoxin-producing Escherichia coli serotype O157 strainsSonghai Shen
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, 110 Stone Road West, Guelph, Ontario, Canada, N1G 3W4
J Clin Microbiol 43:3840-50. 2005..The occurrence of the four OIs in enteropathogenic E. coli O55:H7 strains is consistent with their vertical inheritance by VTEC O157:H7/NM from this clonally related ancestor... - Applicability of phylogenetic methods for characterizing the public health significance of verocytotoxin-producing Escherichia coli strainsKim Ziebell
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, Ontario N1G 3W4, Canada
Appl Environ Microbiol 74:1671-5. 2008..MLST was able to separate 96% of seropathotype D and E serotypes from those that cause serious disease (seropathotypes A to C), whereas the multiplex PCR lacked this level of seropathotype discrimination... - In silico genomic analyses reveal three distinct lineages of Escherichia coli O157:H7, one of which is associated with hyper-virulenceChad R Laing
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB, Canada
BMC Genomics 10:287. 2009..coli genome sequences from 17 O157:H7 strains and single O145:NM and K12 MG1655 strains to provide an overall picture of diversity of the E. coli O157:H7 population, and to compare genotyping methods for O157:H7 strains... 
Verocytotoxin-producing Escherichia coli (VTEC)Mohamed A Karmali
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Canada
Vet Microbiol 140:360-70. 2010..Despite these efforts many scientific, technical and regulatory challenges remain in the control and prevention of VTEC-associated human illness...- Age-specific frequencies of antibodies to Escherichia coli verocytotoxins (Shiga toxins) 1 and 2 among urban and rural populations in southern OntarioMohamed A Karmali
Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
J Infect Dis 188:1724-9. 2003.... - Rapid genoserotyping tool for classification of Salmonella serovarsKristyn Franklin
Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, 110 Stone Road West, Guelph, Ontario, Canada N1G 3W4
J Clin Microbiol 49:2954-65. 2011..Future experiments are planned to test the specificity of the array probes with other Salmonella serovars to demonstrate the versatility and utility of this array as a public health tool in the identification of Salmonella... - Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious diseaseMohamed A Karmali
Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
J Clin Microbiol 41:4930-40. 2003..0001)... - The medical significance of Shiga toxin-producing Escherichia coli infections. An overviewMohamed A Karmali
Laboratory for Foodborne Zoonoses, Health Canada, Guelph, Canada
Methods Mol Med 73:1-7. 2003 - The continuing evolution of a bacterial pathogenJames B Kaper
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 105:4535-6. 2008 - Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strainsBrian K Coombes
Department of Biochemistry and Biomedical Sciences, McMaster University, Health Sciences Centre 4H17, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
Appl Environ Microbiol 74:2153-60. 2008..These results and methods offer a molecular risk assessment strategy to rapidly recognize and respond to non-O157 STEC strains from environmental and animal sources that might pose serious public health risks to humans... - Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infectionsDiana Karpman
Center for Vaccine Development, University of Maryland, Baltimore, USA
Pediatr Nephrol 17:201-11. 2002..In cases of hemolytic uremic syndrome or hemorrhagic colitis this assay may be useful when a fecal strain has not been isolated, or in epidemics of non-O157 infection... - Shiga toxin-producing Escherichia coli infection and antibodies against Stx2 and Stx1 in household contacts of children with enteropathic hemolytic-uremic syndromeKerstin Ludwig
Klinik und Poliklinik für Kinder und Jugendmedizin, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
J Clin Microbiol 40:1773-82. 2002..9 years of age, suggests a protective role for anti-Stx and anti-O157 LPS antibodies... - Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspasesJoyce C Y Ching
Research Institute, Hospital for Sick Children, University of Toronto, Canada
Infect Immun 70:4669-77. 2002.... - Prospects for preventing serious systemic toxemic complications of Shiga toxin-producing Escherichia coli infections using Shiga toxin receptor analoguesMohamed A Karmali
J Infect Dis 189:355-9. 2004 - The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. 1985Mohamed A Karmali
J Infect Dis 189:556-63. 2004 - Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infectionMark E Wickham
Michael Smith Laboratories, University of British Columbia, Vancouver BC, Canada
J Infect Dis 194:819-27. 2006..The present study shows that virulence genes associated epidemiologically with outbreaks and HUS after non-O157 STEC infection are pivotal to the initiation, progression, and outcome of in vivo disease... - Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1Narveen Jandu
Research Institute, Hospital for Sick Children, Ont, Canada
Microb Pathog 42:62-71. 2007..The results of treatment with wortmannin suggest that the bacterial-derived inhibitory factor employs host cell signal transduction to mediate inhibition of Stat1-activation... - SepZ/EspZ is secreted and translocated into HeLa cells by the enteropathogenic Escherichia coli type III secretion systemKristen J Kanack
Center for Vaccine Development and Deparmtent of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore St, Baltimore, Maryland 21201, USA
Infect Immun 73:4327-37. 2005..To indicate its newly identified status as a translocated effector protein, we propose to rename SepZ as EspZ... - Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coliMatthew W Gilmour
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
J Clin Microbiol 45:3771-3. 2007..However, both STEC serotypes are known to cause serious disease, and the significant repertoire of virulence determinants in both strains made it impossible to determine their individual contributions to the clinical symptoms... - Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleEMark E Wickham
Michael Smith Laboratories, The University of British Columbia, 301 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Microbes Infect 9:400-7. 2007..The induction of in vivo disease correlates strongly with the degree of colonisation, suggesting that the colonisation advantage type III secretion genes afford the bacteria, contribute to, and are required for, full virulence...