Hideki Ebihara

Summary

Affiliation: Health Canada
Country: Canada

Publications

  1. ncbi The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
  2. pmc Tyro3 family-mediated cell entry of Ebola and Marburg viruses
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 80:10109-16. 2006
  3. pmc Molecular determinants of Ebola virus virulence in mice
    Hideki Ebihara
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Pathog 2:e73. 2006
  4. ncbi In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein
    Hideki Ebihara
    Department of Special Pathogens, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Infect Dis 196:S313-22. 2007
  5. pmc Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 86:2067-78. 2012
  6. pmc Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport
    Seiya Yamayoshi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Cell Host Microbe 3:168-77. 2008
  7. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
  8. ncbi In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 196:S382-9. 2007
  9. ncbi Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification
    Yohei Kurosaki
    National Research Institute of Police Science, Kashiwa 277 0882, Japan
    J Virol Methods 141:78-83. 2007
  10. pmc Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates
    Gabriele Neumann
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Virol 81:2995-8. 2007

Collaborators

Detail Information

Publications10

  1. ncbi The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
    ..Here we review the existing reverse genetics systems for VHF causing viruses and discuss their use in studying viral replication, pathogenesis, and the development of antivirals and vaccines...
  2. pmc Tyro3 family-mediated cell entry of Ebola and Marburg viruses
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 80:10109-16. 2006
    ..Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection...
  3. pmc Molecular determinants of Ebola virus virulence in mice
    Hideki Ebihara
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Pathog 2:e73. 2006
    ..These findings suggest a critical role for overcoming the interferon-induced antiviral state in the pathogenicity of EBOV and offer new insights into the pathogenesis of EBOV infection...
  4. ncbi In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein
    Hideki Ebihara
    Department of Special Pathogens, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Infect Dis 196:S313-22. 2007
    ..These findings demonstrate that the incorporation of a foreign gene will attenuate ZEBOV in vivo but that these viruses still have potential for in vitro and in vivo research applications...
  5. pmc Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 86:2067-78. 2012
    ..The identification of these four molecules as Lassa virus receptors advances our understanding of Lassa virus cell entry...
  6. pmc Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport
    Seiya Yamayoshi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Cell Host Microbe 3:168-77. 2008
    ..These findings identify a conserved intersection between a host pathway and filovirus replication, an intersection that can be targeted in the development of new antiviral drugs...
  7. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
    ..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
  8. ncbi In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 196:S382-9. 2007
    ..Therefore, we explored the application of minigenomes as screening tools to identify functional siRNA targets under biosafety level 2 conditions...
  9. ncbi Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification
    Yohei Kurosaki
    National Research Institute of Police Science, Kashiwa 277 0882, Japan
    J Virol Methods 141:78-83. 2007
    ..Furthermore, as this technique does not require sophisticated instrumentation, it seems very suitable for diagnosis in the field or laboratories in Ebola outbreak areas such as Central Africa...
  10. pmc Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates
    Gabriele Neumann
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Virol 81:2995-8. 2007
    ..We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates...